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Protein

High mobility group nucleosome-binding domain-containing protein 4

Gene

HMGN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 4
Alternative name(s):
Non-histone chromosomal protein HMG-17-like 3
Short name:
Non-histone chromosomal protein
Gene namesi
Name:HMGN4
Synonyms:HMG17L3, NHC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4989. HMGN4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10473.
OpenTargetsiENSG00000182952.
PharmGKBiPA35090.

Polymorphism and mutation databases

BioMutaiHMGN4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067041 – 90High mobility group nucleosome-binding domain-containing protein 4Add BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29ADP-ribosylserine1 Publication1
Modified residuei80PhosphoserineCombined sources1
Modified residuei82N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiO00479.
MaxQBiO00479.
PaxDbiO00479.
PeptideAtlasiO00479.
PRIDEiO00479.
TopDownProteomicsiO00479.

PTM databases

iPTMnetiO00479.
PhosphoSitePlusiO00479.

Expressioni

Gene expression databases

BgeeiENSG00000182952.
CleanExiHS_HMGN4.
ExpressionAtlasiO00479. baseline and differential.
GenevisibleiO00479. HS.

Organism-specific databases

HPAiHPA077364.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-2867693,EBI-750109

Protein-protein interaction databases

BioGridi115736. 15 interactors.
IntActiO00479. 4 interactors.
STRINGi9606.ENSP00000327691.

Structurei

3D structure databases

ProteinModelPortaliO00479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J2S0. Eukaryota.
ENOG410Z0UC. LUCA.
GeneTreeiENSGT00730000110660.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiO00479.
KOiK11302.
OMAiNRDATTV.
PhylomeDBiO00479.

Family and domain databases

InterProiView protein in InterPro
IPR000079. HMGN_fam.
PfamiView protein in Pfam
PF01101. HMG14_17. 1 hit.
PRINTSiPR00925. NONHISHMG17.
SMARTiView protein in SMART
SM00527. HMG17. 1 hit.
PROSITEiView protein in PROSITE
PS00355. HMG14_17. 1 hit.

Sequencei

Sequence statusi: Complete.

O00479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAKGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPR PKKASAKKGE
60 70 80 90
KLPKGRKGKA DAGKDGNNPA KNRDASTLQS QKAEGTGDAK
Length:90
Mass (Da):9,539
Last modified:January 23, 2007 - v3
Checksum:i18738CF6EEA781CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90549 mRNA. Translation: AAB53427.1.
BT009824 mRNA. Translation: AAP88826.1.
AK311841 mRNA. Translation: BAG34783.1.
AL121936 Genomic DNA. No translation available.
CH471087 Genomic DNA. Translation: EAW55586.1.
BC001282 mRNA. Translation: AAH01282.1.
CCDSiCCDS4615.1.
RefSeqiNP_006344.1. NM_006353.2.
XP_016865660.1. XM_017010171.1.
XP_016865661.1. XM_017010172.1.
XP_016865662.1. XM_017010173.1.
UniGeneiHs.236774.

Genome annotation databases

EnsembliENST00000377575; ENSP00000366798; ENSG00000182952.
GeneIDi10473.
KEGGihsa:10473.
UCSCiuc003nig.4. human.

Similar proteinsi

Entry informationi

Entry nameiHMGN4_HUMAN
AccessioniPrimary (citable) accession number: O00479
Secondary accession number(s): B2R4I6, Q53XL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families