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Reviewed, UniProtKB/Swiss-Prot O00422 (SAP18_HUMAN)

Last modified June 16, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Histone deacetylase complex subunit SAP18
Alternative name(s):
    Sin3-associated polypeptide, 18 kDa
    Sin3-associated polypeptide p18
    Cell growth-inhibiting protein 38
    2HOR0202
Gene names
Name: SAP18
ORF Names: GIG38
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Ref.1

Subunit structure

Forms a complex with SIN3A and HDAC1.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the SAP18 family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Molecular functionRepressor
   Technical term3D-structure
Gene Ontology (GO)
   Biological processregulation of transcription from RNA polymerase II promoter Ref.1

Traceable author statement. Source: ProtInc

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componenthistone deacetylase complex Ref.1

Traceable author statement. Source: ProtInc

   Molecular functiontranscription corepressor activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153Histone deacetylase complex subunit SAP18
PRO_0000220975

Experimental info

Sequence conflict1141K → E in AAF21220. Ref.2
Sequence conflict1461P → T in AAH30836. Ref.7

Secondary structure

.......................... 153
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O00422-1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: C7E479FFE9CA5774

FASTA15317,561
        10         20         30         40         50         60 
MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT 

        70         80         90        100        110        120 
WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM 

       130        140        150 
TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY 

« Hide

References

« Hide 'large scale' references
[1]"Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex."
Zhang Y., Iratni R., Erdjument-Bromage H., Tempst P., Reinberg D.
Cell 89:357-364(1997) [PubMed: 9150135] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SIN3A AND HDAC1.
[2]"Characterization of proteins interacting with CAMPGEF."
Kawasaki H., Housman D.E., Graybiel A.M.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags."
Kim M.K., Kim Y.H., Seo J.M., Lee H.M., Chung H.J., Sohn M.Y., Hwang S.Y., Im S.U., Jung E.J., Lee H.D., Kim J.C.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hair follicle dermal papilla.
[4]"Identification of a human cell growth inhibiting gene."
Kim J.W.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed: 15057823] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hypothalamus.
[8]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

U96915 mRNA. Translation: AAC51322.1.
U78303 mRNA. Translation: AAF21220.1.
AF153608 mRNA. Translation: AAD41090.1.
AY550970 mRNA. Translation: AAT52216.1.
CR457035 mRNA. Translation: CAG33316.1.
AL158032 Genomic DNA. Translation: CAH69949.1.
BC030836 mRNA. Translation: AAH30836.1.
IPIIPI00011698.
RefSeqNP_005861.2.
UniGeneHs.524899

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2HDENMR-A6-149[»]
ModBaseSearch...

Protein-protein interaction databases

IntActO00422. 32 interactions.

Protein family/group databases

TCDB3.A.18.1.1. nuclear mRNA exporter (mRNA-E) family.

PTM databases

PhosphoSiteO00422.

Proteomic databases

PeptideAtlasO00422.
PRIDEO00422.

Genome annotation databases

EnsemblENSG00000150459. Homo sapiens. [Contig view]
GeneID10284.
KEGGhsa:10284.

Organism-specific databases

GeneCardsGC13P020612.
H-InvDBHIX0011163.
HGNCHGNC:10530. SAP18.
HPACAB012273.
HPA011352.
MIM602949. gene.
PharmGKBPA34940.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO00422.
HOVERGENO00422.
OMAO00422. FAIVYPD.

Enzyme and pathway databases

Pathway_Interaction_DBhedgehog_glipathway. Hedgehog signaling events mediated by Gli proteins.
smad2_3nuclearpathway. Regulation of nuclear SMAD2/3 signaling.
telomerasepathway. Regulation of Telomerase.
hdac_classi_pathway. Signaling events mediated by HDAC Class I.

Gene expression databases

ArrayExpressO00422.
BgeeO00422.
CleanExHS_SAP18.
GermOnlineENSG00000150459. Homo sapiens.

Family and domain databases

InterProIPR017250. Hist_deAcase_cplx_SAP18_su.
IPR010516. SAP18.
[Graphical view]
PANTHERPTHR13082. SAP18. 1 hit.
PfamPF06487. SAP18. 1 hit.
[Graphical view]
PIRSFPIRSF037637. HDAC_SAP18. 1 hit.
ProtoNetSearch...

Other Resources

NextBio38964.
SOURCESearch...

Entry information

Entry nameSAP18_HUMAN
AccessionPrimary (citable) accession number: O00422
Secondary accession number(s): Q2TTR4 expand/collapse secondary AC list , Q6IAW9, Q8N606, Q9UF14
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Recent format changes

Overview of recent format changes

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents