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Protein

Leukocyte-specific transcript 1 protein

Gene

LST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.2 Publications

GO - Biological processi

  • anatomical structure morphogenesis Source: UniProtKB
  • cell morphogenesis Source: InterPro
  • dendrite development Source: UniProtKB
  • immune response Source: UniProtKB
  • negative regulation of lymphocyte proliferation Source: UniProtKB
  • regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell shape, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte-specific transcript 1 protein
Alternative name(s):
Protein B144
Gene namesi
Name:LST1
Synonyms:B144
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14189. LST1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7940.
MalaCardsiLST1.
OpenTargetsiENSG00000204482.
ENSG00000206433.
ENSG00000223465.
ENSG00000226182.
ENSG00000230791.
ENSG00000231048.
ENSG00000234514.
ENSG00000235915.
PharmGKBiPA37856.

Polymorphism and mutation databases

BioMutaiLST1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845071 – 97Leukocyte-specific transcript 1 proteinAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00453.
PeptideAtlasiO00453.
PRIDEiO00453.

PTM databases

iPTMnetiO00453.
PhosphoSitePlusiO00453.

Expressioni

Tissue specificityi

Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain.2 Publications

Inductioni

By IFNG/IFN-gamma. Up-regulated upon autoimmune and bacterially-induced inflammation.3 Publications

Gene expression databases

BgeeiENSG00000204482.
CleanExiHS_LST1.
ExpressionAtlasiO00453. baseline and differential.
GenevisibleiO00453. HS.

Organism-specific databases

HPAiHPA043725.

Interactioni

Protein-protein interaction databases

IntActiO00453. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliO00453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LST1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000112003.
HOGENOMiHOG000039999.
HOVERGENiHBG045577.
InParanoidiO00453.
OMAiRLERSWH.
PhylomeDBiO00453.
TreeFamiTF338533.

Family and domain databases

InterProiIPR007775. Leukocyte-sp_tscrpt_1_LST1.
[Graphical view]
PfamiPF05083. LST1. 1 hit.
[Graphical view]
PIRSFiPIRSF037638. Leukocyte-sp_tscrpt_1_LST1. 1 hit.

Sequences (13)i

Sequence statusi: Complete.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.1 Publication
Isoform 11 Publication (identifier: O00453-1) [UniParc]FASTAAdd to basket
Also known as: LST1/A1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRNDDICI YGGLGLGGLL LLAVVLLSAC LCWLHRRVKR LERSWAQGSS
60 70 80 90
EQELHYASLQ RLPVPSSEGP DLRGRDKRGT KEDPRADYAC IAENKPT
Length:97
Mass (Da):10,792
Last modified:September 23, 2008 - v2
Checksum:iAA03C77B5787B524
GO
Isoform 21 Publication (identifier: O00453-2) [UniParc]FASTAAdd to basket
Also known as: LST1/C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MLSRNDDICI...RRVKRLERSW → MIYVSTGAWG...IEEHLLSWSQ

Show »
Length:91
Mass (Da):10,133
Checksum:i84A4FCD274A92DEA
GO
Isoform 31 Publication (identifier: O00453-3) [UniParc]FASTAAdd to basket
Also known as: pLst11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MLSRNDDICI...RRVKRLERSW → MIYVSTGAWGWAGSCFWQWSFCPPACVGCIEEE

Show »
Length:85
Mass (Da):9,410
Checksum:i0276676D528C49A6
GO
Isoform 41 Publication (identifier: O00453-4) [UniParc]FASTAAdd to basket
Also known as: LST1/E1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSWA → MT

Show »
Length:53
Mass (Da):5,887
Checksum:i5A924968D231E74F
GO
Isoform 51 Publication (identifier: O00453-5) [UniParc]FASTAAdd to basket
Also known as: LST1/K1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     38-97: VKRLERSWAQ...YACIAENKPT → GPGLLRAGTPLCISAEAASAQQ

Show »
Length:59
Mass (Da):6,122
Checksum:iFC2FF156D576C486
GO
Isoform 61 Publication (identifier: O00453-6) [UniParc]FASTAAdd to basket
Also known as: LST1/L1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     7-37: Missing.
     46-60: Missing.

