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O00421

- CCRL2_HUMAN

UniProt

O00421 - CCRL2_HUMAN

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Protein

C-C chemokine receptor-like 2

Gene

CCRL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.

GO - Molecular functioni

  1. CCR chemokine receptor binding Source: UniProtKB
  2. chemokine receptor activity Source: ProtInc
  3. chemokine receptor binding Source: UniProtKB

GO - Biological processi

  1. chemokine-mediated signaling pathway Source: GOC
  2. chemotaxis Source: ProtInc
  3. G-protein coupled receptor signaling pathway Source: ProtInc
  4. inflammatory response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor-like 2
Alternative name(s):
Chemokine receptor CCR11
Chemokine receptor X
Putative MCP-1 chemokine receptor
Gene namesi
Name:CCRL2
Synonyms:CCR11, CCR6, CKRX, CRAM, HCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1612. CCRL2.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344C-C chemokine receptor-like 2PRO_0000236798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO00421.
PaxDbiO00421.
PRIDEiO00421.

PTM databases

PhosphoSiteiO00421.

Expressioni

Tissue specificityi

Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.4 Publications

Inductioni

Up-regulated by CCL5 on the pre-B-cell lines NALM-6 and G2.1 Publication

Gene expression databases

BgeeiO00421.
CleanExiHS_CCR6.
HS_CCRL2.
ExpressionAtlasiO00421. baseline and differential.
GenevestigatoriO00421.

Organism-specific databases

HPAiHPA043238.

Interactioni

Protein-protein interaction databases

BioGridi114500. 6 interactions.
STRINGi9606.ENSP00000349967.

Structurei

3D structure databases

ProteinModelPortaliO00421.
SMRiO00421. Positions 28-316.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Topological domaini65 – 7410CytoplasmicSequence Analysis
Topological domaini96 – 1049ExtracellularSequence Analysis
Topological domaini126 – 14419CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini166 – 19833ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 23819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 28627ExtracellularSequence AnalysisAdd
BLAST
Topological domaini308 – 34437CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domaini

Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149863.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
InParanoidiO00421.
KOiK08373.
OMAiFLLMWAP.
OrthoDBiEOG77HDFH.
PhylomeDBiO00421.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00421-1) [UniParc]FASTAAdd to Basket

Also known as: CRAM-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANYTLAPED EYDVLIEGEL ESDEAEQCDK YDAQALSAQL VPSLCSAVFV
60 70 80 90 100
IGVLDNLLVV LILVKYKGLK RVENIYLLNL AVSNLCFLLT LPFWAHAGGD
110 120 130 140 150
PMCKILIGLY FVGLYSETFF NCLLTVQRYL VFLHKGNFFS ARRRVPCGII
160 170 180 190 200
TSVLAWVTAI LATLPEFVVY KPQMEDQKYK CAFSRTPFLP ADETFWKHFL
210 220 230 240 250
TLKMNISVLV LPLFIFTFLY VQMRKTLRFR EQRYSLFKLV FAIMVVFLLM
260 270 280 290 300
WAPYNIAFFL STFKEHFSLS DCKSSYNLDK SVHITKLIAT THCCINPLLY
310 320 330 340
AFLDGTFSKY LCRCFHLRSN TPLQPRGQSA QGTSREEPDH STEV
Length:344
Mass (Da):39,513
Last modified:May 30, 2006 - v2
Checksum:iD8BBF3A0EE5BB14C
GO
Isoform 2 (identifier: O00421-2) [UniParc]FASTAAdd to Basket

Also known as: CRAM-A

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MIYTRFLKGSLKM

Show »
Length:356
Mass (Da):40,952
Checksum:i83883A727B797D00
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451C → S in BAG59270. (PubMed:14702039)Curated
Sequence conflicti135 – 1351K → R in BAG59270. (PubMed:14702039)Curated
Sequence conflicti158 – 1581T → Q in CAC82985. 1 PublicationCurated
Sequence conflicti334 – 3341S → P in BAG59270. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41Y → C.
Corresponds to variant rs11574443 [ dbSNP | Ensembl ].
VAR_049385
Natural varianti167 – 1671F → Y.5 Publications
Corresponds to variant rs3204849 [ dbSNP | Ensembl ].
VAR_026488
Natural varianti168 – 1681V → M.1 Publication
Corresponds to variant rs6441977 [ dbSNP | Ensembl ].
VAR_026489
Natural varianti243 – 2431I → V.1 Publication
Corresponds to variant rs3204850 [ dbSNP | Ensembl ].
VAR_026490

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MIYTRFLKGSLKM in isoform 2. 2 PublicationsVSP_018584

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U97123 mRNA. Translation: AAC39595.1.
AF014958 mRNA. Translation: AAB82106.1.
AF015524 mRNA. Translation: AAC34601.1.
AF015525 mRNA. Translation: AAC34602.1.
AJ344142 mRNA. Translation: CAC82985.1.
AK296673 mRNA. Translation: BAG59270.1.
AY337001 mRNA. Translation: AAQ76789.1.
U95626 Genomic DNA. Translation: AAB57794.1.
BC025717 mRNA. Translation: AAH25717.1.
BC071682 mRNA. Translation: AAH71682.1.
BC096075 mRNA. Translation: AAH96075.1.
BC096076 mRNA. Translation: AAH96076.1.
BC099623 mRNA. Translation: AAH99623.1.
CCDSiCCDS43079.1. [O00421-1]
CCDS46814.1. [O00421-2]
PIRiJC5942.
RefSeqiNP_001124382.1. NM_001130910.1. [O00421-2]
NP_003956.2. NM_003965.4. [O00421-1]
UniGeneiHs.535713.

