O00410 (IPO5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Importin-5
Short name=Imp5

Alternative name(s):
Importin subunit beta-3
Karyopherin beta-3
Ran-binding protein 5
Short name=RanBP5

Gene names

Name:	IPO5
Synonyms:	KPNB3, RANBP5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1097 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Ref.8
Subunit structure	Binds RPL23A, RPS7 and RPL5. Interacts with H2A, H2B, H3 and H4 histones By similarity. Binds to HIV-1 Rev. Ref.8 Ref.10
Subcellular location	Cytoplasm. Nucleus. Nucleus › nucleolus. Note: Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.
Sequence similarities	Belongs to the importin beta family. Contains 6 HEAT repeats. Contains 1 importin N-terminal domain.
Sequence caution	The sequence CAA70103.1 differs from that shown. Reason: Frameshift at position 18. Isoform 3: The sequence CAA70103.1 differs from that shown. Reason: Frameshift at position 18.

Ontologies

Keywords
Biological process	Host-virus interaction Protein transport Transport
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	NLS-bearing substrate import into nucleus Inferred from sequence or structural similarity. Source: UniProtKB ribosomal protein import into nucleus Inferred from direct assay Ref.8. Source: UniProtKB virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Traceable author statement Ref.1. Source: ProtInc nuclear pore Traceable author statement Ref.2. Source: ProtInc nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTPase inhibitor activity Traceable author statement Ref.2. Source: ProtInc Ran GTPase binding Traceable author statement Ref.1. Source: ProtInc protein transporter activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GABARAP	O95166	6	EBI-356424,EBI-712001
GABARAPL1	Q9H0R8	4	EBI-356424,EBI-746969
GABARAPL2	P60520	5	EBI-356424,EBI-720116
MAP1LC3B	Q9GZQ8	2	EBI-356424,EBI-373144
MAP1LC3C	Q9BXW4	2	EBI-356424,EBI-2603996

