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O00410

- IPO5_HUMAN

UniProt

O00410 - IPO5_HUMAN

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Protein
Importin-5
Gene
IPO5, KPNB3, RANBP5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.1 Publication

GO - Molecular functioni

  1. GTPase inhibitor activity Source: ProtInc
  2. Ran GTPase binding Source: ProtInc
  3. poly(A) RNA binding Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. protein transporter activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. NLS-bearing protein import into nucleus Source: UniProtKB
  2. cellular response to amino acid stimulus Source: UniProtKB
  3. negative regulation of catalytic activity Source: GOC
  4. positive regulation of protein import into nucleus Source: UniProtKB
  5. ribosomal protein import into nucleus Source: UniProtKB
  6. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_9434. vRNP Assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-5
Short name:
Imp5
Alternative name(s):
Importin subunit beta-3
Karyopherin beta-3
Ran-binding protein 5
Short name:
RanBP5
Gene namesi
Name:IPO5
Synonyms:KPNB3, RANBP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:6402. IPO5.

Subcellular locationi

Cytoplasm. Nucleus. Nucleusnucleolus
Note: Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. cytoplasm Source: UniProtKB
  3. intracellular membrane-bounded organelle Source: HPA
  4. nuclear membrane Source: HPA
  5. nuclear pore Source: ProtInc
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30193.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 10971096Importin-5
PRO_0000120771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine4 Publications
Modified residuei827 – 8271Phosphoserine5 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO00410.
PaxDbiO00410.
PRIDEiO00410.

PTM databases

PhosphoSiteiO00410.

Expressioni

Gene expression databases

ArrayExpressiO00410.
BgeeiO00410.
CleanExiHS_IPO5.
GenevestigatoriO00410.

Organism-specific databases

HPAiCAB009110.
HPA056548.

Interactioni

Subunit structurei

Binds RPL23A, RPS7 and RPL5. Interacts with H2A, H2B, H3 and H4 histones By similarity. Binds to HIV-1 Rev.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P279585EBI-356424,EBI-8753518From a different organism.
GABARAPO951666EBI-356424,EBI-712001
GABARAPL1Q9H0R84EBI-356424,EBI-746969
GABARAPL2P605205EBI-356424,EBI-720116
MAP1LC3BQ9GZQ82EBI-356424,EBI-373144
MAP1LC3CQ9BXW42EBI-356424,EBI-2603996
RPL7P181244EBI-356424,EBI-350806

Protein-protein interaction databases

BioGridi110041. 56 interactions.
DIPiDIP-41042N.
IntActiO00410. 25 interactions.
MINTiMINT-132356.
STRINGi9606.ENSP00000261574.

Structurei

3D structure databases

ProteinModelPortaliO00410.
SMRiO00410. Positions 14-607.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 9972Importin N-terminal
Add
BLAST
Repeati212 – 24938HEAT 1
Add
BLAST
Repeati395 – 43238HEAT 2
Add
BLAST
Repeati437 – 47539HEAT 3
Add
BLAST
Repeati859 – 89739HEAT 4
Add
BLAST
Repeati901 – 93838HEAT 5
Add
BLAST
Repeati942 – 97938HEAT 6
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni325 – 37551Ran-GTP binding By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 65Poly-Ala
Compositional biasi460 – 4656Poly-Ala

