SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O00398

- P2Y10_HUMAN

UniProt

O00398 - P2Y10_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Putative P2Y purinoceptor 10
Gene
P2RY10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative P2Y purinoceptor 10
Short name:
P2Y10
Alternative name(s):
P2Y-like receptor
Gene namesi
Name:P2RY10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:19906. P2RY10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Extracellular Reviewed prediction
Add
BLAST
Transmembranei40 – 6021Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini61 – 688Cytoplasmic Reviewed prediction
Transmembranei69 – 8921Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini90 – 10314Extracellular Reviewed prediction
Add
BLAST
Transmembranei104 – 12421Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini125 – 14925Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei150 – 17021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini171 – 19323Extracellular Reviewed prediction
Add
BLAST
Transmembranei194 – 21421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini215 – 24430Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei245 – 26521Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini266 – 28823Extracellular Reviewed prediction
Add
BLAST
Transmembranei289 – 30921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini310 – 33930Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Putative P2Y purinoceptor 10
PRO_0000070034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi106 ↔ 181 By similarity
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00398.
PRIDEiO00398.

PTM databases

PhosphoSiteiO00398.

Expressioni

Tissue specificityi

Weakly expressed in blood leukocytes.1 Publication

Developmental stagei

Up-regulated during promyelocytic cell differentiation along the monocytic pathway, but not during granulocytic differentiation.

Gene expression databases

BgeeiO00398.
CleanExiHS_P2RY10.
GenevestigatoriO00398.

Organism-specific databases

HPAiHPA036757.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000171757.

Structurei

3D structure databases

ProteinModelPortaliO00398.
SMRiO00398. Positions 29-316.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147124.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiO00398.
KOiK04274.
OMAiDLGYKQM.
OrthoDBiEOG72JWGC.
PhylomeDBiO00398.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027676. P2Y10_rcpt.
[Graphical view]
PANTHERiPTHR24232:SF6. PTHR24232:SF6. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00398-1 [UniParc]FASTAAdd to Basket

« Hide

MANLDKYTET FKMGSNSTST AEIYCNVTNV KFQYSLYATT YILIFIPGLL    50
ANSAALWVLC RFISKKNKAI IFMINLSVAD LAHVLSLPLR IYYYISHHWP 100
FQRALCLLCF YLKYLNMYAS ICFLTCISLQ RCFFLLKPFR ARDWKRRYDV 150
GISAAIWIVV GTACLPFPIL RSTDLNNNKS CFADLGYKQM NAVALVGMIT 200
VAELAGFVIP VIIIAWCTWK TTISLRQPPM AFQGISERQK ALRMVFMCAA 250
VFFICFTPYH INFIFYTMVK ETIISSCPVV RIALYFHPFC LCLASLCCLL 300
DPILYYFMAS EFRDQLSRHG SSVTRSRLMS KESGSSMIG 339
Length:339
Mass (Da):38,774
Last modified:July 1, 1997 - v1
Checksum:i2C043E4DC342FA0D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31N → H.
Corresponds to variant rs6618868 [ dbSNP | Ensembl ].
VAR_033481

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000545 Genomic DNA. Translation: AAB57836.1.
AY275461 Genomic DNA. Translation: AAP32293.1.
Z82200 Genomic DNA. Translation: CAB36889.1.
CH471104 Genomic DNA. Translation: EAW98594.1.
CH471104 Genomic DNA. Translation: EAW98595.1.
BC051875 mRNA. Translation: AAH51875.2.
BC095498 mRNA. Translation: AAH95498.1.
CCDSiCCDS14442.1.
RefSeqiNP_055314.1. NM_014499.2.
NP_938147.1. NM_198333.1.
XP_005262182.1. XM_005262125.1.
UniGeneiHs.296433.

Genome annotation databases

EnsembliENST00000171757; ENSP00000171757; ENSG00000078589.
ENST00000544091; ENSP00000443138; ENSG00000078589.
GeneIDi27334.
KEGGihsa:27334.
UCSCiuc004ede.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000545 Genomic DNA. Translation: AAB57836.1 .
AY275461 Genomic DNA. Translation: AAP32293.1 .
Z82200 Genomic DNA. Translation: CAB36889.1 .
CH471104 Genomic DNA. Translation: EAW98594.1 .
CH471104 Genomic DNA. Translation: EAW98595.1 .
BC051875 mRNA. Translation: AAH51875.2 .
BC095498 mRNA. Translation: AAH95498.1 .
CCDSi CCDS14442.1.
RefSeqi NP_055314.1. NM_014499.2.
NP_938147.1. NM_198333.1.
XP_005262182.1. XM_005262125.1.
UniGenei Hs.296433.

3D structure databases

ProteinModelPortali O00398.
SMRi O00398. Positions 29-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000171757.

Chemistry

GuidetoPHARMACOLOGYi 165.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O00398.

Proteomic databases

PaxDbi O00398.
PRIDEi O00398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000171757 ; ENSP00000171757 ; ENSG00000078589 .
ENST00000544091 ; ENSP00000443138 ; ENSG00000078589 .
GeneIDi 27334.
KEGGi hsa:27334.
UCSCi uc004ede.3. human.

Organism-specific databases

CTDi 27334.
GeneCardsi GC0XP078200.
HGNCi HGNC:19906. P2RY10.
HPAi HPA036757.
MIMi 300529. gene.
neXtProti NX_O00398.
PharmGKBi PA134873055.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147124.
HOGENOMi HOG000231258.
HOVERGENi HBG099867.
InParanoidi O00398.
KOi K04274.
OMAi DLGYKQM.
OrthoDBi EOG72JWGC.
PhylomeDBi O00398.
TreeFami TF350009.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Miscellaneous databases

GeneWikii P2RY10.
GenomeRNAii 27334.
NextBioi 50386.
PROi O00398.
SOURCEi Search...

Gene expression databases

Bgeei O00398.
CleanExi HS_P2RY10.
Genevestigatori O00398.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027676. P2Y10_rcpt.
[Graphical view ]
PANTHERi PTHR24232:SF6. PTHR24232:SF6. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Putative purinergic receptor related to P2Y5 and P2Y9 is localized on the X chromosome."
    Bohm S.K.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  6. "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells."
    Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A.
    Biochim. Biophys. Acta 1492:127-138(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiP2Y10_HUMAN
AccessioniPrimary (citable) accession number: O00398
Secondary accession number(s): D3DTE5, Q4VBN7, Q86V16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi