Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 593

Gene

ZNF593

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 85C2H2-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • ribosomal large subunit binding Source: GO_Central
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • zinc ion binding Source: CAFA

GO - Biological processi

  • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
  • positive regulation of transcription by RNA polymerase II Source: GO_Central
  • ribosomal large subunit export from nucleus Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 593
Alternative name(s):
Zinc finger protein T86
Gene namesi
Name:ZNF593
Synonyms:ZT86
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142684.7
HGNCiHGNC:30943 ZNF593
MIMi616698 gene
neXtProtiNX_O00488

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51042
OpenTargetsiENSG00000142684
PharmGKBiPA134962156

Polymorphism and mutation databases

BioMutaiZNF593

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476841 – 134Zinc finger protein 593Add BLAST134

Proteomic databases

EPDiO00488
MaxQBiO00488
PaxDbiO00488
PeptideAtlasiO00488
PRIDEiO00488

2D gel databases

SWISS-2DPAGEO00488

PTM databases

iPTMnetiO00488
PhosphoSitePlusiO00488

Expressioni

Tissue specificityi

Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level in thymus and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000142684
CleanExiHS_ZNF593
ExpressionAtlasiO00488 baseline and differential
GenevisibleiO00488 HS

Organism-specific databases

HPAiHPA054363
HPA059387

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-726769,EBI-739832

Protein-protein interaction databases

BioGridi119241, 39 interactors
IntActiO00488, 8 interactors
MINTiO00488
STRINGi9606.ENSP00000363384

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi53 – 55Combined sources3
Helixi56 – 59Combined sources4
Turni64 – 66Combined sources3
Helixi73 – 79Combined sources7
Helixi83 – 92Combined sources10
Turni99 – 101Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZR9NMR-A20-134[»]
DisProtiDP00549
ProteinModelPortaliO00488
SMRiO00488
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00488

Family & Domainsi

Domaini

The protein is largely disordered, with the exception of the zinc finger domain.1 Publication

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 85C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3408 Eukaryota
COG5112 LUCA
GeneTreeiENSGT00390000004173
HOGENOMiHOG000216641
HOVERGENiHBG058255
InParanoidiO00488
KOiK14821
PhylomeDBiO00488
TreeFamiTF315114

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequencei

Sequence statusi: Complete.

O00488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRSRRTGAH RAHSLARQMK AKRRRPDLDE IHRELRPQGS ARPQPDPNAE
60 70 80 90 100
FDPDLPGGGL HRCLACARYF IDSTNLKTHF RSKDHKKRLK QLSVEPYSQE
110 120 130
EAERAAGMGS YVPPRRLAVP TEVSTEVPEM DTST
Length:134
Mass (Da):15,199
Last modified:July 28, 2009 - v2
Checksum:i883BCE4F72459818
GO

Sequence cautioni

The sequence AAH02580 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH19267 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA20369 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG34867 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0599246R → Q. Corresponds to variant dbSNP:rs2232649Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311926 mRNA Translation: BAG34867.1 Different initiation.
AL391650 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07843.1
BC002580 mRNA Translation: AAH02580.1 Different initiation.
BC019267 mRNA Translation: AAH19267.1 Different initiation.
D45213 mRNA Translation: BAA20369.1 Different initiation.
CCDSiCCDS275.2
RefSeqiNP_056955.2, NM_015871.4
UniGeneiHs.477273

Genome annotation databases

EnsembliENST00000374266; ENSP00000363384; ENSG00000142684
GeneIDi51042
KEGGihsa:51042
UCSCiuc001bll.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN593_HUMAN
AccessioniPrimary (citable) accession number: O00488
Secondary accession number(s): B2R4S0, Q5T2H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health