ID   GFRA2_HUMAN             Reviewed;         464 AA.
AC   O00451; O15316; O15328; Q6GTR9; Q7Z5C2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   25-JAN-2012, entry version 98.
DE   RecName: Full=GDNF family receptor alpha-2;
DE            Short=GDNF receptor alpha-2;
DE            Short=GDNFR-alpha-2;
DE            Short=GFR-alpha-2;
DE   AltName: Full=GDNF receptor beta;
DE            Short=GDNFR-beta;
DE   AltName: Full=Neurturin receptor alpha;
DE            Short=NRTNR-alpha;
DE            Short=NTNR-alpha;
DE   AltName: Full=RET ligand 2;
DE   AltName: Full=TGF-beta-related neurotrophic factor receptor 2;
DE   Flags: Precursor;
GN   Name=GFRA2; Synonyms=GDNFRB, RETL2, TRNR2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANT GLN-462.
RX   MEDLINE=97325791; PubMed=9182803; DOI=10.1016/S0896-6273(00)80318-9;
RA   Baloh R.H., Tansey M.G., Golden J.P., Creedon D.J., Heuckeroth R.O.,
RA   Keck C.L., Zimonjic D.B., Popescu N.C., Johnson E.M. Jr.,
RA   Milbrandt J.;
RT   "TrnR2, a novel receptor that mediates neurturin and GDNF signaling
RT   through Ret.";
RL   Neuron 18:793-802(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT GLN-462.
RC   TISSUE=Fetal brain;
RX   MEDLINE=97402208; PubMed=9259272; DOI=10.1093/hmg/6.8.1267;
RA   Suvanto P., Wartiovaara K., Lindahl M., Arumae U., Moshnyakov M.,
RA   Horelli-Kuitunen N., Airaksinen M.S., Palotie A., Sariola H.,
RA   Saarma M.;
RT   "Cloning, mRNA distribution and chromosomal localisation of the gene
RT   for glial cell line-derived neurotrophic factor receptor beta, a
RT   homologue to GDNFR-alpha.";
RL   Hum. Mol. Genet. 6:1267-1273(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Liver;
RX   MEDLINE=97322356; PubMed=9177201; DOI=10.1073/pnas.94.12.6238;
RA   Sanicola M., Hession C.A., Worley D.S., Carmillo P., Ehrenfels C.,
RA   Walus L., Robinson S., Jaworski G., Wei H., Tizard R., Whitty A.,
RA   Pepinsky R.B., Cate R.L.;
RT   "Glial cell line-derived neurotrophic factor-dependent RET activation
RT   can be mediated by two different cell-surface accessory proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:6238-6243(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT GLN-462.
RA   Yoong L.F., Too H.P.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for neurturin. Mediates the NRTN-induced
CC       autophosphorylation and activation of the RET receptor. Also able
CC       to mediate GDNF signaling through the RET tyrosine kinase
CC       receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Long;
CC         IsoId=O00451-1; Sequence=Displayed;
CC       Name=2; Synonyms=Short;
CC         IsoId=O00451-2; Sequence=VSP_001661;
CC   -!- TISSUE SPECIFICITY: Isoform 1 is found in both brain and placenta.
CC   -!- SIMILARITY: Belongs to the GDNFR family.
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DR   EMBL; AF002700; AAC52036.1; -; mRNA.
DR   EMBL; U93703; AAB61922.1; -; mRNA.
DR   EMBL; U97145; AAC51647.1; -; mRNA.
DR   EMBL; AY326396; AAP88378.1; -; mRNA.
DR   EMBL; BC041688; AAH41688.1; -; mRNA.
DR   IPI; IPI00011732; -.
DR   IPI; IPI00398301; -.
DR   RefSeq; NP_001158510.1; NM_001165038.1.
DR   RefSeq; NP_001158511.1; NM_001165039.1.
DR   RefSeq; NP_001486.4; NM_001495.4.
DR   UniGene; Hs.441202; -.
DR   ProteinModelPortal; O00451; -.
DR   SMR; O00451; 157-359.
DR   STRING; O00451; -.
DR   PRIDE; O00451; -.
DR   Ensembl; ENST00000306793; ENSP00000306654; ENSG00000168546.
DR   GeneID; 2675; -.
DR   KEGG; hsa:2675; -.
DR   UCSC; uc003wzu.1; human.
DR   UCSC; uc003wzw.1; human.
DR   CTD; 2675; -.
DR   GeneCards; GC08M021593; -.
DR   H-InvDB; HIX0025538; -.
DR   HGNC; HGNC:4244; GFRA2.
DR   HPA; HPA024704; -.
DR   MIM; 601956; gene.
DR   neXtProt; NX_O00451; -.
DR   PharmGKB; PA28654; -.
DR   eggNOG; prNOG11053; -.
DR   GeneTree; ENSGT00550000074579; -.
DR   HOGENOM; HBG713385; -.
DR   HOVERGEN; HBG051725; -.
DR   InParanoid; O00451; -.
DR   OMA; RSLCRTD; -.
DR   OrthoDB; EOG4S7JQ5; -.
DR   PhylomeDB; O00451; -.
DR   Reactome; REACT_111045; Developmental Biology.
DR   NextBio; 10560; -.
DR   ArrayExpress; O00451; -.
DR   Bgee; O00451; -.
DR   CleanEx; HS_GFRA2; -.
DR   Genevestigator; O00451; -.
DR   GermOnline; ENSG00000168546; Homo sapiens.
DR   GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019898; C:extrinsic to membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016167; F:glial cell-derived neurotrophic factor receptor activity; TAS:ProtInc.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   InterPro; IPR003504; GDNF_rcpt_a2.
DR   InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR   Pfam; PF02351; GDNF; 3.
DR   PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR   PRINTS; PR01318; GDNFRALPHA2.
DR   PRINTS; PR01316; GDNFRECEPTOR.
DR   SMART; SM00907; GDNF; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Complete proteome; Glycoprotein;
KW   GPI-anchor; Lipoprotein; Membrane; Polymorphism; Receptor;
KW   Reference proteome; Signal.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    444       GDNF family receptor alpha-2.
FT                                /FTId=PRO_0000010785.
FT   PROPEP      445    464       Removed in mature form (Potential).
FT                                /FTId=PRO_0000010786.
FT   LIPID       444    444       GPI-anchor amidated serine (Potential).
FT   CARBOHYD     52     52       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    357    357       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    413    413       N-linked (GlcNAc...) (Potential).
FT   VAR_SEQ      14    146       Missing (in isoform 2).
FT                                /FTId=VSP_001661.
FT   VARIANT     462    462       L -> Q (in dbSNP:rs1128397).
FT                                /FTId=VAR_059976.
FT   CONFLICT      6      6       V -> A (in Ref. 2; AAB61922).
SQ   SEQUENCE   464 AA;  51544 MW;  8BC61529530FF21F CRC64;
     MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL
     RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE
     EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS
     YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS
     CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM
     IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD
     VNVSPKGPSF QATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM
     CFTELTTNII PGSNKVIKPN SGPSRARPSA ALTVLSVLML KLAL
//