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O00410

- IPO5_HUMAN

UniProt

O00410 - IPO5_HUMAN

Protein

Importin-5

Gene

IPO5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.By similarity1 Publication

    GO - Molecular functioni

    1. GTPase inhibitor activity Source: ProtInc
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein transporter activity Source: UniProtKB
    5. Ran GTPase binding Source: ProtInc

    GO - Biological processi

    1. cellular response to amino acid stimulus Source: UniProtKB
    2. negative regulation of catalytic activity Source: GOC
    3. NLS-bearing protein import into nucleus Source: UniProtKB
    4. positive regulation of protein import into nucleus Source: UniProtKB
    5. ribosomal protein import into nucleus Source: UniProtKB
    6. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_9434. vRNP Assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Importin-5
    Short name:
    Imp5
    Alternative name(s):
    Importin subunit beta-3
    Karyopherin beta-3
    Ran-binding protein 5
    Short name:
    RanBP5
    Gene namesi
    Name:IPO5
    Synonyms:KPNB3, RANBP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:6402. IPO5.

    Subcellular locationi

    Cytoplasm. Nucleus. Nucleusnucleolus
    Note: Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. Golgi apparatus Source: HPA
    3. intracellular membrane-bounded organelle Source: HPA
    4. membrane Source: UniProtKB
    5. nuclear membrane Source: HPA
    6. nuclear pore Source: ProtInc
    7. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30193.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed4 Publications
    Chaini2 – 10971096Importin-5PRO_0000120771Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine4 Publications
    Modified residuei827 – 8271Phosphoserine5 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO00410.
    PaxDbiO00410.
    PRIDEiO00410.

    PTM databases

    PhosphoSiteiO00410.

    Expressioni

    Gene expression databases

    ArrayExpressiO00410.
    BgeeiO00410.
    CleanExiHS_IPO5.
    GenevestigatoriO00410.

    Organism-specific databases

    HPAiCAB009110.
    HPA056548.

    Interactioni

    Subunit structurei

    Binds RPL23A, RPS7 and RPL5. Interacts with H2A, H2B, H3 and H4 histones By similarity. Binds to HIV-1 Rev.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P279585EBI-356424,EBI-8753518From a different organism.
    GABARAPO951666EBI-356424,EBI-712001
    GABARAPL1Q9H0R84EBI-356424,EBI-746969
    GABARAPL2P605205EBI-356424,EBI-720116
    MAP1LC3BQ9GZQ82EBI-356424,EBI-373144
    MAP1LC3CQ9BXW42EBI-356424,EBI-2603996
    RPL7P181244EBI-356424,EBI-350806

    Protein-protein interaction databases

    BioGridi110041. 56 interactions.
    DIPiDIP-41042N.
    IntActiO00410. 26 interactions.
    MINTiMINT-132356.
    STRINGi9606.ENSP00000261574.

    Structurei

    3D structure databases

    ProteinModelPortaliO00410.
    SMRiO00410. Positions 14-607.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 9972Importin N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Repeati212 – 24938HEAT 1Add
    BLAST
    Repeati395 – 43238HEAT 2Add
    BLAST
    Repeati437 – 47539HEAT 3Add
    BLAST
    Repeati859 – 89739HEAT 4Add
    BLAST
    Repeati901 – 93838HEAT 5Add
    BLAST
    Repeati942 – 97938HEAT 6Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni325 – 37551Ran-GTP bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 65Poly-Ala
    Compositional biasi460 – 4656Poly-Ala

    Sequence similaritiesi

    Belongs to the importin beta family.Curated
    Contains 6 HEAT repeats.Curated
    Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5215.
    HOGENOMiHOG000209725.
    HOVERGENiHBG006156.
    InParanoidiO00410.
    OMAiDTNLNNM.
    OrthoDBiEOG7Q5HCD.
    PhylomeDBiO00410.
    TreeFamiTF300344.

