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Protein

Exocyst complex component 5

Gene

EXOC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_15550. Insulin processing.
REACT_268299. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 5
Alternative name(s):
Exocyst complex component Sec10
Short name:
hSec10
Gene namesi
Name:EXOC5
Synonyms:SEC10, SEC10L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:10696. EXOC5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35619.

Polymorphism and mutation databases

BioMutaiEXOC5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 708707Exocyst complex component 5PRO_0000118943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei122 – 1221Phosphothreonine1 Publication
Modified residuei395 – 3951PhosphothreonineBy similarity
Modified residuei405 – 4051PhosphothreonineBy similarity
Modified residuei412 – 4121PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO00471.
PaxDbiO00471.
PRIDEiO00471.

PTM databases

PhosphoSiteiO00471.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiO00471.
CleanExiHS_EXOC5.
ExpressionAtlasiO00471. baseline and differential.
GenevisibleiO00471. HS.

Organism-specific databases

HPAiHPA060837.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi115884. 47 interactions.
IntActiO00471. 10 interactions.
MINTiMINT-2794857.
STRINGi9606.ENSP00000389934.

Structurei

3D structure databases

ProteinModelPortaliO00471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 10162Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG261139.
GeneTreeiENSGT00390000012837.
HOGENOMiHOG000007911.
HOVERGENiHBG055591.
InParanoidiO00471.
OMAiPYTEGQR.
OrthoDBiEOG7SJD3Z.
PhylomeDBiO00471.
TreeFamiTF314966.

Family and domain databases

InterProiIPR009976. Sec10-like.
[Graphical view]
PANTHERiPTHR12100. PTHR12100. 1 hit.
PfamiPF07393. Sec10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI
60 70 80 90 100
QELQIMDERI QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD
110 120 130 140 150
EHISYVATKV CHLGDQLEGV NTPRQRAVEA QKLMKYFNEF LDGELKSDVF
160 170 180 190 200
TNSEKIKEAA DIIQKLHLIA QELPFDRFSE VKSKIASKYH DLECQLIQEF
210 220 230 240 250
TSAQRRGEIS RMREVAAVLL HFKGYSHCVD VYIKQCQEGA YLRNDIFEDA
260 270 280 290 300
GILCQRVNKQ VGDIFSNPET VLAKLIQNVF EIKLQSFVKE QLEECRKSDA
310 320 330 340 350
EQYLKNLYDL YTRTTNLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI
360 370 380 390 400
EVETGYLKSR SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG
410 420 430 440 450
PSIDTHGETF LSQEVVVNLL QETKQAFERC HRLSDPSDLP RNAFRIFTIL
460 470 480 490 500
VEFLCIEHID YALETGLAGI PSSDSRNANL YFLDVVQQAN TIFHLFDKQF
510 520 530 540 550
NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL NCMIGQMKHI
560 570 580 590 600
LAAEQKKTDF KPEDENNVLI QYTNACVKVC AYVRKQVEKI KNSMDGKNVD
610 620 630 640 650
TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV
660 670 680 690 700
LHLFDTLHAL CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS

ARLARHFS
Length:708
Mass (Da):81,853
Last modified:July 1, 1997 - v1
Checksum:iCB03AC6C64DAB50C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101E → D.
Corresponds to variant rs35132458 [ dbSNP | Ensembl ].
VAR_048957

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85946 mRNA. Translation: AAB53388.1.
AK312523 mRNA. Translation: BAG35422.1.
CH471061 Genomic DNA. Translation: EAW80699.1.
CCDSiCCDS45111.1.
RefSeqiNP_006535.1. NM_006544.3.
UniGeneiHs.743987.

Genome annotation databases

EnsembliENST00000621441; ENSP00000484855; ENSG00000070367.
GeneIDi10640.
KEGGihsa:10640.
UCSCiuc001xcs.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85946 mRNA. Translation: AAB53388.1.
AK312523 mRNA. Translation: BAG35422.1.
CH471061 Genomic DNA. Translation: EAW80699.1.
CCDSiCCDS45111.1.
RefSeqiNP_006535.1. NM_006544.3.
UniGeneiHs.743987.

3D structure databases

ProteinModelPortaliO00471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115884. 47 interactions.
IntActiO00471. 10 interactions.
MINTiMINT-2794857.
STRINGi9606.ENSP00000389934.

PTM databases

PhosphoSiteiO00471.

Polymorphism and mutation databases

BioMutaiEXOC5.

Proteomic databases

MaxQBiO00471.
PaxDbiO00471.
PRIDEiO00471.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621441; ENSP00000484855; ENSG00000070367.
GeneIDi10640.
KEGGihsa:10640.
UCSCiuc001xcs.3. human.

Organism-specific databases

CTDi10640.
GeneCardsiGC14M057669.
HGNCiHGNC:10696. EXOC5.
HPAiHPA060837.
MIMi604469. gene.
neXtProtiNX_O00471.
PharmGKBiPA35619.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG261139.
GeneTreeiENSGT00390000012837.
HOGENOMiHOG000007911.
HOVERGENiHBG055591.
InParanoidiO00471.
OMAiPYTEGQR.
OrthoDBiEOG7SJD3Z.
PhylomeDBiO00471.
TreeFamiTF314966.

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_15550. Insulin processing.
REACT_268299. VxPx cargo-targeting to cilium.

Miscellaneous databases

ChiTaRSiEXOC5. human.
GeneWikiiEXOC5.
GenomeRNAii10640.
NextBioi40439.
PROiO00471.
SOURCEiSearch...

Gene expression databases

BgeeiO00471.
CleanExiHS_EXOC5.
ExpressionAtlasiO00471. baseline and differential.
GenevisibleiO00471. HS.

Family and domain databases

InterProiIPR009976. Sec10-like.
[Graphical view]
PANTHERiPTHR12100. PTHR12100. 1 hit.
PfamiPF07393. Sec10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of homologues of the exocyst component Sec10p."
    Guo W., Roth D., Gatti E., De Camilli P., Novick P.
    FEBS Lett. 404:135-139(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEXOC5_HUMAN
AccessioniPrimary (citable) accession number: O00471
Secondary accession number(s): B2R6C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 1, 1997
Last modified: June 24, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.