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O00425

- IF2B3_HUMAN

UniProt

O00425 - IF2B3_HUMAN

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Protein

Insulin-like growth factor 2 mRNA-binding protein 3

Gene
IGF2BP3, IMP3, KOC1, VICKZ3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.2 Publications

GO - Molecular functioni

  1. mRNA 3'-UTR binding Source: UniProtKB
  2. mRNA 5'-UTR binding Source: BHF-UCL
  3. nucleotide binding Source: InterPro
  4. poly(A) RNA binding Source: UniProtKB
  5. protein binding Source: UniProtKB
  6. RNA binding Source: ProtInc
  7. translation regulator activity Source: BHF-UCL

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. gene expression Source: Reactome
  3. mRNA transport Source: UniProtKB-KW
  4. negative regulation of translation Source: BHF-UCL
  5. regulation of cytokine biosynthetic process Source: BHF-UCL
  6. translation Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Translation regulation, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_22166. Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor 2 mRNA-binding protein 3
Short name:
IGF2 mRNA-binding protein 3
Short name:
IMP-3
Alternative name(s):
IGF-II mRNA-binding protein 3
KH domain-containing protein overexpressed in cancer
Short name:
hKOC
VICKZ family member 3
Gene namesi
Name:IGF2BP3
Synonyms:IMP3, KOC1, VICKZ3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:28868. IGF2BP3.

Subcellular locationi

Nucleus. Cytoplasm
Note: Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.8 Publications

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytosol Source: Reactome
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi213 – 2131K → E: Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-, DHX9- and HNRNPU-binding, nor on subcellular location; when associated with E-294; 422-E-E-423 and 505-E-E-506. 1 Publication
Mutagenesisi294 – 2941K → E: Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, Modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-, DHX9- and HNRNPU-binding, nor on subcellular location; when associated with E-213; 422-E-E-423 and 505-E-E-506. 1 Publication
Mutagenesisi423 – 4242KQ → EE: Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, Modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-, DHX9- and HNRNPU-binding, nor on subcellular location; when associated with E-213; E-294 and 505-E-E-506. 1 Publication
Mutagenesisi505 – 5062KG → EE: Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, Modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-, DHX9- and HNRNPU-binding, nor on subcellular location; when associated with E-213; E-294 and 422-E-E-423. 1 Publication

Organism-specific databases

PharmGKBiPA128394576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Insulin-like growth factor 2 mRNA-binding protein 3PRO_0000282538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841Phosphoserine1 Publication
Modified residuei187 – 1871Phosphoserine1 Publication
Modified residuei189 – 1891Phosphoserine1 Publication
Modified residuei528 – 5281Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO00425.
PaxDbiO00425.
PRIDEiO00425.

PTM databases

PhosphoSiteiO00425.

Expressioni

Tissue specificityi

Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.8 Publications

Gene expression databases

ArrayExpressiO00425.
BgeeiO00425.
CleanExiHS_IGF2BP3.
HS_IMP3.
GenevestigatoriO00425.

Organism-specific databases

HPAiHPA002037.

Interactioni

Subunit structurei

Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU.2 Publications

Protein-protein interaction databases

BioGridi115887. 59 interactions.
IntActiO00425. 17 interactions.
MINTiMINT-2997694.
STRINGi9606.ENSP00000258729.

Structurei

Secondary structure

1
579
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi83 – 886
Beta strandi90 – 923
Helixi94 – 10411
Beta strandi107 – 1137
Beta strandi116 – 12813
Helixi129 – 13911
Beta strandi150 – 1534

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E44NMR-A73-161[»]
ProteinModelPortaliO00425.
SMRiO00425. Positions 1-161, 198-349, 406-562.

Miscellaneous databases

EvolutionaryTraceiO00425.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7574RRM 1Add
BLAST
Domaini81 – 15676RRM 2Add
BLAST
Domaini195 – 26066KH 1Add
BLAST
Domaini276 – 34368KH 2Add
BLAST
Domaini405 – 47066KH 3Add
BLAST
Domaini487 – 55367KH 4Add
BLAST

Domaini

All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.2 Publications

Sequence similaritiesi

Belongs to the RRM IMP/VICKZ family.
Contains 4 KH domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG249985.
HOGENOMiHOG000000675.
HOVERGENiHBG052725.
InParanoidiO00425.
KOiK13197.
OMAiNPSQQPR.
OrthoDBiEOG7T7GSK.
PhylomeDBiO00425.
TreeFamiTF320229.

