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O00421

- CCRL2_HUMAN

UniProt

O00421 - CCRL2_HUMAN

Protein

C-C chemokine receptor-like 2

Gene

CCRL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
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    Functioni

    Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.

    GO - Molecular functioni

    1. CCR chemokine receptor binding Source: UniProtKB
    2. chemokine receptor activity Source: ProtInc
    3. chemokine receptor binding Source: UniProtKB

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: GOC
    2. chemotaxis Source: ProtInc
    3. G-protein coupled receptor signaling pathway Source: ProtInc
    4. inflammatory response Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor-like 2
    Alternative name(s):
    Chemokine receptor CCR11
    Chemokine receptor X
    Putative MCP-1 chemokine receptor
    Gene namesi
    Name:CCRL2
    Synonyms:CCR11, CCR6, CKRX, CRAM, HCR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1612. CCRL2.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26175.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344C-C chemokine receptor-like 2PRO_0000236798Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi103 ↔ 181PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO00421.
    PRIDEiO00421.

    PTM databases

    PhosphoSiteiO00421.

    Expressioni

    Tissue specificityi

    Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.4 Publications

    Inductioni

    Up-regulated by CCL5 on the pre-B-cell lines NALM-6 and G2.1 Publication

    Gene expression databases

    ArrayExpressiO00421.
    BgeeiO00421.
    CleanExiHS_CCR6.
    HS_CCRL2.
    GenevestigatoriO00421.

    Organism-specific databases

    HPAiHPA043238.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000349967.

    Structurei

    3D structure databases

    ProteinModelPortaliO00421.
    SMRiO00421. Positions 28-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 7410CytoplasmicSequence Analysis
    Topological domaini96 – 1049ExtracellularSequence Analysis
    Topological domaini126 – 14419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 19833ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 28627ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini308 – 34437CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149863.
    HOVERGENiHBG106917.
    InParanoidiO00421.
    KOiK08373.
    OMAiFLLMWAP.
    OrthoDBiEOG77HDFH.
    PhylomeDBiO00421.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O00421-1) [UniParc]FASTAAdd to Basket

    Also known as: CRAM-B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MANYTLAPED EYDVLIEGEL ESDEAEQCDK YDAQALSAQL VPSLCSAVFV    50
    IGVLDNLLVV LILVKYKGLK RVENIYLLNL AVSNLCFLLT LPFWAHAGGD 100
    PMCKILIGLY FVGLYSETFF NCLLTVQRYL VFLHKGNFFS ARRRVPCGII 150
    TSVLAWVTAI LATLPEFVVY KPQMEDQKYK CAFSRTPFLP ADETFWKHFL 200
    TLKMNISVLV LPLFIFTFLY VQMRKTLRFR EQRYSLFKLV FAIMVVFLLM 250
    WAPYNIAFFL STFKEHFSLS DCKSSYNLDK SVHITKLIAT THCCINPLLY 300
    AFLDGTFSKY LCRCFHLRSN TPLQPRGQSA QGTSREEPDH STEV 344
    Length:344
    Mass (Da):39,513
    Last modified:May 30, 2006 - v2
    Checksum:iD8BBF3A0EE5BB14C
    GO
    Isoform 2 (identifier: O00421-2) [UniParc]FASTAAdd to Basket

    Also known as: CRAM-A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MIYTRFLKGSLKM

    Show »
    Length:356
    Mass (Da):40,952
    Checksum:i83883A727B797D00
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451C → S in BAG59270. (PubMed:14702039)Curated
    Sequence conflicti135 – 1351K → R in BAG59270. (PubMed:14702039)Curated
    Sequence conflicti158 – 1581T → Q in CAC82985. 1 PublicationCurated
    Sequence conflicti334 – 3341S → P in BAG59270. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41Y → C.
    Corresponds to variant rs11574443 [ dbSNP | Ensembl ].
    VAR_049385
    Natural varianti167 – 1671F → Y.5 Publications
    Corresponds to variant rs3204849 [ dbSNP | Ensembl ].
    VAR_026488
    Natural varianti168 – 1681V → M.1 Publication
    Corresponds to variant rs6441977 [ dbSNP | Ensembl ].
    VAR_026489
    Natural varianti243 – 2431I → V.1 Publication
    Corresponds to variant rs3204850 [ dbSNP | Ensembl ].
    VAR_026490

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MIYTRFLKGSLKM in isoform 2. 2 PublicationsVSP_018584

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U97123 mRNA. Translation: AAC39595.1.
    AF014958 mRNA. Translation: AAB82106.1.
    AF015524 mRNA. Translation: AAC34601.1.
    AF015525 mRNA. Translation: AAC34602.1.
    AJ344142 mRNA. Translation: CAC82985.1.
    AK296673 mRNA. Translation: BAG59270.1.
    AY337001 mRNA. Translation: AAQ76789.1.
    U95626 Genomic DNA. Translation: AAB57794.1.
    BC025717 mRNA. Translation: AAH25717.1.
    BC071682 mRNA. Translation: AAH71682.1.
    BC096075 mRNA. Translation: AAH96075.1.
    BC096076 mRNA. Translation: AAH96076.1.
    BC099623 mRNA. Translation: AAH99623.1.
    CCDSiCCDS43079.1. [O00421-1]
    CCDS46814.1. [O00421-2]
    PIRiJC5942.
    RefSeqiNP_001124382.1. NM_001130910.1. [O00421-2]
    NP_003956.2. NM_003965.4. [O00421-1]
    UniGeneiHs.535713.

