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O00459

- P85B_HUMAN

UniProt

O00459 - P85B_HUMAN

Protein

Phosphatidylinositol 3-kinase regulatory subunit beta

Gene

PIK3R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

    GO - Molecular functioni

    1. phosphatidylinositol 3-kinase regulator activity Source: InterPro
    2. protein binding Source: IntAct
    3. receptor tyrosine kinase binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. epidermal growth factor receptor signaling pathway Source: Reactome
    3. Fc-epsilon receptor signaling pathway Source: Reactome
    4. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    5. fibroblast growth factor receptor signaling pathway Source: Reactome
    6. innate immune response Source: Reactome
    7. insulin receptor signaling pathway Source: Reactome
    8. leukocyte migration Source: Reactome
    9. neurotrophin TRK receptor signaling pathway Source: Reactome
    10. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    11. phosphatidylinositol biosynthetic process Source: Reactome
    12. phosphatidylinositol-mediated signaling Source: Reactome
    13. phospholipid metabolic process Source: Reactome
    14. regulation of small GTPase mediated signal transduction Source: Reactome
    15. small GTPase mediated signal transduction Source: Reactome
    16. small molecule metabolic process Source: Reactome
    17. T cell receptor signaling pathway Source: Reactome

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000105647-MONOMER.
    ReactomeiREACT_11051. Rho GTPase cycle.
    REACT_111040. Signaling by SCF-KIT.
    REACT_115529. Interleukin-7 signaling.
    REACT_121025. Synthesis of PIPs at the plasma membrane.
    REACT_12464. PI3K/AKT activation.
    REACT_12555. Downstream TCR signaling.
    REACT_12621. Tie2 Signaling.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_147814. DAP12 signaling.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_1695. GPVI-mediated activation cascade.
    REACT_17025. Downstream signal transduction.
    REACT_18283. G alpha (q) signalling events.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19344. Costimulation by the CD28 family.
    REACT_19358. CD28 dependent PI3K/Akt signaling.
    REACT_23787. Regulation of signaling by CBL.
    REACT_23832. Nephrin interactions.
    REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
    REACT_23891. Interleukin receptor SHC signaling.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_976. PI3K Cascade.
    SignaLinkiO00459.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase regulatory subunit beta
    Short name:
    PI3-kinase regulatory subunit beta
    Short name:
    PI3K regulatory subunit beta
    Short name:
    PtdIns-3-kinase regulatory subunit beta
    Alternative name(s):
    Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
    Short name:
    PI3-kinase subunit p85-beta
    Short name:
    PtdIns-3-kinase regulatory subunit p85-beta
    Gene namesi
    Name:PIK3R2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8980. PIK3R2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. phosphatidylinositol 3-kinase complex Source: InterPro

    Pathology & Biotechi

    Involvement in diseasei

    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH) [MIM:603387]: A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti373 – 3731G → R in MPPH. 1 Publication
    VAR_069262

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi603387. phenotype.
    Orphaneti83473. Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus.
    PharmGKBiPA33313.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 728728Phosphatidylinositol 3-kinase regulatory subunit betaPRO_0000080763Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei464 – 4641Phosphotyrosine2 Publications
    Modified residuei605 – 6051Phosphotyrosine2 Publications

    Post-translational modificationi

    Phosphorylated in response to signaling from activated receptor-type protein kinases. Dephosphorylated by PTPRJ.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO00459.
    PaxDbiO00459.
    PRIDEiO00459.

    PTM databases

    PhosphoSiteiO00459.

    Expressioni

    Gene expression databases

    BgeeiO00459.
    CleanExiHS_PIK3R2.
    GenevestigatoriO00459.

    Interactioni

    Subunit structurei

    Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated). Interacts with NYAP1, NYAP2 and MYO16.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARP1027514EBI-346930,EBI-608057
    EGFRP005332EBI-346930,EBI-297353
    ERBB2P046266EBI-346930,EBI-641062
    ERBB3P2186016EBI-346930,EBI-720706
    GAB1Q1348023EBI-346930,EBI-517684
    GRB2P629934EBI-346930,EBI-401755
    HTTP428586EBI-346930,EBI-466029
    KITP1072119EBI-346930,EBI-1379503
    METP0858111EBI-346930,EBI-1039152
    NSP034968EBI-346930,EBI-2547442From a different organism.
    PIK3CBP423383EBI-346930,EBI-2609540

    Protein-protein interaction databases

    BioGridi111314. 88 interactions.
    IntActiO00459. 48 interactions.
    MINTiMINT-1210047.
    STRINGi9606.ENSP00000222254.

