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Protein

Serine/threonine-protein kinase PLK4

Gene

PLK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).7 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPCurated1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • centriole replication Source: UniProtKB
  • de novo centriole assembly Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: Reactome
  • positive regulation of centriole replication Source: UniProtKB
  • protein phosphorylation Source: ProtInc
  • trophoblast giant cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS06956-MONOMER.
BRENDAi2.7.11.21. 2681.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.
SignaLinkiO00444.
SIGNORiO00444.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PLK4 (EC:2.7.11.21)
Alternative name(s):
Polo-like kinase 4
Short name:
PLK-4
Serine/threonine-protein kinase 18
Serine/threonine-protein kinase Sak
Gene namesi
Name:PLK4
Synonyms:SAK, STK18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:11397. PLK4.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: UniProtKB
  • cleavage furrow Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • deuterosome Source: UniProtKB
  • nucleolus Source: UniProtKB
  • XY body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Microcephaly and chorioretinopathy, autosomal recessive, 2 (MCCRP2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe disorder characterized by microcephaly, delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities.
See also OMIM:616171

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41K → M: Abolishes ability to phosphorylate CDC25C and CHEK2. 2 Publications1
Mutagenesisi154D → A: Catalytically inactive mutant that causes some centrosome amplification above background levels when overexpressed. 1 Publication1
Mutagenesisi170T → D: Activating mutant. 2 Publications1

Keywords - Diseasei

Dwarfism

Organism-specific databases

DisGeNETi10733.
MalaCardsiPLK4.
MIMi616171. phenotype.
OpenTargetsiENSG00000142731.
PharmGKBiPA36205.

Chemistry databases

ChEMBLiCHEMBL3788.
GuidetoPHARMACOLOGYi2171.

Polymorphism and mutation databases

BioMutaiPLK4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865671 – 970Serine/threonine-protein kinase PLK4Add BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei401PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated; leading to its degradation by the proteasome.By similarity
Tyrosine-phosphorylated by TEC.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO00444.
PaxDbiO00444.
PeptideAtlasiO00444.
PRIDEiO00444.

PTM databases

iPTMnetiO00444.
PhosphoSitePlusiO00444.

Expressioni

Inductioni

Down-regulated in HCT 116 colorectal cancer cells, leading to aberrant centrioles composed of disorganized cylindrical microtubules and displaced appendages. Down-regulated by p53/TP53.2 Publications

Gene expression databases

BgeeiENSG00000142731.
CleanExiHS_PLK4.
ExpressionAtlasiO00444. baseline and differential.
GenevisibleiO00444. HS.

Organism-specific databases

HPAiHPA035026.
HPA043198.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with CEP152 (via N-terminus). Interacts with CEP78; this interaction may be important for proper PLK4 localization to the centriole and PLK4-induced overduplication of centrioles (PubMed:27246242).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-746202,EBI-746202
ARR3P365753EBI-746202,EBI-718116
C1orf109Q9NX043EBI-746202,EBI-8643161
SFNP319472EBI-746202,EBI-476295
TCEB3Q142415EBI-746202,EBI-742350

Protein-protein interaction databases

BioGridi115956. 51 interactors.
DIPiDIP-34467N.
IntActiO00444. 29 interactors.
MINTiMINT-1460432.
STRINGi9606.ENSP00000270861.

Chemistry databases

BindingDBiO00444.

