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Protein

Putative P2Y purinoceptor 10

Gene

P2RY10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative P2Y purinoceptor 10
Short name:
P2Y10
Alternative name(s):
P2Y-like receptor
Gene namesi
Name:P2RY10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000078589.12.
HGNCiHGNC:19906. P2RY10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 68CytoplasmicSequence analysis8
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 103ExtracellularSequence analysisAdd BLAST14
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 149CytoplasmicSequence analysisAdd BLAST25
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 193ExtracellularSequence analysisAdd BLAST23
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 244CytoplasmicSequence analysisAdd BLAST30
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 288ExtracellularSequence analysisAdd BLAST23
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 339CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27334.
OpenTargetsiENSG00000078589.
PharmGKBiPA134873055.

Chemistry databases

ChEMBLiCHEMBL3562166.
GuidetoPHARMACOLOGYi165.

Polymorphism and mutation databases

BioMutaiP2RY10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700341 – 339Putative P2Y purinoceptor 10Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00398.
PeptideAtlasiO00398.
PRIDEiO00398.

PTM databases

PhosphoSitePlusiO00398.

Expressioni

Tissue specificityi

Weakly expressed in blood leukocytes.1 Publication

Developmental stagei

Up-regulated during promyelocytic cell differentiation along the monocytic pathway, but not during granulocytic differentiation.

Gene expression databases

BgeeiENSG00000078589.
CleanExiHS_P2RY10.
GenevisibleiO00398. HS.

Organism-specific databases

HPAiHPA036757.
HPA065766.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000171757.

Chemistry databases

BindingDBiO00398.

Structurei

3D structure databases

ProteinModelPortaliO00398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHMZ. Eukaryota.
ENOG410ZZCA. LUCA.
GeneTreeiENSGT00900000140808.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiO00398.
KOiK04274.
OMAiQSTLYFH.
OrthoDBiEOG091G0DAI.
PhylomeDBiO00398.
TreeFamiTF350009.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027676. P2Y10_rcpt.
PANTHERiPTHR24232:SF47. PTHR24232:SF47. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O00398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLDKYTET FKMGSNSTST AEIYCNVTNV KFQYSLYATT YILIFIPGLL
60 70 80 90 100
ANSAALWVLC RFISKKNKAI IFMINLSVAD LAHVLSLPLR IYYYISHHWP
110 120 130 140 150
FQRALCLLCF YLKYLNMYAS ICFLTCISLQ RCFFLLKPFR ARDWKRRYDV
160 170 180 190 200
GISAAIWIVV GTACLPFPIL RSTDLNNNKS CFADLGYKQM NAVALVGMIT
210 220 230 240 250
VAELAGFVIP VIIIAWCTWK TTISLRQPPM AFQGISERQK ALRMVFMCAA
260 270 280 290 300
VFFICFTPYH INFIFYTMVK ETIISSCPVV RIALYFHPFC LCLASLCCLL
310 320 330
DPILYYFMAS EFRDQLSRHG SSVTRSRLMS KESGSSMIG
Length:339
Mass (Da):38,774
Last modified:July 1, 1997 - v1
Checksum:i2C043E4DC342FA0D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0334813N → H. Corresponds to variant dbSNP:rs6618868Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000545 Genomic DNA. Translation: AAB57836.1.
AY275461 Genomic DNA. Translation: AAP32293.1.
Z82200 Genomic DNA. Translation: CAB36889.1.
CH471104 Genomic DNA. Translation: EAW98594.1.
CH471104 Genomic DNA. Translation: EAW98595.1.
BC051875 mRNA. Translation: AAH51875.2.
BC095498 mRNA. Translation: AAH95498.1.
CCDSiCCDS14442.1.
RefSeqiNP_001311147.1. NM_001324218.1.
NP_055314.1. NM_014499.3.
NP_938147.1. NM_198333.2.
UniGeneiHs.296433.
Hs.445500.

Genome annotation databases

EnsembliENST00000171757; ENSP00000171757; ENSG00000078589.
ENST00000544091; ENSP00000443138; ENSG00000078589.
GeneIDi27334.
KEGGihsa:27334.
UCSCiuc004ede.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP2Y10_HUMAN
AccessioniPrimary (citable) accession number: O00398
Secondary accession number(s): D3DTE5, Q4VBN7, Q86V16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 1, 1997
Last modified: October 25, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families