O00481 (BT3A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Butyrophilin subfamily 3 member A1

Alternative name(s):
CD_antigen=CD277

Gene names

Name:	BTN3A1
Synonyms:	BTF5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. Ref.9 Ref.10 Ref.11 Ref.12
Subunit structure	Homodimer. Ref.12
Subcellular location	Cell membrane; Single-pass type I membrane protein Ref.9 Ref.10 Ref.11.
Tissue specificity	Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous. Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle. Ref.2 Ref.8 Ref.9 Ref.10
Post-translational modification	N-glycosylated. Ref.8
Sequence similarities	Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 B30.2/SPRY domain. Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Sequence caution	The sequence CAA69164.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell receptor signaling pathway Inferred from direct assay Ref.10. Source: UniProtKB activated T cell proliferation Inferred from mutant phenotype Ref.10. Source: UniProtKB interferon-gamma secretion Inferred from mutant phenotype Ref.10. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay Ref.10. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TFF1	P04155	3	EBI-2809309,EBI-743871

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O00481-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O00481-2)

The sequence of this isoform differs from the canonical sequence as follows:
     340-352: ADVILDPKTANPI → GEEMLQMRLHFVK
     353-513: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O00481-3)

The sequence of this isoform differs from the canonical sequence as follows:
     340-513: ADVILDPKTA...EPTALTICPA → GPPIGQTQQQ...SWGPEEGGES

Note: No experimental confirmation available.

Isoform 4 (identifier: O00481-4)

The sequence of this isoform differs from the canonical sequence as follows:
     143-194: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Potential

Chain

30 – 513

484

Butyrophilin subfamily 3 member A1

PRO_0000014532

Regions

Topological domain

30 – 254

225

Extracellular Potential

Transmembrane

255 – 271

17

Helical; Potential

Topological domain

272 – 513

242

Cytoplasmic Potential

Domain

30 – 139

110

Ig-like V-type 1

Domain

145 – 236

92

Ig-like V-type 2

Domain

322 – 513

192

B30.2/SPRY

Amino acid modifications

Glycosylation

115

1

N-linked (GlcNAc...) Potential

Disulfide bond

52 ↔ 126

Ref.12

Disulfide bond

166 ↔ 220

Ref.12

Natural variations

Alternative sequence

143 – 194

52

Missing in isoform 4.

VSP_045062

Alternative sequence

340 – 513

174

ADVIL…TICPA → GPPIGQTQQQTRGQGSPVAL SQESAQRTDSWGPEEGGES in isoform 3.

VSP_042034

Alternative sequence

340 – 352

13

ADVIL…TANPI → GEEMLQMRLHFVK in isoform 2.

VSP_012714

Alternative sequence

353 – 513

161

Missing in isoform 2.

VSP_012715

Natural variant

15

1

R → H. Ref.3
Corresponds to variant rs56161420 [ dbSNP | Ensembl ].

VAR_061305

Natural variant

224

1

S → N. Ref.1
Corresponds to variant rs1057933 [ dbSNP | Ensembl ].

VAR_021170

Natural variant

282

1

R → T. Ref.3
Corresponds to variant rs41266839 [ dbSNP | Ensembl ].

VAR_061306

Natural variant

456

1

P → T. Ref.7
Corresponds to variant rs4712990 [ dbSNP | Ensembl ].

VAR_028788

Experimental info

Sequence conflict

13

1

N → S in BAG58563. Ref.3

Sequence conflict

25

1

M → T in BAD97194. Ref.4

Sequence conflict

46

1

E → K in BAG61334. Ref.3

Sequence conflict

111

1

L → F in CAA69164. Ref.1

Sequence conflict

118

1

A → G in CAA69164. Ref.1

Sequence conflict

121 – 122

2

SG → RW in CAA69164. Ref.1

Sequence conflict

130

1

D → G in BAG58563. Ref.3

Sequence conflict

239

1

D → R in CAA69164. Ref.1

Sequence conflict

254

1

G → R in AAB53430. Ref.2

Sequence conflict

509

1

T → S in AAB53430. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

513

Helix Strand Turn

Details...

