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O00341

- EAA5_HUMAN

UniProt

O00341 - EAA5_HUMAN

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Protein

Excitatory amino acid transporter 5

Gene
SLC1A7, EAAT5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

GO - Molecular functioni

  1. L-glutamate transmembrane transporter activity Source: UniProtKB
  2. sodium:dicarboxylate symporter activity Source: InterPro

GO - Biological processi

  1. dicarboxylic acid transport Source: UniProtKB
  2. ion transport Source: Reactome
  3. L-glutamate transport Source: GOC
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_19397. Transport of inorganic cations/anions and amino acids/oligopeptides.

Protein family/group databases

TCDBi2.A.23.2.5. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 5
Alternative name(s):
Retinal glutamate transporter
Solute carrier family 1 member 7
Gene namesi
Name:SLC1A7
Synonyms:EAAT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10945. SLC1A7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei17 – 3721Helical; Reviewed predictionAdd
BLAST
Transmembranei60 – 8021Helical; Reviewed predictionAdd
BLAST
Transmembranei94 – 11421Helical; Reviewed predictionAdd
BLAST
Topological domaini115 – 216102Extracellular Reviewed predictionAdd
BLAST
Transmembranei217 – 23721Helical; Reviewed predictionAdd
BLAST
Transmembranei260 – 28021Helical; Reviewed predictionAdd
BLAST
Transmembranei300 – 32021Helical; Reviewed predictionAdd
BLAST
Transmembranei330 – 35021Helical; Reviewed predictionAdd
BLAST
Transmembranei372 – 39221Helical; Reviewed predictionAdd
BLAST
Transmembranei414 – 43421Helical; Reviewed predictionAdd
BLAST
Transmembranei457 – 47721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35832.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Excitatory amino acid transporter 5PRO_0000202073Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO00341.
PRIDEiO00341.

PTM databases

PhosphoSiteiO00341.

Expressioni

Tissue specificityi

Expressed primarily in retina. Detectable in liver, heart, muscle and brain.

Gene expression databases

ArrayExpressiO00341.
BgeeiO00341.
CleanExiHS_SLC1A7.
GenevestigatoriO00341.

Organism-specific databases

HPAiHPA049124.

Interactioni

Subunit structurei

Interacts with the PDZ domains of DLG4.

Protein-protein interaction databases

BioGridi112403. 2 interactions.
IntActiO00341. 1 interaction.
STRINGi9606.ENSP00000360549.

Structurei

3D structure databases

ProteinModelPortaliO00341.
SMRiO00341. Positions 19-474.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1301.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiO00341.
KOiK05618.
OMAiKLLPCET.
OrthoDBiEOG7RV9G2.
PhylomeDBiO00341.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00341-1 [UniParc]FASTAAdd to Basket

« Hide

MVPHAILARG RDVCRRNGLL ILSVLSVIVG CLLGFFLRTR RLSPQEISYF    50
QFPGELLMRM LKMMILPLVV SSLMSGLASL DAKTSSRLGV LTVAYYLWTT 100
FMAVIVGIFM VSIIHPGSAA QKETTEQSGK PIMSSADALL DLIRNMFPAN 150
LVEATFKQYR TKTTPVVKSP KVAPEEAPPR RILIYGVQEE NGSHVQNFAL 200
DLTPPPEVVY KSEPGTSDGM NVLGIVFFSA TMGIMLGRMG DSGAPLVSFC 250
QCLNESVMKI VAVAVWYFPF GIVFLIAGKI LEMDDPRAVG KKLGFYSVTV 300
VCGLVLHGLF ILPLLYFFIT KKNPIVFIRG ILQALLIALA TSSSSATLPI 350
TFKCLLENNH IDRRIARFVL PVGATINMDG TALYEAVAAI FIAQVNNYEL 400
DFGQIITISI TATAASIGAA GIPQAGLVTM VIVLTSVGLP TDDITLIIAV 450
DWALDRFRTM INVLGDALAA GIMAHICRKD FARDTGTEKL LPCETKPVSL 500
QEIVAAQQNG CVKSVAEASE LTLGPTCPHH VPVQVEQDEE LPAASLNHCT 550
IQISELETNV 560
Length:560
Mass (Da):60,658
Last modified:September 23, 2008 - v2
Checksum:i17C527B745BB01E6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411R → C in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035707
Natural varianti537 – 5371Q → R.3 Publications
Corresponds to variant rs1288401 [ dbSNP | Ensembl ].
VAR_052488

