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Protein

Phosphatidylinositol 3-kinase regulatory subunit beta

Gene

PIK3R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Stress response, Transport

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000105647-MONOMER.
ZFISH:ENSG00000105647-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1266695. Interleukin-7 signaling.
R-HSA-1433557. Signaling by SCF-KIT.
R-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-186763. Downstream signal transduction.
R-HSA-194840. Rho GTPase cycle.
R-HSA-198203. PI3K/AKT activation.
R-HSA-202424. Downstream TCR signaling.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-210993. Tie2 Signaling.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-2424491. DAP12 signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-373753. Nephrin interactions.
R-HSA-388841. Costimulation by the CD28 family.
R-HSA-389357. CD28 dependent PI3K/Akt signaling.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-4420097. VEGFA-VEGFR2 Pathway.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8853659. RET signaling.
R-HSA-912526. Interleukin receptor SHC signaling.
R-HSA-912631. Regulation of signaling by CBL.
SignaLinkiO00459.
SIGNORiO00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Short name:
PI3-kinase regulatory subunit beta
Short name:
PI3K regulatory subunit beta
Short name:
PtdIns-3-kinase regulatory subunit beta
Alternative name(s):
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
Short name:
PI3-kinase subunit p85-beta
Short name:
PtdIns-3-kinase regulatory subunit p85-beta
Gene namesi
Name:PIK3R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8980. PIK3R2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
See also OMIM:603387
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069262373G → R in MPPH1. 2 PublicationsCorresponds to variant rs587776934dbSNPEnsembl.1
Natural variantiVAR_075556376K → E in MPPH1; unknown pathological significance. 1 Publication1
Natural variantiVAR_075683401L → P in MPPH1. 1 PublicationCorresponds to variant rs587777624dbSNPEnsembl.1
Natural variantiVAR_075684557D → H in MPPH1. 1 PublicationCorresponds to variant rs372272045dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi651Q → A: Loss of interaction with FBXL2 and increased half-life; when associated with A-652. 1 Publication1
Mutagenesisi652R → A: Loss of interaction with FBXL2 and increased half-life; when associated with A-651. 1 Publication1
Mutagenesisi655Y → A: Stabilized interaction with FBXL2 and decreased half-life. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi5296.
MalaCardsiPIK3R2.
MIMi603387. phenotype.
OpenTargetsiENSG00000105647.
ENSG00000268173.
Orphaneti83473. Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus.
PharmGKBiPA33313.

Chemistry databases

ChEMBLiCHEMBL3559703.
DrugBankiDB01064. Isoprenaline.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000807631 – 728Phosphatidylinositol 3-kinase regulatory subunit betaAdd BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei464PhosphotyrosineCombined sources1
Modified residuei605PhosphotyrosineCombined sources1
Modified residuei655Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).2 Publications
Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO00459.
MaxQBiO00459.
PaxDbiO00459.
PeptideAtlasiO00459.
PRIDEiO00459.

PTM databases

iPTMnetiO00459.
PhosphoSitePlusiO00459.

Expressioni

Gene expression databases

BgeeiENSG00000105647.
CleanExiHS_PIK3R2.
ExpressionAtlasiO00459. baseline and differential.
GenevisibleiO00459. HS.

Interactioni

Subunit structurei

Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD) (PubMed:23604317). Interacts with AXL (PubMed:9178760). Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated) (PubMed:9600074, PubMed:15102829). Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex (PubMed:23604317). Interacts with PTPN13; dephosphorylates PIK3R2 (PubMed:23604317). Interacts with XBP1 isoform 2; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus in a ER stress- and/or insulin-dependent but PI3K-independent manner (By similarity). Interacts with PIK3R1; the interaction is dissociated in an insulin-dependent manner (By similarity).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP1027514EBI-346930,EBI-608057
CBLP226814EBI-346930,EBI-518228
DYDC1Q8WWB33EBI-346930,EBI-740680
EGFRP005333EBI-346930,EBI-297353
ERBB2P046266EBI-346930,EBI-641062
ERBB3P2186016EBI-346930,EBI-720706
GAB1Q1348023EBI-346930,EBI-517684
GOLGA2Q083793EBI-346930,EBI-618309
GRB2P629934EBI-346930,EBI-401755
HTTP428586EBI-346930,EBI-466029
IKZF3Q9UKT93EBI-346930,EBI-747204
KITP1072119EBI-346930,EBI-1379503
KRT15P190123EBI-346930,EBI-739566
KRT20P359003EBI-346930,EBI-742094
KRT38O760153EBI-346930,EBI-1047263
METP0858111EBI-346930,EBI-1039152
MRFAP1L1Q96HT84EBI-346930,EBI-748896
NSP034969EBI-346930,EBI-2547442From a different organism.
PIK3CBP423383EBI-346930,EBI-2609540
RINT1Q6NUQ13EBI-346930,EBI-726876
TRIM23P364063EBI-346930,EBI-740098

GO - Molecular functioni

  • protein heterodimerization activity Source: ParkinsonsUK-UCL
  • protein phosphatase binding Source: UniProtKB
  • receptor tyrosine kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111314. 116 interactors.
DIPiDIP-31811N.
IntActiO00459. 64 interactors.
MINTiMINT-1210047.
STRINGi9606.ENSP00000471914.

