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Protein

Putative P2Y purinoceptor 10

Gene

P2RY10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative P2Y purinoceptor 10
Short name:
P2Y10
Alternative name(s):
P2Y-like receptor
Gene namesi
Name:P2RY10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:19906. P2RY10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 688CytoplasmicSequence Analysis
Transmembranei69 – 8921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini90 – 10314ExtracellularSequence AnalysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14925CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini171 – 19323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 24430CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 28823ExtracellularSequence AnalysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 33930CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873055.

Polymorphism and mutation databases

BioMutaiP2RY10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Putative P2Y purinoceptor 10PRO_0000070034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00398.
PRIDEiO00398.

PTM databases

PhosphoSiteiO00398.

Expressioni

Tissue specificityi

Weakly expressed in blood leukocytes.1 Publication

Developmental stagei

Up-regulated during promyelocytic cell differentiation along the monocytic pathway, but not during granulocytic differentiation.

Gene expression databases

BgeeiO00398.
CleanExiHS_P2RY10.
GenevestigatoriO00398.

Organism-specific databases

HPAiHPA036757.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000171757.

Structurei

3D structure databases

ProteinModelPortaliO00398.
SMRiO00398. Positions 29-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147124.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiO00398.
KOiK04274.
OMAiLYFHPFC.
OrthoDBiEOG72JWGC.
PhylomeDBiO00398.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027676. P2Y10_rcpt.
[Graphical view]
PANTHERiPTHR24232:SF6. PTHR24232:SF6. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLDKYTET FKMGSNSTST AEIYCNVTNV KFQYSLYATT YILIFIPGLL
60 70 80 90 100
ANSAALWVLC RFISKKNKAI IFMINLSVAD LAHVLSLPLR IYYYISHHWP
110 120 130 140 150
FQRALCLLCF YLKYLNMYAS ICFLTCISLQ RCFFLLKPFR ARDWKRRYDV
160 170 180 190 200
GISAAIWIVV GTACLPFPIL RSTDLNNNKS CFADLGYKQM NAVALVGMIT
210 220 230 240 250
VAELAGFVIP VIIIAWCTWK TTISLRQPPM AFQGISERQK ALRMVFMCAA
260 270 280 290 300
VFFICFTPYH INFIFYTMVK ETIISSCPVV RIALYFHPFC LCLASLCCLL
310 320 330
DPILYYFMAS EFRDQLSRHG SSVTRSRLMS KESGSSMIG
Length:339
Mass (Da):38,774
Last modified:July 1, 1997 - v1
Checksum:i2C043E4DC342FA0D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31N → H.
Corresponds to variant rs6618868 [ dbSNP | Ensembl ].
VAR_033481

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000545 Genomic DNA. Translation: AAB57836.1.
AY275461 Genomic DNA. Translation: AAP32293.1.
Z82200 Genomic DNA. Translation: CAB36889.1.
CH471104 Genomic DNA. Translation: EAW98594.1.
CH471104 Genomic DNA. Translation: EAW98595.1.
BC051875 mRNA. Translation: AAH51875.2.
BC095498 mRNA. Translation: AAH95498.1.
CCDSiCCDS14442.1.
RefSeqiNP_055314.1. NM_014499.2.
NP_938147.1. NM_198333.1.
XP_005262182.1. XM_005262125.1.
UniGeneiHs.296433.

Genome annotation databases

EnsembliENST00000171757; ENSP00000171757; ENSG00000078589.
ENST00000544091; ENSP00000443138; ENSG00000078589.
GeneIDi27334.
KEGGihsa:27334.
UCSCiuc004ede.3. human.

Polymorphism and mutation databases

BioMutaiP2RY10.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000545 Genomic DNA. Translation: AAB57836.1.
AY275461 Genomic DNA. Translation: AAP32293.1.
Z82200 Genomic DNA. Translation: CAB36889.1.
CH471104 Genomic DNA. Translation: EAW98594.1.
CH471104 Genomic DNA. Translation: EAW98595.1.
BC051875 mRNA. Translation: AAH51875.2.
BC095498 mRNA. Translation: AAH95498.1.
CCDSiCCDS14442.1.
RefSeqiNP_055314.1. NM_014499.2.
NP_938147.1. NM_198333.1.
XP_005262182.1. XM_005262125.1.
UniGeneiHs.296433.

3D structure databases

ProteinModelPortaliO00398.
SMRiO00398. Positions 29-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000171757.

Chemistry

GuidetoPHARMACOLOGYi165.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO00398.

Polymorphism and mutation databases

BioMutaiP2RY10.

Proteomic databases

PaxDbiO00398.
PRIDEiO00398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000171757; ENSP00000171757; ENSG00000078589.
ENST00000544091; ENSP00000443138; ENSG00000078589.
GeneIDi27334.
KEGGihsa:27334.
UCSCiuc004ede.3. human.

Organism-specific databases

CTDi27334.
GeneCardsiGC0XP078200.
HGNCiHGNC:19906. P2RY10.
HPAiHPA036757.
MIMi300529. gene.
neXtProtiNX_O00398.
PharmGKBiPA134873055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147124.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiO00398.
KOiK04274.
OMAiLYFHPFC.
OrthoDBiEOG72JWGC.
PhylomeDBiO00398.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Miscellaneous databases

GeneWikiiP2RY10.
GenomeRNAii27334.
NextBioi50386.
PROiO00398.
SOURCEiSearch...

Gene expression databases

BgeeiO00398.
CleanExiHS_P2RY10.
GenevestigatoriO00398.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027676. P2Y10_rcpt.
[Graphical view]
PANTHERiPTHR24232:SF6. PTHR24232:SF6. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Putative purinergic receptor related to P2Y5 and P2Y9 is localized on the X chromosome."
    Bohm S.K.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  6. "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells."
    Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A.
    Biochim. Biophys. Acta 1492:127-138(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiP2Y10_HUMAN
AccessioniPrimary (citable) accession number: O00398
Secondary accession number(s): D3DTE5, Q4VBN7, Q86V16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 1, 1997
Last modified: April 29, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.