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O00471

- EXOC5_HUMAN

UniProt

O00471 - EXOC5_HUMAN

Protein

Exocyst complex component 5

Gene

EXOC5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. exocytosis Source: UniProtKB-KW
    3. membrane organization Source: Reactome
    4. post-Golgi vesicle-mediated transport Source: ProtInc
    5. protein transport Source: UniProtKB-KW
    6. vesicle docking Source: InterPro

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_15550. Insulin processing.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exocyst complex component 5
    Alternative name(s):
    Exocyst complex component Sec10
    Short name:
    hSec10
    Gene namesi
    Name:EXOC5
    Synonyms:SEC10, SEC10L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:10696. EXOC5.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35619.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 708707Exocyst complex component 5PRO_0000118943Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei122 – 1221Phosphothreonine1 Publication
    Modified residuei395 – 3951PhosphothreonineBy similarity
    Modified residuei405 – 4051PhosphothreonineBy similarity
    Modified residuei412 – 4121PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO00471.
    PaxDbiO00471.
    PRIDEiO00471.

    PTM databases

    PhosphoSiteiO00471.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiO00471.
    BgeeiO00471.
    CleanExiHS_EXOC5.
    GenevestigatoriO00471.

    Organism-specific databases

    HPAiHPA060837.

    Interactioni

    Subunit structurei

    The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi115884. 16 interactions.
    IntActiO00471. 10 interactions.
    MINTiMINT-2794857.
    STRINGi9606.ENSP00000389934.

    Structurei

    3D structure databases

    ProteinModelPortaliO00471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili40 – 10162Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SEC10 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG261139.
    HOGENOMiHOG000007911.
    HOVERGENiHBG055591.
    InParanoidiO00471.
    OMAiPYTEGQR.
    OrthoDBiEOG7SJD3Z.
    PhylomeDBiO00471.
    TreeFamiTF314966.

    Family and domain databases

    InterProiIPR009976. Sec10-like.
    [Graphical view]
    PANTHERiPTHR12100. PTHR12100. 1 hit.
    PfamiPF07393. Sec10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O00471-1 [UniParc]FASTAAdd to Basket

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    MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI    50
    QELQIMDERI QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD 100
    EHISYVATKV CHLGDQLEGV NTPRQRAVEA QKLMKYFNEF LDGELKSDVF 150
    TNSEKIKEAA DIIQKLHLIA QELPFDRFSE VKSKIASKYH DLECQLIQEF 200
    TSAQRRGEIS RMREVAAVLL HFKGYSHCVD VYIKQCQEGA YLRNDIFEDA 250
    GILCQRVNKQ VGDIFSNPET VLAKLIQNVF EIKLQSFVKE QLEECRKSDA 300
    EQYLKNLYDL YTRTTNLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI 350
    EVETGYLKSR SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG 400
    PSIDTHGETF LSQEVVVNLL QETKQAFERC HRLSDPSDLP RNAFRIFTIL 450
    VEFLCIEHID YALETGLAGI PSSDSRNANL YFLDVVQQAN TIFHLFDKQF 500
    NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL NCMIGQMKHI 550
    LAAEQKKTDF KPEDENNVLI QYTNACVKVC AYVRKQVEKI KNSMDGKNVD 600
    TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV 650
    LHLFDTLHAL CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS 700
    ARLARHFS 708
    Length:708
    Mass (Da):81,853
    Last modified:July 1, 1997 - v1
    Checksum:iCB03AC6C64DAB50C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101E → D.
    Corresponds to variant rs35132458 [ dbSNP | Ensembl ].
    VAR_048957

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85946 mRNA. Translation: AAB53388.1.
    AK312523 mRNA. Translation: BAG35422.1.
    CH471061 Genomic DNA. Translation: EAW80699.1.
    CCDSiCCDS45111.1.
    RefSeqiNP_006535.1. NM_006544.3.
    UniGeneiHs.743987.

    Genome annotation databases

    EnsembliENST00000413566; ENSP00000389934; ENSG00000070367.
    GeneIDi10640.
    KEGGihsa:10640.
    UCSCiuc001xcs.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85946 mRNA. Translation: AAB53388.1 .
    AK312523 mRNA. Translation: BAG35422.1 .
    CH471061 Genomic DNA. Translation: EAW80699.1 .
    CCDSi CCDS45111.1.
    RefSeqi NP_006535.1. NM_006544.3.
    UniGenei Hs.743987.

    3D structure databases

    ProteinModelPortali O00471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115884. 16 interactions.
    IntActi O00471. 10 interactions.
    MINTi MINT-2794857.
    STRINGi 9606.ENSP00000389934.

    PTM databases

    PhosphoSitei O00471.

    Proteomic databases

    MaxQBi O00471.
    PaxDbi O00471.
    PRIDEi O00471.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000413566 ; ENSP00000389934 ; ENSG00000070367 .
    GeneIDi 10640.
    KEGGi hsa:10640.
    UCSCi uc001xcs.3. human.

    Organism-specific databases

    CTDi 10640.
    GeneCardsi GC14M057669.
    HGNCi HGNC:10696. EXOC5.
    HPAi HPA060837.
    MIMi 604469. gene.
    neXtProti NX_O00471.
    PharmGKBi PA35619.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261139.
    HOGENOMi HOG000007911.
    HOVERGENi HBG055591.
    InParanoidi O00471.
    OMAi PYTEGQR.
    OrthoDBi EOG7SJD3Z.
    PhylomeDBi O00471.
    TreeFami TF314966.

    Enzyme and pathway databases

    Reactomei REACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_15550. Insulin processing.

    Miscellaneous databases

    GeneWikii EXOC5.
    GenomeRNAii 10640.
    NextBioi 40439.
    PROi O00471.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00471.
    Bgeei O00471.
    CleanExi HS_EXOC5.
    Genevestigatori O00471.

    Family and domain databases

    InterProi IPR009976. Sec10-like.
    [Graphical view ]
    PANTHERi PTHR12100. PTHR12100. 1 hit.
    Pfami PF07393. Sec10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of homologues of the exocyst component Sec10p."
      Guo W., Roth D., Gatti E., De Camilli P., Novick P.
      FEBS Lett. 404:135-139(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEXOC5_HUMAN
    AccessioniPrimary (citable) accession number: O00471
    Secondary accession number(s): B2R6C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3