Show »
Length:51
Mass (Da):5,869
Checksum:iB5A041EAFE936EDC
GO
Isoform 71 Publication (identifier: O00453-7) [UniParc]FASTAAdd to basket
Also known as: LST1/J1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     7-37: Missing.
     46-97: AQGSSEQELH...YACIAENKPT → HLSVLVPGPGLLRAGTPLCISAEAASAQQ

Show »
Length:43
Mass (Da):4,629
Checksum:iE19730B87CE1D4B6
GO
Isoform 81 Publication (identifier: O00453-8) [UniParc]FASTAAdd to basket
Also known as: LST1/M1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     7-97: DICIYGGLGL...YACIAENKPT → APSVLVPGPGLLRAGTPLCISAEAASAQQ

Show »
Length:35
Mass (Da):3,492
Checksum:iB2C9F24119316035
GO
Isoform 91 Publication (identifier: O00453-9) [UniParc]FASTAAdd to basket
Also known as: LST1/N1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     7-13: DICIYGG → EAASAQQ
     14-97: Missing.

Show »
Length:13
Mass (Da):1,421
Checksum:i9E7701449EE4DB1A
GO
Isoform 10 (identifier: O00453-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-37: Missing.

Show »
Length:66
Mass (Da):7,498
Checksum:iF6ECD034EE4D29B1
GO
Isoform 11 (identifier: O00453-11) [UniParc]FASTAAdd to basket
Also known as: LST1/P

The sequence of this isoform differs from the canonical sequence as follows:
     45-45: W → WHLLSWSQ

Show »
Length:104
Mass (Da):11,644
Checksum:i78F66572BADB20E3
GO
Isoform 12 (identifier: O00453-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-97: VKRLERSWAQ...YACIAENKPT → APSVLVPGPGLLRAGTPLCISAEAASAQQ

Note: No experimental confirmation available.
Show »
Length:66
Mass (Da):6,786
Checksum:iEAFB5CA007926ED4
GO
Isoform 13 (identifier: O00453-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-37: Missing.
     45-45: W → WHLLSWSQ

Note: No experimental confirmation available.
Show »
Length:73
Mass (Da):8,350
Checksum:iF379101B30F3A4CF
GO