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O00410-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O00410-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Isoform 3 (identifier: O00410-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPEDQVGKLEATENTISAM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.7
	Chain	2 – 1097	1096	Importin-5		PRO_0000120771
Regions
	Domain	28 – 99	72	Importin N-terminal
	Repeat	212 – 249	38	HEAT 1
	Repeat	395 – 432	38	HEAT 2
	Repeat	437 – 475	39	HEAT 3
	Repeat	859 – 897	39	HEAT 4
	Repeat	901 – 938	38	HEAT 5
	Repeat	942 – 979	38	HEAT 6
	Region	325 – 375	51	Ran-GTP binding By similarity
	Compositional bias	2 – 6	5	Poly-Ala
	Compositional bias	460 – 465	6	Poly-Ala
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.7
	Modified residue	827	1	Phosphoserine Ref.9 Ref.11 Ref.12 Ref.13 Ref.14
Natural variations
	Alternative sequence	1 – 60	60	Missing in isoform 2.		VSP_037587
	Alternative sequence	1	1	M → MPEDQVGKLEATENTISAM in isoform 3.		VSP_037774
	Natural variant	286	1	L → I. Corresponds to variant rs1053814 [ dbSNP | Ensembl ].		VAR_012029
	Natural variant	525	1	E → K. Corresponds to variant rs632729 [ dbSNP | Ensembl ].		VAR_012030
	Natural variant	549	1	E → K. Corresponds to variant rs484770 [ dbSNP | Ensembl ].		VAR_012031
	Natural variant	905	1	Y → C. Corresponds to variant rs1804740 [ dbSNP | Ensembl ].		VAR_012032
	Natural variant	969	1	T → I. Corresponds to variant rs1804741 [ dbSNP | Ensembl ].		VAR_012033
Experimental info
	Sequence conflict	538	1	L → R in AAH45640. Ref.6
	Sequence conflict	826 – 827	2	ES → GT in AAC51317. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 1864AD23513F2DE1	FASTA	1,097	123,630
	10 20 30 40 50 60 MAAAAAEQQQ FYLLLGNLLS PDNVVRKQAE ETYENIPGQS KITFLLQAIR NTTAAEEARQ 70 80 90 100 110 120 MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME TQSSMRKKVC DIAAELARNL 130 140 150 160 170 180 IDEDGNNQWP EGLKFLFDSV SSQNVGLREA ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC 190 200 210 220 230 240 MQDQEHPSIR TLSARATAAF ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL 250 260 270 280 290 300 VEIADTVPKY LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI 310 320 330 340 350 360 VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL GGKLVLPMIK 370 380 390 400 410 420 EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI VNFVLLFLQD PHPRVRYAAC 430 440 450 460 470 480 NAVGQMATDF APGFQKKFHE KVIAALLQTM EDQGNQRVQA HAAAALINFT EDCPKSLLIP 490 500 510 520 530 540 YLDNLVKHLH SIMVLKLQEL IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH 550 560 570 580 590 600 IVENAVQKEL RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ 610 620 630 640 650 660 ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN MSDDDGWEFV 670 680 690 700 710 720 NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT EQVVKLMVPL LKFYFHDGVR 730 740 750 760 770 780 VAAAESMPLL LECARVRGPE YLTQMWHFMC DALIKAIGTE PDSDVLSEIM HSFAKCIEVM 790 800 810 820 830 840 GDGCLNNEHF EELGGILKAK LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT 850 860 870 880 890 900 KVSDILHSIF SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF 910 920 930 940 950 960 KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL LVRVIQSADS 970 980 990 1000 1010 1020 KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL PLHEDKEEAV QTFNYLCDLI 1030 1040 1050 1060 1070 1080 ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA IKHEDPCAKR LANVVRQVQT SGGLWTECIA 1090 QLSPEQQAAI QELLNSA
	Isoform 2 [UniParc]. Checksum: 7D9A925F7DBC1DE0	FASTA	1,037	116,982
	10 20 30 40 50 60 MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME TQSSMRKKVC DIAAELARNL 70 80 90 100 110 120 IDEDGNNQWP EGLKFLFDSV SSQNVGLREA ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC 130 140 150 160 170 180 MQDQEHPSIR TLSARATAAF ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL 190 200 210 220 230 240 VEIADTVPKY LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI 250 260 270 280 290 300 VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL GGKLVLPMIK 310 320 330 340 350 360 EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI VNFVLLFLQD PHPRVRYAAC 370 380 390 400 410 420 NAVGQMATDF APGFQKKFHE KVIAALLQTM EDQGNQRVQA HAAAALINFT EDCPKSLLIP 430 440 450 460 470 480 YLDNLVKHLH SIMVLKLQEL IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH 490 500 510 520 530 540 IVENAVQKEL RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ 550 560 570 580 590 600 ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN MSDDDGWEFV 610 620 630 640 650 660 NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT EQVVKLMVPL LKFYFHDGVR 670 680 690 700 710 720 VAAAESMPLL LECARVRGPE YLTQMWHFMC DALIKAIGTE PDSDVLSEIM HSFAKCIEVM 730 740 750 760 770 780 GDGCLNNEHF EELGGILKAK LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT 790 800 810 820 830 840 KVSDILHSIF SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF 850 860 870 880 890 900 KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL LVRVIQSADS 910 920 930 940 950 960 KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL PLHEDKEEAV QTFNYLCDLI 970 980 990 1000 1010 1020 ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA IKHEDPCAKR LANVVRQVQT SGGLWTECIA 1030 QLSPEQQAAI QELLNSA
