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O00409 (FOXN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein N3
Alternative name(s):
Checkpoint suppressor 1
Gene names
Name:FOXN3
Synonyms:C14orf116, CHES1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). Ref.4

Subunit structure

Interacts through its C-terminus with the C-terminus of SNW1/SKIP. Ref.4

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SNW1Q135733EBI-372721,EBI-632715

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O00409-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O00409-2)

The sequence of this isoform differs from the canonical sequence as follows:
     249-271: DPDIDAASAMMLLNTPPEIQAGF → V
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Forkhead box protein N3
PRO_0000091869

Regions

DNA binding113 – 20492Fork-head

Amino acid modifications

Modified residue851Phosphoserine Ref.5

Natural variations

Alternative sequence249 – 27123DPDID…IQAGF → V in isoform 2.
VSP_001551
Natural variant3371Y → H.
Corresponds to variant rs1804717 [ dbSNP | Ensembl ].
VAR_049163

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: EE07975A592C8C01

FASTA49053,835
        10         20         30         40         50         60 
MGPVMPPSKK PESSGISVSS GLSQCYGGSG FSKALQEDDD LDFSLPDIRL EEGAMEDEEL 

        70         80         90        100        110        120 
TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH SDMPYDARQN PNCKPPYSFS 

       130        140        150        160        170        180 
CLIFMAIEDS PTKRLPVKDI YNWILEHFPY FANAPTGWKN SVRHNLSLNK CFKKVDKERS 

       190        200        210        220        230        240 
QSIGKGSLWC IDPEYRQNLI QALKKTPYHP HPHVFNTPPT CPQAYQSTSG PPIWPGSTFF 

       250        260        270        280        290        300 
KRNGALLQDP DIDAASAMML LNTPPEIQAG FPPGVIQNGA RVLSRGLFPG VRPLPITPIG 

       310        320        330        340        350        360 
VTAAMRNGIT SCRMRTESEP SCGSPVVSGD PKEDHNYSSA KSSNARSTSP TSDSISSSSS 

       370        380        390        400        410        420 
SADDHYEFAT KGSQEGSEGS EGSFRSHESP SDTEEDDRKH SQKEPKDSLG DSGYASQHKK 

       430        440        450        460        470        480 
RQHFAKARKV PSDTLPLKKR RTEKPPESDD EEMKEAAGSL LHLAGIRSCL NNITNRTAKG 

       490 
QKEQKETTKN 

« Hide

Isoform 2 [UniParc].

Checksum: FE3B5805FE885680
Show »

FASTA46851,534

References

« Hide 'large scale' references
[1]"Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA."
Pati D., Keller C., Groudine M., Plon S.E.
Mol. Cell. Biol. 17:3037-3046(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Muscle.
[4]"CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor."
Scott K.L., Plon S.E.
Gene 359:119-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SNW1.
[5]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[6]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U68723 mRNA. Translation: AAB58252.1.
AC007263 Genomic DNA. Translation: AAF18259.1.
AL138478 Genomic DNA. No translation available.
AL356805 Genomic DNA. No translation available.
AL357093 Genomic DNA. No translation available.
BC007506 mRNA. Translation: AAH07506.1.
RefSeqNP_001078940.1. NM_001085471.1.
NP_005188.2. NM_005197.3.
UniGeneHs.434286.

3D structure databases

ProteinModelPortalO00409.
SMRO00409. Positions 114-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107537. 4 interactions.
IntActO00409. 3 interactions.
STRING9606.ENSP00000261302.

PTM databases

PhosphoSiteO00409.

Proteomic databases

PaxDbO00409.
PRIDEO00409.

Protocols and materials databases

DNASU1112.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261302; ENSP00000261302; ENSG00000053254. [O00409-1]
ENST00000345097; ENSP00000343288; ENSG00000053254. [O00409-1]
ENST00000555353; ENSP00000452227; ENSG00000053254. [O00409-2]
ENST00000557258; ENSP00000452005; ENSG00000053254. [O00409-2]
GeneID1112.
KEGGhsa:1112.
UCSCuc001xxn.4. human. [O00409-2]
uc001xxo.4. human. [O00409-1]

Organism-specific databases

CTD1112.
GeneCardsGC14M089882.
HGNCHGNC:1928. FOXN3.
MIM602628. gene.
neXtProtNX_O00409.
PharmGKBPA26460.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000095166.
HOVERGENHBG051654.
InParanoidO00409.
KOK09407.
OMAMRTESEQ.
PhylomeDBO00409.
TreeFamTF105083.

Gene expression databases

ArrayExpressO00409.
BgeeO00409.
CleanExHS_FOXN3.
GenevestigatorO00409.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOXN3. human.
GeneWikiFOXN3.
GenomeRNAi1112.
NextBio4612.
PROO00409.
SOURCESearch...

Entry information

Entry nameFOXN3_HUMAN
AccessionPrimary (citable) accession number: O00409
Secondary accession number(s): Q96II7, Q9UIE7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM