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O00482

- NR5A2_HUMAN

UniProt

O00482 - NR5A2_HUMAN

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Protein
Nuclear receptor subfamily 5 group A member 2
Gene
NR5A2, B1F, CPF, FTF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei516 – 5161Lipid headgroup
Binding sitei520 – 5201Lipid headgroup

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi83 – 15472Nuclear receptor
Add
BLAST
Zinc fingeri86 – 10621NR C4-type
Add
BLAST
Zinc fingeri122 – 14625NR C4-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: ProtInc
  3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
  4. phospholipid binding Source: UniProtKB
  5. protein binding Source: UniProtKB
  6. sequence-specific DNA binding Source: UniProtKB
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. steroid hormone receptor activity Source: InterPro
  9. transcription regulatory region DNA binding Source: BHF-UCL
  10. zinc ion binding Source: InterPro

GO - Biological processi

  1. bile acid metabolic process Source: Ensembl
  2. cholesterol homeostasis Source: Ensembl
  3. embryo development Source: UniProtKB
  4. endocrine pancreas development Source: Reactome
  5. gene expression Source: Reactome
  6. homeostatic process Source: UniProtKB
  7. intracellular receptor signaling pathway Source: GOC
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. positive regulation of transcription, DNA-templated Source: BHF-UCL
  10. positive regulation of viral genome replication Source: BHF-UCL
  11. regulation of cell proliferation Source: Ensembl
  12. regulation of transcription, DNA-templated Source: UniProtKB
  13. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_13778. Regulation of gene expression in early pancreatic precursor cells.
REACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiO00482.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 5 group A member 2
Alternative name(s):
Alpha-1-fetoprotein transcription factor
B1-binding factor
Short name:
hB1F
CYP7A promoter-binding factor
Hepatocytic transcription factor
Liver receptor homolog 1
Short name:
LRH-1
Gene namesi
Name:NR5A2
Synonyms:B1F, CPF, FTF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7984. NR5A2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. nucleoplasm Source: Reactome
  3. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi96 – 961Y → A: Slightly reduced DNA binding. Strongly reduced transactivation; when associated with A-168 and A-172. 1 Publication
Mutagenesisi168 – 1681F → A: Slightly reduced DNA binding. Strongly reduced transactivation; when associated with A-96 and A-172. 1 Publication
Mutagenesisi169 – 1702GP → VA: Reduced DNA binding. Loss of transactivation.
Mutagenesisi172 – 1721Y → A: Slightly reduced DNA binding. Strongly reduced transactivation; when associated with A-96 and A-168. 1 Publication
Mutagenesisi342 – 3421F → W: Reduced phospholipid binding. Strongly reduced transactivation; when associated with W-416. 1 Publication
Mutagenesisi416 – 4161I → W: Reduced phospholipid binding. Strongly reduced transactivation; when associated with W-342. 1 Publication

Organism-specific databases

PharmGKBiPA31765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Nuclear receptor subfamily 5 group A member 2
PRO_0000053735Add
BLAST

Proteomic databases

PaxDbiO00482.
PRIDEiO00482.

PTM databases

PhosphoSiteiO00482.

Expressioni

Tissue specificityi

Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.

Gene expression databases

ArrayExpressiO00482.
BgeeiO00482.
CleanExiHS_NR5A2.
GenevestigatoriO00482.

Organism-specific databases

HPAiHPA005455.
HPA017067.

Interactioni

Subunit structurei

Binds DNA as a monomer By similarity. Interacts with GRIP1, NCOA2 and NR0B2.

Binary interactionsi

WithEntry#Exp.IntActNotes
EDF1O608692EBI-781320,EBI-781301

Protein-protein interaction databases

BioGridi108772. 21 interactions.
DIPiDIP-37952N.
IntActiO00482. 2 interactions.
MINTiMINT-2997724.
STRINGi9606.ENSP00000356331.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni87 – 893
Beta strandi92 – 976
Beta strandi100 – 1034
Helixi104 – 11512
Turni132 – 1376
Helixi139 – 14810
Helixi153 – 1553
Helixi169 – 1779
Helixi303 – 3108
Helixi315 – 32814
Helixi335 – 3373
Helixi341 – 36222
Helixi366 – 3683
Helixi371 – 39727
Beta strandi402 – 4043
Beta strandi410 – 4123
Helixi413 – 4175
Helixi422 – 44019
Helixi445 – 45612
Helixi467 – 48822
Beta strandi490 – 4923
Helixi495 – 5006
Helixi502 – 52221
Helixi531 – 5366

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YOKX-ray2.50A300-541[»]
1YUCX-ray1.90A/B290-541[»]
1ZDUX-ray2.50A297-541[»]
2A66X-ray2.20A79-187[»]
3PLZX-ray1.75A/B300-541[»]
3TX7X-ray2.76B191-541[»]
4DORX-ray1.90A/B290-541[»]
4DOSX-ray2.00A299-538[»]
4IS8X-ray2.78A/B300-538[»]
ProteinModelPortaliO00482.
SMRiO00482. Positions 84-540.