	Isoform 3 [UniParc]. Checksum: 5296EF23A427A0FB	FASTA	1,115	125,545
	10 20 30 40 50 60 MPEDQVGKLE ATENTISAMA AAAAEQQQFY LLLGNLLSPD NVVRKQAEET YENIPGQSKI 70 80 90 100 110 120 TFLLQAIRNT TAAEEARQMA AVLLRRLLSS AFDEVYPALP SDVQTAIKSE LLMIIQMETQ 130 140 150 160 170 180 SSMRKKVCDI AAELARNLID EDGNNQWPEG LKFLFDSVSS QNVGLREAAL HIFWNFPGIF 190 200 210 220 230 240 GNQQQHYLDV IKRMLVQCMQ DQEHPSIRTL SARATAAFIL ANEHNVALFK HFADLLPGFL 250 260 270 280 290 300 QAVNDSCYQN DDSVLKSLVE IADTVPKYLR PHLEATLQLS LKLCGDTSLN NMQRQLALEV 310 320 330 340 350 360 IVTLSETAAA MLRKHTNIVA QTIPQMLAMM VDLEEDEDWA NADELEDDDF DSNAVAGESA 370 380 390 400 410 420 LDRMACGLGG KLVLPMIKEH IMQMLQNPDW KYRHAGLMAL SAIGEGCHQQ MEGILNEIVN 430 440 450 460 470 480 FVLLFLQDPH PRVRYAACNA VGQMATDFAP GFQKKFHEKV IAALLQTMED QGNQRVQAHA 490 500 510 520 530 540 AAALINFTED CPKSLLIPYL DNLVKHLHSI MVLKLQELIQ KGTKLVLEQV VTSIASVADT 550 560 570 580 590 600 AEEKFVPYYD LFMPSLKHIV ENAVQKELRL LRGKTIECIS LIGLAVGKEK FMQDASDVMQ 610 620 630 640 650 660 LLLKTQTDFN DMEDDDPQIS YMISAWARMC KILGKEFQQY LPVVMGPLMK TASIKPEVAL 670 680 690 700 710 720 LDTQDMENMS DDDGWEFVNL GDQQSFGIKT AGLEEKSTAC QMLVCYAKEL KEGFVEYTEQ 730 740 750 760 770 780 VVKLMVPLLK FYFHDGVRVA AAESMPLLLE CARVRGPEYL TQMWHFMCDA LIKAIGTEPD 790 800 810 820 830 840 SDVLSEIMHS FAKCIEVMGD GCLNNEHFEE LGGILKAKLE EHFKNQELRQ VKRQDEDYDE 850 860 870 880 890 900 QVEESLQDED DNDVYILTKV SDILHSIFSS YKEKVLPWFE QLLPLIVNLI CPHRPWPDRQ 910 920 930 940 950 960 WGLCIFDDVI EHCSPASFKY AEYFLRPMLQ YVCDNSPEVR QAAAYGLGVM AQYGGDNYRP 970 980 990 1000 1010 1020 FCTEALPLLV RVIQSADSKT KENVNATENC ISAVGKIMKF KPDCVNVEEV LPHWLSWLPL 1030 1040 1050 1060 1070 1080 HEDKEEAVQT FNYLCDLIES NHPIVLGPNN TNLPKIFSII AEGEMHEAIK HEDPCAKRLA 1090 1100 1110 NVVRQVQTSG GLWTECIAQL SPEQQAAIQE LLNSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of human karyopherin beta3." Yaseen N.R., Blobel G. Proc. Natl. Acad. Sci. U.S.A. 94:4451-4456(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION. Tissue: Bone marrow.
[2]	"Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1." Deane R., Schaeffer W., Zimmermann H.-P., Mueller L., Goerlich D., Prehn S., Ponstingl H., Bischoff F.R. Mol. Cell. Biol. 17:5087-5096(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Lung and Testis.
[7]	Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M. Submitted (MAY-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-13, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: T-cell.
[8]	"Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells." Jaekel S., Goerlich D. EMBO J. 17:4491-4502(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, NUCLEAR LOCALIZATION SIGNAL RECOGNITION, INTERACTION WITH RPL23A; RPS7 AND RPL5.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1." Arnold M., Nath A., Hauber J., Kehlenbach R.H. J. Biol. Chem. 281:20883-20890(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HIV-1 REV.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U72761 mRNA. Translation: AAC51317.1. Y08890 mRNA. Translation: CAA70103.1. Frameshift. AK302812 mRNA. Translation: BAG64012.1. AL356580, AL137120 Genomic DNA. Translation: CAI13757.1. AL137120, AL356580 Genomic DNA. Translation: CAI16520.1. CH471085 Genomic DNA. Translation: EAX08980.1. BC001497 mRNA. Translation: AAH01497.1. BC019309 mRNA. Translation: AAH19309.1. BC045640 mRNA. Translation: AAH45640.1.
IPI	IPI00793443. IPI00937471. IPI00939304.
RefSeq	NP_002262.3. NM_002271.4.
UniGene	Hs.712598.
3D structure databases
ProteinModelPortal	O00410.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-41042N.
IntAct	O00410. 16 interactions.
MINT	MINT-132356.
STRING	9606.ENSP00000261574.
PTM databases
PhosphoSite	O00410.
Proteomic databases
PaxDb	O00410.
PRIDE	O00410.
Protocols and materials databases
DNASU	3843.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261574; ENSP00000261574; ENSG00000065150. ENST00000357602; ENSP00000350219; ENSG00000065150. ENST00000490680; ENSP00000418393; ENSG00000065150.
GeneID	3843.
KEGG	hsa:3843.
UCSC	uc001vne.3. human. uc001vnf.1. human.
Organism-specific databases
CTD	3843.
GeneCards	GC13P098605.
H-InvDB	HIX0174410.
HGNC	HGNC:6402. IPO5.
HPA	CAB009110.
MIM	602008. gene.
neXtProt	NX_O00410.
PharmGKB	PA30193.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5215.
HOGENOM	HOG000209725.
HOVERGEN	HBG006156.
InParanoid	O00410.
OMA	FHDGVRV.
OrthoDB	EOG4XGZZ8.
Gene expression databases
ArrayExpress	O00410.
Bgee	O00410.
CleanEx	HS_IPO5.
Genevestigator	O00410.
GermOnline	ENSG00000065150. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 3 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000357. HEAT. IPR001494. Importin-beta_N. [Graphical view]
Pfam	PF02985. HEAT. 2 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 2 hits.
PROSITE	PS50077. HEAT_REPEAT. False negative. PS50166. IMPORTIN_B_NT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IPO5. human.
GenomeRNAi	3843.
NextBio	15125.
SOURCE	Search...

Entry information

Entry name

IPO5_HUMAN

Accession

Primary (citable) accession number: O00410
Secondary accession number(s): B4DZA0 , O15257, Q5T578, Q86XC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 129 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.