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O00479

- HMGN4_HUMAN

UniProt

O00479 - HMGN4_HUMAN

Protein

High mobility group nucleosome-binding domain-containing protein 4

Gene

HMGN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High mobility group nucleosome-binding domain-containing protein 4
    Alternative name(s):
    Non-histone chromosomal protein HMG-17-like 3
    Short name:
    Non-histone chromosomal protein
    Gene namesi
    Name:HMGN4
    Synonyms:HMG17L3, NHC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4989. HMGN4.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. chromatin Source: InterPro
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35090.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9090High mobility group nucleosome-binding domain-containing protein 4PRO_0000206704Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801Phosphoserine1 Publication
    Modified residuei82 – 821N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO00479.
    PaxDbiO00479.
    PeptideAtlasiO00479.
    PRIDEiO00479.

    PTM databases

    PhosphoSiteiO00479.

    Expressioni

    Gene expression databases

    BgeeiO00479.
    CleanExiHS_HMGN4.
    GenevestigatoriO00479.

    Organism-specific databases

    HPAiHPA048518.

    Interactioni

    Protein-protein interaction databases

    BioGridi115736. 5 interactions.
    IntActiO00479. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO00479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMGN family.Curated

    Phylogenomic databases

    eggNOGiNOG44189.
    HOGENOMiHOG000116395.
    HOVERGENiHBG073479.
    InParanoidiO00479.
    KOiK11302.
    OMAiEGNNAAK.
    OrthoDBiEOG7KDFFF.
    PhylomeDBiO00479.

    Family and domain databases

    InterProiIPR000079. HMGN_fam.
    [Graphical view]
    PANTHERiPTHR23087. PTHR23087. 1 hit.
    PfamiPF01101. HMG14_17. 1 hit.
    [Graphical view]
    PRINTSiPR00925. NONHISHMG17.
    SMARTiSM00527. HMG17. 1 hit.
    [Graphical view]
    PROSITEiPS00355. HMG14_17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00479-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKRKAKGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPR PKKASAKKGE   50
    KLPKGRKGKA DAGKDGNNPA KNRDASTLQS QKAEGTGDAK 90
    Length:90
    Mass (Da):9,539
    Last modified:January 23, 2007 - v3
    Checksum:i18738CF6EEA781CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90549 mRNA. Translation: AAB53427.1.
    BT009824 mRNA. Translation: AAP88826.1.
    AK311841 mRNA. Translation: BAG34783.1.
    AL121936 Genomic DNA. Translation: CAC16803.1.
    CH471087 Genomic DNA. Translation: EAW55586.1.
    BC001282 mRNA. Translation: AAH01282.1.
    CCDSiCCDS4615.1.
    RefSeqiNP_006344.1. NM_006353.2.
    UniGeneiHs.236774.

    Genome annotation databases

    EnsembliENST00000377575; ENSP00000366798; ENSG00000182952.
    GeneIDi10473.
    KEGGihsa:10473.
    UCSCiuc003nig.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90549 mRNA. Translation: AAB53427.1 .
    BT009824 mRNA. Translation: AAP88826.1 .
    AK311841 mRNA. Translation: BAG34783.1 .
    AL121936 Genomic DNA. Translation: CAC16803.1 .
    CH471087 Genomic DNA. Translation: EAW55586.1 .
    BC001282 mRNA. Translation: AAH01282.1 .
    CCDSi CCDS4615.1.
    RefSeqi NP_006344.1. NM_006353.2.
    UniGenei Hs.236774.

    3D structure databases

    ProteinModelPortali O00479.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115736. 5 interactions.
    IntActi O00479. 1 interaction.

    PTM databases

    PhosphoSitei O00479.

    Proteomic databases

    MaxQBi O00479.
    PaxDbi O00479.
    PeptideAtlasi O00479.
    PRIDEi O00479.

    Protocols and materials databases

    DNASUi 10473.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377575 ; ENSP00000366798 ; ENSG00000182952 .
    GeneIDi 10473.
    KEGGi hsa:10473.
    UCSCi uc003nig.3. human.

    Organism-specific databases

    CTDi 10473.
    GeneCardsi GC06P026538.
    HGNCi HGNC:4989. HMGN4.
    HPAi HPA048518.
    neXtProti NX_O00479.
    PharmGKBi PA35090.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44189.
    HOGENOMi HOG000116395.
    HOVERGENi HBG073479.
    InParanoidi O00479.
    KOi K11302.
    OMAi EGNNAAK.
    OrthoDBi EOG7KDFFF.
    PhylomeDBi O00479.

    Miscellaneous databases

    GeneWikii HMGN4.
    GenomeRNAii 10473.
    NextBioi 39720.
    PROi O00479.

    Gene expression databases

    Bgeei O00479.
    CleanExi HS_HMGN4.
    Genevestigatori O00479.

    Family and domain databases

    InterProi IPR000079. HMGN_fam.
    [Graphical view ]
    PANTHERi PTHR23087. PTHR23087. 1 hit.
    Pfami PF01101. HMG14_17. 1 hit.
    [Graphical view ]
    PRINTSi PR00925. NONHISHMG17.
    SMARTi SM00527. HMG17. 1 hit.
    [Graphical view ]
    PROSITEi PS00355. HMG14_17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHMGN4_HUMAN
    AccessioniPrimary (citable) accession number: O00479
    Secondary accession number(s): B2R4I6, Q53XL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3