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O00479

- HMGN4_HUMAN

UniProt

O00479 - HMGN4_HUMAN

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Protein

High mobility group nucleosome-binding domain-containing protein 4

Gene

HMGN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 4
Alternative name(s):
Non-histone chromosomal protein HMG-17-like 3
Short name:
Non-histone chromosomal protein
Gene namesi
Name:HMGN4
Synonyms:HMG17L3, NHC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4989. HMGN4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. chromatin Source: InterPro
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090High mobility group nucleosome-binding domain-containing protein 4PRO_0000206704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801Phosphoserine1 Publication
Modified residuei82 – 821N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO00479.
PaxDbiO00479.
PeptideAtlasiO00479.
PRIDEiO00479.

PTM databases

PhosphoSiteiO00479.

Expressioni

Gene expression databases

BgeeiO00479.
CleanExiHS_HMGN4.
GenevestigatoriO00479.

Organism-specific databases

HPAiHPA048518.

Interactioni

Protein-protein interaction databases

BioGridi115736. 5 interactions.
IntActiO00479. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO00479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiNOG44189.
GeneTreeiENSGT00730000110660.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiO00479.
KOiK11302.
OMAiEGNNAAK.
OrthoDBiEOG7KDFFF.
PhylomeDBiO00479.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087. PTHR23087. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00479-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKRKAKGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPR PKKASAKKGE
60 70 80 90
KLPKGRKGKA DAGKDGNNPA KNRDASTLQS QKAEGTGDAK
Length:90
Mass (Da):9,539
Last modified:January 23, 2007 - v3
Checksum:i18738CF6EEA781CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90549 mRNA. Translation: AAB53427.1.
BT009824 mRNA. Translation: AAP88826.1.
AK311841 mRNA. Translation: BAG34783.1.
AL121936 Genomic DNA. Translation: CAC16803.1.
CH471087 Genomic DNA. Translation: EAW55586.1.
BC001282 mRNA. Translation: AAH01282.1.
CCDSiCCDS4615.1.
RefSeqiNP_006344.1. NM_006353.2.
UniGeneiHs.236774.

Genome annotation databases

EnsembliENST00000377575; ENSP00000366798; ENSG00000182952.
GeneIDi10473.
KEGGihsa:10473.
UCSCiuc003nig.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90549 mRNA. Translation: AAB53427.1 .
BT009824 mRNA. Translation: AAP88826.1 .
AK311841 mRNA. Translation: BAG34783.1 .
AL121936 Genomic DNA. Translation: CAC16803.1 .
CH471087 Genomic DNA. Translation: EAW55586.1 .
BC001282 mRNA. Translation: AAH01282.1 .
CCDSi CCDS4615.1.
RefSeqi NP_006344.1. NM_006353.2.
UniGenei Hs.236774.

3D structure databases

ProteinModelPortali O00479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115736. 5 interactions.
IntActi O00479. 1 interaction.

PTM databases

PhosphoSitei O00479.

Proteomic databases

MaxQBi O00479.
PaxDbi O00479.
PeptideAtlasi O00479.
PRIDEi O00479.

Protocols and materials databases

DNASUi 10473.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377575 ; ENSP00000366798 ; ENSG00000182952 .
GeneIDi 10473.
KEGGi hsa:10473.
UCSCi uc003nig.3. human.

Organism-specific databases

CTDi 10473.
GeneCardsi GC06P026538.
HGNCi HGNC:4989. HMGN4.
HPAi HPA048518.
neXtProti NX_O00479.
PharmGKBi PA35090.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44189.
GeneTreei ENSGT00730000110660.
HOGENOMi HOG000116395.
HOVERGENi HBG073479.
InParanoidi O00479.
KOi K11302.
OMAi EGNNAAK.
OrthoDBi EOG7KDFFF.
PhylomeDBi O00479.

Miscellaneous databases

ChiTaRSi HMGN4. human.
GeneWikii HMGN4.
GenomeRNAii 10473.
NextBioi 39720.
PROi O00479.

Gene expression databases

Bgeei O00479.
CleanExi HS_HMGN4.
Genevestigatori O00479.

Family and domain databases

InterProi IPR000079. HMGN_fam.
[Graphical view ]
PANTHERi PTHR23087. PTHR23087. 1 hit.
Pfami PF01101. HMG14_17. 1 hit.
[Graphical view ]
PRINTSi PR00925. NONHISHMG17.
SMARTi SM00527. HMG17. 1 hit.
[Graphical view ]
PROSITEi PS00355. HMG14_17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHMGN4_HUMAN
AccessioniPrimary (citable) accession number: O00479
Secondary accession number(s): B2R4I6, Q53XL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3