Beta strand

32 – 34

3

Beta strand

40 – 43

4

Beta strand

48 – 56

9

Beta strand

63 – 69

7

Turn

70 – 72

3

Beta strand

75 – 80

6

Helix

86 – 88

3

Turn

91 – 96

6

Beta strand

97 – 100

4

Helix

104 – 106

3

Beta strand

108 – 115

8

Helix

118 – 120

3

Beta strand

122 – 130

9

Beta strand

133 – 145

13

Beta strand

151 – 158

8

Beta strand

161 – 173

13

Beta strand

176 – 180

5

Beta strand

202 – 210

9

Beta strand

218 – 224

7

Turn

225 – 228

4

Beta strand

229 – 235

7

Turn

239 – 241

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 3. Checksum: 8D834D70526D1F6F	FASTA	513	57,677
	10 20 30 40 50 60 MKMASFLAFL LLNFRVCLLL LQLLMPHSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA 70 80 90 100 110 120 ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD 130 140 150 160 170 180 SGKYLCYFQD GDFYEKALVE LKVAALGSDL HVDVKGYKDG GIHLECRSTG WYPQPQIQWS 190 200 210 220 230 240 NNKGENIPTV EAPVVADGVG LYAVAASVIM RGSSGEGVSC TIRSSLLGLE KTASISIADP 250 260 270 280 290 300 FFRSAQRWIA ALAGTLPVLL LLLGGAGYFL WQQQEEKKTQ FRKKKREQEL REMAWSTMKQ 310 320 330 340 350 360 EQSTRVKLLE ELRWRSIQYA SRGERHSAYN EWKKALFKPA DVILDPKTAN PILLVSEDQR 370 380 390 400 410 420 SVQRAKEPQD LPDNPERFNW HYCVLGCESF ISGRHYWEVE VGDRKEWHIG VCSKNVQRKG 430 440 450 460 470 480 WVKMTPENGF WTMGLTDGNK YRTLTEPRTN LKLPKPPKKV GVFLDYETGD ISFYNAVDGS 490 500 510 HIHTFLDVSF SEALYPVFRI LTLEPTALTI CPA
	Isoform 2 [UniParc]. Checksum: 274CA3723C653772	FASTA	352	39,397
	10 20 30 40 50 60 MKMASFLAFL LLNFRVCLLL LQLLMPHSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA 70 80 90 100 110 120 ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD 130 140 150 160 170 180 SGKYLCYFQD GDFYEKALVE LKVAALGSDL HVDVKGYKDG GIHLECRSTG WYPQPQIQWS 190 200 210 220 230 240 NNKGENIPTV EAPVVADGVG LYAVAASVIM RGSSGEGVSC TIRSSLLGLE KTASISIADP 250 260 270 280 290 300 FFRSAQRWIA ALAGTLPVLL LLLGGAGYFL WQQQEEKKTQ FRKKKREQEL REMAWSTMKQ 310 320 330 340 350 EQSTRVKLLE ELRWRSIQYA SRGERHSAYN EWKKALFKPG EEMLQMRLHF VK
	Isoform 3 [UniParc]. Checksum: 274B31308FA9B73D	FASTA	378	41,819
	10 20 30 40 50 60 MKMASFLAFL LLNFRVCLLL LQLLMPHSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA 70 80 90 100 110 120 ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD 130 140 150 160 170 180 SGKYLCYFQD GDFYEKALVE LKVAALGSDL HVDVKGYKDG GIHLECRSTG WYPQPQIQWS 190 200 210 220 230 240 NNKGENIPTV EAPVVADGVG LYAVAASVIM RGSSGEGVSC TIRSSLLGLE KTASISIADP 250 260 270 280 290 300 FFRSAQRWIA ALAGTLPVLL LLLGGAGYFL WQQQEEKKTQ FRKKKREQEL REMAWSTMKQ 310 320 330 340 350 360 EQSTRVKLLE ELRWRSIQYA SRGERHSAYN EWKKALFKPG PPIGQTQQQT RGQGSPVALS 370 QESAQRTDSW GPEEGGES
	Isoform 4 [UniParc]. Checksum: 72FE04DA9664783D	FASTA	461	52,019
	10 20 30 40 50 60 MKMASFLAFL LLNFRVCLLL LQLLMPHSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA 70 80 90 100 110 120 ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD 130 140 150 160 170 180 SGKYLCYFQD GDFYEKALVE LKVADGVGLY AVAASVIMRG SSGEGVSCTI RSSLLGLEKT 190 200 210 220 230 240 ASISIADPFF RSAQRWIAAL AGTLPVLLLL LGGAGYFLWQ QQEEKKTQFR KKKREQELRE 250 260 270 280 290 300 MAWSTMKQEQ STRVKLLEEL RWRSIQYASR GERHSAYNEW KKALFKPADV ILDPKTANPI 310 320 330 340 350 360 LLVSEDQRSV QRAKEPQDLP DNPERFNWHY CVLGCESFIS GRHYWEVEVG DRKEWHIGVC 370 380 390 400 410 420 SKNVQRKGWV KMTPENGFWT MGLTDGNKYR TLTEPRTNLK LPKPPKKVGV FLDYETGDIS 430 440 450 460 FYNAVDGSHI HTFLDVSFSE ALYPVFRILT LEPTALTICP A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex." Tazi-Ahnini R., Henry J., Offer C., Bouissou-Bouchouata C., Mather I.H., Pontarotti P. Immunogenetics 47:55-63(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ASN-224.
[2]	"A 1.1-Mb transcript map of the hereditary hemochromatosis locus." Ruddy D.A., Kronmal G.S., Lee V.K., Mintier G.A., Quintana L., Domingo R. Jr., Meyer N.C., Irrinki A., McClelland E.E., Fullan A., Mapa F.A., Moore T., Thomas W., Loeb D.B., Harmon C., Tsuchihashi Z., Wolff R.K., Schatzman R.C., Feder J.N. Genome Res. 7:441-456(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANTS HIS-15 AND THR-282. Tissue: Hippocampus and Thalamus.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Synovium.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-456.
[8]	"Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity." Yamashiro H., Yoshizaki S., Tadaki T., Egawa K., Seo N. J. Leukoc. Biol. 88:757-767(2010) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION, TISSUE SPECIFICITY.
[9]	"CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells." Cubillos-Ruiz J.R., Martinez D., Scarlett U.K., Rutkowski M.R., Nesbeth Y.C., Camposeco-Jacobs A.L., Conejo-Garcia J.R. Oncotarget 1:329-338(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[10]	"Differential role for CD277 as a co-regulator of the immune signal in T and NK cells." Messal N., Mamessier E., Sylvain A., Celis-Gutierrez J., Thibult M.L., Chetaille B., Firaguay G., Pastor S., Guillaume Y., Wang Q., Hirsch I., Nunes J.A., Olive D. Eur. J. Immunol. 41:3443-3454(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]	"Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset." Harly C., Guillaume Y., Nedellec S., Peigne C.M., Monkkonen H., Monkkonen J., Li J., Kuball J., Adams E.J., Netzer S., Dechanet-Merville J., Leger A., Herrmann T., Breathnach R., Olive D., Bonneville M., Scotet E. Blood 120:2269-2279(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[12]	"The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies." Palakodeti A., Sandstrom A., Sundaresan L., Harly C., Nedellec S., Olive D., Scotet E., Bonneville M., Adams E.J. J. Biol. Chem. 287:32780-32790(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 30-246, FUNCTION, SUBUNIT, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Y07827 mRNA. Translation: CAA69164.1. Different initiation.
U90552 mRNA. Translation: AAB53430.1.
AK223474 mRNA. Translation: BAD97194.1.
AK290193 mRNA. Translation: BAF82882.1.
AK295720 mRNA. Translation: BAG58563.1.
AK299327 mRNA. Translation: BAG61334.1.
AL021917 Genomic DNA. Translation: CAC03424.3.
AL021917 Genomic DNA. Translation: CAM28245.1.
CH471087 Genomic DNA. Translation: EAW55566.1.
CH471087 Genomic DNA. Translation: EAW55567.1.
BC118586 mRNA. Translation: AAI18587.1.
BC121800 mRNA. Translation: AAI21801.1.