Sequence cautioni

The sequence AAX45332 differs from that shown. Reason: Erroneous termination at position 47. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21L → P in AAX45332 (PubMed:16362817).Curated1
Sequence conflicti46A → T in AAB86999 (PubMed:9367684).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0505771 – 46MLSRN…ERSWA → MT in isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_0505781 – 45MLSRN…LERSW → MIYVSTGAWGWAGSCFWQWS FCPPACVGCIEEHLLSWSQ in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0505791 – 45MLSRN…LERSW → MIYVSTGAWGWAGSCFWQWS FCPPACVGCIEEE in isoform 3. CuratedAdd BLAST45
Alternative sequenceiVSP_0505807 – 97DICIY…ENKPT → APSVLVPGPGLLRAGTPLCI SAEAASAQQ in isoform 8. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_0505837 – 37Missing in isoform 6, isoform 7, isoform 10 and isoform 13. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_0505817 – 13DICIYGG → EAASAQQ in isoform 9. 1 Publication7
Alternative sequenceiVSP_05058214 – 97Missing in isoform 9. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_04736738 – 97VKRLE…ENKPT → APSVLVPGPGLLRAGTPLCI SAEAASAQQ in isoform 12. CuratedAdd BLAST60
Alternative sequenceiVSP_05058438 – 97VKRLE…ENKPT → GPGLLRAGTPLCISAEAASA QQ in isoform 5. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_04645945W → WHLLSWSQ in isoform 11 and isoform 13. 1 Publication1
Alternative sequenceiVSP_05058646 – 97AQGSS…ENKPT → HLSVLVPGPGLLRAGTPLCI SAEAASAQQ in isoform 7. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_05058746 – 60Missing in isoform 6. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00921 Genomic DNA. Translation: AAB57724.1.
AF000424 mRNA. Translation: AAB86998.1.
AF000425 mRNA. Translation: AAB86999.1.
AF000426 mRNA. Translation: AAB87000.1.
Y18486 mRNA. Translation: CAB59904.1.
Y18487 mRNA. Translation: CAB59905.1.
Y18488 mRNA. Translation: CAB60038.1.
Y18489 mRNA. Translation: CAB59906.1.
Y18490 mRNA. Translation: CAB59903.1.
AF129756 Genomic DNA. Translation: AAD18090.1.
BA000025 Genomic DNA. Translation: BAB63394.1.
AL662847 Genomic DNA. Translation: CAI17681.1.
AL662847 Genomic DNA. Translation: CAI17682.1.
AL662847 Genomic DNA. Translation: CAI17684.1.
AL662847 Genomic DNA. Translation: CAI17687.1.
AL662801 Genomic DNA. Translation: CAI18295.1.
AL662801 Genomic DNA. Translation: CAI18296.1.
AL662801 Genomic DNA. Translation: CAI18298.2.
AL662801 Genomic DNA. Translation: CAI18299.1.
AL662801 Genomic DNA. Translation: CAI18300.1.
AL929587 Genomic DNA. Translation: CAI18653.1.
AL929587 Genomic DNA. Translation: CAI18654.1.
AL929587 Genomic DNA. Translation: CAI18655.1.
AL929587 Genomic DNA. Translation: CAI18658.1.
AL929587 Genomic DNA. Translation: CAI18659.2.
AL929587 Genomic DNA. Translation: CAM45790.1.
BX248519 Genomic DNA. Translation: CAI41945.1.
BX248519 Genomic DNA. Translation: CAI41946.1.
BX248519 Genomic DNA. Translation: CAI41949.1.
BX248519 Genomic DNA. Translation: CAI41950.1.
BX248519 Genomic DNA. Translation: CAI41952.1.
BX248519 Genomic DNA. Translation: CAM26060.1.
AL662847 Genomic DNA. Translation: CAO72097.1.
CR753892 Genomic DNA. Translation: CAQ06939.1.
CR753892 Genomic DNA. Translation: CAQ06940.1.
CR753892 Genomic DNA. Translation: CAQ06943.1.
CR753892 Genomic DNA. Translation: CAQ06944.1.
CR753892 Genomic DNA. Translation: CAQ06946.1.
CR753892 Genomic DNA. Translation: CAQ06947.1.
CR759886 Genomic DNA. Translation: CAQ07231.1.
CR759886 Genomic DNA. Translation: CAQ07232.1.
CR759886 Genomic DNA. Translation: CAQ07235.1.
CR759886 Genomic DNA. Translation: CAQ07236.1.
CR759886 Genomic DNA. Translation: CAQ07238.1.
CR759886 Genomic DNA. Translation: CAQ07239.1.
CR942185 Genomic DNA. Translation: CAQ07715.1.
CR942185 Genomic DNA. Translation: CAQ07716.1.
CR942185 Genomic DNA. Translation: CAQ07719.1.
CR942185 Genomic DNA. Translation: CAQ07720.1.
CR942185 Genomic DNA. Translation: CAQ07722.1.
CR942185 Genomic DNA. Translation: CAQ07723.1.
BX927320 Genomic DNA. Translation: CAQ09997.1.
BX927320 Genomic DNA. Translation: CAQ09998.1.
BX927320 Genomic DNA. Translation: CAQ10001.1.
BX927320 Genomic DNA. Translation: CAQ10002.1.
BX927320 Genomic DNA. Translation: CAQ10004.1.
BX927320 Genomic DNA. Translation: CAQ10005.1.
CH471081 Genomic DNA. Translation: EAX03427.1.
CH471081 Genomic DNA. Translation: EAX03431.1.
BC103855 mRNA. Translation: AAI03856.1.
BC103856 mRNA. Translation: AAI03857.1.
AY852266 mRNA. Translation: AAX45332.1. Sequence problems.
CCDSiCCDS43450.2. [O00453-1]
CCDS4705.2. [O00453-10]
CCDS54984.1. [O00453-11]
CCDS54985.1. [O00453-12]
CCDS54986.1. [O00453-5]
CCDS54987.1. [O00453-13]
RefSeqiNP_001160010.1. NM_001166538.1. [O00453-13]
NP_009092.3. NM_007161.3. [O00453-11]
NP_995309.2. NM_205837.2. [O00453-12]
NP_995310.2. NM_205838.2. [O00453-10]
NP_995311.2. NM_205839.2. [O00453-1]
NP_995312.2. NM_205840.2. [O00453-5]
XP_006715269.1. XM_006715206.3. [O00453-11]
XP_006715272.1. XM_006715209.3. [O00453-13]
XP_006715273.1. XM_006715210.3. [O00453-5]
XP_011513216.1. XM_011514914.2. [O00453-11]
UniGeneiHs.436066.

