O00398 (P2Y10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative P2Y purinoceptor 10
Short name=P2Y10

Alternative name(s):
P2Y-like receptor

Gene names

Name:

P2RY10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative receptor for purines coupled to G-proteins.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Weakly expressed in blood leukocytes. Ref.6
Developmental stage	Up-regulated during promyelocytic cell differentiation along the monocytic pathway, but not during granulocytic differentiation.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Putative P2Y purinoceptor 10		PRO_0000070034
Regions
	Topological domain	1 – 39	39	Extracellular Potential
	Transmembrane	40 – 60	21	Helical; Name=1; Potential
	Topological domain	61 – 68	8	Cytoplasmic Potential
	Transmembrane	69 – 89	21	Helical; Name=2; Potential
	Topological domain	90 – 103	14	Extracellular Potential
	Transmembrane	104 – 124	21	Helical; Name=3; Potential
	Topological domain	125 – 149	25	Cytoplasmic Potential
	Transmembrane	150 – 170	21	Helical; Name=4; Potential
	Topological domain	171 – 193	23	Extracellular Potential
	Transmembrane	194 – 214	21	Helical; Name=5; Potential
	Topological domain	215 – 244	30	Cytoplasmic Potential
	Transmembrane	245 – 265	21	Helical; Name=6; Potential
	Topological domain	266 – 288	23	Extracellular Potential
	Transmembrane	289 – 309	21	Helical; Name=7; Potential
	Topological domain	310 – 339	30	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	16	1	N-linked (GlcNAc...) Potential
	Glycosylation	26	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 181		By similarity
Natural variations
	Natural variant	3	1	N → H. Corresponds to variant rs6618868 [ dbSNP | Ensembl ].		VAR_033481

Sequences

	Sequence		Length	Mass (Da)
	O00398 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 2C043E4DC342FA0D	FASTA	339	38,774
	10 20 30 40 50 60 MANLDKYTET FKMGSNSTST AEIYCNVTNV KFQYSLYATT YILIFIPGLL ANSAALWVLC 70 80 90 100 110 120 RFISKKNKAI IFMINLSVAD LAHVLSLPLR IYYYISHHWP FQRALCLLCF YLKYLNMYAS 130 140 150 160 170 180 ICFLTCISLQ RCFFLLKPFR ARDWKRRYDV GISAAIWIVV GTACLPFPIL RSTDLNNNKS 190 200 210 220 230 240 CFADLGYKQM NAVALVGMIT VAELAGFVIP VIIIAWCTWK TTISLRQPPM AFQGISERQK 250 260 270 280 290 300 ALRMVFMCAA VFFICFTPYH INFIFYTMVK ETIISSCPVV RIALYFHPFC LCLASLCCLL 310 320 330 DPILYYFMAS EFRDQLSRHG SSVTRSRLMS KESGSSMIG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Putative purinergic receptor related to P2Y5 and P2Y9 is localized on the X chromosome." Bohm S.K. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Warren C.N., Aronstam R.S., Sharma S.V. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[6]	"Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells." Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A. Biochim. Biophys. Acta 1492:127-138(2000) [PubMed: 11004484] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF000545 Genomic DNA. Translation: AAB57836.1. AY275461 Genomic DNA. Translation: AAP32293.1. Z82200 Genomic DNA. Translation: CAB36889.1. CH471104 Genomic DNA. Translation: EAW98594.1. CH471104 Genomic DNA. Translation: EAW98595.1. BC051875 mRNA. Translation: AAH51875.2. BC095498 mRNA. Translation: AAH95498.1.
IPI	IPI00004964.
RefSeq	NP_055314.1. NM_014499.2. NP_938147.1. NM_198333.1.
UniGene	Hs.296433.
3D structure databases
ProteinModelPortal	O00398.
SMR	O00398. Positions 118-148, 288-323.
ModBase	Search...
Protein-protein interaction databases
STRING	O00398.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O00398.
Proteomic databases
PRIDE	O00398.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000171757; ENSP00000171757; ENSG00000078589.
GeneID	27334.
KEGG	hsa:27334.
UCSC	uc004ede.1. human.
Organism-specific databases
CTD	27334.
GeneCards	GC0XP078200.
HGNC	HGNC:19906. P2RY10.
HPA	HPA036757.
MIM	300529. gene.
neXtProt	NX_O00398.
PharmGKB	PA134873055.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15075.
GeneTree	ENSGT00590000082782.
HOGENOM	HBG714985.
HOVERGEN	HBG099867.
InParanoid	O00398.
OMA	LYFHPFC.
OrthoDB	EOG4M398R.
PhylomeDB	O00398.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O00398.
Bgee	O00398.
CleanEx	HS_P2RY10.
Genevestigator	O00398.
GermOnline	ENSG00000078589. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002286. P2_purnocptor. [Graphical view]
KO	K04274.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	50386.
SOURCE	Search...

Entry information

Entry name

P2Y10_HUMAN

Accession

Primary (citable) accession number: O00398
Secondary accession number(s): D3DTE5, Q4VBN7, Q86V16

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	July 1, 1997
Last modified:	January 25, 2012
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.