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O00423

- EMAL1_HUMAN

UniProt

O00423 - EMAL1_HUMAN

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Protein

Echinoderm microtubule-associated protein-like 1

Gene
EML1, EMAP1, EMAPL, EMAPL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. protein binding Source: IntAct
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiO00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 1
Short name:
EMAP-1
Short name:
HuEMAP-1
Gene namesi
Name:EML1
Synonyms:EMAP1, EMAPL, EMAPL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:3330. EML1.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Cytoplasmcytoskeleton By similarity
Note: Detected in cytoplasmic punctae. Co-localizes with microtubules. Enriched in perinuclear regions during interphase and in the region of spindle microtubules during metaphase. Enriched at the midzone during telophase and cytokinesis. Detected at growth cones in neurons By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule Source: UniProtKB-KW
  3. microtubule associated complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Mutations in this gene are associated with atypical heterotopia, epilepsy and mental retardation. Patients present giant bilateral periventricular and ribbon-like subcortical heterotopia with polymicrogyria and agenesis of the corpus callosum.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi59 – 613LAD → AAA: No effect on tubulin binding.
Mutagenesisi192 – 1921R → S: Abolishes tubulin binding; when associated with S-194; A-547; T-626; S-627; A-646 and A-786.
Mutagenesisi194 – 1941R → S: Abolishes tubulin binding; when associated with S-192; A-547; T-626; S-627; A-646 and A-786.
Mutagenesisi547 – 5471W → A: Abolishes tubulin binding; when associated with S-192; S-194; T-626; S-627; A-646 and A-786.
Mutagenesisi626 – 6261N → T: Abolishes tubulin binding; when associated with S-192; S-194; A-547; S-627; A-646 and A-786.
Mutagenesisi627 – 6271E → S: Abolishes tubulin binding; when associated with S-192; S-194; A-547; T-626; A-646 and A-786.
Mutagenesisi646 – 6461H → A: Abolishes tubulin binding; when associated with S-192; S-194; A-547; T-626; S-627 and A-786.
Mutagenesisi786 – 7861H → A: Abolishes tubulin binding; when associated with S-192; S-194; A-547; T-626; S-627 and A-646.

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

PharmGKBiPA27767.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Echinoderm microtubule-associated protein-like 1PRO_0000050961Add
BLAST

Proteomic databases

MaxQBiO00423.
PaxDbiO00423.
PRIDEiO00423.

PTM databases

PhosphoSiteiO00423.

Expressioni

Tissue specificityi

Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes.1 Publication

Gene expression databases

ArrayExpressiO00423.
BgeeiO00423.
CleanExiHS_EML1.
GenevestigatoriO00423.

Organism-specific databases

HPAiCAB033137.
HPA049105.

Interactioni

Subunit structurei

Binds repolymerizing microtubules By similarity. Binds unpolymerized tubulins via its WD repeat region.