Miscellaneous databases

EvolutionaryTraceiO00482.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni342 – 39049Ligand-binding
Add
BLAST
Regioni419 – 4246Lipid binding

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi155 – 18430FTZ-F1 box
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG240365.
HOGENOMiHOG000063718.
HOVERGENiHBG106677.
InParanoidiO00482.
KOiK08027.
OMAiNTFGLMC.
OrthoDBiEOG7BS4B9.
PhylomeDBiO00482.
TreeFamiTF350737.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR016355. Steroidogenic_factor_1.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002530. Nuc_orph_FTZ-F1. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: O00482-1) [UniParc]FASTAAdd to Basket

Also known as: B1F2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSNSDTGDL QESLKHGLTP IGAGLPDRHG SPIPARGRLV MLPKVETEAL    50
GLARSHGEQG QMPENMQVSQ FKMVNYSYDE DLEELCPVCG DKVSGYHYGL 100
LTCESCKGFF KRTVQNNKRY TCIENQNCQI DKTQRKRCPY CRFQKCLSVG 150
MKLEAVRADR MRGGRNKFGP MYKRDRALKQ QKKALIRANG LKLEAMSQVI 200
QAMPSDLTIS SAIQNIHSAS KGLPLNHAAL PPTDYDRSPF VTSPISMTMP 250
PHGSLQGYQT YGHFPSRAIK SEYPDPYTSS PESIMGYSYM DSYQTSSPAS 300
IPHLILELLK CEPDEPQVQA KIMAYLQQEQ ANRSKHEKLS TFGLMCKMAD 350
QTLFSIVEWA RSSIFFRELK VDDQMKLLQN CWSELLILDH IYRQVVHGKE 400
GSIFLVTGQQ VDYSIIASQA GATLNNLMSH AQELVAKLRS LQFDQREFVC 450
LKFLVLFSLD VKNLENFQLV EGVQEQVNAA LLDYTMCNYP QQTEKFGQLL 500
LRLPEIRAIS MQAEEYLYYK HLNGDVPYNN LLIEMLHAKR A 541
Length:541
Mass (Da):61,331
Last modified:May 30, 2000 - v2
Checksum:i7B07170C075490FE
GO
Isoform 1 (identifier: O00482-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-67: Missing.

Show »
Length:495
Mass (Da):56,459
Checksum:iE73E60DCE9880855
GO
Isoform 3 (identifier: O00482-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     199-370: Missing.

Note: Does not induce CYP7A promoter activity.

Show »
Length:369
Mass (Da):42,102
Checksum:i1357C2AAEFB4E46B
GO
Isoform 4 (identifier: O00482-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.

Show »
Length:469
Mass (Da):53,657
Checksum:i49F21C2F09CF0AB4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7272Missing in isoform 4.
VSP_054548Add
BLAST
Alternative sequencei22 – 6746Missing in isoform 1.
VSP_003716Add
BLAST
Alternative sequencei199 – 370172Missing in isoform 3.
VSP_003717Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti250 – 2512PP → L in AAD03155. 1 Publication
Sequence conflicti353 – 3531L → V in AAD03155. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80251 mRNA. Translation: AAC78727.1.
AF146343 mRNA. Translation: AAD37378.1.
AF124247 mRNA. Translation: AAD26565.1.
AF190464 Genomic DNA. Translation: AAG17124.1.
AF190464 Genomic DNA. Translation: AAG17125.1.
AK304365 mRNA. Translation: BAG65205.1.
AK316513 mRNA. Translation: BAH14884.1.
AC096633 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91306.1.
BC118571 mRNA. Translation: AAI18572.1.
BC118652 mRNA. Translation: AAI18653.1.
U93553 mRNA. Translation: AAD03155.1.
CCDSiCCDS1400.1. [O00482-2]
CCDS1401.1. [O00482-1]
CCDS60383.1. [O00482-4]
RefSeqiNP_001263393.1. NM_001276464.1. [O00482-4]
NP_003813.1. NM_003822.4. [O00482-2]
NP_995582.1. NM_205860.2. [O00482-1]
XP_005245119.1. XM_005245062.1. [O00482-4]
UniGeneiHs.33446.

