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O00445

- SYT5_HUMAN

UniProt

O00445 - SYT5_HUMAN

Protein

Synaptotagmin-5

Gene

SYT5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (11 Jul 2003)
      Previous versions | rss
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    Functioni

    May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface By similarity.By similarity

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi138 – 1381Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi139 – 1391Calcium 1By similarity
    Metal bindingi139 – 1391Calcium 2By similarity
    Metal bindingi145 – 1451Calcium 1By similarity
    Metal bindingi197 – 1971Calcium 1By similarity
    Metal bindingi197 – 1971Calcium 2By similarity
    Metal bindingi198 – 1981Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi199 – 1991Calcium 1By similarity
    Metal bindingi199 – 1991Calcium 2By similarity
    Metal bindingi199 – 1991Calcium 3By similarity
    Metal bindingi202 – 2021Calcium 3By similarity
    Metal bindingi205 – 2051Calcium 2By similarity
    Metal bindingi205 – 2051Calcium 3By similarity

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. transporter activity Source: InterPro

    GO - Biological processi

    1. calcium ion-dependent exocytosis Source: InterPro
    2. energy reserve metabolic process Source: Reactome
    3. regulation of insulin secretion Source: Reactome
    4. small molecule metabolic process Source: Reactome
    5. synaptic transmission Source: ProtInc

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_18325. Regulation of insulin secretion.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-5
    Alternative name(s):
    Synaptotagmin V
    Short name:
    SytV
    Gene namesi
    Name:SYT5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11513. SYT5.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Single-pass membrane protein By similarity. Recycling endosome membrane By similarity; Single-pass membrane protein By similarity
    Note: In mast cells, localizes to the endocytic recycling compartment.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dense core granule Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. neuronal cell body Source: Ensembl
    5. neuron projection Source: Ensembl
    6. perinuclear region of cytoplasm Source: Ensembl
    7. recycling endosome membrane Source: UniProtKB-SubCell
    8. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36294.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386Synaptotagmin-5PRO_0000183951Add
    BLAST

    Proteomic databases

    MaxQBiO00445.
    PaxDbiO00445.
    PRIDEiO00445.

    PTM databases

    PhosphoSiteiO00445.

    Expressioni

    Gene expression databases

    ArrayExpressiO00445.
    BgeeiO00445.
    CleanExiHS_SYT5.
    GenevestigatoriO00445.

    Organism-specific databases

    HPAiHPA010688.

    Interactioni

    Subunit structurei

    Homodimer. Can also form heterodimers with SYT6. Interacts with both alpha- and beta-tubulin By similarity.By similarity

    Protein-protein interaction databases

    BioGridi112725. 2 interactions.
    IntActiO00445. 2 interactions.
    MINTiMINT-1388417.
    STRINGi9606.ENSP00000346265.

    Structurei

    3D structure databases

    ProteinModelPortaliO00445.
    SMRiO00445. Positions 108-380.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424VesicularSequence AnalysisAdd
    BLAST
    Topological domaini46 – 386341CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 21188C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini253 – 34492C2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG292488.
    HOGENOMiHOG000232127.
    HOVERGENiHBG005010.
    InParanoidiO00445.
    OMAiNFAFKVP.
    PhylomeDBiO00445.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028689. SYT5.
    [Graphical view]
    PANTHERiPTHR10024:SF37. PTHR10024:SF37. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00445-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL    50
    YRKSCRRRTG KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG 100
    QQVADKHELG RLQYSLDYDF QSGQLLVGIL QAMGLAALDL GGSSDPYVRV 150
    YLLPDKRRRY ETKVHRQTLN PHFGETFAFK VPYVELGGRV LVMAVYDFDR 200
    FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL GDICFSLRYV 250
    PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN 300
    TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG 350
    GAGLRHWADM LANPRRPIAQ WHSLRPPDRV RLLPAP 386
    Length:386
    Mass (Da):42,900
    Last modified:July 11, 2003 - v2
    Checksum:i96A36792D177FD55
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241H → R in BAG54160. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41E → D.
    Corresponds to variant rs2301279 [ dbSNP | Ensembl ].
    VAR_052240
    Natural varianti111 – 1111R → Q.1 Publication
    Corresponds to variant rs11542503 [ dbSNP | Ensembl ].
    VAR_034528

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96783 Genomic DNA. Translation: CAA65579.1.
    AK125182 mRNA. Translation: BAG54160.1.
    AC010327 Genomic DNA. No translation available.
    BC046157 mRNA. Translation: AAH46157.1.
    CCDSiCCDS12919.1.
    RefSeqiNP_003171.2. NM_003180.2.
    XP_006723401.1. XM_006723338.1.
    XP_006723402.1. XM_006723339.1.
    UniGeneiHs.631566.

    Genome annotation databases

    EnsembliENST00000354308; ENSP00000346265; ENSG00000129990.
    ENST00000537500; ENSP00000442896; ENSG00000129990.
    GeneIDi6861.
    KEGGihsa:6861.
    UCSCiuc002qjm.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96783 Genomic DNA. Translation: CAA65579.1 .
    AK125182 mRNA. Translation: BAG54160.1 .
    AC010327 Genomic DNA. No translation available.
    BC046157 mRNA. Translation: AAH46157.1 .
    CCDSi CCDS12919.1.
    RefSeqi NP_003171.2. NM_003180.2.
    XP_006723401.1. XM_006723338.1.
    XP_006723402.1. XM_006723339.1.
    UniGenei Hs.631566.

    3D structure databases

    ProteinModelPortali O00445.
    SMRi O00445. Positions 108-380.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112725. 2 interactions.
    IntActi O00445. 2 interactions.
    MINTi MINT-1388417.
    STRINGi 9606.ENSP00000346265.

    PTM databases

    PhosphoSitei O00445.

    Proteomic databases

    MaxQBi O00445.
    PaxDbi O00445.
    PRIDEi O00445.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354308 ; ENSP00000346265 ; ENSG00000129990 .
    ENST00000537500 ; ENSP00000442896 ; ENSG00000129990 .
    GeneIDi 6861.
    KEGGi hsa:6861.
    UCSCi uc002qjm.1. human.

    Organism-specific databases

    CTDi 6861.
    GeneCardsi GC19M055684.
    HGNCi HGNC:11513. SYT5.
    HPAi HPA010688.
    MIMi 600782. gene.
    neXtProti NX_O00445.
    PharmGKBi PA36294.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292488.
    HOGENOMi HOG000232127.
    HOVERGENi HBG005010.
    InParanoidi O00445.
    OMAi NFAFKVP.
    PhylomeDBi O00445.
    TreeFami TF315600.

    Enzyme and pathway databases

    Reactomei REACT_18325. Regulation of insulin secretion.

    Miscellaneous databases

    GeneWikii SYT5.
    GenomeRNAii 6861.
    NextBioi 26775.
    PROi O00445.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00445.
    Bgeei O00445.
    CleanExi HS_SYT5.
    Genevestigatori O00445.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028689. SYT5.
    [Graphical view ]
    PANTHERi PTHR10024:SF37. PTHR10024:SF37. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location."
      Craxton M.A., Olsen A., Goedert M.
      Genomics 42:165-169(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-111.
      Tissue: Brain.

    Entry informationi

    Entry nameiSYT5_HUMAN
    AccessioniPrimary (citable) accession number: O00445
    Secondary accession number(s): B3KWJ8, Q86X72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 11, 2003
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3