Structurei

Secondary structure

1970
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 5Combined sources4
Helixi9 – 11Combined sources3
Beta strandi12 – 20Combined sources9
Beta strandi22 – 31Combined sources10
Turni32 – 34Combined sources3
Beta strandi37 – 44Combined sources8
Helixi45 – 50Combined sources6
Helixi54 – 64Combined sources11
Beta strandi75 – 80Combined sources6
Beta strandi82 – 90Combined sources9
Helixi97 – 102Combined sources6
Beta strandi104 – 106Combined sources3
Helixi110 – 129Combined sources20
Helixi139 – 141Combined sources3
Beta strandi142 – 144Combined sources3
Beta strandi150 – 152Combined sources3
Turni158 – 161Combined sources4
Helixi193 – 206Combined sources14
Helixi217 – 225Combined sources9
Helixi236 – 245Combined sources10
Helixi250 – 252Combined sources3
Helixi256 – 259Combined sources4
Turni263 – 265Combined sources3
Helixi587 – 590Combined sources4
Beta strandi602 – 605Combined sources4
Beta strandi607 – 613Combined sources7
Beta strandi619 – 627Combined sources9
Beta strandi630 – 639Combined sources10
Beta strandi645 – 649Combined sources5
Helixi651 – 654Combined sources4
Beta strandi671 – 674Combined sources4
Helixi675 – 677Combined sources3
Helixi680 – 682Combined sources3
Helixi683 – 698Combined sources16
Beta strandi700 – 706Combined sources7
Beta strandi708 – 716Combined sources9
Beta strandi723 – 727Combined sources5
Beta strandi732 – 735Combined sources4
Beta strandi740 – 743Combined sources4
Beta strandi749 – 752Combined sources4
Helixi755 – 759Combined sources5
Helixi765 – 793Combined sources29
Beta strandi800 – 804Combined sources5
Beta strandi887 – 893Combined sources7
Turni894 – 896Combined sources3
Beta strandi897 – 902Combined sources6
Beta strandi905 – 911Combined sources7
Beta strandi916 – 922Combined sources7
Beta strandi926 – 929Combined sources4
Turni931 – 933Combined sources3
Beta strandi935 – 938Combined sources4
Helixi946 – 958Combined sources13
Helixi959 – 961Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N19NMR-A884-970[»]
3COKX-ray2.25A/B2-275[»]
4JXFX-ray2.40A4-269[»]
4N7VX-ray2.76A/B580-808[»]
4N7ZX-ray2.85A580-808[»]
4N9JX-ray2.60A/B581-808[»]
4YURX-ray2.65A2-275[»]
4YYPX-ray2.60A884-970[»]
ProteinModelPortaliO00444.
SMRiO00444.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00444.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 265Protein kinasePROSITE-ProRule annotationAdd BLAST254
Domaini892 – 956POLO boxPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.PROSITE-ProRule annotation
Contains 1 POLO box domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0575. Eukaryota.
ENOG410XQBP. LUCA.
GeneTreeiENSGT00850000132295.
HOVERGENiHBG053617.
InParanoidiO00444.
KOiK08863.
OMAiFPIIVGR.
OrthoDBiEOG091G05NQ.
PhylomeDBiO00444.
TreeFamiTF101090.

Family and domain databases

CDDicd13114. POLO_box_Plk4_1. 1 hit.
cd13115. POLO_box_Plk4_2. 1 hit.
cd13116. POLO_box_Plk4_3. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR033700. Plk4.
IPR000959. POLO_box_dom.
IPR033699. POLO_box_Plk4_1.
IPR033698. POLO_box_Plk4_2.
IPR033696. POLO_box_Plk4_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PANTHERiPTHR24345:SF50. PTHR24345:SF50. 3 hits.
PfamiPF00069. Pkinase. 1 hit.
PF00659. POLO_box. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50078. POLO_BOX. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O00444-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK
60 70 80 90 100
AGMVQRVQNE VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY
110 120 130 140 150
LKNRVKPFSE NEARHFMHQI ITGMLYLHSH GILHRDLTLS NLLLTRNMNI
160 170 180 190 200
KIADFGLATQ LKMPHEKHYT LCGTPNYISP EIATRSAHGL ESDVWSLGCM
210 220 230 240 250
FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PSFLSIEAKD LIHQLLRRNP
260 270 280 290 300
ADRLSLSSVL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST
310 320 330 340 350
SISGSLFDKR RLLIGQPLPN KMTVFPKNKS STDFSSSGDG NSFYTQWGNQ
360 370 380 390 400
ETSNSGRGRV IQDAEERPHS RYLRRAYSSD RSGTSNSQSQ AKTYTMERCH
410 420 430 440 450
SAEMLSVSKR SGGGENEERY SPTDNNANIF NFFKEKTSSS SGSFERPDNN
460 470 480 490 500
QALSNHLCPG KTPFPFADPT PQTETVQQWF GNLQINAHLR KTTEYDSISP
510 520 530 540 550
NRDFQGHPDL QKDTSKNAWT DTKVKKNSDA SDNAHSVKQQ NTMKYMTALH
560 570 580 590 600
SKPEIIQQEC VFGSDPLSEQ SKTRGMEPPW GYQNRTLRSI TSPLVAHRLK
610 620 630 640 650
PIRQKTKKAV VSILDSEEVC VELVKEYASQ EYVKEVLQIS SDGNTITIYY
660 670 680 690 700
PNGGRGFPLA DRPPSPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS
710 720 730 740 750
PKITYFTRYA KCILMENSPG ADFEVWFYDG VKIHKTEDFI QVIEKTGKSY
760 770 780 790 800
TLKSESEVNS LKEEIKMYMD HANEGHRICL ALESIISEEE RKTRSAPFFP
810 820 830 840 850
IIIGRKPGST SSPKALSPPP SVDSNYPTRE RASFNRMVMH SAASPTQAPI
860 870 880 890 900
LNPSMVTNEG LGLTTTASGT DISSNSLKDC LPKSAQLLKS VFVKNVGWAT
910 920 930 940 950
QLTSGAVWVQ FNDGSQLVVQ AGVSSISYTS PNGQTTRYGE NEKLPDYIKQ
960 970
KLQCLSSILL MFSNPTPNFH
Length:970
Mass (Da):108,972
Last modified:November 13, 2007 - v3
Checksum:i4D56F5FD983211A6
GO
Isoform 2 (identifier: O00444-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-74: Missing.