Family and domain databases

Gene3Di3.30.1370.10. 4 hits.
3.30.70.330. 2 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00013. KH_1. 4 hits.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00322. KH. 4 hits.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 4 hits.
PROSITEiPS50084. KH_TYPE_1. 4 hits.
PS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00425-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNKLYIGNLS ENAAPSDLES IFKDAKIPVS GPFLVKTGYA FVDCPDESWA    50
LKAIEALSGK IELHGKPIEV EHSVPKRQRI RKLQIRNIPP HLQWEVLDSL 100
LVQYGVVESC EQVNTDSETA VVNVTYSSKD QARQALDKLN GFQLENFTLK 150
VAYIPDEMAA QQNPLQQPRG RRGLGQRGSS RQGSPGSVSK QKPCDLPLRL 200
LVPTQFVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA EKSITILSTP 250
EGTSAACKSI LEIMHKEAQD IKFTEEIPLK ILAHNNFVGR LIGKEGRNLK 300
KIEQDTDTKI TISPLQELTL YNPERTITVK GNVETCAKAE EEIMKKIRES 350
YENDIASMNL QAHLIPGLNL NALGLFPPTS GMPPPTSGPP SAMTPPYPQF 400
EQSETETVHL FIPALSVGAI IGKQGQHIKQ LSRFAGASIK IAPAEAPDAK 450
VRMVIITGPP EAQFKAQGRI YGKIKEENFV SPKEEVKLEA HIRVPSFAAG 500
RVIGKGGKTV NELQNLSSAE VVVPRDQTPD ENDQVVVKIT GHFYACQVAQ 550
RKIQEILTQV KQHQQQKALQ SGPPQSRRK 579
Length:579
Mass (Da):63,705
Last modified:July 28, 2009 - v2
Checksum:i78884F56A9D98CDE
GO
Isoform 2 (identifier: O00425-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: Missing.

Show »
Length:198
Mass (Da):21,630
Checksum:i69BEB7C296373BE7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 381381Missing in isoform 2. VSP_024172Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti410 – 4101L → Q in AAD09223. 1 Publication
Sequence conflicti410 – 4101L → Q in AAC35208. 1 Publication
Sequence conflicti494 – 4941V → A in CAH56186. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76705 mRNA. Translation: AAD09223.1.
U97188 mRNA. Translation: AAC35208.1.
BX640800 mRNA. Translation: CAE45883.1.
BX648488 mRNA. Translation: CAH56186.1.
AC005082 Genomic DNA. No translation available.
AC021876 Genomic DNA. No translation available.
AC079780 Genomic DNA. No translation available.
BC065269 mRNA. Translation: AAH65269.1.
CCDSiCCDS5382.1. [O00425-1]
RefSeqiNP_006538.2. NM_006547.2. [O00425-1]
UniGeneiHs.700696.

Genome annotation databases

EnsembliENST00000258729; ENSP00000258729; ENSG00000136231. [O00425-1]
GeneIDi10643.
KEGGihsa:10643.
UCSCiuc003swf.3. human. [O00425-2]
uc003swg.3. human. [O00425-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76705 mRNA. Translation: AAD09223.1 .
U97188 mRNA. Translation: AAC35208.1 .
BX640800 mRNA. Translation: CAE45883.1 .
BX648488 mRNA. Translation: CAH56186.1 .
AC005082 Genomic DNA. No translation available.
AC021876 Genomic DNA. No translation available.
AC079780 Genomic DNA. No translation available.
BC065269 mRNA. Translation: AAH65269.1 .
CCDSi CCDS5382.1. [O00425-1 ]
RefSeqi NP_006538.2. NM_006547.2. [O00425-1 ]
UniGenei Hs.700696.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E44 NMR - A 73-161 [» ]
ProteinModelPortali O00425.
SMRi O00425. Positions 1-161, 198-349, 406-562.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115887. 59 interactions.
IntActi O00425. 17 interactions.
MINTi MINT-2997694.
STRINGi 9606.ENSP00000258729.

PTM databases

PhosphoSitei O00425.

Proteomic databases

MaxQBi O00425.
PaxDbi O00425.
PRIDEi O00425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258729 ; ENSP00000258729 ; ENSG00000136231 . [O00425-1 ]
GeneIDi 10643.
KEGGi hsa:10643.
UCSCi uc003swf.3. human. [O00425-2 ]
uc003swg.3. human. [O00425-1 ]

Organism-specific databases

CTDi 10643.
GeneCardsi GC07M023316.
HGNCi HGNC:28868. IGF2BP3.
HPAi HPA002037.
MIMi 608259. gene.
neXtProti NX_O00425.
PharmGKBi PA128394576.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249985.
HOGENOMi HOG000000675.
HOVERGENi HBG052725.
InParanoidi O00425.
KOi K13197.
OMAi NPSQQPR.
OrthoDBi EOG7T7GSK.
PhylomeDBi O00425.
TreeFami TF320229.

Enzyme and pathway databases

Reactomei REACT_22166. Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA.

Miscellaneous databases

ChiTaRSi Igf2bp3. human.
EvolutionaryTracei O00425.
GeneWikii IGF2BP3.
GenomeRNAii 10643.
NextBioi 40451.
PROi O00425.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00425.
Bgeei O00425.
CleanExi HS_IGF2BP3.
HS_IMP3.
Genevestigatori O00425.

Family and domain databases

Gene3Di 3.30.1370.10. 4 hits.
3.30.70.330. 2 hits.
InterProi IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00013. KH_1. 4 hits.
PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00322. KH. 4 hits.
SM00360. RRM. 2 hits.
[Graphical view ]
SUPFAMi SSF54791. SSF54791. 4 hits.
PROSITEi PS50084. KH_TYPE_1. 4 hits.
PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein."
    Mueller-Pillasch F., Lacher U., Wallrapp C., Micha A., Zimmerhackl F., Hameister H., Varga G., Friess H., Buechler M., Beger H.G., Vila M.R., Adler G., Gress T.M.
    Oncogene 14:2729-2733(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Pancreas and Pancreatic cancer.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrial tumor.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  5. "Expression of the highly conserved RNA binding protein KOC in embryogenesis."
    Mueller-Pillasch F., Pohl B., Wilda M., Lacher U., Beil M., Wallrapp C., Hameister H., Knoechel W., Adler G., Gress T.M.
    Mech. Dev. 88:95-99(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development."
    Nielsen J., Christiansen J., Lykke-Andersen J., Johnsen A.H., Wewer U.M., Nielsen F.C.
    Mol. Cell. Biol. 19:1262-1270(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NOMENCLATURE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, RNA-BINDING.
  7. "Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies."
    Zhang J.-Y., Chan E.K., Peng X.-X., Lu M., Wang X., Mueller F., Tan E.M.
    Clin. Immunol. 100:149-156(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS A CARCINOMA ANTIGEN.
  8. "Characterisation of the growth regulating gene IMP3, a candidate for Silver-Russell syndrome."
    Monk D., Bentley L., Beechey C., Hitchins M., Peters J., Preece M.A., Stanier P., Moore G.E.
    J. Med. Genet. 39:575-581(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. Cited for: SUBCELLULAR LOCATION.
  10. "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins."
    Yisraeli J.K.
    Biol. Cell 97:87-96(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. "KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas."
    Yantiss R.K., Woda B.A., Fanger G.R., Kalos M., Whalen G.F., Tada H., Andersen D.K., Rock K.L., Dresser K.
    Diagn. Mol. Pathol. 29:188-195(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  12. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  13. "RNA-binding IMPs promote cell adhesion and invadopodia formation."
    Vikesaa J., Hansen T.V., Joenson L., Borup R., Wewer U.M., Christiansen J., Nielsen F.C.
    EMBO J. 25:1456-1468(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RNA-BINDING, SUBCELLULAR LOCATION.
  14. "Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study."
    Jiang Z., Chu P.G., Woda B.A., Rock K.L., Liu Q., Hsieh C.-C., Li C., Chen W., Duan H.O., McDougal S., Wu C.-L.
    Lancet Oncol. 7:556-564(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  15. "IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression."
    Li C., Rock K.L., Woda B.A., Jiang Z., Fraire A.E., Dresser K.
    Mod. Pathol. 20:242-247(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  16. Cited for: INTERACTION WITH IGF2BP1.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-528, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  19. "ZBP1 recognition of beta-actin zipcode induces RNA looping."
    Chao J.A., Patskovsky Y., Patel V., Levy M., Almo S.C., Singer R.H.
    Genes Dev. 24:148-158(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA-BINDING, DOMAIN.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184; SER-187; SER-189 AND THR-528, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains."
    Wachter K., Kohn M., Stohr N., Huttelmaier S.
    Biol. Chem. 394:1077-1090(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RNA-BINDING, OLIGOMERIZATION, INTERACTION WITH ELAVL1; DHX9 AND HNRNPU, DOMAIN, SUBCELLULAR LOCATION, MUTAGENESIS OF 213-LYS-GLU-214; 294-LYS-GLU-295; 423-LYS-LYS-424 AND 505-LYS-GLY-506.
  23. "Solution structure of RNA binding domain in insulin-like growth factor 2 mRNA-binding protein 3."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 73-161.

Entry informationi

Entry nameiIF2B3_HUMAN
AccessioniPrimary (citable) accession number: O00425
Secondary accession number(s): A0A4Z5
, Q63HM0, Q6MZZ2, Q86VB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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