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O00445

- SYT5_HUMAN

UniProt

O00445 - SYT5_HUMAN

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Protein

Synaptotagmin-5

Gene

SYT5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).By similarity

Cofactori

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi138 – 1381Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi139 – 1391Calcium 1By similarity
Metal bindingi139 – 1391Calcium 2By similarity
Metal bindingi145 – 1451Calcium 1By similarity
Metal bindingi197 – 1971Calcium 1By similarity
Metal bindingi197 – 1971Calcium 2By similarity
Metal bindingi198 – 1981Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi199 – 1991Calcium 1By similarity
Metal bindingi199 – 1991Calcium 2By similarity
Metal bindingi199 – 1991Calcium 3By similarity
Metal bindingi202 – 2021Calcium 3By similarity
Metal bindingi205 – 2051Calcium 2By similarity
Metal bindingi205 – 2051Calcium 3By similarity

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. transporter activity Source: InterPro

GO - Biological processi

  1. calcium ion-dependent exocytosis Source: InterPro
  2. energy reserve metabolic process Source: Reactome
  3. regulation of insulin secretion Source: Reactome
  4. small molecule metabolic process Source: Reactome
  5. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_18325. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-5
Alternative name(s):
Synaptotagmin V
Short name:
SytV
Gene namesi
Name:SYT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11513. SYT5.

Subcellular locationi

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Single-pass membrane protein By similarity. Recycling endosome membrane By similarity; Single-pass membrane protein By similarity
Note: In mast cells, localizes to the endocytic recycling compartment.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dense core granule Source: Ensembl
  3. endosome Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. neuronal cell body Source: Ensembl
  6. neuron projection Source: Ensembl
  7. perinuclear region of cytoplasm Source: Ensembl
  8. synaptic vesicle Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Synaptotagmin-5PRO_0000183951Add
BLAST

Proteomic databases

MaxQBiO00445.
PaxDbiO00445.
PRIDEiO00445.

PTM databases

PhosphoSiteiO00445.

Expressioni

Gene expression databases

BgeeiO00445.
CleanExiHS_SYT5.
ExpressionAtlasiO00445. baseline and differential.
GenevestigatoriO00445.

Organism-specific databases

HPAiHPA010688.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers with SYT6. Interacts with both alpha- and beta-tubulin (By similarity).By similarity

Protein-protein interaction databases

BioGridi112725. 5 interactions.
IntActiO00445. 2 interactions.
MINTiMINT-1388417.
STRINGi9606.ENSP00000346265.

Structurei

3D structure databases

ProteinModelPortaliO00445.
SMRiO00445. Positions 108-380.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424VesicularSequence AnalysisAdd
BLAST
Topological domaini46 – 386341CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 21188C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini253 – 34492C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292488.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232127.
HOVERGENiHBG005010.
InParanoidiO00445.
OMAiNFAFKVP.
PhylomeDBiO00445.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028689. SYT5.
[Graphical view]
PANTHERiPTHR10024:SF37. PTHR10024:SF37. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00445-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL
60 70 80 90 100
YRKSCRRRTG KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG
110 120 130 140 150
QQVADKHELG RLQYSLDYDF QSGQLLVGIL QAMGLAALDL GGSSDPYVRV
160 170 180 190 200
YLLPDKRRRY ETKVHRQTLN PHFGETFAFK VPYVELGGRV LVMAVYDFDR
210 220 230 240 250
FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL GDICFSLRYV
260 270 280 290 300
PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN
310 320 330 340 350
TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG
360 370 380
GAGLRHWADM LANPRRPIAQ WHSLRPPDRV RLLPAP
Length:386
Mass (Da):42,900
Last modified:July 11, 2003 - v2
Checksum:i96A36792D177FD55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241H → R in BAG54160. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41E → D.
Corresponds to variant rs2301279 [ dbSNP | Ensembl ].
VAR_052240
Natural varianti111 – 1111R → Q.1 Publication
Corresponds to variant rs11542503 [ dbSNP | Ensembl ].
VAR_034528

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96783 Genomic DNA. Translation: CAA65579.1.
AK125182 mRNA. Translation: BAG54160.1.
AC010327 Genomic DNA. No translation available.
BC046157 mRNA. Translation: AAH46157.1.
CCDSiCCDS12919.1.
RefSeqiNP_003171.2. NM_003180.2.
XP_006723401.1. XM_006723338.1.
XP_006723402.1. XM_006723339.1.
UniGeneiHs.631566.

Genome annotation databases

EnsembliENST00000354308; ENSP00000346265; ENSG00000129990.
ENST00000537500; ENSP00000442896; ENSG00000129990.
GeneIDi6861.
KEGGihsa:6861.
UCSCiuc002qjm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96783 Genomic DNA. Translation: CAA65579.1 .
AK125182 mRNA. Translation: BAG54160.1 .
AC010327 Genomic DNA. No translation available.
BC046157 mRNA. Translation: AAH46157.1 .
CCDSi CCDS12919.1.
RefSeqi NP_003171.2. NM_003180.2.
XP_006723401.1. XM_006723338.1.
XP_006723402.1. XM_006723339.1.
UniGenei Hs.631566.

3D structure databases

ProteinModelPortali O00445.
SMRi O00445. Positions 108-380.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112725. 5 interactions.
IntActi O00445. 2 interactions.
MINTi MINT-1388417.
STRINGi 9606.ENSP00000346265.

PTM databases

PhosphoSitei O00445.

Proteomic databases

MaxQBi O00445.
PaxDbi O00445.
PRIDEi O00445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354308 ; ENSP00000346265 ; ENSG00000129990 .
ENST00000537500 ; ENSP00000442896 ; ENSG00000129990 .
GeneIDi 6861.
KEGGi hsa:6861.
UCSCi uc002qjm.1. human.

Organism-specific databases

CTDi 6861.
GeneCardsi GC19M055684.
HGNCi HGNC:11513. SYT5.
HPAi HPA010688.
MIMi 600782. gene.
neXtProti NX_O00445.
PharmGKBi PA36294.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292488.
GeneTreei ENSGT00760000118973.
HOGENOMi HOG000232127.
HOVERGENi HBG005010.
InParanoidi O00445.
OMAi NFAFKVP.
PhylomeDBi O00445.
TreeFami TF315600.

Enzyme and pathway databases

Reactomei REACT_18325. Regulation of insulin secretion.

Miscellaneous databases

GeneWikii SYT5.
GenomeRNAii 6861.
NextBioi 26775.
PROi O00445.
SOURCEi Search...

Gene expression databases

Bgeei O00445.
CleanExi HS_SYT5.
ExpressionAtlasi O00445. baseline and differential.
Genevestigatori O00445.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028689. SYT5.
[Graphical view ]
PANTHERi PTHR10024:SF37. PTHR10024:SF37. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location."
    Craxton M.A., Olsen A., Goedert M.
    Genomics 42:165-169(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-111.
    Tissue: Brain.

Entry informationi

Entry nameiSYT5_HUMAN
AccessioniPrimary (citable) accession number: O00445
Secondary accession number(s): B3KWJ8, Q86X72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2003
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3