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O00409

- FOXN3_HUMAN

UniProt

O00409 - FOXN3_HUMAN

Protein

Forkhead box protein N3

Gene

FOXN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi113 – 20492Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein C-terminus binding Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. DNA damage checkpoint Source: ProtInc
    2. mitotic G2 phase Source: ProtInc
    3. negative regulation of transcription, DNA-templated Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein N3
    Alternative name(s):
    Checkpoint suppressor 1
    Gene namesi
    Name:FOXN3
    Synonyms:C14orf116, CHES1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:1928. FOXN3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Forkhead box protein N3PRO_0000091869Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei85 – 851Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO00409.
    PRIDEiO00409.

    PTM databases

    PhosphoSiteiO00409.

    Expressioni

    Gene expression databases

    ArrayExpressiO00409.
    BgeeiO00409.
    CleanExiHS_FOXN3.
    GenevestigatoriO00409.

    Interactioni

    Subunit structurei

    Interacts through its C-terminus with the C-terminus of SNW1/SKIP.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SNW1Q135733EBI-372721,EBI-632715

    Protein-protein interaction databases

    BioGridi107537. 4 interactions.
    IntActiO00409. 3 interactions.
    STRINGi9606.ENSP00000261302.

    Structurei

    3D structure databases

    ProteinModelPortaliO00409.
    SMRiO00409. Positions 114-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000095166.
    HOVERGENiHBG051654.
    InParanoidiO00409.
    KOiK09407.
    OMAiMRTESEQ.
    PhylomeDBiO00409.
    TreeFamiTF105083.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O00409-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPVMPPSKK PESSGISVSS GLSQCYGGSG FSKALQEDDD LDFSLPDIRL    50
    EEGAMEDEEL TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH 100
    SDMPYDARQN PNCKPPYSFS CLIFMAIEDS PTKRLPVKDI YNWILEHFPY 150
    FANAPTGWKN SVRHNLSLNK CFKKVDKERS QSIGKGSLWC IDPEYRQNLI 200
    QALKKTPYHP HPHVFNTPPT CPQAYQSTSG PPIWPGSTFF KRNGALLQDP 250
    DIDAASAMML LNTPPEIQAG FPPGVIQNGA RVLSRGLFPG VRPLPITPIG 300
    VTAAMRNGIT SCRMRTESEP SCGSPVVSGD PKEDHNYSSA KSSNARSTSP 350
    TSDSISSSSS SADDHYEFAT KGSQEGSEGS EGSFRSHESP SDTEEDDRKH 400
    SQKEPKDSLG DSGYASQHKK RQHFAKARKV PSDTLPLKKR RTEKPPESDD 450
    EEMKEAAGSL LHLAGIRSCL NNITNRTAKG QKEQKETTKN 490
    Length:490
    Mass (Da):53,835
    Last modified:July 1, 1997 - v1
    Checksum:iEE07975A592C8C01
    GO
    Isoform 2 (identifier: O00409-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         249-271: DPDIDAASAMMLLNTPPEIQAGF → V

    Note: No experimental confirmation available.

    Show »
    Length:468
    Mass (Da):51,534
    Checksum:iFE3B5805FE885680
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti337 – 3371Y → H.
    Corresponds to variant rs1804717 [ dbSNP | Ensembl ].
    VAR_049163

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei249 – 27123DPDID…IQAGF → V in isoform 2. 1 PublicationVSP_001551Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U68723 mRNA. Translation: AAB58252.1.
    AC007263 Genomic DNA. Translation: AAF18259.1.
    AL138478 Genomic DNA. No translation available.
    AL356805 Genomic DNA. No translation available.
    AL357093 Genomic DNA. No translation available.
    BC007506 mRNA. Translation: AAH07506.1.
    CCDSiCCDS32138.1. [O00409-2]
    CCDS41977.1. [O00409-1]
    RefSeqiNP_001078940.1. NM_001085471.1. [O00409-1]
    NP_005188.2. NM_005197.3. [O00409-2]
    UniGeneiHs.434286.

    Genome annotation databases

    EnsembliENST00000261302; ENSP00000261302; ENSG00000053254. [O00409-1]
    ENST00000345097; ENSP00000343288; ENSG00000053254. [O00409-1]
    ENST00000555353; ENSP00000452227; ENSG00000053254. [O00409-2]
    ENST00000557258; ENSP00000452005; ENSG00000053254. [O00409-2]
    GeneIDi1112.
    KEGGihsa:1112.
    UCSCiuc001xxn.4. human. [O00409-2]
    uc001xxo.4. human. [O00409-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U68723 mRNA. Translation: AAB58252.1 .
    AC007263 Genomic DNA. Translation: AAF18259.1 .
    AL138478 Genomic DNA. No translation available.
    AL356805 Genomic DNA. No translation available.
    AL357093 Genomic DNA. No translation available.
    BC007506 mRNA. Translation: AAH07506.1 .
    CCDSi CCDS32138.1. [O00409-2 ]
    CCDS41977.1. [O00409-1 ]
    RefSeqi NP_001078940.1. NM_001085471.1. [O00409-1 ]
    NP_005188.2. NM_005197.3. [O00409-2 ]
    UniGenei Hs.434286.

    3D structure databases

    ProteinModelPortali O00409.
    SMRi O00409. Positions 114-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107537. 4 interactions.
    IntActi O00409. 3 interactions.
    STRINGi 9606.ENSP00000261302.

    PTM databases

    PhosphoSitei O00409.

    Proteomic databases

    PaxDbi O00409.
    PRIDEi O00409.

    Protocols and materials databases

    DNASUi 1112.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261302 ; ENSP00000261302 ; ENSG00000053254 . [O00409-1 ]
    ENST00000345097 ; ENSP00000343288 ; ENSG00000053254 . [O00409-1 ]
    ENST00000555353 ; ENSP00000452227 ; ENSG00000053254 . [O00409-2 ]
    ENST00000557258 ; ENSP00000452005 ; ENSG00000053254 . [O00409-2 ]
    GeneIDi 1112.
    KEGGi hsa:1112.
    UCSCi uc001xxn.4. human. [O00409-2 ]
    uc001xxo.4. human. [O00409-1 ]

    Organism-specific databases

    CTDi 1112.
    GeneCardsi GC14M089882.
    HGNCi HGNC:1928. FOXN3.
    MIMi 602628. gene.
    neXtProti NX_O00409.
    PharmGKBi PA26460.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000095166.
    HOVERGENi HBG051654.
    InParanoidi O00409.
    KOi K09407.
    OMAi MRTESEQ.
    PhylomeDBi O00409.
    TreeFami TF105083.

    Miscellaneous databases

    ChiTaRSi FOXN3. human.
    GeneWikii FOXN3.
    GenomeRNAii 1112.
    NextBioi 4612.
    PROi O00409.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00409.
    Bgeei O00409.
    CleanExi HS_FOXN3.
    Genevestigatori O00409.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA."
      Pati D., Keller C., Groudine M., Plon S.E.
      Mol. Cell. Biol. 17:3037-3046(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Muscle.
    4. "CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor."
      Scott K.L., Plon S.E.
      Gene 359:119-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SNW1.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFOXN3_HUMAN
    AccessioniPrimary (citable) accession number: O00409
    Secondary accession number(s): Q96II7, Q9UIE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3