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O00398

- P2Y10_HUMAN

UniProt

O00398 - P2Y10_HUMAN

Protein

Putative P2Y purinoceptor 10

Gene

P2RY10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Putative receptor for purines coupled to G-proteins.

    GO - Molecular functioni

    1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative P2Y purinoceptor 10
    Short name:
    P2Y10
    Alternative name(s):
    P2Y-like receptor
    Gene namesi
    Name:P2RY10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:19906. P2RY10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134873055.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Putative P2Y purinoceptor 10PRO_0000070034Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO00398.
    PRIDEiO00398.

    PTM databases

    PhosphoSiteiO00398.

    Expressioni

    Tissue specificityi

    Weakly expressed in blood leukocytes.1 Publication

    Developmental stagei

    Up-regulated during promyelocytic cell differentiation along the monocytic pathway, but not during granulocytic differentiation.

    Gene expression databases

    BgeeiO00398.
    CleanExiHS_P2RY10.
    GenevestigatoriO00398.

    Organism-specific databases

    HPAiHPA036757.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000171757.

    Structurei

    3D structure databases

    ProteinModelPortaliO00398.
    SMRiO00398. Positions 29-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 688CytoplasmicSequence Analysis
    Topological domaini90 – 10314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14925CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 24430CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 28823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 33930CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147124.
    HOGENOMiHOG000231258.
    HOVERGENiHBG099867.
    InParanoidiO00398.
    KOiK04274.
    OMAiDLGYKQM.
    OrthoDBiEOG72JWGC.
    PhylomeDBiO00398.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027676. P2Y10_rcpt.
    [Graphical view]
    PANTHERiPTHR24232:SF6. PTHR24232:SF6. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00398-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANLDKYTET FKMGSNSTST AEIYCNVTNV KFQYSLYATT YILIFIPGLL    50
    ANSAALWVLC RFISKKNKAI IFMINLSVAD LAHVLSLPLR IYYYISHHWP 100
    FQRALCLLCF YLKYLNMYAS ICFLTCISLQ RCFFLLKPFR ARDWKRRYDV 150
    GISAAIWIVV GTACLPFPIL RSTDLNNNKS CFADLGYKQM NAVALVGMIT 200
    VAELAGFVIP VIIIAWCTWK TTISLRQPPM AFQGISERQK ALRMVFMCAA 250
    VFFICFTPYH INFIFYTMVK ETIISSCPVV RIALYFHPFC LCLASLCCLL 300
    DPILYYFMAS EFRDQLSRHG SSVTRSRLMS KESGSSMIG 339
    Length:339
    Mass (Da):38,774
    Last modified:July 1, 1997 - v1
    Checksum:i2C043E4DC342FA0D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31N → H.
    Corresponds to variant rs6618868 [ dbSNP | Ensembl ].
    VAR_033481

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000545 Genomic DNA. Translation: AAB57836.1.
    AY275461 Genomic DNA. Translation: AAP32293.1.
    Z82200 Genomic DNA. Translation: CAB36889.1.
    CH471104 Genomic DNA. Translation: EAW98594.1.
    CH471104 Genomic DNA. Translation: EAW98595.1.
    BC051875 mRNA. Translation: AAH51875.2.
    BC095498 mRNA. Translation: AAH95498.1.
    CCDSiCCDS14442.1.
    RefSeqiNP_055314.1. NM_014499.2.
    NP_938147.1. NM_198333.1.
    XP_005262182.1. XM_005262125.1.
    UniGeneiHs.296433.

    Genome annotation databases

    EnsembliENST00000171757; ENSP00000171757; ENSG00000078589.
    ENST00000544091; ENSP00000443138; ENSG00000078589.
    GeneIDi27334.
    KEGGihsa:27334.
    UCSCiuc004ede.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000545 Genomic DNA. Translation: AAB57836.1 .
    AY275461 Genomic DNA. Translation: AAP32293.1 .
    Z82200 Genomic DNA. Translation: CAB36889.1 .
    CH471104 Genomic DNA. Translation: EAW98594.1 .
    CH471104 Genomic DNA. Translation: EAW98595.1 .
    BC051875 mRNA. Translation: AAH51875.2 .
    BC095498 mRNA. Translation: AAH95498.1 .
    CCDSi CCDS14442.1.
    RefSeqi NP_055314.1. NM_014499.2.
    NP_938147.1. NM_198333.1.
    XP_005262182.1. XM_005262125.1.
    UniGenei Hs.296433.

    3D structure databases

    ProteinModelPortali O00398.
    SMRi O00398. Positions 29-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000171757.

    Chemistry

    GuidetoPHARMACOLOGYi 165.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O00398.

    Proteomic databases

    PaxDbi O00398.
    PRIDEi O00398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000171757 ; ENSP00000171757 ; ENSG00000078589 .
    ENST00000544091 ; ENSP00000443138 ; ENSG00000078589 .
    GeneIDi 27334.
    KEGGi hsa:27334.
    UCSCi uc004ede.3. human.

    Organism-specific databases

    CTDi 27334.
    GeneCardsi GC0XP078200.
    HGNCi HGNC:19906. P2RY10.
    HPAi HPA036757.
    MIMi 300529. gene.
    neXtProti NX_O00398.
    PharmGKBi PA134873055.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147124.
    HOGENOMi HOG000231258.
    HOVERGENi HBG099867.
    InParanoidi O00398.
    KOi K04274.
    OMAi DLGYKQM.
    OrthoDBi EOG72JWGC.
    PhylomeDBi O00398.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.

    Miscellaneous databases

    GeneWikii P2RY10.
    GenomeRNAii 27334.
    NextBioi 50386.
    PROi O00398.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00398.
    CleanExi HS_P2RY10.
    Genevestigatori O00398.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027676. P2Y10_rcpt.
    [Graphical view ]
    PANTHERi PTHR24232:SF6. PTHR24232:SF6. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Putative purinergic receptor related to P2Y5 and P2Y9 is localized on the X chromosome."
      Bohm S.K.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    6. "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells."
      Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A.
      Biochim. Biophys. Acta 1492:127-138(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiP2Y10_HUMAN
    AccessioniPrimary (citable) accession number: O00398
    Secondary accession number(s): D3DTE5, Q4VBN7, Q86V16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3