Genome annotation databases

EnsembliENST00000236914; ENSP00000236914; ENSG00000116833. [O00482-2]
ENST00000367362; ENSP00000356331; ENSG00000116833. [O00482-1]
ENST00000544748; ENSP00000439116; ENSG00000116833.
GeneIDi2494.
KEGGihsa:2494.
UCSCiuc001gvb.4. human. [O00482-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80251 mRNA. Translation: AAC78727.1 .
AF146343 mRNA. Translation: AAD37378.1 .
AF124247 mRNA. Translation: AAD26565.1 .
AF190464 Genomic DNA. Translation: AAG17124.1 .
AF190464 Genomic DNA. Translation: AAG17125.1 .
AK304365 mRNA. Translation: BAG65205.1 .
AK316513 mRNA. Translation: BAH14884.1 .
AC096633 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91306.1 .
BC118571 mRNA. Translation: AAI18572.1 .
BC118652 mRNA. Translation: AAI18653.1 .
U93553 mRNA. Translation: AAD03155.1 .
CCDSi CCDS1400.1. [O00482-2 ]
CCDS1401.1. [O00482-1 ]
CCDS60383.1. [O00482-4 ]
RefSeqi NP_001263393.1. NM_001276464.1. [O00482-4 ]
NP_003813.1. NM_003822.4. [O00482-2 ]
NP_995582.1. NM_205860.2. [O00482-1 ]
XP_005245119.1. XM_005245062.1. [O00482-4 ]
UniGenei Hs.33446.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YOK X-ray 2.50 A 300-541 [» ]
1YUC X-ray 1.90 A/B 290-541 [» ]
1ZDU X-ray 2.50 A 297-541 [» ]
2A66 X-ray 2.20 A 79-187 [» ]
3PLZ X-ray 1.75 A/B 300-541 [» ]
3TX7 X-ray 2.76 B 191-541 [» ]
4DOR X-ray 1.90 A/B 290-541 [» ]
4DOS X-ray 2.00 A 299-538 [» ]
4IS8 X-ray 2.78 A/B 300-538 [» ]
ProteinModelPortali O00482.
SMRi O00482. Positions 84-540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108772. 21 interactions.
DIPi DIP-37952N.
IntActi O00482. 2 interactions.
MINTi MINT-2997724.
STRINGi 9606.ENSP00000356331.

Chemistry

BindingDBi O00482.
ChEMBLi CHEMBL3544.

PTM databases

PhosphoSitei O00482.

Proteomic databases

PaxDbi O00482.
PRIDEi O00482.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000236914 ; ENSP00000236914 ; ENSG00000116833 . [O00482-2 ]
ENST00000367362 ; ENSP00000356331 ; ENSG00000116833 . [O00482-1 ]
ENST00000544748 ; ENSP00000439116 ; ENSG00000116833 .
GeneIDi 2494.
KEGGi hsa:2494.
UCSCi uc001gvb.4. human. [O00482-1 ]

Organism-specific databases

CTDi 2494.
GeneCardsi GC01P199996.
HGNCi HGNC:7984. NR5A2.
HPAi HPA005455.
HPA017067.
MIMi 604453. gene.
neXtProti NX_O00482.
PharmGKBi PA31765.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240365.
HOGENOMi HOG000063718.
HOVERGENi HBG106677.
InParanoidi O00482.
KOi K08027.
OMAi NTFGLMC.
OrthoDBi EOG7BS4B9.
PhylomeDBi O00482.
TreeFami TF350737.

Enzyme and pathway databases

Reactomei REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
REACT_15525. Nuclear Receptor transcription pathway.
SignaLinki O00482.

Miscellaneous databases

EvolutionaryTracei O00482.
GeneWikii Liver_receptor_homolog-1.
GenomeRNAii 2494.
NextBioi 35477332.
PROi O00482.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00482.
Bgeei O00482.
CleanExi HS_NR5A2.
Genevestigatori O00482.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR016355. Steroidogenic_factor_1.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002530. Nuc_orph_FTZ-F1. 1 hit.
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 2 hits.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus."
    Li M., Xie Y.-H., Kong Y.-Y., Wu X., Zhu L., Wang Y.
    J. Biol. Chem. 273:29022-29031(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
    Tissue: Liver.
  2. Li M., Xie Y.-H., Wang Y.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Hepatoma.
  3. "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene."
    Nitta M., Ku S., Brown C., Okamoto A.Y., Shan B.
    Proc. Natl. Acad. Sci. U.S.A. 96:6660-6665(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Liver.
  4. "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene."
    Zhang C.K., Lin W., Cai Y.N., Xu P.L., Dong H., Li M., Kong Y.Y., Fu G., Xie Y.H., Huang G.M., Wang Y.
    Gene 273:239-249(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Trachea.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  9. "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization."
    Galarneau L., Drouin R., Belanger L.
    Cytogenet. Cell Genet. 82:269-270(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-541.
  10. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 300-541 IN COMPLEX WITH NCOA2 AND PHOSPHOLIPIDS.
  11. "Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity."
    Solomon I.H., Hager J.M., Safi R., McDonnell D.P., Redinbo M.R., Ortlund E.A.
    J. Mol. Biol. 354:1091-1102(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 79-187 IN COMPLEX WITH DNA, MUTAGENESIS OF TYR-96; PHE-168; 169-GLY-PRO-170 AND TYR-172.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 290-541 IN COMPLEX WITH NR0B2 AND PHOSPHOLIPID, MUTAGENESIS OF PHE-342 AND ILE-416.
  13. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 297-541 IN COMPLEX WITH NCOA2 AND PHOSPHOLIPID.

Entry informationi

Entry nameiNR5A2_HUMAN
AccessioniPrimary (citable) accession number: O00482
Secondary accession number(s): B4E2P3, O95642, Q147U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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