Note: No experimental confirmation available.
Show »
Length:938
Mass (Da):105,253
Checksum:i3605FA717C82C2B7
GO
Isoform 3 (identifier: O00444-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: No experimental confirmation available.
Show »
Length:929
Mass (Da):104,636
Checksum:iECD6808B29B9D8D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34T → S in BAB69958 (PubMed:11489907).Curated1
Sequence conflicti58Q → K in CAA73575 (Ref. 1) Curated1
Sequence conflicti333D → N in BAH13823 (PubMed:14702039).Curated1
Sequence conflicti387S → R in BAB69958 (PubMed:11489907).Curated1
Sequence conflicti692F → S in BAH13823 (PubMed:14702039).Curated1
Sequence conflicti696V → L in BAB69958 (PubMed:11489907).Curated1
Sequence conflicti768Y → F in CAA73575 (Ref. 1) Curated1
Sequence conflicti842A → D in BAB69958 (PubMed:11489907).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04102786Y → C.1 PublicationCorresponds to variant rs34156294dbSNPEnsembl.1
Natural variantiVAR_041028146R → H.1 PublicationCorresponds to variant rs35232579dbSNPEnsembl.1
Natural variantiVAR_041029226A → T.1 PublicationCorresponds to variant rs35448573dbSNPEnsembl.1
Natural variantiVAR_019632232S → T.4 PublicationsCorresponds to variant rs3811740dbSNPEnsembl.1
Natural variantiVAR_041030317P → L.1 PublicationCorresponds to variant rs35049837dbSNPEnsembl.1
Natural variantiVAR_041031449N → D.1 PublicationCorresponds to variant rs34906574dbSNPEnsembl.1
Natural variantiVAR_041032519W → S.1 PublicationCorresponds to variant rs56043017dbSNPEnsembl.1
Natural variantiVAR_041033830E → D.4 PublicationsCorresponds to variant rs17012739dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0381161 – 41Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_03811743 – 74Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13115 mRNA. Translation: CAA73575.1.
AB006972 mRNA. Translation: BAB69958.1.
AK302858 mRNA. Translation: BAH13823.1.
AK303399 mRNA. Translation: BAH13953.1.
AK314238 mRNA. Translation: BAG36907.1.
BC036023 mRNA. Translation: AAH36023.1.
CCDSiCCDS3735.1. [O00444-1]
CCDS54803.1. [O00444-2]
CCDS54804.1. [O00444-3]
RefSeqiNP_001177728.1. NM_001190799.1. [O00444-2]
NP_001177730.1. NM_001190801.1. [O00444-3]
NP_055079.3. NM_014264.4. [O00444-1]
UniGeneiHs.172052.