Genome annotation databases

EnsembliENST00000303757; ENSP00000303649; ENSG00000204482. [O00453-5]
ENST00000339530; ENSP00000339201; ENSG00000204482. [O00453-12]
ENST00000376086; ENSP00000365254; ENSG00000204482. [O00453-13]
ENST00000376089; ENSP00000365257; ENSG00000204482. [O00453-10]
ENST00000376092; ENSP00000365260; ENSG00000204482. [O00453-8]
ENST00000376093; ENSP00000365261; ENSG00000204482. [O00453-11]
ENST00000376096; ENSP00000365264; ENSG00000204482. [O00453-9]
ENST00000376110; ENSP00000365278; ENSG00000204482. [O00453-6]
ENST00000383480; ENSP00000372972; ENSG00000206433. [O00453-13]
ENST00000383482; ENSP00000372974; ENSG00000206433. [O00453-8]
ENST00000383484; ENSP00000372976; ENSG00000206433. [O00453-12]
ENST00000383486; ENSP00000372978; ENSG00000206433. [O00453-11]
ENST00000400250; ENSP00000383109; ENSG00000206433. [O00453-5]
ENST00000400257; ENSP00000383116; ENSG00000206433. [O00453-9]
ENST00000400262; ENSP00000383121; ENSG00000206433. [O00453-10]
ENST00000400263; ENSP00000383122; ENSG00000206433. [O00453-10]
ENST00000400264; ENSP00000383123; ENSG00000206433. [O00453-1]
ENST00000400265; ENSP00000383124; ENSG00000206433. [O00453-6]
ENST00000411490; ENSP00000395409; ENSG00000235915. [O00453-1]
ENST00000412041; ENSP00000399411; ENSG00000231048. [O00453-11]
ENST00000412623; ENSP00000409229; ENSG00000226182. [O00453-11]
ENST00000413426; ENSP00000408876; ENSG00000231048. [O00453-9]
ENST00000414266; ENSP00000402707; ENSG00000223465. [O00453-10]
ENST00000415419; ENSP00000415143; ENSG00000235915. [O00453-6]
ENST00000415490; ENSP00000390658; ENSG00000234514. [O00453-8]
ENST00000415781; ENSP00000401655; ENSG00000226182. [O00453-9]
ENST00000417428; ENSP00000394614; ENSG00000223465. [O00453-1]
ENST00000418507; ENSP00000405900; ENSG00000204482. [O00453-10]
ENST00000420157; ENSP00000398700; ENSG00000226182. [O00453-10]
ENST00000420333; ENSP00000411547; ENSG00000230791. [O00453-5]
ENST00000420676; ENSP00000414246; ENSG00000226182. [O00453-13]
ENST00000420785; ENSP00000393345; ENSG00000234514. [O00453-12]
ENST00000420797; ENSP00000390587; ENSG00000235915. [O00453-10]
ENST00000422035; ENSP00000396431; ENSG00000226182. [O00453-6]
ENST00000422533; ENSP00000412627; ENSG00000226182. [O00453-5]
ENST00000423107; ENSP00000406438; ENSG00000234514. [O00453-10]
ENST00000423871; ENSP00000400069; ENSG00000223465. [O00453-6]
ENST00000425760; ENSP00000409698; ENSG00000231048. [O00453-8]
ENST00000426938; ENSP00000404051; ENSG00000234514. [O00453-1]
ENST00000427186; ENSP00000399439; ENSG00000235915. [O00453-8]
ENST00000427507; ENSP00000416283; ENSG00000223465. [O00453-1]
ENST00000428227; ENSP00000413526; ENSG00000234514. [O00453-10]
ENST00000428405; ENSP00000391963; ENSG00000230791. [O00453-10]
ENST00000428898; ENSP00000389694; ENSG00000230791. [O00453-9]
ENST00000429874; ENSP00000387560; ENSG00000230791. [O00453-1]
ENST00000429910; ENSP00000399063; ENSG00000223465. [O00453-5]
ENST00000430632; ENSP00000392949; ENSG00000231048. [O00453-1]
ENST00000430680; ENSP00000398918; ENSG00000235915. [O00453-12]
ENST00000430997; ENSP00000389795; ENSG00000235915. [O00453-5]
ENST00000432009; ENSP00000409433; ENSG00000226182. [O00453-10]