    Structurei

    Secondary structure

    1
    728
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 117
    Beta strandi30 – 345
    Helixi35 – 406
    Helixi47 – 493
    Helixi51 – 544
    Beta strandi56 – 616
    Turni62 – 643
    Beta strandi67 – 715
    Helixi72 – 743
    Beta strandi75 – 817
    Helixi114 – 1174
    Helixi126 – 13813
    Helixi144 – 1463
    Helixi162 – 1643
    Helixi167 – 18014
    Beta strandi181 – 1833
    Helixi188 – 19912
    Helixi206 – 2094
    Turni211 – 2133
    Helixi216 – 23520
    Helixi239 – 25517
    Helixi279 – 29315
    Helixi439 – 51274
    Helixi515 – 58369
    Helixi588 – 5947

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KT1NMR-A1-80[»]
    2XS6X-ray2.09A108-298[»]
    3MTTX-ray3.30A433-610[»]
    3O5ZX-ray2.01A/B1-85[»]
    ProteinModelPortaliO00459.
    SMRiO00459. Positions 3-84, 109-294, 324-720.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO00459.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 8077SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini109 – 295187Rho-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini330 – 42596SH2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini622 – 71695SH2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3K p85 subunit family.Curated
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 2 SH2 domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiNOG263689.
    HOGENOMiHOG000008438.
    HOVERGENiHBG082100.
    InParanoidiO00459.
    KOiK02649.
    OMAiHCVIYKT.
    PhylomeDBiO00459.
    TreeFamiTF102033.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    3.30.505.10. 2 hits.
    InterProiIPR001720. PI3kinase_P85.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR10155. PTHR10155. 1 hit.
    PfamiPF00620. RhoGAP. 1 hit.
    PF00017. SH2. 2 hits.
    [Graphical view]
    PRINTSiPR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTiSM00324. RhoGAP. 1 hit.
    SM00252. SH2. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEiPS50238. RHOGAP. 1 hit.
    PS50001. SH2. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00459-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPEGFQYR ALYPFRRERP EDLELLPGDV LVVSRAALQA LGVAEGGERC    50
    PQSVGWMPGL NERTRQRGDF PGTYVEFLGP VALARPGPRP RGPRPLPARP 100
    RDGAPEPGLT LPDLPEQFSP PDVAPPLLVK LVEAIERTGL DSESHYRPEL 150
    PAPRTDWSLS DVDQWDTAAL ADGIKSFLLA LPAPLVTPEA SAEARRALRE 200
    AAGPVGPALE PPTLPLHRAL TLRFLLQHLG RVASRAPALG PAVRALGATF 250
    GPLLLRAPPP PSSPPPGGAP DGSEPSPDFP ALLVEKLLQE HLEEQEVAPP 300
    ALPPKPPKAK PASTVLANGG SPPSLQDAEW YWGDISREEV NEKLRDTPDG 350
    TFLVRDASSK IQGEYTLTLR KGGNNKLIKV FHRDGHYGFS EPLTFCSVVD 400
    LINHYRHESL AQYNAKLDTR LLYPVSKYQQ DQIVKEDSVE AVGAQLKVYH 450
    QQYQDKSREY DQLYEEYTRT SQELQMKRTA IEAFNETIKI FEEQGQTQEK 500
    CSKEYLERFR REGNEKEMQR ILLNSERLKS RIAEIHESRT KLEQQLRAQA 550
    SDNREIDKRM NSLKPDLMQL RKIRDQYLVW LTQKGARQKK INEWLGIKNE 600
    TEDQYALMED EDDLPHHEER TWYVGKINRT QAEEMLSGKR DGTFLIRESS 650
    QRGCYACSVV VDGDTKHCVI YRTATGFGFA EPYNLYGSLK ELVLHYQHAS 700
    LVQHNDALTV TLAHPVRAPG PGPPPAAR 728
    Length:728
    Mass (Da):81,545
    Last modified:January 11, 2011 - v2
    Checksum:iADAC3E4B61F3F44A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti234 – 2341S → R.3 Publications
    Corresponds to variant rs2241088 [ dbSNP | Ensembl ].
    VAR_030679
    Natural varianti313 – 3131S → P.3 Publications
    Corresponds to variant rs1011320 [ dbSNP | Ensembl ].
    VAR_030680
    Natural varianti373 – 3731G → R in MPPH. 1 Publication
    VAR_069262

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80907 mRNA. Translation: CAA56868.1.
    AC007192 Genomic DNA. Translation: AAD22671.1.
    BC070082 mRNA. Translation: AAH70082.1.
    BC090249 mRNA. Translation: AAH90249.1.
    CCDSiCCDS12371.1.
    PIRiH59435.
    RefSeqiNP_005018.1. NM_005027.3.
    UniGeneiHs.371344.

