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Protein

Zinc finger protein 593

Gene

ZNF593

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 85C2H2-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • ribosomal large subunit binding Source: GO_Central
  • zinc ion binding Source: CAFA

GO - Biological processi

  • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
  • positive regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • ribosomal large subunit export from nucleus Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 593
Alternative name(s):
Zinc finger protein T86
Gene namesi
Name:ZNF593
Synonyms:ZT86
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142684.7.
HGNCiHGNC:30943. ZNF593.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51042.
OpenTargetsiENSG00000142684.
PharmGKBiPA134962156.

Polymorphism and mutation databases

BioMutaiZNF593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476841 – 134Zinc finger protein 593Add BLAST134

Proteomic databases

EPDiO00488.
MaxQBiO00488.
PaxDbiO00488.
PeptideAtlasiO00488.
PRIDEiO00488.

2D gel databases

SWISS-2DPAGEiO00488.

PTM databases

iPTMnetiO00488.
PhosphoSitePlusiO00488.

Expressioni

Tissue specificityi

Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level in thymus and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000142684.
CleanExiHS_ZNF593.
ExpressionAtlasiO00488. baseline and differential.
GenevisibleiO00488. HS.

Organism-specific databases

HPAiHPA054363.
HPA059387.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-726769,EBI-739832

Protein-protein interaction databases

BioGridi119241. 39 interactors.
IntActiO00488. 8 interactors.
MINTiMINT-1387753.
STRINGi9606.ENSP00000363384.

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi53 – 55Combined sources3
Helixi56 – 59Combined sources4
Turni64 – 66Combined sources3
Helixi73 – 79Combined sources7
Helixi83 – 92Combined sources10
Turni99 – 101Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZR9NMR-A20-134[»]
DisProtiDP00549.
ProteinModelPortaliO00488.
SMRiO00488.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00488.

Family & Domainsi

Domaini

The protein is largely disordered, with the exception of the zinc finger domain.1 Publication

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 85C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3408. Eukaryota.
COG5112. LUCA.
GeneTreeiENSGT00390000004173.
HOGENOMiHOG000216641.
HOVERGENiHBG058255.
InParanoidiO00488.
KOiK14821.
PhylomeDBiO00488.
TreeFamiTF315114.

Family and domain databases

InterProiView protein in InterPro
IPR003604. Matrin/U1-like-C_Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF12171. zf-C2H2_jaz. 1 hit.
SMARTiView protein in SMART
SM00451. ZnF_U1. 1 hit.
SUPFAMiSSF57667. SSF57667. 1 hit.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O00488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRSRRTGAH RAHSLARQMK AKRRRPDLDE IHRELRPQGS ARPQPDPNAE
60 70 80 90 100
FDPDLPGGGL HRCLACARYF IDSTNLKTHF RSKDHKKRLK QLSVEPYSQE
110 120 130
EAERAAGMGS YVPPRRLAVP TEVSTEVPEM DTST
Length:134
Mass (Da):15,199
Last modified:July 28, 2009 - v2
Checksum:i883BCE4F72459818
GO

Sequence cautioni

The sequence AAH02580 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH19267 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA20369 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG34867 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0599246R → Q. Corresponds to variant dbSNP:rs2232649Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311926 mRNA. Translation: BAG34867.1. Different initiation.
AL391650 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07843.1.
BC002580 mRNA. Translation: AAH02580.1. Different initiation.
BC019267 mRNA. Translation: AAH19267.1. Different initiation.
D45213 mRNA. Translation: BAA20369.1. Different initiation.
CCDSiCCDS275.2.
RefSeqiNP_056955.2. NM_015871.4.
UniGeneiHs.477273.

Genome annotation databases

EnsembliENST00000374266; ENSP00000363384; ENSG00000142684.
GeneIDi51042.
KEGGihsa:51042.
UCSCiuc001bll.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN593_HUMAN
AccessioniPrimary (citable) accession number: O00488
Secondary accession number(s): B2R4S0, Q5T2H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 28, 2009
Last modified: September 27, 2017
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families