Sequence similaritiesi

Belongs to the importin beta family.
Contains 6 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5215.
HOGENOMiHOG000209725.
HOVERGENiHBG006156.
InParanoidiO00410.
OMAiDTNLNNM.
OrthoDBiEOG7Q5HCD.
PhylomeDBiO00410.
TreeFamiTF300344.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF02985. HEAT. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00410-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAAAAEQQQ FYLLLGNLLS PDNVVRKQAE ETYENIPGQS KITFLLQAIR     50
NTTAAEEARQ MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME 100
TQSSMRKKVC DIAAELARNL IDEDGNNQWP EGLKFLFDSV SSQNVGLREA 150
ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC MQDQEHPSIR TLSARATAAF 200
ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL VEIADTVPKY 250
LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI 300
VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL 350
GGKLVLPMIK EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI 400
VNFVLLFLQD PHPRVRYAAC NAVGQMATDF APGFQKKFHE KVIAALLQTM 450
EDQGNQRVQA HAAAALINFT EDCPKSLLIP YLDNLVKHLH SIMVLKLQEL 500
IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH IVENAVQKEL 550
RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ 600
ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN 650
MSDDDGWEFV NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT 700
EQVVKLMVPL LKFYFHDGVR VAAAESMPLL LECARVRGPE YLTQMWHFMC 750
DALIKAIGTE PDSDVLSEIM HSFAKCIEVM GDGCLNNEHF EELGGILKAK 800
LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT KVSDILHSIF 850
SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF 900
KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL 950
LVRVIQSADS KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL 1000
PLHEDKEEAV QTFNYLCDLI ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA 1050
IKHEDPCAKR LANVVRQVQT SGGLWTECIA QLSPEQQAAI QELLNSA 1097
Length:1,097
Mass (Da):123,630
Last modified:January 23, 2007 - v4
Checksum:i1864AD23513F2DE1
GO
Isoform 2 (identifier: O00410-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Show »
Length:1,037
Mass (Da):116,982
Checksum:i7D9A925F7DBC1DE0
GO
Isoform 3 (identifier: O00410-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPEDQVGKLEATENTISAM

Show »
Length:1,115
Mass (Da):125,545
Checksum:i5296EF23A427A0FB
GO

Sequence cautioni

The sequence CAA70103.1 differs from that shown. Reason: Frameshift at position 18.
Isoform 3 : The sequence CAA70103.1 differs from that shown. Reason: Frameshift at position 18.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti286 – 2861L → I.
Corresponds to variant rs1053814 [ dbSNP | Ensembl ].
VAR_012029
Natural varianti525 – 5251E → K.
Corresponds to variant rs632729 [ dbSNP | Ensembl ].
VAR_012030
Natural varianti549 – 5491E → K.
Corresponds to variant rs484770 [ dbSNP | Ensembl ].
VAR_012031
Natural varianti905 – 9051Y → C.
Corresponds to variant rs1804740 [ dbSNP | Ensembl ].
VAR_012032
Natural varianti969 – 9691T → I.
Corresponds to variant rs1804741 [ dbSNP | Ensembl ].
VAR_012033

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6060Missing in isoform 2.
VSP_037587Add
BLAST
Alternative sequencei1 – 11M → MPEDQVGKLEATENTISAM in isoform 3.
VSP_037774

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti538 – 5381L → R in AAH45640. 1 Publication
Sequence conflicti826 – 8272ES → GT in AAC51317. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72761 mRNA. Translation: AAC51317.1.
Y08890 mRNA. Translation: CAA70103.1. Frameshift.
AK302812 mRNA. Translation: BAG64012.1.
AL356580, AL137120 Genomic DNA. Translation: CAI13757.1.
AL137120, AL356580 Genomic DNA. Translation: CAI16520.1.
CH471085 Genomic DNA. Translation: EAX08980.1.
BC001497 mRNA. Translation: AAH01497.1.
BC019309 mRNA. Translation: AAH19309.1.
BC045640 mRNA. Translation: AAH45640.1.
CCDSiCCDS31999.1. [O00410-3]
RefSeqiNP_002262.3. NM_002271.4. [O00410-3]
XP_005254106.1. XM_005254049.1. [O00410-3]
XP_005254109.1. XM_005254052.1. [O00410-3]
XP_005254110.1. XM_005254053.1. [O00410-3]
UniGeneiHs.712598.