Chemistry databases

BindingDBiO00459.

Structurei

Secondary structure

1728
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Beta strandi30 – 34Combined sources5
Helixi35 – 40Combined sources6
Helixi47 – 49Combined sources3
Helixi51 – 54Combined sources4
Beta strandi56 – 61Combined sources6
Turni62 – 64Combined sources3
Beta strandi67 – 71Combined sources5
Helixi72 – 74Combined sources3
Beta strandi75 – 81Combined sources7
Helixi114 – 117Combined sources4
Helixi126 – 138Combined sources13
Helixi144 – 146Combined sources3
Helixi162 – 164Combined sources3
Helixi167 – 180Combined sources14
Beta strandi181 – 183Combined sources3
Helixi188 – 199Combined sources12
Helixi206 – 209Combined sources4
Turni211 – 213Combined sources3
Helixi216 – 235Combined sources20
Helixi239 – 255Combined sources17
Helixi279 – 293Combined sources15
Helixi439 – 512Combined sources74
Helixi515 – 583Combined sources69
Helixi588 – 594Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KT1NMR-A1-80[»]
2XS6X-ray2.09A108-298[»]
3MTTX-ray3.30A433-610[»]
3O5ZX-ray2.01A/B1-85[»]
ProteinModelPortaliO00459.
SMRiO00459.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00459.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 80SH3PROSITE-ProRule annotationAdd BLAST77
Domaini109 – 295Rho-GAPPROSITE-ProRule annotationAdd BLAST187
Domaini330 – 425SH2 1PROSITE-ProRule annotationAdd BLAST96
Domaini622 – 716SH2 2PROSITE-ProRule annotationAdd BLAST95

Domaini

The SH2 2 domain is required for interaction with FBXL2 and PTPN13.1 Publication

Sequence similaritiesi

Belongs to the PI3K p85 subunit family.Curated
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 2 SH2 domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG4637. Eukaryota.
ENOG410XP6R. LUCA.
GeneTreeiENSGT00390000010431.
HOGENOMiHOG000008438.
HOVERGENiHBG082100.
InParanoidiO00459.
KOiK02649.
OMAiHYKHTSL.
OrthoDBiEOG091G0C3Z.
PhylomeDBiO00459.
TreeFamiTF102033.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR032498. PI3K_P85_iSH2.
IPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF16454. PI3K_P85_iSH2. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPEGFQYR ALYPFRRERP EDLELLPGDV LVVSRAALQA LGVAEGGERC
60 70 80 90 100
PQSVGWMPGL NERTRQRGDF PGTYVEFLGP VALARPGPRP RGPRPLPARP
110 120 130 140 150
RDGAPEPGLT LPDLPEQFSP PDVAPPLLVK LVEAIERTGL DSESHYRPEL
160 170 180 190 200
PAPRTDWSLS DVDQWDTAAL ADGIKSFLLA LPAPLVTPEA SAEARRALRE
210 220 230 240 250
AAGPVGPALE PPTLPLHRAL TLRFLLQHLG RVASRAPALG PAVRALGATF
260 270 280 290 300
GPLLLRAPPP PSSPPPGGAP DGSEPSPDFP ALLVEKLLQE HLEEQEVAPP
310 320 330 340 350
ALPPKPPKAK PASTVLANGG SPPSLQDAEW YWGDISREEV NEKLRDTPDG
360 370 380 390 400
TFLVRDASSK IQGEYTLTLR KGGNNKLIKV FHRDGHYGFS EPLTFCSVVD
410 420 430 440 450
LINHYRHESL AQYNAKLDTR LLYPVSKYQQ DQIVKEDSVE AVGAQLKVYH
460 470 480 490 500
QQYQDKSREY DQLYEEYTRT SQELQMKRTA IEAFNETIKI FEEQGQTQEK
510 520 530 540 550
CSKEYLERFR REGNEKEMQR ILLNSERLKS RIAEIHESRT KLEQQLRAQA
560 570 580 590 600
SDNREIDKRM NSLKPDLMQL RKIRDQYLVW LTQKGARQKK INEWLGIKNE
610 620 630 640 650
TEDQYALMED EDDLPHHEER TWYVGKINRT QAEEMLSGKR DGTFLIRESS
660 670 680 690 700
QRGCYACSVV VDGDTKHCVI YRTATGFGFA EPYNLYGSLK ELVLHYQHAS
710 720
LVQHNDALTV TLAHPVRAPG PGPPPAAR
Length:728
Mass (Da):81,545
Last modified:January 11, 2011 - v2
Checksum:iADAC3E4B61F3F44A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030679234S → R.3 PublicationsCorresponds to variant rs2241088dbSNPEnsembl.1
Natural variantiVAR_030680313S → P.3 PublicationsCorresponds to variant rs1011320dbSNPEnsembl.1
Natural variantiVAR_069262373G → R in MPPH1. 2 PublicationsCorresponds to variant rs587776934dbSNPEnsembl.1
Natural variantiVAR_075556376K → E in MPPH1; unknown pathological significance. 1 Publication1
Natural variantiVAR_075683401L → P in MPPH1. 1 PublicationCorresponds to variant rs587777624dbSNPEnsembl.1
Natural variantiVAR_075684557D → H in MPPH1. 1 PublicationCorresponds to variant rs372272045dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80907 mRNA. Translation: CAA56868.1.
AC007192 Genomic DNA. Translation: AAD22671.1.
BC070082 mRNA. Translation: AAH70082.1.
BC090249 mRNA. Translation: AAH90249.1.
CCDSiCCDS12371.1.
PIRiH59435.
RefSeqiNP_005018.1. NM_005027.3.
UniGeneiHs.371344.