ENST00000432164; ENSP00000394834; ENSG00000223465. [O00453-8]
ENST00000433004; ENSP00000390430; ENSG00000226182. [O00453-10]
ENST00000433305; ENSP00000407417; ENSG00000230791. [O00453-8]
ENST00000433676; ENSP00000411866; ENSG00000235915. [O00453-10]
ENST00000434314; ENSP00000414173; ENSG00000226182. [O00453-1]
ENST00000436037; ENSP00000398685; ENSG00000234514. [O00453-11]
ENST00000436185; ENSP00000396579; ENSG00000235915. [O00453-10]
ENST00000437137; ENSP00000412276; ENSG00000231048. [O00453-1]
ENST00000437436; ENSP00000394891; ENSG00000231048. [O00453-6]
ENST00000437812; ENSP00000396179; ENSG00000223465. [O00453-11]
ENST00000438075; ENSP00000391929; ENSG00000204482. [O00453-1]
ENST00000438335; ENSP00000403097; ENSG00000235915. [O00453-11]
ENST00000438349; ENSP00000391057; ENSG00000234514. [O00453-6]
ENST00000438381; ENSP00000393282; ENSG00000230791. [O00453-12]
ENST00000440242; ENSP00000394815; ENSG00000223465. [O00453-13]
ENST00000440253; ENSP00000396235; ENSG00000223465. [O00453-10]
ENST00000440323; ENSP00000414744; ENSG00000231048. [O00453-10]
ENST00000440328; ENSP00000401516; ENSG00000226182. [O00453-8]
ENST00000442052; ENSP00000399474; ENSG00000226182. [O00453-12]
ENST00000443340; ENSP00000396533; ENSG00000206433. [O00453-1]
ENST00000443655; ENSP00000411961; ENSG00000231048. [O00453-5]
ENST00000443741; ENSP00000388956; ENSG00000235915. [O00453-1]
ENST00000446239; ENSP00000402873; ENSG00000230791. [O00453-6]
ENST00000447141; ENSP00000397826; ENSG00000235915. [O00453-9]
ENST00000447391; ENSP00000411087; ENSG00000230791. [O00453-10]
ENST00000448236; ENSP00000406455; ENSG00000230791. [O00453-11]
ENST00000448441; ENSP00000409008; ENSG00000206433. [O00453-10]
ENST00000449236; ENSP00000391420; ENSG00000231048. [O00453-10]
ENST00000449273; ENSP00000415623; ENSG00000234514. [O00453-5]
ENST00000450291; ENSP00000404500; ENSG00000230791. [O00453-13]
ENST00000450425; ENSP00000415168; ENSG00000223465. [O00453-10]
ENST00000451641; ENSP00000406625; ENSG00000223465. [O00453-12]
ENST00000451922; ENSP00000401567; ENSG00000231048. [O00453-13]
ENST00000452169; ENSP00000416808; ENSG00000231048. [O00453-12]
ENST00000453995; ENSP00000409163; ENSG00000230791. [O00453-1]
ENST00000454168; ENSP00000396004; ENSG00000234514. [O00453-13]
ENST00000455003; ENSP00000396181; ENSG00000226182. [O00453-1]
ENST00000455052; ENSP00000398228; ENSG00000234514. [O00453-10]
ENST00000455426; ENSP00000398780; ENSG00000231048. [O00453-10]
ENST00000455493; ENSP00000401650; ENSG00000223465. [O00453-9]
ENST00000455655; ENSP00000415526; ENSG00000230791. [O00453-10]
ENST00000455901; ENSP00000396378; ENSG00000234514. [O00453-1]
ENST00000457549; ENSP00000390885; ENSG00000235915. [O00453-13]
ENST00000458456; ENSP00000405920; ENSG00000234514. [O00453-9]
GeneIDi7940.
KEGGihsa:7940.
UCSCiuc021yus.1. human. [O00453-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00921 Genomic DNA. Translation: AAB57724.1.
AF000424 mRNA. Translation: AAB86998.1.
AF000425 mRNA. Translation: AAB86999.1.
AF000426 mRNA. Translation: AAB87000.1.
Y18486 mRNA. Translation: CAB59904.1.
Y18487 mRNA. Translation: CAB59905.1.
Y18488 mRNA. Translation: CAB60038.1.