Binary interactionsi

WithEntry#Exp.IntActNotes
ISG20L2Q9H9L33EBI-751327,EBI-751335

Protein-protein interaction databases

BioGridi108324. 2 interactions.
IntActiO00423. 1 interaction.
MINTiMINT-1457362.
STRINGi9606.ENSP00000334314.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi179 – 1813
Turni182 – 1854
Beta strandi186 – 19914
Helixi202 – 2054
Beta strandi220 – 2278
Beta strandi238 – 2403
Beta strandi246 – 2505
Beta strandi253 – 2586
Turni259 – 2624
Beta strandi263 – 2675
Beta strandi274 – 2796
Beta strandi283 – 2919
Beta strandi305 – 3095
Turni310 – 3123
Beta strandi315 – 3195
Turni321 – 3233
Beta strandi326 – 3338
Beta strandi335 – 3395
Beta strandi342 – 3465
Beta strandi348 – 3503
Beta strandi352 – 3576
Helixi358 – 3603
Beta strandi362 – 3687
Beta strandi374 – 3796
Beta strandi386 – 3927
Beta strandi394 – 4018
Beta strandi404 – 4096
Beta strandi419 – 4268
Beta strandi432 – 4365
Beta strandi441 – 4444
Beta strandi449 – 4557
Beta strandi458 – 4614
Beta strandi463 – 4686
Beta strandi474 – 4785
Turni479 – 4813
Beta strandi483 – 4875
Beta strandi493 – 4986
Turni501 – 5033
Beta strandi505 – 5117
Beta strandi517 – 5215
Beta strandi526 – 5294
Beta strandi536 – 5394
Beta strandi546 – 5516
Beta strandi553 – 56210
Beta strandi565 – 5717
Turni572 – 5754
Beta strandi576 – 5827
Beta strandi587 – 5926
Beta strandi596 – 61217
Turni613 – 6153
Beta strandi618 – 6236
Beta strandi625 – 6273
Beta strandi629 – 6346
Beta strandi638 – 6458
Beta strandi650 – 6567
Turni657 – 6604
Beta strandi661 – 6688
Beta strandi675 – 6817
Beta strandi687 – 6915
Beta strandi697 – 7004
Helixi701 – 7033
Helixi710 – 7134
Beta strandi724 – 7263
Turni727 – 7315
Beta strandi741 – 7477
Beta strandi749 – 75810
Beta strandi763 – 7686
Beta strandi772 – 7743
Beta strandi778 – 7803
Beta strandi789 – 7924
Beta strandi796 – 8027
Beta strandi809 – 8157

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CI8X-ray2.60A/B167-815[»]
ProteinModelPortaliO00423.
SMRiO00423. Positions 210-792.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati269 – 31850WD 1Add
BLAST
Repeati323 – 36644WD 2Add
BLAST
Repeati369 – 40840WD 3Add
BLAST
Repeati416 – 45439WD 4Add
BLAST
Repeati458 – 49740WD 5Add
BLAST
Repeati541 – 58040WD 6Add
BLAST
Repeati582 – 62140WD 7Add
BLAST
Repeati624 – 66340WD 8Add
BLAST
Repeati670 – 70940WD 9Add
BLAST
Repeati737 – 77640WD 10Add
BLAST
Repeati782 – 81534WD 11Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 815640Tandem atypical propeller in EMLsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi160 – 1667Poly-Ser

Domaini

Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain.

Sequence similaritiesi

Belongs to the WD repeat EMAP family.
Contains 11 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000294061.
HOVERGENiHBG051470.
OMAiFRAPSHV.
PhylomeDBiO00423.
TreeFamiTF317832.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR005108. HELP.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03451. HELP. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00423-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVTDRIAS LEQRVQMQED    50
DIQLLKSALA DVVRRLNITE EQQAVLNRKG PTKARPLMQT LPLRTTVNNG 100
TVLPKKPTGS LPSPSGVRKE TAVPATKSNI KRTSSSERVS PGGRRESNGD 150
SRGNRNRTGS TSSSSSGKKN SESKPKEPVF SAEEGYVKMF LRGRPVTMYM 200
PKDQVDSYSL EAKVELPTKR LKLEWVYGYR GRDCRNNLYL LPTGETVYFI 250
ASVVVLYNVE EQLQRHYAGH NDDVKCLAVH PDRITIATGQ VAGTSKDGKQ 300
LPPHVRIWDS VTLNTLHVIG IGFFDRAVTC IAFSKSNGGT NLCAVDDSND 350
HVLSVWDWQK EEKLADVKCS NEAVFAADFH PTDTNIIVTC GKSHLYFWTL 400
EGSSLNKKQG LFEKQEKPKF VLCVTFSENG DTITGDSSGN ILVWGKGTNR 450
ISYAVQGAHE GGIFALCMLR DGTLVSGGGK DRKLISWSGN YQKLRKTEIP 500
EQFGPIRTVA EGKGDVILIG TTRNFVLQGT LSGDFTPITQ GHTDELWGLA 550
IHASKSQFLT CGHDKHATLW DAVGHRPVWD KIIEDPAQSS GFHPSGSVVA 600
VGTLTGRWFV FDTETKDLVT VHTDGNEQLS VMRYSPDGNF LAIGSHDNCI 650
YIYGVSDNGR KYTRVGKCSG HSSFITHLDW SVNSQFLVSN SGDYEILYWV 700
PSACKQVVSV ETTRDIEWAT YTCTLGFHVF GVWPEGSDGT DINAVCRAHE 750
KKLLSTGDDF GKVHLFSYPC SQFRAPSHIY GGHSSHVTNV DFLCEDSHLI 800
STGGKDTSIM QWRVI 815
Length:815
Mass (Da):89,861
Last modified:July 28, 2009 - v3
Checksum:iA1476F75F3537205
GO
Isoform 3 (identifier: O00423-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-127: K → KRLNRSVSLLNACKLNRSTP