IPI

IPI00375709.
IPI00383474.
IPI00909099.

RefSeq

NP_001138480.1. NM_001145008.1.
NP_001138481.1. NM_001145009.1.
NP_008979.3. NM_007048.5.
NP_919423.1. NM_194441.2.

UniGene

Hs.191510.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4F80	X-ray	1.94	A	30-246	[»]
4F9L	X-ray	3.14	A/B	30-246	[»]
4F9P	X-ray	3.52	A/B	30-246	[»]

ProteinModelPortal

O00481.

ModBase

Search...

Protein-protein interaction databases

IntAct

O00481. 2 interactions.

STRING

9606.ENSP00000289361.

PTM databases

PhosphoSite

O00481.

Proteomic databases

PaxDb

O00481.

PRIDE

O00481.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000289361; ENSP00000289361; ENSG00000026950.
ENST00000414912; ENSP00000406667; ENSG00000026950.
ENST00000425234; ENSP00000396684; ENSG00000026950.
ENST00000476549; ENSP00000420010; ENSG00000026950.

GeneID

11119.

KEGG

hsa:11119.

UCSC

uc003nhv.3. human.
uc010jqj.3. human.
uc011dkj.2. human.
uc011dkk.2. human.

Organism-specific databases

CTD

11119.

GeneCards

GC06P026402.

HGNC

HGNC:1138. BTN3A1.

HPA

HPA012565.

MIM

613593. gene.

neXtProt

NX_O00481.

PharmGKB

PA25459.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG326834.

HOGENOM

HOG000230860.

HOVERGEN

HBG050747.

InParanoid

O00481.

KO

K06712.

OMA

ERFNWHY.

OrthoDB

EOG408N7V.

PhylomeDB

O00481.

Gene expression databases

ArrayExpress

O00481.

Bgee

O00481.

CleanEx

HS_BTN3A1.

Genevestigator

O00481.

GermOnline

ENSG00000026950. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR008985. ConA-like_lec_gl_sf.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]

Pfam

PF08205. C2-set_2. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]

PRINTS

PR01407. BUTYPHLNCDUF.

SMART

SM00409. IG. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 1 hit.

PROSITE

PS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

11119.

NextBio

42260.

SOURCE

Search...

Entry information

Entry name

BT3A1_HUMAN

Accession

Primary (citable) accession number: O00481
Secondary accession number(s): A2A278 , A8K2C8, B4DIQ1, B4DRM2, E9PGB4, E9PHG8, Q0P515, Q147X5, Q53F15, Q99420, Q9HCY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 31, 2006
Last modified:	May 29, 2013
This is version 118 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.