    Genome annotation databases

    EnsembliENST00000222254; ENSP00000222254; ENSG00000105647.
    GeneIDi5296.
    KEGGihsa:5296.
    UCSCiuc002nia.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80907 mRNA. Translation: CAA56868.1 .
    AC007192 Genomic DNA. Translation: AAD22671.1 .
    BC070082 mRNA. Translation: AAH70082.1 .
    BC090249 mRNA. Translation: AAH90249.1 .
    CCDSi CCDS12371.1.
    PIRi H59435.
    RefSeqi NP_005018.1. NM_005027.3.
    UniGenei Hs.371344.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KT1 NMR - A 1-80 [» ]
    2XS6 X-ray 2.09 A 108-298 [» ]
    3MTT X-ray 3.30 A 433-610 [» ]
    3O5Z X-ray 2.01 A/B 1-85 [» ]
    ProteinModelPortali O00459.
    SMRi O00459. Positions 3-84, 109-294, 324-720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111314. 88 interactions.
    IntActi O00459. 48 interactions.
    MINTi MINT-1210047.
    STRINGi 9606.ENSP00000222254.

    Chemistry

    BindingDBi O00459.

    PTM databases

    PhosphoSitei O00459.

    Proteomic databases

    MaxQBi O00459.
    PaxDbi O00459.
    PRIDEi O00459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222254 ; ENSP00000222254 ; ENSG00000105647 .
    GeneIDi 5296.
    KEGGi hsa:5296.
    UCSCi uc002nia.2. human.

    Organism-specific databases

    CTDi 5296.
    GeneCardsi GC19P018263.
    HGNCi HGNC:8980. PIK3R2.
    MIMi 603157. gene.
    603387. phenotype.
    neXtProti NX_O00459.
    Orphaneti 83473. Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus.
    PharmGKBi PA33313.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263689.
    HOGENOMi HOG000008438.
    HOVERGENi HBG082100.
    InParanoidi O00459.
    KOi K02649.
    OMAi HCVIYKT.
    PhylomeDBi O00459.
    TreeFami TF102033.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000105647-MONOMER.
    Reactomei REACT_11051. Rho GTPase cycle.
    REACT_111040. Signaling by SCF-KIT.
    REACT_115529. Interleukin-7 signaling.
    REACT_121025. Synthesis of PIPs at the plasma membrane.
    REACT_12464. PI3K/AKT activation.
    REACT_12555. Downstream TCR signaling.
    REACT_12621. Tie2 Signaling.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_147814. DAP12 signaling.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_1695. GPVI-mediated activation cascade.
    REACT_17025. Downstream signal transduction.
    REACT_18283. G alpha (q) signalling events.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19344. Costimulation by the CD28 family.
    REACT_19358. CD28 dependent PI3K/Akt signaling.
    REACT_23787. Regulation of signaling by CBL.
    REACT_23832. Nephrin interactions.
    REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
    REACT_23891. Interleukin receptor SHC signaling.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_976. PI3K Cascade.
    SignaLinki O00459.

    Miscellaneous databases

    ChiTaRSi PIK3R2. human.
    EvolutionaryTracei O00459.
    GeneWikii PIK3R2.
    GenomeRNAii 5296.
    NextBioi 20470.
    PROi O00459.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00459.
    CleanExi HS_PIK3R2.
    Genevestigatori O00459.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    3.30.505.10. 2 hits.
    InterProi IPR001720. PI3kinase_P85.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR10155. PTHR10155. 1 hit.
    Pfami PF00620. RhoGAP. 1 hit.
    PF00017. SH2. 2 hits.
    [Graphical view ]
    PRINTSi PR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTi SM00324. RhoGAP. 1 hit.
    SM00252. SH2. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEi PS50238. RHOGAP. 1 hit.
    PS50001. SH2. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta."
      Volinia S., Patracchini P., Otsu M., Hiles I., Gout I., Calzolari E., Bernardi F., Rooke L., Waterfield M.D.
      Oncogene 7:789-793(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-234 AND PRO-313.
    2. "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme."
      Janssen J.W.G., Schleithhoff L., Bartram C.R., Schulz A.S.
      Oncogene 16:1767-1772(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-234 AND PRO-313.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-234 AND PRO-313.
      Tissue: Brain and Placenta.
    5. "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site."
      Braunger J., Schleithoff L., Schulz A.S., Kessler H., Lammers R., Ullrich A., Bartram C.R., Janssen J.W.
      Oncogene 14:2619-2631(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AXL.
    6. "Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2."
      Igarashi K., Isohara T., Kato T., Shigeta K., Yamano T., Uno I.
      Biochem. Biophys. Res. Commun. 246:95-99(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FLT1.
    7. "Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress."
      Wang J.F., Zhang X., Groopman J.E.
      J. Biol. Chem. 279:27088-27097(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FLT4.
    8. "The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase."
      Tsuboi N., Utsunomiya T., Roberts R.L., Ito H., Takahashi K., Noda M., Takahashi T.
      Biochem. J. 413:193-200(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY PTPRJ.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-605, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-464, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: VARIANT MPPH ARG-373.

    Entry informationi

    Entry nameiP85B_HUMAN
    AccessioniPrimary (citable) accession number: O00459
    Secondary accession number(s): Q5EAT5, Q9UPH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 148 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3