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O00461

- GOLI4_HUMAN

UniProt

O00461 - GOLI4_HUMAN

Protein

Golgi integral membrane protein 4

Gene

GOLIM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.1 Publication

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi integral membrane protein 4
    Alternative name(s):
    Golgi integral membrane protein, cis
    Short name:
    GIMPc
    Golgi phosphoprotein 4
    Golgi-localized phosphoprotein of 130 kDa
    Short name:
    Golgi phosphoprotein of 130 kDa
    Gene namesi
    Name:GOLIM4
    Synonyms:GIMPC, GOLPH4, GPP130
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:15448. GOLIM4.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein
    Note: Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.

    GO - Cellular componenti

    1. cis-Golgi network Source: ProtInc
    2. endocytic vesicle Source: ProtInc
    3. endosome membrane Source: UniProtKB-SubCell
    4. Golgi apparatus Source: HPA
    5. Golgi cisterna membrane Source: UniProtKB-SubCell
    6. Golgi lumen Source: ProtInc
    7. integral component of membrane Source: ProtInc
    8. membrane Source: UniProtKB
    9. nucleus Source: HPA

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162390001.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 696696Golgi integral membrane protein 4PRO_0000285097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Modified residuei673 – 6731PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.1 Publication
    O-glycosylated; modified by sialic acid residues.By similarity
    N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO00461.
    PaxDbiO00461.
    PeptideAtlasiO00461.
    PRIDEiO00461.

    PTM databases

    PhosphoSiteiO00461.

    Expressioni

    Gene expression databases

    ArrayExpressiO00461.
    BgeeiO00461.
    CleanExiHS_GOLIM4.
    GenevestigatoriO00461.

    Organism-specific databases

    HPAiHPA001677.
    HPA002315.

    Interactioni

    Protein-protein interaction databases

    BioGridi118146. 3 interactions.
    MINTiMINT-5002147.
    STRINGi9606.ENSP00000417354.

    Structurei

    3D structure databases

    ProteinModelPortaliO00461.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 696663LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni38 – 10770Golgi targetingAdd
    BLAST
    Regioni80 – 17596Endosome targetingAdd
    BLAST
    Regioni176 – 24873Golgi targetingAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili35 – 244210Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi311 – 681371Glu-richAdd
    BLAST
    Compositional biasi404 – 513110Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GOLIM4 family.Curated

    Keywords - Domaini

    Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG122835.
    HOGENOMiHOG000112755.
    HOVERGENiHBG107959.
    InParanoidiO00461.
    OMAiRQQAHYD.
    OrthoDBiEOG7G4QDS.
    PhylomeDBiO00461.
    TreeFamiTF333101.

    Sequencei

    Sequence statusi: Complete.

    O00461-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNGMCSRKQ KRIFQTLLLL TVVFGFLYGA MLYYELQTQL RKAEAVALKY    50
    QQHQESLSAQ LQVVYEHRSR LEKSLQKERL EHKKAKEDFL VYKLEAQETL 100
    NKGRQDSNSR YSALNVQHQM LKSQHEELKK QHSDLEEEHR KQGEDFSRTF 150
    NDHKQKYLQL QQEKEQELSK LKETVYNLRE ENRQLRKAHQ DIHTQLQDVK 200
    QQHKNLLSEH EQLVVTLEDH KSALAAAQTQ VAEYKQLKDT LNRIPSLRKP 250
    DPAEQQNVTQ VAHSPQGYNT AREKPTREVQ EVSRNNDVWQ NHEAVPGRAE 300
    DTKLYAPTHK EAEFQAPPEP IQQEVERREP EEHQVEEEHR KALEEEEMEQ 350
    VGQAEHLEEE HDPSPEEQDR EWKEQHEQRE AANLLEGHAR AEVYPSAKPM 400
    IKFQSPYEEQ LEQQRLAVQQ VEEAQQLREH QEALHQQRLQ GHLLRQQEQQ 450
    QQQVAREMAL QRQAELEEGR PQHQEQLRQQ AHYDAMDNDI VQGAEDQGIQ 500
    GEEGAYERDN QHQDEAEGDP GNRHEPREQG PREADPESEA DRAAVEDINP 550
    ADDPNNQGED EFEEAEQVRE ENLPDENEEQ KQSNQKQENT EVEEHLVMAG 600
    NPDQQEDNVD EQYQEEAEEE VQEDLTEEKK RELEHNAEET YGENDENTDD 650
    KNNDGEEQEV RDDNRPKGRE EHYEEEEEEE EDGAAVAEKS HRRAEM 696
    Length:696
    Mass (Da):81,880
    Last modified:July 1, 1997 - v1
    Checksum:iA3BA9AE3D52F7174
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti312 – 3121A → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036611

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55853 mRNA. Translation: AAB58419.1.
    CCDSiCCDS3204.1.
    RefSeqiNP_055313.1. NM_014498.3.
    UniGeneiHs.143600.

    Genome annotation databases

    EnsembliENST00000470487; ENSP00000417354; ENSG00000173905.
    GeneIDi27333.
    KEGGihsa:27333.
    UCSCiuc003ffe.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55853 mRNA. Translation: AAB58419.1 .
    CCDSi CCDS3204.1.
    RefSeqi NP_055313.1. NM_014498.3.
    UniGenei Hs.143600.

    3D structure databases

    ProteinModelPortali O00461.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118146. 3 interactions.
    MINTi MINT-5002147.
    STRINGi 9606.ENSP00000417354.

    PTM databases

    PhosphoSitei O00461.

    Proteomic databases

    MaxQBi O00461.
    PaxDbi O00461.
    PeptideAtlasi O00461.
    PRIDEi O00461.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000470487 ; ENSP00000417354 ; ENSG00000173905 .
    GeneIDi 27333.
    KEGGi hsa:27333.
    UCSCi uc003ffe.2. human.

    Organism-specific databases

    CTDi 27333.
    GeneCardsi GC03M167727.
    HGNCi HGNC:15448. GOLIM4.
    HPAi HPA001677.
    HPA002315.
    MIMi 606805. gene.
    neXtProti NX_O00461.
    PharmGKBi PA162390001.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG122835.
    HOGENOMi HOG000112755.
    HOVERGENi HBG107959.
    InParanoidi O00461.
    OMAi RQQAHYD.
    OrthoDBi EOG7G4QDS.
    PhylomeDBi O00461.
    TreeFami TF333101.

    Miscellaneous databases

    ChiTaRSi GOLIM4. human.
    GenomeRNAii 27333.
    NextBioi 50382.
    PROi O00461.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00461.
    Bgeei O00461.
    CleanExi HS_GOLIM4.
    Genevestigatori O00461.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein."
      Linstedt A.D., Mehta A., Suhan J., Reggio H., Hauri H.-P.
      Mol. Biol. Cell 8:1073-1087(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION, GLYCOSYLATION, TOPOLOGY.
      Tissue: Small intestine.
    2. "Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein."
      Bachert C., Lee T.H., Linstedt A.D.
      Mol. Biol. Cell 12:3152-3160(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    3. "A cycling cis-Golgi protein mediates endosome-to-Golgi traffic."
      Natarajan R., Linstedt A.D.
      Mol. Biol. Cell 15:4798-4806(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-312.

    Entry informationi

    Entry nameiGOLI4_HUMAN
    AccessioniPrimary (citable) accession number: O00461
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3