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Protein

Exocyst complex component 5

Gene

EXOC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • protein N-terminus binding Source: Ensembl
  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-264876. Insulin processing.
R-HSA-5620916. VxPx cargo-targeting to cilium.

Protein family/group databases

TCDBi1.F.2.1.2. the octameric exocyst (exocyst) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 5
Alternative name(s):
Exocyst complex component Sec10
Short name:
hSec10
Gene namesi
Name:EXOC5
Synonyms:SEC10, SEC10L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000070367.15.
HGNCiHGNC:10696. EXOC5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10640.
OpenTargetsiENSG00000070367.
PharmGKBiPA35619.

Polymorphism and mutation databases

BioMutaiEXOC5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001189432 – 708Exocyst complex component 5Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei122PhosphothreonineCombined sources1
Modified residuei395PhosphothreonineBy similarity1
Modified residuei405PhosphothreonineBy similarity1
Modified residuei412PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO00471.
MaxQBiO00471.
PaxDbiO00471.
PeptideAtlasiO00471.
PRIDEiO00471.

PTM databases

iPTMnetiO00471.
PhosphoSitePlusiO00471.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000070367.
CleanExiHS_EXOC5.
ExpressionAtlasiO00471. baseline and differential.
GenevisibleiO00471. HS.

Organism-specific databases

HPAiHPA060837.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein N-terminus binding Source: Ensembl
  • Ral GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115884. 66 interactors.
CORUMiO00471.
IntActiO00471. 54 interactors.
MINTiMINT-2794857.
STRINGi9606.ENSP00000389934.

Structurei

3D structure databases

ProteinModelPortaliO00471.
SMRiO00471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 101Sequence analysisAdd BLAST62

Sequence similaritiesi

Belongs to the SEC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3745. Eukaryota.
ENOG410XSQQ. LUCA.
GeneTreeiENSGT00390000012837.
HOGENOMiHOG000007911.
HOVERGENiHBG055591.
InParanoidiO00471.
KOiK19984.
PhylomeDBiO00471.
TreeFamiTF314966.

Family and domain databases

InterProiView protein in InterPro
IPR033960. EXOC5/Sec10.
IPR009976. Sec10-like.
PANTHERiPTHR12100. PTHR12100. 1 hit.
PTHR12100:SF0. PTHR12100:SF0. 1 hit.
PfamiView protein in Pfam
PF07393. Sec10. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI
60 70 80 90 100
QELQIMDERI QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD
110 120 130 140 150
EHISYVATKV CHLGDQLEGV NTPRQRAVEA QKLMKYFNEF LDGELKSDVF
160 170 180 190 200
TNSEKIKEAA DIIQKLHLIA QELPFDRFSE VKSKIASKYH DLECQLIQEF
210 220 230 240 250
TSAQRRGEIS RMREVAAVLL HFKGYSHCVD VYIKQCQEGA YLRNDIFEDA
260 270 280 290 300
GILCQRVNKQ VGDIFSNPET VLAKLIQNVF EIKLQSFVKE QLEECRKSDA
310 320 330 340 350
EQYLKNLYDL YTRTTNLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI
360 370 380 390 400
EVETGYLKSR SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG
410 420 430 440 450
PSIDTHGETF LSQEVVVNLL QETKQAFERC HRLSDPSDLP RNAFRIFTIL
460 470 480 490 500
VEFLCIEHID YALETGLAGI PSSDSRNANL YFLDVVQQAN TIFHLFDKQF
510 520 530 540 550
NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL NCMIGQMKHI
560 570 580 590 600
LAAEQKKTDF KPEDENNVLI QYTNACVKVC AYVRKQVEKI KNSMDGKNVD
610 620 630 640 650
TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV
660 670 680 690 700
LHLFDTLHAL CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS

ARLARHFS
Length:708
Mass (Da):81,853
Last modified:July 1, 1997 - v1
Checksum:iCB03AC6C64DAB50C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti545G → R in AAH41126 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04895710E → D. Corresponds to variant dbSNP:rs35132458Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85946 mRNA. Translation: AAB53388.1.
AK312523 mRNA. Translation: BAG35422.1.
CH471061 Genomic DNA. Translation: EAW80699.1.
BC041126 mRNA. Translation: AAH41126.1.
CCDSiCCDS45111.1.
RefSeqiNP_006535.1. NM_006544.3.
UniGeneiHs.743987.

Genome annotation databases

EnsembliENST00000621441; ENSP00000484855; ENSG00000070367.
GeneIDi10640.
KEGGihsa:10640.
UCSCiuc001xct.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEXOC5_HUMAN
AccessioniPrimary (citable) accession number: O00471
Secondary accession number(s): B2R6C5, Q8IW24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 1, 1997
Last modified: October 25, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families