Note: No experimental confirmation available.

Show »
Length:834
Mass (Da):91,985
Checksum:i66B7AE5D761B3AA3
GO

Sequence cautioni

The sequence AAB57824.1 differs from that shown. Reason: Frameshift at positions 168, 392, 405, 414 and 420.
The sequence CAD62313.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti225 – 2251W → R Probable disease-associated mutation found in a patient with atypical heterotopia and mental retardation.
VAR_071075
Natural varianti243 – 2431T → A Probable disease-associated mutation found in a patient with atypical heterotopia and mental retardation; the patient carries a truncating mutation in the other copy of this gene.
VAR_071076
Natural varianti377 – 3771A → V.
Corresponds to variant rs34198557 [ dbSNP | Ensembl ].
VAR_031720
Natural varianti552 – 5521H → N.1 Publication
Corresponds to variant rs17853154 [ dbSNP | Ensembl ].
VAR_031721
Natural varianti556 – 5561S → P.3 Publications
Corresponds to variant rs2250718 [ dbSNP | Ensembl ].
VAR_031722

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei127 – 1271K → KRLNRSVSLLNACKLNRSTP in isoform 3. VSP_024476

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 953LRT → FRS in AAB57824. 1 Publication
Sequence conflicti106 – 1061K → I in AAB57824. 1 Publication
Sequence conflicti117 – 1171V → F in AAB57824. 1 Publication
Sequence conflicti120 – 1201E → D in AAB57824. 1 Publication
Sequence conflicti189 – 1891M → L in AAB57824. 1 Publication
Sequence conflicti464 – 4652FA → SP in AAB57824. 1 Publication
Sequence conflicti464 – 4652FA → SP in CAD12600. 1 Publication
Sequence conflicti499 – 5002IP → VS in CAD62313. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U97018 mRNA. Translation: AAB57824.1. Frameshift.
AJ420603
, AJ428183, AJ428184, AJ428185, AJ428189, AJ428191, AJ428193, AJ428195, AJ428197, AJ496645, AJ496644, AJ428200, AJ428199, AJ428198, AJ428196, AJ428194, AJ428192, AJ428190, AJ428188, AJ428187, AJ428186 Genomic DNA. Translation: CAD12600.2.
BC032541 mRNA. Translation: AAH32541.1.
BC033043 mRNA. Translation: AAH33043.1.
BX247979 mRNA. Translation: CAD62313.1. Different initiation.
CCDSiCCDS32154.1. [O00423-3]
CCDS32155.1. [O00423-1]
RefSeqiNP_001008707.1. NM_001008707.1. [O00423-3]
NP_004425.2. NM_004434.2. [O00423-1]
UniGeneiHs.12451.

