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Protein

Golgi integral membrane protein 4

Gene

GOLIM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173905-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi integral membrane protein 4
Alternative name(s):
Golgi integral membrane protein, cis
Short name:
GIMPc
Golgi phosphoprotein 4
Golgi-localized phosphoprotein of 130 kDa
Short name:
Golgi phosphoprotein of 130 kDa
Gene namesi
Name:GOLIM4
Synonyms:GIMPC, GOLPH4, GPP130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:15448. GOLIM4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12CytoplasmicSequence analysisAdd BLAST11
Transmembranei13 – 33Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini34 – 696LumenalSequence analysisAdd BLAST663

GO - Cellular componenti

  • cis-Golgi network Source: ProtInc
  • endocytic vesicle Source: ProtInc
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: HPA
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • Golgi lumen Source: ProtInc
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: ProtInc
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • transport vesicle Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27333.
OpenTargetsiENSG00000173905.
PharmGKBiPA162390001.

Polymorphism and mutation databases

BioMutaiGOLIM4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002850972 – 696Golgi integral membrane protein 4Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Modified residuei364PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1
Modified residuei613PhosphotyrosineCombined sources1
Modified residuei626PhosphothreonineCombined sources1
Modified residuei673PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.1 Publication
O-glycosylated; modified by sialic acid residues.By similarity
N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiO00461.
MaxQBiO00461.
PaxDbiO00461.
PeptideAtlasiO00461.
PRIDEiO00461.

PTM databases

iPTMnetiO00461.
PhosphoSitePlusiO00461.
SwissPalmiO00461.

Expressioni

Gene expression databases

BgeeiENSG00000173905.
CleanExiHS_GOLIM4.
ExpressionAtlasiO00461. baseline and differential.
GenevisibleiO00461. HS.

Organism-specific databases

HPAiHPA001677.
HPA002315.

Interactioni

Protein-protein interaction databases

BioGridi118146. 54 interactors.
DIPiDIP-61898N.
IntActiO00461. 28 interactors.
MINTiMINT-5002147.
STRINGi9606.ENSP00000417354.

Structurei

3D structure databases

ProteinModelPortaliO00461.
SMRiO00461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 107Golgi targetingAdd BLAST70
Regioni80 – 175Endosome targetingAdd BLAST96
Regioni176 – 248Golgi targetingAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili35 – 244Sequence analysisAdd BLAST210

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 681Glu-richAdd BLAST371
Compositional biasi404 – 513Gln-richAdd BLAST110

Sequence similaritiesi

Belongs to the GOLIM4 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGPG. Eukaryota.
ENOG410XRK9. LUCA.
GeneTreeiENSGT00390000004096.
HOGENOMiHOG000112755.
HOVERGENiHBG107959.
InParanoidiO00461.
OMAiQTQVAEY.
OrthoDBiEOG091G053H.
PhylomeDBiO00461.
TreeFamiTF333101.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGMCSRKQ KRIFQTLLLL TVVFGFLYGA MLYYELQTQL RKAEAVALKY
60 70 80 90 100
QQHQESLSAQ LQVVYEHRSR LEKSLQKERL EHKKAKEDFL VYKLEAQETL
110 120 130 140 150
NKGRQDSNSR YSALNVQHQM LKSQHEELKK QHSDLEEEHR KQGEDFSRTF
160 170 180 190 200
NDHKQKYLQL QQEKEQELSK LKETVYNLRE ENRQLRKAHQ DIHTQLQDVK
210 220 230 240 250
QQHKNLLSEH EQLVVTLEDH KSALAAAQTQ VAEYKQLKDT LNRIPSLRKP
260 270 280 290 300
DPAEQQNVTQ VAHSPQGYNT AREKPTREVQ EVSRNNDVWQ NHEAVPGRAE
310 320 330 340 350
DTKLYAPTHK EAEFQAPPEP IQQEVERREP EEHQVEEEHR KALEEEEMEQ
360 370 380 390 400
VGQAEHLEEE HDPSPEEQDR EWKEQHEQRE AANLLEGHAR AEVYPSAKPM
410 420 430 440 450
IKFQSPYEEQ LEQQRLAVQQ VEEAQQLREH QEALHQQRLQ GHLLRQQEQQ
460 470 480 490 500
QQQVAREMAL QRQAELEEGR PQHQEQLRQQ AHYDAMDNDI VQGAEDQGIQ
510 520 530 540 550
GEEGAYERDN QHQDEAEGDP GNRHEPREQG PREADPESEA DRAAVEDINP
560 570 580 590 600
ADDPNNQGED EFEEAEQVRE ENLPDENEEQ KQSNQKQENT EVEEHLVMAG
610 620 630 640 650
NPDQQEDNVD EQYQEEAEEE VQEDLTEEKK RELEHNAEET YGENDENTDD
660 670 680 690
KNNDGEEQEV RDDNRPKGRE EHYEEEEEEE EDGAAVAEKS HRRAEM
Length:696
Mass (Da):81,880
Last modified:July 1, 1997 - v1
Checksum:iA3BA9AE3D52F7174
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036611312A → V in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55853 mRNA. Translation: AAB58419.1.
CCDSiCCDS3204.1.
RefSeqiNP_055313.1. NM_014498.4.
UniGeneiHs.143600.
Hs.592880.

Genome annotation databases

EnsembliENST00000470487; ENSP00000417354; ENSG00000173905.
GeneIDi27333.
KEGGihsa:27333.
UCSCiuc003ffe.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55853 mRNA. Translation: AAB58419.1.
CCDSiCCDS3204.1.
RefSeqiNP_055313.1. NM_014498.4.
UniGeneiHs.143600.
Hs.592880.

3D structure databases

ProteinModelPortaliO00461.
SMRiO00461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118146. 54 interactors.
DIPiDIP-61898N.
IntActiO00461. 28 interactors.
MINTiMINT-5002147.
STRINGi9606.ENSP00000417354.

PTM databases

iPTMnetiO00461.
PhosphoSitePlusiO00461.
SwissPalmiO00461.

Polymorphism and mutation databases

BioMutaiGOLIM4.

Proteomic databases

EPDiO00461.
MaxQBiO00461.
PaxDbiO00461.
PeptideAtlasiO00461.
PRIDEiO00461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000470487; ENSP00000417354; ENSG00000173905.
GeneIDi27333.
KEGGihsa:27333.
UCSCiuc003ffe.3. human.

Organism-specific databases

CTDi27333.
DisGeNETi27333.
GeneCardsiGOLIM4.
HGNCiHGNC:15448. GOLIM4.
HPAiHPA001677.
HPA002315.
MIMi606805. gene.
neXtProtiNX_O00461.
OpenTargetsiENSG00000173905.
PharmGKBiPA162390001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGPG. Eukaryota.
ENOG410XRK9. LUCA.
GeneTreeiENSGT00390000004096.
HOGENOMiHOG000112755.
HOVERGENiHBG107959.
InParanoidiO00461.
OMAiQTQVAEY.
OrthoDBiEOG091G053H.
PhylomeDBiO00461.
TreeFamiTF333101.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173905-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Miscellaneous databases

ChiTaRSiGOLIM4. human.
GenomeRNAii27333.
PROiO00461.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173905.
CleanExiHS_GOLIM4.
ExpressionAtlasiO00461. baseline and differential.
GenevisibleiO00461. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiGOLI4_HUMAN
AccessioniPrimary (citable) accession number: O00461
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.