Genome annotation databases

EnsembliENST00000357392; ENSP00000349967; ENSG00000121797. [O00421-2]
ENST00000399036; ENSP00000381994; ENSG00000121797. [O00421-1]
ENST00000400880; ENSP00000383677; ENSG00000121797. [O00421-1]
ENST00000400882; ENSP00000383678; ENSG00000121797. [O00421-1]
GeneIDi9034.
KEGGihsa:9034.
UCSCiuc003cpp.4. human. [O00421-1]
uc010hjg.3. human. [O00421-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U97123 mRNA. Translation: AAC39595.1 .
AF014958 mRNA. Translation: AAB82106.1 .
AF015524 mRNA. Translation: AAC34601.1 .
AF015525 mRNA. Translation: AAC34602.1 .
AJ344142 mRNA. Translation: CAC82985.1 .
AK296673 mRNA. Translation: BAG59270.1 .
AY337001 mRNA. Translation: AAQ76789.1 .
U95626 Genomic DNA. Translation: AAB57794.1 .
BC025717 mRNA. Translation: AAH25717.1 .
BC071682 mRNA. Translation: AAH71682.1 .
BC096075 mRNA. Translation: AAH96075.1 .
BC096076 mRNA. Translation: AAH96076.1 .
BC099623 mRNA. Translation: AAH99623.1 .
CCDSi CCDS43079.1. [O00421-1 ]
CCDS46814.1. [O00421-2 ]
PIRi JC5942.
RefSeqi NP_001124382.1. NM_001130910.1. [O00421-2 ]
NP_003956.2. NM_003965.4. [O00421-1 ]
UniGenei Hs.535713.

3D structure databases

ProteinModelPortali O00421.
SMRi O00421. Positions 28-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114500. 6 interactions.
STRINGi 9606.ENSP00000349967.

Chemistry

ChEMBLi CHEMBL2321627.
GuidetoPHARMACOLOGYi 78.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O00421.

Proteomic databases

MaxQBi O00421.
PaxDbi O00421.
PRIDEi O00421.

Protocols and materials databases

DNASUi 9034.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357392 ; ENSP00000349967 ; ENSG00000121797 . [O00421-2 ]
ENST00000399036 ; ENSP00000381994 ; ENSG00000121797 . [O00421-1 ]
ENST00000400880 ; ENSP00000383677 ; ENSG00000121797 . [O00421-1 ]
ENST00000400882 ; ENSP00000383678 ; ENSG00000121797 . [O00421-1 ]
GeneIDi 9034.
KEGGi hsa:9034.
UCSCi uc003cpp.4. human. [O00421-1 ]
uc010hjg.3. human. [O00421-2 ]

Organism-specific databases

CTDi 9034.
GeneCardsi GC03P046448.
HGNCi HGNC:1612. CCRL2.
HPAi HPA043238.
MIMi 608379. gene.
neXtProti NX_O00421.
PharmGKBi PA26175.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149863.
GeneTreei ENSGT00760000118785.
HOVERGENi HBG106917.
InParanoidi O00421.
KOi K08373.
OMAi FLLMWAP.
OrthoDBi EOG77HDFH.
PhylomeDBi O00421.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.

Miscellaneous databases

GeneWikii CCRL2.
GenomeRNAii 9034.
NextBioi 33847.
PROi O00421.
SOURCEi Search...

Gene expression databases

Bgeei O00421.
CleanExi HS_CCR6.
HS_CCRL2.
ExpressionAtlasi O00421. baseline and differential.
Genevestigatori O00421.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human chemokine receptor."
    Fan P., Kyaw H., Su K., Zeng Z., Augustus M., Carter K.C., Li Y.
    Biochem. Biophys. Res. Commun. 243:264-268(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT TYR-167.
  2. "Haplotype analysis of a gene cluster containing CCR5 and a new member of chemokine receptor gene family."
    Ansari-Lari M.A., Liu X.-M., Gorrell J.H., Gibbs R.A.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT TYR-167.
    Tissue: Leukocyte.
  3. "CRAM: a novel human chemokine receptor-like gene expressed in activated monocytes."
    Gish K., McClanahan T.K., Moore K.W.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-243.
    Tissue: Monocyte.
  4. "Cloning and characterisation of a new MCP-1 chemokine receptor CCR11."
    Biber K.P.H.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Microglia.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-167.
    Tissue: Lung.
  7. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TYR-167.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS TYR-167 AND MET-168.
    Tissue: Brain, Lung, Pancreas, Spleen and Testis.
  9. "Distribution and regulation of expression of the putative human chemokine receptor HCR in leukocyte populations."
    Migeotte I., Franssen J.D., Goriely S., Willems F., Parmentier M.
    Eur. J. Immunol. 32:494-501(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis."
    Galligan C.L., Matsuyama W., Matsukawa A., Mizuta H., Hodge D.R., Howard O.M., Yoshimura T.
    Arthritis Rheum. 50:1806-1814(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, LACK OF RESPOND BY CCL2.
  11. "Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner."
    Hartmann T.N., Leick M., Ewers S., Diefenbacher A., Schraufstatter I., Honczarenko M., Burger M.
    Immunology 125:252-262(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
  12. "CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B."
    Leick M., Catusse J., Follo M., Nibbs R.J., Hartmann T.N., Veelken H., Burger M.
    Immunology 129:536-546(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, LIGAND-BINDING.

Entry informationi

Entry nameiCCRL2_HUMAN
AccessioniPrimary (citable) accession number: O00421
Secondary accession number(s): B4DKQ8
, O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report. These results are now controversial, and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed:15188357).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3