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O00461

- GOLI4_HUMAN

UniProt

O00461 - GOLI4_HUMAN

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Protein

Golgi integral membrane protein 4

Gene

GOLIM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.1 Publication

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi integral membrane protein 4
Alternative name(s):
Golgi integral membrane protein, cis
Short name:
GIMPc
Golgi phosphoprotein 4
Golgi-localized phosphoprotein of 130 kDa
Short name:
Golgi phosphoprotein of 130 kDa
Gene namesi
Name:GOLIM4
Synonyms:GIMPC, GOLPH4, GPP130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:15448. GOLIM4.

Subcellular locationi

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein
Note: Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei13 – 3321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini34 – 696663LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cis-Golgi network Source: ProtInc
  2. endocytic vesicle Source: ProtInc
  3. endosome Source: UniProtKB-KW
  4. Golgi apparatus Source: HPA
  5. Golgi lumen Source: ProtInc
  6. integral component of membrane Source: ProtInc
  7. membrane Source: UniProtKB
  8. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390001.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Golgi integral membrane protein 4PRO_0000285097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
Modified residuei673 – 6731PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.1 Publication
O-glycosylated; modified by sialic acid residues.By similarity
N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO00461.
PaxDbiO00461.
PeptideAtlasiO00461.
PRIDEiO00461.

PTM databases

PhosphoSiteiO00461.

Expressioni

Gene expression databases

BgeeiO00461.
CleanExiHS_GOLIM4.
ExpressionAtlasiO00461. baseline and differential.
GenevestigatoriO00461.

Organism-specific databases

HPAiHPA001677.
HPA002315.

Interactioni

Protein-protein interaction databases

BioGridi118146. 10 interactions.
MINTiMINT-5002147.
STRINGi9606.ENSP00000417354.

Structurei

3D structure databases

ProteinModelPortaliO00461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 10770Golgi targetingAdd
BLAST
Regioni80 – 17596Endosome targetingAdd
BLAST
Regioni176 – 24873Golgi targetingAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili35 – 244210Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi311 – 681371Glu-richAdd
BLAST
Compositional biasi404 – 513110Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the GOLIM4 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG122835.
GeneTreeiENSGT00390000004096.
HOGENOMiHOG000112755.
HOVERGENiHBG107959.
InParanoidiO00461.
OMAiRQQAHYD.
OrthoDBiEOG7G4QDS.
PhylomeDBiO00461.
TreeFamiTF333101.

Sequencei

Sequence statusi: Complete.

O00461-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNGMCSRKQ KRIFQTLLLL TVVFGFLYGA MLYYELQTQL RKAEAVALKY
60 70 80 90 100
QQHQESLSAQ LQVVYEHRSR LEKSLQKERL EHKKAKEDFL VYKLEAQETL
110 120 130 140 150
NKGRQDSNSR YSALNVQHQM LKSQHEELKK QHSDLEEEHR KQGEDFSRTF
160 170 180 190 200
NDHKQKYLQL QQEKEQELSK LKETVYNLRE ENRQLRKAHQ DIHTQLQDVK
210 220 230 240 250
QQHKNLLSEH EQLVVTLEDH KSALAAAQTQ VAEYKQLKDT LNRIPSLRKP
260 270 280 290 300
DPAEQQNVTQ VAHSPQGYNT AREKPTREVQ EVSRNNDVWQ NHEAVPGRAE
310 320 330 340 350
DTKLYAPTHK EAEFQAPPEP IQQEVERREP EEHQVEEEHR KALEEEEMEQ
360 370 380 390 400
VGQAEHLEEE HDPSPEEQDR EWKEQHEQRE AANLLEGHAR AEVYPSAKPM
410 420 430 440 450
IKFQSPYEEQ LEQQRLAVQQ VEEAQQLREH QEALHQQRLQ GHLLRQQEQQ
460 470 480 490 500
QQQVAREMAL QRQAELEEGR PQHQEQLRQQ AHYDAMDNDI VQGAEDQGIQ
510 520 530 540 550
GEEGAYERDN QHQDEAEGDP GNRHEPREQG PREADPESEA DRAAVEDINP
560 570 580 590 600
ADDPNNQGED EFEEAEQVRE ENLPDENEEQ KQSNQKQENT EVEEHLVMAG
610 620 630 640 650
NPDQQEDNVD EQYQEEAEEE VQEDLTEEKK RELEHNAEET YGENDENTDD
660 670 680 690
KNNDGEEQEV RDDNRPKGRE EHYEEEEEEE EDGAAVAEKS HRRAEM
Length:696
Mass (Da):81,880
Last modified:July 1, 1997 - v1
Checksum:iA3BA9AE3D52F7174
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti312 – 3121A → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036611

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55853 mRNA. Translation: AAB58419.1.
CCDSiCCDS3204.1.
RefSeqiNP_055313.1. NM_014498.3.
UniGeneiHs.143600.

Genome annotation databases

EnsembliENST00000470487; ENSP00000417354; ENSG00000173905.
GeneIDi27333.
KEGGihsa:27333.
UCSCiuc003ffe.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55853 mRNA. Translation: AAB58419.1 .
CCDSi CCDS3204.1.
RefSeqi NP_055313.1. NM_014498.3.
UniGenei Hs.143600.

3D structure databases

ProteinModelPortali O00461.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118146. 10 interactions.
MINTi MINT-5002147.
STRINGi 9606.ENSP00000417354.

PTM databases

PhosphoSitei O00461.

Proteomic databases

MaxQBi O00461.
PaxDbi O00461.
PeptideAtlasi O00461.
PRIDEi O00461.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000470487 ; ENSP00000417354 ; ENSG00000173905 .
GeneIDi 27333.
KEGGi hsa:27333.
UCSCi uc003ffe.2. human.

Organism-specific databases

CTDi 27333.
GeneCardsi GC03M167727.
HGNCi HGNC:15448. GOLIM4.
HPAi HPA001677.
HPA002315.
MIMi 606805. gene.
neXtProti NX_O00461.
PharmGKBi PA162390001.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG122835.
GeneTreei ENSGT00390000004096.
HOGENOMi HOG000112755.
HOVERGENi HBG107959.
InParanoidi O00461.
OMAi RQQAHYD.
OrthoDBi EOG7G4QDS.
PhylomeDBi O00461.
TreeFami TF333101.

Miscellaneous databases

ChiTaRSi GOLIM4. human.
GenomeRNAii 27333.
NextBioi 50382.
PROi O00461.
SOURCEi Search...

Gene expression databases

Bgeei O00461.
CleanExi HS_GOLIM4.
ExpressionAtlasi O00461. baseline and differential.
Genevestigatori O00461.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein."
    Linstedt A.D., Mehta A., Suhan J., Reggio H., Hauri H.-P.
    Mol. Biol. Cell 8:1073-1087(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION, GLYCOSYLATION, TOPOLOGY.
    Tissue: Small intestine.
  2. "Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein."
    Bachert C., Lee T.H., Linstedt A.D.
    Mol. Biol. Cell 12:3152-3160(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "A cycling cis-Golgi protein mediates endosome-to-Golgi traffic."
    Natarajan R., Linstedt A.D.
    Mol. Biol. Cell 15:4798-4806(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-312.

Entry informationi

Entry nameiGOLI4_HUMAN
AccessioniPrimary (citable) accession number: O00461
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3