Y18489 mRNA. Translation: CAB59906.1.
Y18490 mRNA. Translation: CAB59903.1.
AF129756 Genomic DNA. Translation: AAD18090.1.
BA000025 Genomic DNA. Translation: BAB63394.1.
AL662847 Genomic DNA. Translation: CAI17681.1.
AL662847 Genomic DNA. Translation: CAI17682.1.
AL662847 Genomic DNA. Translation: CAI17684.1.
AL662847 Genomic DNA. Translation: CAI17687.1.
AL662801 Genomic DNA. Translation: CAI18295.1.
AL662801 Genomic DNA. Translation: CAI18296.1.
AL662801 Genomic DNA. Translation: CAI18298.2.
AL662801 Genomic DNA. Translation: CAI18299.1.
AL662801 Genomic DNA. Translation: CAI18300.1.
AL929587 Genomic DNA. Translation: CAI18653.1.
AL929587 Genomic DNA. Translation: CAI18654.1.
AL929587 Genomic DNA. Translation: CAI18655.1.
AL929587 Genomic DNA. Translation: CAI18658.1.
AL929587 Genomic DNA. Translation: CAI18659.2.
AL929587 Genomic DNA. Translation: CAM45790.1.
BX248519 Genomic DNA. Translation: CAI41945.1.
BX248519 Genomic DNA. Translation: CAI41946.1.
BX248519 Genomic DNA. Translation: CAI41949.1.
BX248519 Genomic DNA. Translation: CAI41950.1.
BX248519 Genomic DNA. Translation: CAI41952.1.
BX248519 Genomic DNA. Translation: CAM26060.1.
AL662847 Genomic DNA. Translation: CAO72097.1.
CR753892 Genomic DNA. Translation: CAQ06939.1.
CR753892 Genomic DNA. Translation: CAQ06940.1.
CR753892 Genomic DNA. Translation: CAQ06943.1.
CR753892 Genomic DNA. Translation: CAQ06944.1.
CR753892 Genomic DNA. Translation: CAQ06946.1.
CR753892 Genomic DNA. Translation: CAQ06947.1.
CR759886 Genomic DNA. Translation: CAQ07231.1.
CR759886 Genomic DNA. Translation: CAQ07232.1.
CR759886 Genomic DNA. Translation: CAQ07235.1.
CR759886 Genomic DNA. Translation: CAQ07236.1.
CR759886 Genomic DNA. Translation: CAQ07238.1.
CR759886 Genomic DNA. Translation: CAQ07239.1.
CR942185 Genomic DNA. Translation: CAQ07715.1.
CR942185 Genomic DNA. Translation: CAQ07716.1.
CR942185 Genomic DNA. Translation: CAQ07719.1.
CR942185 Genomic DNA. Translation: CAQ07720.1.
CR942185 Genomic DNA. Translation: CAQ07722.1.
CR942185 Genomic DNA. Translation: CAQ07723.1.
BX927320 Genomic DNA. Translation: CAQ09997.1.
BX927320 Genomic DNA. Translation: CAQ09998.1.
BX927320 Genomic DNA. Translation: CAQ10001.1.
BX927320 Genomic DNA. Translation: CAQ10002.1.
BX927320 Genomic DNA. Translation: CAQ10004.1.
BX927320 Genomic DNA. Translation: CAQ10005.1.
CH471081 Genomic DNA. Translation: EAX03427.1.
CH471081 Genomic DNA. Translation: EAX03431.1.
BC103855 mRNA. Translation: AAI03856.1.
BC103856 mRNA. Translation: AAI03857.1.
AY852266 mRNA. Translation: AAX45332.1. Sequence problems.
CCDSiCCDS43450.2. [O00453-1]
CCDS4705.2. [O00453-10]
CCDS54984.1. [O00453-11]
CCDS54985.1. [O00453-12]
CCDS54986.1. [O00453-5]
CCDS54987.1. [O00453-13]
RefSeqiNP_001160010.1. NM_001166538.1. [O00453-13]
NP_009092.3. NM_007161.3. [O00453-11]
NP_995309.2. NM_205837.2. [O00453-12]
NP_995310.2. NM_205838.2. [O00453-10]
NP_995311.2. NM_205839.2. [O00453-1]
NP_995312.2. NM_205840.2. [O00453-5]
XP_006715269.1. XM_006715206.3. [O00453-11]
XP_006715272.1. XM_006715209.3. [O00453-13]
XP_006715273.1. XM_006715210.3. [O00453-5]
XP_011513216.1. XM_011514914.2. [O00453-11]
UniGeneiHs.436066.