    Genome annotation databases

    EnsembliENST00000357392; ENSP00000349967; ENSG00000121797. [O00421-2]
    ENST00000399036; ENSP00000381994; ENSG00000121797. [O00421-1]
    ENST00000400880; ENSP00000383677; ENSG00000121797. [O00421-1]
    ENST00000400882; ENSP00000383678; ENSG00000121797. [O00421-1]
    GeneIDi9034.
    KEGGihsa:9034.
    UCSCiuc003cpp.4. human. [O00421-1]
    uc010hjg.3. human. [O00421-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U97123 mRNA. Translation: AAC39595.1 .
    AF014958 mRNA. Translation: AAB82106.1 .
    AF015524 mRNA. Translation: AAC34601.1 .
    AF015525 mRNA. Translation: AAC34602.1 .
    AJ344142 mRNA. Translation: CAC82985.1 .
    AK296673 mRNA. Translation: BAG59270.1 .
    AY337001 mRNA. Translation: AAQ76789.1 .
    U95626 Genomic DNA. Translation: AAB57794.1 .
    BC025717 mRNA. Translation: AAH25717.1 .
    BC071682 mRNA. Translation: AAH71682.1 .
    BC096075 mRNA. Translation: AAH96075.1 .
    BC096076 mRNA. Translation: AAH96076.1 .
    BC099623 mRNA. Translation: AAH99623.1 .
    CCDSi CCDS43079.1. [O00421-1 ]
    CCDS46814.1. [O00421-2 ]
    PIRi JC5942.
    RefSeqi NP_001124382.1. NM_001130910.1. [O00421-2 ]
    NP_003956.2. NM_003965.4. [O00421-1 ]
    UniGenei Hs.535713.

    3D structure databases

    ProteinModelPortali O00421.
    SMRi O00421. Positions 28-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000349967.

    Chemistry

    ChEMBLi CHEMBL2321627.
    GuidetoPHARMACOLOGYi 78.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O00421.

    Proteomic databases

    PaxDbi O00421.
    PRIDEi O00421.

    Protocols and materials databases

    DNASUi 9034.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357392 ; ENSP00000349967 ; ENSG00000121797 . [O00421-2 ]
    ENST00000399036 ; ENSP00000381994 ; ENSG00000121797 . [O00421-1 ]
    ENST00000400880 ; ENSP00000383677 ; ENSG00000121797 . [O00421-1 ]
    ENST00000400882 ; ENSP00000383678 ; ENSG00000121797 . [O00421-1 ]
    GeneIDi 9034.
    KEGGi hsa:9034.
    UCSCi uc003cpp.4. human. [O00421-1 ]
    uc010hjg.3. human. [O00421-2 ]

    Organism-specific databases

    CTDi 9034.
    GeneCardsi GC03P046448.
    HGNCi HGNC:1612. CCRL2.
    HPAi HPA043238.
    MIMi 608379. gene.
    neXtProti NX_O00421.
    PharmGKBi PA26175.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149863.
    HOVERGENi HBG106917.
    InParanoidi O00421.
    KOi K08373.
    OMAi FLLMWAP.
    OrthoDBi EOG77HDFH.
    PhylomeDBi O00421.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.

    Miscellaneous databases

    GeneWikii CCRL2.
    GenomeRNAii 9034.
    NextBioi 33847.
    PROi O00421.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00421.
    Bgeei O00421.
    CleanExi HS_CCR6.
    HS_CCRL2.
    Genevestigatori O00421.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel human chemokine receptor."
      Fan P., Kyaw H., Su K., Zeng Z., Augustus M., Carter K.C., Li Y.
      Biochem. Biophys. Res. Commun. 243:264-268(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT TYR-167.
    2. "Haplotype analysis of a gene cluster containing CCR5 and a new member of chemokine receptor gene family."
      Ansari-Lari M.A., Liu X.-M., Gorrell J.H., Gibbs R.A.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT TYR-167.
      Tissue: Leukocyte.
    3. "CRAM: a novel human chemokine receptor-like gene expressed in activated monocytes."
      Gish K., McClanahan T.K., Moore K.W.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-243.
      Tissue: Monocyte.
    4. "Cloning and characterisation of a new MCP-1 chemokine receptor CCR11."
      Biber K.P.H.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Microglia.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Umbilical cord blood.
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-167.
      Tissue: Lung.
    7. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TYR-167.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS TYR-167 AND MET-168.
      Tissue: Brain, Lung, Pancreas, Spleen and Testis.
    9. "Distribution and regulation of expression of the putative human chemokine receptor HCR in leukocyte populations."
      Migeotte I., Franssen J.D., Goriely S., Willems F., Parmentier M.
      Eur. J. Immunol. 32:494-501(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    10. "Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis."
      Galligan C.L., Matsuyama W., Matsukawa A., Mizuta H., Hodge D.R., Howard O.M., Yoshimura T.
      Arthritis Rheum. 50:1806-1814(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, LACK OF RESPOND BY CCL2.
    11. "Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner."
      Hartmann T.N., Leick M., Ewers S., Diefenbacher A., Schraufstatter I., Honczarenko M., Burger M.
      Immunology 125:252-262(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
    12. "CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B."
      Leick M., Catusse J., Follo M., Nibbs R.J., Hartmann T.N., Veelken H., Burger M.
      Immunology 129:536-546(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, LIGAND-BINDING.

    Entry informationi

    Entry nameiCCRL2_HUMAN
    AccessioniPrimary (citable) accession number: O00421
    Secondary accession number(s): B4DKQ8
    , O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report. These results are now controversial, and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed:15188357).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3