Genome annotation databases

EnsembliENST00000262233; ENSP00000262233; ENSG00000066629. [O00423-1]
ENST00000334192; ENSP00000334314; ENSG00000066629. [O00423-3]
GeneIDi2009.
KEGGihsa:2009.
UCSCiuc001ygq.3. human. [O00423-3]
uc001ygs.3. human. [O00423-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U97018 mRNA. Translation: AAB57824.1 . Frameshift.
AJ420603
, AJ428183 , AJ428184 , AJ428185 , AJ428189 , AJ428191 , AJ428193 , AJ428195 , AJ428197 , AJ496645 , AJ496644 , AJ428200 , AJ428199 , AJ428198 , AJ428196 , AJ428194 , AJ428192 , AJ428190 , AJ428188 , AJ428187 , AJ428186 Genomic DNA. Translation: CAD12600.2 .
BC032541 mRNA. Translation: AAH32541.1 .
BC033043 mRNA. Translation: AAH33043.1 .
BX247979 mRNA. Translation: CAD62313.1 . Different initiation.
CCDSi CCDS32154.1. [O00423-3 ]
CCDS32155.1. [O00423-1 ]
RefSeqi NP_001008707.1. NM_001008707.1. [O00423-3 ]
NP_004425.2. NM_004434.2. [O00423-1 ]
UniGenei Hs.12451.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CI8 X-ray 2.60 A/B 167-815 [» ]
ProteinModelPortali O00423.
SMRi O00423. Positions 210-792.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108324. 2 interactions.
IntActi O00423. 1 interaction.
MINTi MINT-1457362.
STRINGi 9606.ENSP00000334314.

PTM databases

PhosphoSitei O00423.

Proteomic databases

MaxQBi O00423.
PaxDbi O00423.
PRIDEi O00423.

Protocols and materials databases

DNASUi 2009.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262233 ; ENSP00000262233 ; ENSG00000066629 . [O00423-1 ]
ENST00000334192 ; ENSP00000334314 ; ENSG00000066629 . [O00423-3 ]
GeneIDi 2009.
KEGGi hsa:2009.
UCSCi uc001ygq.3. human. [O00423-3 ]
uc001ygs.3. human. [O00423-1 ]

Organism-specific databases

CTDi 2009.
GeneCardsi GC14P100259.
H-InvDB HIX0011963.
HGNCi HGNC:3330. EML1.
HPAi CAB033137.
HPA049105.
MIMi 602033. gene.
neXtProti NX_O00423.
PharmGKBi PA27767.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000294061.
HOVERGENi HBG051470.
OMAi FRAPSHV.
PhylomeDBi O00423.
TreeFami TF317832.

Enzyme and pathway databases

SignaLinki O00423.

Miscellaneous databases

ChiTaRSi EML1. human.
GeneWikii EML1.
GenomeRNAii 2009.
NextBioi 8131.
PROi O00423.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00423.
Bgeei O00423.
CleanExi HS_EML1.
Genevestigatori O00423.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR005108. HELP.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF03451. HELP. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view ]
SMARTi SM00320. WD40. 10 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel human homologue of the gene coding for echinoderm microtubule-associated protein (EMAP) from the Usher syndrome type 1a locus at 14q32."
    Eudy J.D., Ma-Edmonds M., Yao S.F., Talmadge C.B., Kelley P.M., Weston M.D., Kimberling W.J., Sumegi J.
    Genomics 43:104-106(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-556.
  2. "Complete exon-intron structure of human homologue of the gene coding the echinoderm microtubule-associated protein (EMAP)."
    Gerber S., Sumegi J., Rozet J.-M., Perrault I., Ducroq D., Munnich A., Kaplan J.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-556.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-552 AND PRO-556.
    Tissue: Brain and Uterus.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-500 (ISOFORM 3).
    Tissue: Fetal brain.
  5. "Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2)."
    Lepley D.M., Palange J.M., Suprenant K.A.
    Gene 237:343-349(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: ROLE IN DISEASE, VARIANTS ARG-225 AND ALA-243.
  7. "Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical ?-propeller domain."
    Richards M.W., Law E.W., Rennalls L.P., Busacca S., O'Regan L., Fry A.M., Fennell D.A., Bayliss R.
    Proc. Natl. Acad. Sci. U.S.A. 111:5195-5200(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 167-815, DOMAIN, INTERACTION WITH TUBULIN, MUTAGENESIS OF 59-LEU--ASP-61; ARG-192; ARG-194; TRP-547; ASN-626; GLU-627; HIS-646 AND HIS-786.

Entry informationi

Entry nameiEMAL1_HUMAN
AccessioniPrimary (citable) accession number: O00423
Secondary accession number(s): Q86U15
, Q8N536, Q8N5C4, Q8WWL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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