Genome annotation databases

EnsembliENST00000261574; ENSP00000261574; ENSG00000065150. [O00410-3]
ENST00000357602; ENSP00000350219; ENSG00000065150. [O00410-1]
ENST00000490680; ENSP00000418393; ENSG00000065150. [O00410-1]
GeneIDi3843.
KEGGihsa:3843.
UCSCiuc001vne.3. human. [O00410-3]
uc001vnf.1. human. [O00410-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72761 mRNA. Translation: AAC51317.1 .
Y08890 mRNA. Translation: CAA70103.1 . Frameshift.
AK302812 mRNA. Translation: BAG64012.1 .
AL356580 , AL137120 Genomic DNA. Translation: CAI13757.1 .
AL137120 , AL356580 Genomic DNA. Translation: CAI16520.1 .
CH471085 Genomic DNA. Translation: EAX08980.1 .
BC001497 mRNA. Translation: AAH01497.1 .
BC019309 mRNA. Translation: AAH19309.1 .
BC045640 mRNA. Translation: AAH45640.1 .
CCDSi CCDS31999.1. [O00410-3 ]
RefSeqi NP_002262.3. NM_002271.4. [O00410-3 ]
XP_005254106.1. XM_005254049.1. [O00410-3 ]
XP_005254109.1. XM_005254052.1. [O00410-3 ]
XP_005254110.1. XM_005254053.1. [O00410-3 ]
UniGenei Hs.712598.

3D structure databases

ProteinModelPortali O00410.
SMRi O00410. Positions 14-607.
ModBasei Search...

Protein-protein interaction databases

BioGridi 110041. 56 interactions.
DIPi DIP-41042N.
IntActi O00410. 25 interactions.
MINTi MINT-132356.
STRINGi 9606.ENSP00000261574.

PTM databases

PhosphoSitei O00410.

Proteomic databases

MaxQBi O00410.
PaxDbi O00410.
PRIDEi O00410.

Protocols and materials databases

DNASUi 3843.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261574 ; ENSP00000261574 ; ENSG00000065150 . [O00410-3 ]
ENST00000357602 ; ENSP00000350219 ; ENSG00000065150 . [O00410-1 ]
ENST00000490680 ; ENSP00000418393 ; ENSG00000065150 . [O00410-1 ]
GeneIDi 3843.
KEGGi hsa:3843.
UCSCi uc001vne.3. human. [O00410-3 ]
uc001vnf.1. human. [O00410-1 ]

Organism-specific databases

CTDi 3843.
GeneCardsi GC13P098605.
H-InvDB HIX0174410.
HGNCi HGNC:6402. IPO5.
HPAi CAB009110.
HPA056548.
MIMi 602008. gene.
neXtProti NX_O00410.
PharmGKBi PA30193.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5215.
HOGENOMi HOG000209725.
HOVERGENi HBG006156.
InParanoidi O00410.
OMAi DTNLNNM.
OrthoDBi EOG7Q5HCD.
PhylomeDBi O00410.
TreeFami TF300344.

Enzyme and pathway databases

Reactomei REACT_9434. vRNP Assembly.

Miscellaneous databases

ChiTaRSi IPO5. human.
GeneWikii RANBP5.
GenomeRNAii 3843.
NextBioi 15125.
PROi O00410.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00410.
Bgeei O00410.
CleanExi HS_IPO5.
Genevestigatori O00410.

Family and domain databases

Gene3Di 1.25.10.10. 3 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR001494. Importin-beta_N.
[Graphical view ]
Pfami PF02985. HEAT. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human karyopherin beta3."
    Yaseen N.R., Blobel G.
    Proc. Natl. Acad. Sci. U.S.A. 94:4451-4456(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
    Tissue: Bone marrow.
  2. "Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1."
    Deane R., Schaeffer W., Zimmermann H.-P., Mueller L., Goerlich D., Prehn S., Ponstingl H., Bischoff F.R.
    Mol. Cell. Biol. 17:5087-5096(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Lung and Testis.
  7. Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.
    Submitted (MAY-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: T-cell.
  8. "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells."
    Jaekel S., Goerlich D.
    EMBO J. 17:4491-4502(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, NUCLEAR LOCALIZATION SIGNAL RECOGNITION, INTERACTION WITH RPL23A; RPS7 AND RPL5.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1."
    Arnold M., Nath A., Hauber J., Kehlenbach R.H.
    J. Biol. Chem. 281:20883-20890(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIV-1 REV.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIPO5_HUMAN
AccessioniPrimary (citable) accession number: O00410
Secondary accession number(s): B4DZA0
, O15257, Q5T578, Q86XC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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