3D structure databases

ProteinModelPortaliO00453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO00453. 2 interactors.

PTM databases

iPTMnetiO00453.
PhosphoSitePlusiO00453.

Polymorphism and mutation databases

BioMutaiLST1.

Proteomic databases

EPDiO00453.
PeptideAtlasiO00453.
PRIDEiO00453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303757; ENSP00000303649; ENSG00000204482. [O00453-5]
ENST00000339530; ENSP00000339201; ENSG00000204482. [O00453-12]
ENST00000376086; ENSP00000365254; ENSG00000204482. [O00453-13]
ENST00000376089; ENSP00000365257; ENSG00000204482. [O00453-10]
ENST00000376092; ENSP00000365260; ENSG00000204482. [O00453-8]
ENST00000376093; ENSP00000365261; ENSG00000204482. [O00453-11]
ENST00000376096; ENSP00000365264; ENSG00000204482. [O00453-9]
ENST00000376110; ENSP00000365278; ENSG00000204482. [O00453-6]
ENST00000383480; ENSP00000372972; ENSG00000206433. [O00453-13]
ENST00000383482; ENSP00000372974; ENSG00000206433. [O00453-8]
ENST00000383484; ENSP00000372976; ENSG00000206433. [O00453-12]
ENST00000383486; ENSP00000372978; ENSG00000206433. [O00453-11]
ENST00000400250; ENSP00000383109; ENSG00000206433. [O00453-5]
ENST00000400257; ENSP00000383116; ENSG00000206433. [O00453-9]
ENST00000400262; ENSP00000383121; ENSG00000206433. [O00453-10]
ENST00000400263; ENSP00000383122; ENSG00000206433. [O00453-10]
ENST00000400264; ENSP00000383123; ENSG00000206433. [O00453-1]
ENST00000400265; ENSP00000383124; ENSG00000206433. [O00453-6]
ENST00000411490; ENSP00000395409; ENSG00000235915. [O00453-1]
ENST00000412041; ENSP00000399411; ENSG00000231048. [O00453-11]
ENST00000412623; ENSP00000409229; ENSG00000226182. [O00453-11]
ENST00000413426; ENSP00000408876; ENSG00000231048. [O00453-9]
ENST00000414266; ENSP00000402707; ENSG00000223465. [O00453-10]
ENST00000415419; ENSP00000415143; ENSG00000235915. [O00453-6]
ENST00000415490; ENSP00000390658; ENSG00000234514. [O00453-8]
ENST00000415781; ENSP00000401655; ENSG00000226182. [O00453-9]
ENST00000417428; ENSP00000394614; ENSG00000223465. [O00453-1]
ENST00000418507; ENSP00000405900; ENSG00000204482. [O00453-10]
ENST00000420157; ENSP00000398700; ENSG00000226182. [O00453-10]
ENST00000420333; ENSP00000411547; ENSG00000230791. [O00453-5]
ENST00000420676; ENSP00000414246; ENSG00000226182. [O00453-13]
ENST00000420785; ENSP00000393345; ENSG00000234514. [O00453-12]
ENST00000420797; ENSP00000390587; ENSG00000235915. [O00453-10]
ENST00000422035; ENSP00000396431; ENSG00000226182. [O00453-6]
ENST00000422533; ENSP00000412627; ENSG00000226182. [O00453-5]
ENST00000423107; ENSP00000406438; ENSG00000234514. [O00453-10]
ENST00000423871; ENSP00000400069; ENSG00000223465. [O00453-6]
ENST00000425760; ENSP00000409698; ENSG00000231048. [O00453-8]
ENST00000426938; ENSP00000404051; ENSG00000234514. [O00453-1]
ENST00000427186; ENSP00000399439; ENSG00000235915. [O00453-8]
ENST00000427507; ENSP00000416283; ENSG00000223465. [O00453-1]
ENST00000428227; ENSP00000413526; ENSG00000234514. [O00453-10]
ENST00000428405; ENSP00000391963; ENSG00000230791. [O00453-10]
ENST00000428898; ENSP00000389694; ENSG00000230791. [O00453-9]
ENST00000429874; ENSP00000387560; ENSG00000230791. [O00453-1]
ENST00000429910; ENSP00000399063; ENSG00000223465. [O00453-5]
ENST00000430632; ENSP00000392949; ENSG00000231048. [O00453-1]
ENST00000430680; ENSP00000398918; ENSG00000235915. [O00453-12]
ENST00000430997; ENSP00000389795; ENSG00000235915. [O00453-5]
ENST00000432009; ENSP00000409433; ENSG00000226182. [O00453-10]
ENST00000432164; ENSP00000394834; ENSG00000223465. [O00453-8]
ENST00000433004; ENSP00000390430; ENSG00000226182. [O00453-10]
ENST00000433305; ENSP00000407417; ENSG00000230791. [O00453-8]
ENST00000433676; ENSP00000411866; ENSG00000235915. [O00453-10]
ENST00000434314; ENSP00000414173; ENSG00000226182. [O00453-1]
ENST00000436037; ENSP00000398685; ENSG00000234514. [O00453-11]
ENST00000436185; ENSP00000396579; ENSG00000235915. [O00453-10]
ENST00000437137; ENSP00000412276; ENSG00000231048. [O00453-1]
ENST00000437436; ENSP00000394891; ENSG00000231048. [O00453-6]
ENST00000437812; ENSP00000396179; ENSG00000223465. [O00453-11]
ENST00000438075; ENSP00000391929; ENSG00000204482. [O00453-1]
ENST00000438335; ENSP00000403097; ENSG00000235915. [O00453-11]
ENST00000438349; ENSP00000391057; ENSG00000234514. [O00453-6]
ENST00000438381; ENSP00000393282; ENSG00000230791. [O00453-12]
ENST00000440242; ENSP00000394815; ENSG00000223465. [O00453-13]
ENST00000440253; ENSP00000396235; ENSG00000223465. [O00453-10]
ENST00000440323; ENSP00000414744; ENSG00000231048. [O00453-10]
ENST00000440328; ENSP00000401516; ENSG00000226182. [O00453-8]
ENST00000442052; ENSP00000399474; ENSG00000226182. [O00453-12]
ENST00000443340; ENSP00000396533; ENSG00000206433. [O00453-1]
ENST00000443655; ENSP00000411961; ENSG00000231048. [O00453-5]
ENST00000443741; ENSP00000388956; ENSG00000235915. [O00453-1]
ENST00000446239; ENSP00000402873; ENSG00000230791. [O00453-6]
ENST00000447141; ENSP00000397826; ENSG00000235915. [O00453-9]
ENST00000447391; ENSP00000411087; ENSG00000230791. [O00453-10]
ENST00000448236; ENSP00000406455; ENSG00000230791. [O00453-11]
ENST00000448441; ENSP00000409008; ENSG00000206433. [O00453-10]
ENST00000449236; ENSP00000391420; ENSG00000231048. [O00453-10]
ENST00000449273; ENSP00000415623; ENSG00000234514. [O00453-5]
ENST00000450291; ENSP00000404500; ENSG00000230791. [O00453-13]
ENST00000450425; ENSP00000415168; ENSG00000223465. [O00453-10]
ENST00000451641; ENSP00000406625; ENSG00000223465. [O00453-12]
ENST00000451922; ENSP00000401567; ENSG00000231048. [O00453-13]
ENST00000452169; ENSP00000416808; ENSG00000231048. [O00453-12]
ENST00000453995; ENSP00000409163; ENSG00000230791. [O00453-1]
ENST00000454168; ENSP00000396004; ENSG00000234514. [O00453-13]
ENST00000455003; ENSP00000396181; ENSG00000226182. [O00453-1]
ENST00000455052; ENSP00000398228; ENSG00000234514. [O00453-10]
ENST00000455426; ENSP00000398780; ENSG00000231048. [O00453-10]
ENST00000455493; ENSP00000401650; ENSG00000223465. [O00453-9]
ENST00000455655; ENSP00000415526; ENSG00000230791. [O00453-10]
ENST00000455901; ENSP00000396378; ENSG00000234514. [O00453-1]
ENST00000457549; ENSP00000390885; ENSG00000235915. [O00453-13]
ENST00000458456; ENSP00000405920; ENSG00000234514. [O00453-9]
GeneIDi7940.
KEGGihsa:7940.
UCSCiuc021yus.1. human. [O00453-1]