    Family and domain databases

    Gene3Di1.25.10.10. 3 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000357. HEAT.
    IPR001494. Importin-beta_N.
    [Graphical view]
    PfamiPF02985. HEAT. 2 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.
    PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O00410-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAAEQQQ FYLLLGNLLS PDNVVRKQAE ETYENIPGQS KITFLLQAIR     50
    NTTAAEEARQ MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME 100
    TQSSMRKKVC DIAAELARNL IDEDGNNQWP EGLKFLFDSV SSQNVGLREA 150
    ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC MQDQEHPSIR TLSARATAAF 200
    ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL VEIADTVPKY 250
    LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI 300
    VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL 350
    GGKLVLPMIK EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI 400
    VNFVLLFLQD PHPRVRYAAC NAVGQMATDF APGFQKKFHE KVIAALLQTM 450
    EDQGNQRVQA HAAAALINFT EDCPKSLLIP YLDNLVKHLH SIMVLKLQEL 500
    IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH IVENAVQKEL 550
    RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ 600
    ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN 650
    MSDDDGWEFV NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT 700
    EQVVKLMVPL LKFYFHDGVR VAAAESMPLL LECARVRGPE YLTQMWHFMC 750
    DALIKAIGTE PDSDVLSEIM HSFAKCIEVM GDGCLNNEHF EELGGILKAK 800
    LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT KVSDILHSIF 850
    SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF 900
    KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL 950
    LVRVIQSADS KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL 1000
    PLHEDKEEAV QTFNYLCDLI ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA 1050
    IKHEDPCAKR LANVVRQVQT SGGLWTECIA QLSPEQQAAI QELLNSA 1097
    Length:1,097
    Mass (Da):123,630
    Last modified:January 23, 2007 - v4
    Checksum:i1864AD23513F2DE1
    GO
    Isoform 2 (identifier: O00410-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: Missing.

    Show »
    Length:1,037
    Mass (Da):116,982
    Checksum:i7D9A925F7DBC1DE0
    GO
    Isoform 3 (identifier: O00410-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MPEDQVGKLEATENTISAM

    Show »
    Length:1,115
    Mass (Da):125,545
    Checksum:i5296EF23A427A0FB
    GO

    Sequence cautioni

    The sequence CAA70103.1 differs from that shown. Reason: Frameshift at position 18.
    Isoform 3 : The sequence CAA70103.1 differs from that shown. Reason: Frameshift at position 18.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti538 – 5381L → R in AAH45640. (PubMed:15489334)Curated
    Sequence conflicti826 – 8272ES → GT in AAC51317. (PubMed:9114010)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti286 – 2861L → I.
    Corresponds to variant rs1053814 [ dbSNP | Ensembl ].
    VAR_012029
    Natural varianti525 – 5251E → K.
    Corresponds to variant rs632729 [ dbSNP | Ensembl ].
    VAR_012030
    Natural varianti549 – 5491E → K.
    Corresponds to variant rs484770 [ dbSNP | Ensembl ].
    VAR_012031
    Natural varianti905 – 9051Y → C.
    Corresponds to variant rs1804740 [ dbSNP | Ensembl ].
    VAR_012032
    Natural varianti969 – 9691T → I.
    Corresponds to variant rs1804741 [ dbSNP | Ensembl ].
    VAR_012033

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6060Missing in isoform 2. 1 PublicationVSP_037587Add
    BLAST
    Alternative sequencei1 – 11M → MPEDQVGKLEATENTISAM in isoform 3. 2 PublicationsVSP_037774

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72761 mRNA. Translation: AAC51317.1.
    Y08890 mRNA. Translation: CAA70103.1. Frameshift.
    AK302812 mRNA. Translation: BAG64012.1.
    AL356580, AL137120 Genomic DNA. Translation: CAI13757.1.
    AL137120, AL356580 Genomic DNA. Translation: CAI16520.1.
    CH471085 Genomic DNA. Translation: EAX08980.1.
    BC001497 mRNA. Translation: AAH01497.1.
    BC019309 mRNA. Translation: AAH19309.1.
    BC045640 mRNA. Translation: AAH45640.1.
    CCDSiCCDS31999.1. [O00410-3]
    RefSeqiNP_002262.3. NM_002271.4. [O00410-3]
    XP_005254106.1. XM_005254049.1. [O00410-3]
    XP_005254109.1. XM_005254052.1. [O00410-3]
    XP_005254110.1. XM_005254053.1. [O00410-3]
    UniGeneiHs.712598.