Genome annotation databases

EnsembliENST00000270861; ENSP00000270861; ENSG00000142731. [O00444-1]
ENST00000513090; ENSP00000427554; ENSG00000142731. [O00444-2]
ENST00000514379; ENSP00000423582; ENSG00000142731. [O00444-3]
GeneIDi10733.
KEGGihsa:10733.
UCSCiuc003ifo.4. human. [O00444-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13115 mRNA. Translation: CAA73575.1.
AB006972 mRNA. Translation: BAB69958.1.
AK302858 mRNA. Translation: BAH13823.1.
AK303399 mRNA. Translation: BAH13953.1.
AK314238 mRNA. Translation: BAG36907.1.
BC036023 mRNA. Translation: AAH36023.1.
CCDSiCCDS3735.1. [O00444-1]
CCDS54803.1. [O00444-2]
CCDS54804.1. [O00444-3]
RefSeqiNP_001177728.1. NM_001190799.1. [O00444-2]
NP_001177730.1. NM_001190801.1. [O00444-3]
NP_055079.3. NM_014264.4. [O00444-1]
UniGeneiHs.172052.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N19NMR-A884-970[»]
3COKX-ray2.25A/B2-275[»]
4JXFX-ray2.40A4-269[»]
4N7VX-ray2.76A/B580-808[»]
4N7ZX-ray2.85A580-808[»]
4N9JX-ray2.60A/B581-808[»]
4YURX-ray2.65A2-275[»]
4YYPX-ray2.60A884-970[»]
ProteinModelPortaliO00444.
SMRiO00444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115956. 51 interactors.
DIPiDIP-34467N.
IntActiO00444. 29 interactors.
MINTiMINT-1460432.
STRINGi9606.ENSP00000270861.

Chemistry databases

BindingDBiO00444.
ChEMBLiCHEMBL3788.
GuidetoPHARMACOLOGYi2171.

PTM databases

iPTMnetiO00444.
PhosphoSitePlusiO00444.

Polymorphism and mutation databases

BioMutaiPLK4.

Proteomic databases

MaxQBiO00444.
PaxDbiO00444.
PeptideAtlasiO00444.
PRIDEiO00444.

Protocols and materials databases

DNASUi10733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270861; ENSP00000270861; ENSG00000142731. [O00444-1]
ENST00000513090; ENSP00000427554; ENSG00000142731. [O00444-2]
ENST00000514379; ENSP00000423582; ENSG00000142731. [O00444-3]
GeneIDi10733.
KEGGihsa:10733.
UCSCiuc003ifo.4. human. [O00444-1]

Organism-specific databases

CTDi10733.
DisGeNETi10733.
GeneCardsiPLK4.
HGNCiHGNC:11397. PLK4.
HPAiHPA035026.
HPA043198.
MalaCardsiPLK4.
MIMi605031. gene.
616171. phenotype.
neXtProtiNX_O00444.
OpenTargetsiENSG00000142731.
PharmGKBiPA36205.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0575. Eukaryota.
ENOG410XQBP. LUCA.
GeneTreeiENSGT00850000132295.
HOVERGENiHBG053617.
InParanoidiO00444.
KOiK08863.
OMAiFPIIVGR.
OrthoDBiEOG091G05NQ.
PhylomeDBiO00444.
TreeFamiTF101090.

Enzyme and pathway databases

BioCyciZFISH:HS06956-MONOMER.
BRENDAi2.7.11.21. 2681.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.
SignaLinkiO00444.
SIGNORiO00444.

Miscellaneous databases

EvolutionaryTraceiO00444.
GeneWikiiPLK4.
GenomeRNAii10733.
PROiO00444.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142731.
CleanExiHS_PLK4.
ExpressionAtlasiO00444. baseline and differential.
GenevisibleiO00444. HS.

Family and domain databases

CDDicd13114. POLO_box_Plk4_1. 1 hit.
cd13115. POLO_box_Plk4_2. 1 hit.
cd13116. POLO_box_Plk4_3. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR033700. Plk4.
IPR000959. POLO_box_dom.
IPR033699. POLO_box_Plk4_1.
IPR033698. POLO_box_Plk4_2.
IPR033696. POLO_box_Plk4_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PANTHERiPTHR24345:SF50. PTHR24345:SF50. 3 hits.
PfamiPF00069. Pkinase. 1 hit.
PF00659. POLO_box. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50078. POLO_BOX. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLK4_HUMAN
AccessioniPrimary (citable) accession number: O00444
Secondary accession number(s): B2RAL0
, B7Z837, B7Z8G7, Q8IYF0, Q96Q95, Q9UD84, Q9UDE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.