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Protein

TNF receptor-associated factor 5

Gene

TRAF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri45 – 85RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri127 – 181TRAF-type 1PROSITE-ProRule annotationAdd BLAST55
Zinc fingeri182 – 239TRAF-type 2PROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • thioesterase binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  • regulation of apoptotic process Source: InterPro
  • signal transduction Source: ProtInc

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiO00463.
SIGNORiO00463.

Names & Taxonomyi

Protein namesi
Recommended name:
TNF receptor-associated factor 5
Alternative name(s):
RING finger protein 84
Gene namesi
Name:TRAF5
Synonyms:RNF84
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12035. TRAF5.

Subcellular locationi

GO - Cellular componenti

  • CD40 receptor complex Source: BHF-UCL
  • centrosome Source: UniProtKB
  • cytoplasmic side of plasma membrane Source: BHF-UCL
  • cytosol Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi7188.
OpenTargetsiENSG00000082512.
PharmGKBiPA36712.

Polymorphism and mutation databases

BioMutaiTRAF5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564051 – 557TNF receptor-associated factor 5Add BLAST557

Proteomic databases

EPDiO00463.
PaxDbiO00463.
PeptideAtlasiO00463.
PRIDEiO00463.

PTM databases

iPTMnetiO00463.
PhosphoSitePlusiO00463.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

Gene expression databases

BgeeiENSG00000082512.
CleanExiHS_TRAF5.
GenevisibleiO00463. HS.

Organism-specific databases

HPAiCAB010277.
HPA008052.

Interactioni

Subunit structurei

Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain).Curated15 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • thioesterase binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113040. 66 interactors.
IntActiO00463. 58 interactors.
MINTiMINT-1535869.
STRINGi9606.ENSP00000261464.

Structurei

3D structure databases

ProteinModelPortaliO00463.
SMRiO00463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini403 – 549MATHPROSITE-ProRule annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni345 – 557Interaction with EIF2AK2/PKR1 PublicationAdd BLAST213

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili237 – 342Sequence analysisAdd BLAST106

Domaini

The MATH/TRAF domain binds to receptor cytoplasmic domains.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri45 – 85RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri127 – 181TRAF-type 1PROSITE-ProRule annotationAdd BLAST55
Zinc fingeri182 – 239TRAF-type 2PROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KDGU. Eukaryota.
ENOG410ZHGV. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000231557.
HOVERGENiHBG058222.
InParanoidiO00463.
KOiK09849.
OMAiIDKSAWL.
OrthoDBiEOG091G0GHD.
PhylomeDBiO00463.
TreeFamiTF321154.

Family and domain databases

CDDicd00162. RING. 1 hit.
Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 4 hits.
InterProiView protein in InterPro
IPR002083. MATH/TRAF_dom.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027130. TRAF5.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
PANTHERiPTHR10131:SF102. PTHR10131:SF102. 1 hit.
PfamiView protein in Pfam
PF00097. zf-C3HC4. 1 hit.
PF02176. zf-TRAF. 1 hit.
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiView protein in SMART
SM00061. MATH. 1 hit.
SM00184. RING. 1 hit.
SUPFAMiSSF49599. SSF49599. 3 hits.
PROSITEiView protein in PROSITE
PS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O00463-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS
60 70 80 90 100
VLHNPHQTGC GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK
110 120 130 140 150
REVLNLYVYC SNAPGCNAKV ILGRYQDHLQ QCLFQPVQCS NEKCREPVLR
160 170 180 190 200
KDLKEHLSAS CQFRKEKCLY CKKDVVVINL QNHEENLCPE YPVFCPNNCA
210 220 230 240 250
KIILKTEVDE HLAVCPEAEQ DCPFKHYGCA VTDKRRNLQQ HEHSALREHM
260 270 280 290 300
RLVLEKNVQL EEQISDLHKS LEQKESKIQQ LAETIKKLEK EFKQFAQLFG
310 320 330 340 350
KNGSFLPNIQ VFASHIDKSA WLEAQVHQLL QMVNQQQNKF DLRPLMEAVD
360 370 380 390 400
TVKQKITLLE NNDQRLAVLE EETNKHDTHI NIHKAQLSKN EERFKLLEGT
410 420 430 440 450
CYNGKLIWKV TDYKMKKREA VDGHTVSIFS QSFYTSRCGY RLCARAYLNG
460 470 480 490 500
DGSGRGSHLS LYFVVMRGEF DSLLQWPFRQ RVTLMLLDQS GKKNIMETFK
510 520 530 540 550
PDPNSSSFKR PDGEMNIASG CPRFVAHSVL ENAKNAYIKD DTLFLKVAVD

LTDLEDL
Length:557
Mass (Da):64,406
Last modified:November 1, 1998 - v2
Checksum:i86EB3724CE111176
GO
Isoform 2 (identifier: O00463-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-126: Q → QQVPLACCYLLQ

Note: No experimental confirmation available.
Show »
Length:568
Mass (Da):65,638
Checksum:i6FDF94A0E03DA62A
GO
Isoform 3 (identifier: O00463-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-232: Missing.