    Genome annotation databases

    EnsembliENST00000261574; ENSP00000261574; ENSG00000065150. [O00410-3]
    ENST00000357602; ENSP00000350219; ENSG00000065150. [O00410-1]
    ENST00000490680; ENSP00000418393; ENSG00000065150. [O00410-1]
    GeneIDi3843.
    KEGGihsa:3843.
    UCSCiuc001vne.3. human. [O00410-3]
    uc001vnf.1. human. [O00410-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72761 mRNA. Translation: AAC51317.1 .
    Y08890 mRNA. Translation: CAA70103.1 . Frameshift.
    AK302812 mRNA. Translation: BAG64012.1 .
    AL356580 , AL137120 Genomic DNA. Translation: CAI13757.1 .
    AL137120 , AL356580 Genomic DNA. Translation: CAI16520.1 .
    CH471085 Genomic DNA. Translation: EAX08980.1 .
    BC001497 mRNA. Translation: AAH01497.1 .
    BC019309 mRNA. Translation: AAH19309.1 .
    BC045640 mRNA. Translation: AAH45640.1 .
    CCDSi CCDS31999.1. [O00410-3 ]
    RefSeqi NP_002262.3. NM_002271.4. [O00410-3 ]
    XP_005254106.1. XM_005254049.1. [O00410-3 ]
    XP_005254109.1. XM_005254052.1. [O00410-3 ]
    XP_005254110.1. XM_005254053.1. [O00410-3 ]
    UniGenei Hs.712598.

    3D structure databases

    ProteinModelPortali O00410.
    SMRi O00410. Positions 14-607.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110041. 56 interactions.
    DIPi DIP-41042N.
    IntActi O00410. 26 interactions.
    MINTi MINT-132356.
    STRINGi 9606.ENSP00000261574.

    PTM databases

    PhosphoSitei O00410.

    Proteomic databases

    MaxQBi O00410.
    PaxDbi O00410.
    PRIDEi O00410.

    Protocols and materials databases

    DNASUi 3843.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261574 ; ENSP00000261574 ; ENSG00000065150 . [O00410-3 ]
    ENST00000357602 ; ENSP00000350219 ; ENSG00000065150 . [O00410-1 ]
    ENST00000490680 ; ENSP00000418393 ; ENSG00000065150 . [O00410-1 ]
    GeneIDi 3843.
    KEGGi hsa:3843.
    UCSCi uc001vne.3. human. [O00410-3 ]
    uc001vnf.1. human. [O00410-1 ]

    Organism-specific databases

    CTDi 3843.
    GeneCardsi GC13P098605.
    H-InvDB HIX0174410.
    HGNCi HGNC:6402. IPO5.
    HPAi CAB009110.
    HPA056548.
    MIMi 602008. gene.
    neXtProti NX_O00410.
    PharmGKBi PA30193.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5215.
    HOGENOMi HOG000209725.
    HOVERGENi HBG006156.
    InParanoidi O00410.
    OMAi DTNLNNM.
    OrthoDBi EOG7Q5HCD.
    PhylomeDBi O00410.
    TreeFami TF300344.

    Enzyme and pathway databases

    Reactomei REACT_9434. vRNP Assembly.

    Miscellaneous databases

    ChiTaRSi IPO5. human.
    GeneWikii RANBP5.
    GenomeRNAii 3843.
    NextBioi 15125.
    PROi O00410.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00410.
    Bgeei O00410.
    CleanExi HS_IPO5.
    Genevestigatori O00410.

    Family and domain databases

    Gene3Di 1.25.10.10. 3 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000357. HEAT.
    IPR001494. Importin-beta_N.
    [Graphical view ]
    Pfami PF02985. HEAT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human karyopherin beta3."
      Yaseen N.R., Blobel G.
      Proc. Natl. Acad. Sci. U.S.A. 94:4451-4456(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
      Tissue: Bone marrow.
    2. "Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1."
      Deane R., Schaeffer W., Zimmermann H.-P., Mueller L., Goerlich D., Prehn S., Ponstingl H., Bischoff F.R.
      Mol. Cell. Biol. 17:5087-5096(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Lung and Testis.
    7. Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.
      Submitted (MAY-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: T-cell.
    8. "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells."
      Jaekel S., Goerlich D.
      EMBO J. 17:4491-4502(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, NUCLEAR LOCALIZATION SIGNAL RECOGNITION, INTERACTION WITH RPL23A; RPS7 AND RPL5.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1."
      Arnold M., Nath A., Hauber J., Kehlenbach R.H.
      J. Biol. Chem. 281:20883-20890(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HIV-1 REV.
    11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIPO5_HUMAN
    AccessioniPrimary (citable) accession number: O00410
    Secondary accession number(s): B4DZA0
    , O15257, Q5T578, Q86XC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 143 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3