Organism-specific databases

CTDi7940.
DisGeNETi7940.
GeneCardsiLST1.
HGNCiHGNC:14189. LST1.
HPAiHPA043725.
MalaCardsiLST1.
MIMi109170. gene.
neXtProtiNX_O00453.
OpenTargetsiENSG00000204482.
ENSG00000206433.
ENSG00000223465.
ENSG00000226182.
ENSG00000230791.
ENSG00000231048.
ENSG00000234514.
ENSG00000235915.
PharmGKBiPA37856.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000112003.
HOGENOMiHOG000039999.
HOVERGENiHBG045577.
InParanoidiO00453.
OMAiRLERSWH.
PhylomeDBiO00453.
TreeFamiTF338533.

Miscellaneous databases

ChiTaRSiLST1. human.
GeneWikiiLST1.
GenomeRNAii7940.
PROiO00453.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204482.
CleanExiHS_LST1.
ExpressionAtlasiO00453. baseline and differential.
GenevisibleiO00453. HS.

Family and domain databases

InterProiIPR007775. Leukocyte-sp_tscrpt_1_LST1.
[Graphical view]
PfamiPF05083. LST1. 1 hit.
[Graphical view]
PIRSFiPIRSF037638. Leukocyte-sp_tscrpt_1_LST1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLST1_HUMAN
AccessioniPrimary (citable) accession number: O00453
Secondary accession number(s): B0S8E0
, B0S8E1, B0S8E5, O00452, O00454, Q13669, Q2HNT3, Q5HYS9, Q5SP24, Q5STA5, Q5STA6, Q5STA7, Q5STA8, Q5STW6, Q9UJR5, Q9UJR6, Q9UJR7, Q9UJR8, Q9UJS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.