Genome annotation databases

EnsembliENST00000222254; ENSP00000222254; ENSG00000105647.
GeneIDi5296.
KEGGihsa:5296.
UCSCiuc002nia.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80907 mRNA. Translation: CAA56868.1.
AC007192 Genomic DNA. Translation: AAD22671.1.
BC070082 mRNA. Translation: AAH70082.1.
BC090249 mRNA. Translation: AAH90249.1.
CCDSiCCDS12371.1.
PIRiH59435.
RefSeqiNP_005018.1. NM_005027.3.
UniGeneiHs.371344.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KT1NMR-A1-80[»]
2XS6X-ray2.09A108-298[»]
3MTTX-ray3.30A433-610[»]
3O5ZX-ray2.01A/B1-85[»]
ProteinModelPortaliO00459.
SMRiO00459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111314. 116 interactors.
DIPiDIP-31811N.
IntActiO00459. 64 interactors.
MINTiMINT-1210047.
STRINGi9606.ENSP00000471914.

Chemistry databases

BindingDBiO00459.
ChEMBLiCHEMBL3559703.
DrugBankiDB01064. Isoprenaline.

PTM databases

iPTMnetiO00459.
PhosphoSitePlusiO00459.

Proteomic databases

EPDiO00459.
MaxQBiO00459.
PaxDbiO00459.
PeptideAtlasiO00459.
PRIDEiO00459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222254; ENSP00000222254; ENSG00000105647.
GeneIDi5296.
KEGGihsa:5296.
UCSCiuc002nia.3. human.

Organism-specific databases

CTDi5296.
DisGeNETi5296.
GeneCardsiPIK3R2.
HGNCiHGNC:8980. PIK3R2.
MalaCardsiPIK3R2.
MIMi603157. gene.
603387. phenotype.
neXtProtiNX_O00459.
OpenTargetsiENSG00000105647.
ENSG00000268173.
Orphaneti83473. Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus.
PharmGKBiPA33313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4637. Eukaryota.
ENOG410XP6R. LUCA.
GeneTreeiENSGT00390000010431.
HOGENOMiHOG000008438.
HOVERGENiHBG082100.
InParanoidiO00459.
KOiK02649.
OMAiHYKHTSL.
OrthoDBiEOG091G0C3Z.
PhylomeDBiO00459.
TreeFamiTF102033.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000105647-MONOMER.
ZFISH:ENSG00000105647-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1266695. Interleukin-7 signaling.
R-HSA-1433557. Signaling by SCF-KIT.
R-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-186763. Downstream signal transduction.
R-HSA-194840. Rho GTPase cycle.
R-HSA-198203. PI3K/AKT activation.
R-HSA-202424. Downstream TCR signaling.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-210993. Tie2 Signaling.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-2424491. DAP12 signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-373753. Nephrin interactions.
R-HSA-388841. Costimulation by the CD28 family.
R-HSA-389357. CD28 dependent PI3K/Akt signaling.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-4420097. VEGFA-VEGFR2 Pathway.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8853659. RET signaling.
R-HSA-912526. Interleukin receptor SHC signaling.
R-HSA-912631. Regulation of signaling by CBL.
SignaLinkiO00459.
SIGNORiO00459.

Miscellaneous databases

ChiTaRSiPIK3R2. human.
EvolutionaryTraceiO00459.
GeneWikiiPIK3R2.
GenomeRNAii5296.
PROiO00459.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105647.
CleanExiHS_PIK3R2.
ExpressionAtlasiO00459. baseline and differential.
GenevisibleiO00459. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR032498. PI3K_P85_iSH2.
IPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF16454. PI3K_P85_iSH2. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP85B_HUMAN
AccessioniPrimary (citable) accession number: O00459
Secondary accession number(s): Q5EAT5, Q9UPH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 172 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.