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):52,158
Checksum:i82936A6A81BA59AF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052151120V → G. Corresponds to variant dbSNP:rs3946808Ensembl.1
Natural variantiVAR_020117186N → H. Corresponds to variant dbSNP:rs2271458Ensembl.1
Natural variantiVAR_071060268H → Y1 PublicationCorresponds to variant dbSNP:rs200398415Ensembl.1
Natural variantiVAR_052152358L → V. Corresponds to variant dbSNP:rs2230780Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055449126Q → QQVPLACCYLLQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_055450127 – 232Missing in isoform 3. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000509 mRNA. Translation: BAA25262.1.
AK295766 mRNA. Translation: BAG58591.1.
AK303286 mRNA. Translation: BAG64364.1.
CR536557 mRNA. Translation: CAG38794.1.
AL590101 Genomic DNA. Translation: CAH72434.1.
CH471100 Genomic DNA. Translation: EAW93420.1.
CH471100 Genomic DNA. Translation: EAW93422.1.
BC029600 mRNA. Translation: AAH29600.1.
U69108 mRNA. Translation: AAC51329.1.
CCDSiCCDS1497.1. [O00463-1]
PIRiJC6539.
RefSeqiNP_001029082.1. NM_001033910.2. [O00463-1]
NP_001306136.1. NM_001319207.1. [O00463-2]
NP_004610.1. NM_004619.3. [O00463-1]
NP_665702.1. NM_145759.2. [O00463-1]
XP_011508261.1. XM_011509959.2. [O00463-2]
XP_011508262.1. XM_011509960.2. [O00463-2]
XP_016857710.1. XM_017002221.1. [O00463-1]
UniGeneiHs.523930.

Genome annotation databases

EnsembliENST00000261464; ENSP00000261464; ENSG00000082512. [O00463-1]
ENST00000336184; ENSP00000336825; ENSG00000082512. [O00463-1]
ENST00000367004; ENSP00000355971; ENSG00000082512. [O00463-1]
GeneIDi7188.
KEGGihsa:7188.
UCSCiuc001hih.4. human. [O00463-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000509 mRNA. Translation: BAA25262.1.
AK295766 mRNA. Translation: BAG58591.1.
AK303286 mRNA. Translation: BAG64364.1.
CR536557 mRNA. Translation: CAG38794.1.
AL590101 Genomic DNA. Translation: CAH72434.1.
CH471100 Genomic DNA. Translation: EAW93420.1.
CH471100 Genomic DNA. Translation: EAW93422.1.
BC029600 mRNA. Translation: AAH29600.1.
U69108 mRNA. Translation: AAC51329.1.
CCDSiCCDS1497.1. [O00463-1]
PIRiJC6539.
RefSeqiNP_001029082.1. NM_001033910.2. [O00463-1]
NP_001306136.1. NM_001319207.1. [O00463-2]
NP_004610.1. NM_004619.3. [O00463-1]
NP_665702.1. NM_145759.2. [O00463-1]
XP_011508261.1. XM_011509959.2. [O00463-2]
XP_011508262.1. XM_011509960.2. [O00463-2]
XP_016857710.1. XM_017002221.1. [O00463-1]
UniGeneiHs.523930.

3D structure databases

ProteinModelPortaliO00463.
SMRiO00463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113040. 66 interactors.
IntActiO00463. 58 interactors.
MINTiMINT-1535869.
STRINGi9606.ENSP00000261464.

PTM databases

iPTMnetiO00463.
PhosphoSitePlusiO00463.

Polymorphism and mutation databases

BioMutaiTRAF5.

Proteomic databases

EPDiO00463.
PaxDbiO00463.
PeptideAtlasiO00463.
PRIDEiO00463.

Protocols and materials databases

DNASUi7188.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261464; ENSP00000261464; ENSG00000082512. [O00463-1]
ENST00000336184; ENSP00000336825; ENSG00000082512. [O00463-1]
ENST00000367004; ENSP00000355971; ENSG00000082512. [O00463-1]
GeneIDi7188.
KEGGihsa:7188.
UCSCiuc001hih.4. human. [O00463-1]

Organism-specific databases

CTDi7188.
DisGeNETi7188.
GeneCardsiTRAF5.
HGNCiHGNC:12035. TRAF5.
HPAiCAB010277.
HPA008052.
MIMi602356. gene.
neXtProtiNX_O00463.
OpenTargetsiENSG00000082512.
PharmGKBiPA36712.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDGU. Eukaryota.
ENOG410ZHGV. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000231557.
HOVERGENiHBG058222.
InParanoidiO00463.
KOiK09849.
OMAiIDKSAWL.
OrthoDBiEOG091G0GHD.
PhylomeDBiO00463.
TreeFamiTF321154.

Enzyme and pathway databases

SignaLinkiO00463.
SIGNORiO00463.

Miscellaneous databases

ChiTaRSiTRAF5. human.
GeneWikiiTRAF5.
GenomeRNAii7188.
PROiPR:O00463.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082512.
CleanExiHS_TRAF5.
GenevisibleiO00463. HS.

Family and domain databases

CDDicd00162. RING. 1 hit.
Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 4 hits.
InterProiView protein in InterPro
IPR002083. MATH/TRAF_dom.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027130. TRAF5.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
PANTHERiPTHR10131:SF102. PTHR10131:SF102. 1 hit.
PfamiView protein in Pfam
PF00097. zf-C3HC4. 1 hit.
PF02176. zf-TRAF. 1 hit.
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiView protein in SMART
SM00061. MATH. 1 hit.
SM00184. RING. 1 hit.
SUPFAMiSSF49599. SSF49599. 3 hits.
PROSITEiView protein in PROSITE
PS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTRAF5_HUMAN
AccessioniPrimary (citable) accession number: O00463
Secondary accession number(s): B4DIS9, B4E0A2, Q6FHY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1998
Last modified: May 10, 2017
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.