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51A → T in AAB53971. 1 Publication
Sequence conflicti70 – 701V → F in AAB53971. 1 Publication
Sequence conflicti244 – 2441A → G in AAB53971. 1 Publication
Sequence conflicti412 – 4121A → G in AAB53971. 1 Publication
Sequence conflicti449 – 4491A → G in AAB53971. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76362 mRNA. Translation: AAB53971.1.
AL445183 Genomic DNA. Translation: CAH72594.1.
CH471059 Genomic DNA. Translation: EAX06755.1.
BC012119 mRNA. Translation: AAH12119.1.
BC017242 mRNA. Translation: AAH17242.1.
CCDSiCCDS574.1.
RefSeqiNP_001274526.1. NM_001287597.1.
NP_006662.3. NM_006671.5.
UniGeneiHs.104637.

Genome annotation databases

EnsembliENST00000371494; ENSP00000360549; ENSG00000162383.
GeneIDi6512.
KEGGihsa:6512.
UCSCiuc001cuy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76362 mRNA. Translation: AAB53971.1 .
AL445183 Genomic DNA. Translation: CAH72594.1 .
CH471059 Genomic DNA. Translation: EAX06755.1 .
BC012119 mRNA. Translation: AAH12119.1 .
BC017242 mRNA. Translation: AAH17242.1 .
CCDSi CCDS574.1.
RefSeqi NP_001274526.1. NM_001287597.1.
NP_006662.3. NM_006671.5.
UniGenei Hs.104637.

3D structure databases

ProteinModelPortali O00341.
SMRi O00341. Positions 19-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112403. 2 interactions.
IntActi O00341. 1 interaction.
STRINGi 9606.ENSP00000360549.

Chemistry

BindingDBi O00341.
ChEMBLi CHEMBL4390.
DrugBanki DB00142. L-Glutamic Acid.
GuidetoPHARMACOLOGYi 872.

Protein family/group databases

TCDBi 2.A.23.2.5. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

PTM databases

PhosphoSitei O00341.

Proteomic databases

PaxDbi O00341.
PRIDEi O00341.

Protocols and materials databases

DNASUi 6512.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371494 ; ENSP00000360549 ; ENSG00000162383 .
GeneIDi 6512.
KEGGi hsa:6512.
UCSCi uc001cuy.3. human.

Organism-specific databases

CTDi 6512.
GeneCardsi GC01M053552.
H-InvDB HIX0000592.
HIX0159667.
HGNCi HGNC:10945. SLC1A7.
HPAi HPA049124.
MIMi 604471. gene.
neXtProti NX_O00341.
PharmGKBi PA35832.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1301.
HOGENOMi HOG000208776.
HOVERGENi HBG000080.
InParanoidi O00341.
KOi K05618.
OMAi KLLPCET.
OrthoDBi EOG7RV9G2.
PhylomeDBi O00341.
TreeFami TF315206.

Enzyme and pathway databases

Reactomei REACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_19397. Transport of inorganic cations/anions and amino acids/oligopeptides.

Miscellaneous databases

GeneWikii Excitatory_amino-acid_transporter_5.
GenomeRNAii 6512.
NextBioi 25323.
PROi O00341.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00341.
Bgeei O00341.
CleanExi HS_SLC1A7.
Genevestigatori O00341.

Family and domain databases

Gene3Di 1.10.3860.10. 2 hits.
InterProi IPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view ]
PANTHERi PTHR11958. PTHR11958. 1 hit.
Pfami PF00375. SDF. 1 hit.
[Graphical view ]
PRINTSi PR00173. EDTRNSPORT.
SUPFAMi SSF118215. SSF118215. 2 hits.
PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance."
    Arriza J.L., Eliasof S., Kavanaugh M.P., Amara S.G.
    Proc. Natl. Acad. Sci. U.S.A. 94:4155-4160(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-537.
    Tissue: Retina.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-537.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-537.
    Tissue: Eye.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-41.

Entry informationi

Entry nameiEAA5_HUMAN
AccessioniPrimary (citable) accession number: O00341
Secondary accession number(s): Q5VVZ0, Q969Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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