O00339 (MATN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Matrilin-2

Gene names

Name:	MATN2
ORF Names:	UNQ193/PRO219

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	956 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in matrix assembly By similarity.
Subcellular location	Secreted.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR.
Sequence similarities	Contains 10 EGF-like domains. Contains 2 VWFA domains.
Sequence caution	The sequence CAD38787.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil EGF-like domain Repeat Signal
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from electronic annotation. Source: Compara dendrite regeneration Inferred from electronic annotation. Source: Compara glial cell migration Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara response to axon injury Inferred from electronic annotation. Source: Compara
Cellular_component	basement membrane Inferred from electronic annotation. Source: Compara proteinaceous extracellular matrix Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN7	O15265	2	EBI-949020,EBI-708350
CACNA1A	O00555	2	EBI-949020,EBI-766279

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O00339-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O00339-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     861-879: Missing.

Isoform 3 (identifier: O00339-3)

The sequence of this isoform differs from the canonical sequence as follows:
     361-401: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: O00339-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-284: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 956	933	Matrilin-2		PRO_0000007655
Regions
	Domain	57 – 232	176	VWFA 1
	Domain	238 – 278	41	EGF-like 1
	Domain	279 – 319	41	EGF-like 2
	Domain	320 – 360	41	EGF-like 3
	Domain	361 – 401	41	EGF-like 4
	Domain	402 – 442	41	EGF-like 5
	Domain	443 – 483	41	EGF-like 6
	Domain	484 – 524	41	EGF-like 7
	Domain	525 – 565	41	EGF-like 8
	Domain	566 – 606	41	EGF-like 9
	Domain	607 – 647	41	EGF-like 10
	Domain	655 – 830	176	VWFA 2
	Coiled coil	917 – 955	39	Potential
Amino acid modifications
	Glycosylation	221	1	N-linked (GlcNAc...) Potential
	Disulfide bond	242 ↔ 253		By similarity
	Disulfide bond	249 ↔ 262		By similarity
	Disulfide bond	264 ↔ 277		By similarity
	Disulfide bond	283 ↔ 294		By similarity
	Disulfide bond	290 ↔ 303		By similarity
	Disulfide bond	305 ↔ 318		By similarity
	Disulfide bond	324 ↔ 335		By similarity
	Disulfide bond	331 ↔ 344		By similarity
	Disulfide bond	346 ↔ 359		By similarity
	Disulfide bond	365 ↔ 376		By similarity
	Disulfide bond	372 ↔ 385		By similarity
	Disulfide bond	387 ↔ 400		By similarity
	Disulfide bond	406 ↔ 417		By similarity
	Disulfide bond	413 ↔ 426		By similarity
	Disulfide bond	428 ↔ 441		By similarity
	Disulfide bond	447 ↔ 458		By similarity
	Disulfide bond	454 ↔ 467		By similarity
	Disulfide bond	469 ↔ 482		By similarity
	Disulfide bond	488 ↔ 499		By similarity
	Disulfide bond	495 ↔ 508		By similarity
	Disulfide bond	510 ↔ 523		By similarity
	Disulfide bond	529 ↔ 540		By similarity
	Disulfide bond	536 ↔ 549		By similarity
	Disulfide bond	551 ↔ 564		By similarity
	Disulfide bond	570 ↔ 581		By similarity
	Disulfide bond	577 ↔ 590		By similarity
	Disulfide bond	592 ↔ 605		By similarity
	Disulfide bond	611 ↔ 622		By similarity
	Disulfide bond	618 ↔ 631		By similarity
	Disulfide bond	633 ↔ 646		By similarity
Natural variations
	Alternative sequence	1 – 284	284	Missing in isoform 4.		VSP_014540
	Alternative sequence	361 – 401	41	Missing in isoform 3.		VSP_013284
	Alternative sequence	861 – 879	19	Missing in isoform 2.		VSP_001399
	Natural variant	14	1	G → A. Corresponds to variant rs35804177 [ dbSNP | Ensembl ].		VAR_055753
	Natural variant	187	1	T → M. Ref.3 Corresponds to variant rs2290472 [ dbSNP | Ensembl ].		VAR_055754
	Natural variant	356	1	K → E. Ref.4 Ref.6 Corresponds to variant rs1869609 [ dbSNP | Ensembl ].		VAR_021568
	Natural variant	599	1	A → T. Corresponds to variant rs35120814 [ dbSNP | Ensembl ].		VAR_055755
	Natural variant	855	1	T → M. Corresponds to variant rs2255317 [ dbSNP | Ensembl ].		VAR_055756
	Natural variant	932	1	V → I. Corresponds to variant rs17831160 [ dbSNP | Ensembl ].		VAR_055757
Experimental info
	Sequence conflict	58	1	L → P in BAF82410. Ref.3
	Sequence conflict	594	1	E → V in AAC51260. Ref.1
	Sequence conflict	644	1	R → G no nucleotide entry Ref.7
	Sequence conflict	755	1	L → F in AAC51260. Ref.1
	Sequence conflict	890	1	N → D in BAF82410. Ref.3
	Sequence conflict	935	1	L → F no nucleotide entry Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified June 28, 2011. Version 4. Checksum: D0868FBF62744EF2	FASTA	956	106,837
	10 20 30 40 50 60 MEKMLAGCFL LILGQIVLLP AEARERSRGR SISRGRHART HPQTALLESS CENKRADLVF 70 80 90 100 110 120 IIDSSRSVNT HDYAKVKEFI VDILQFLDIG PDVTRVGLLQ YGSTVKNEFS LKTFKRKSEV 130 140 150 160 170 180 ERAVKRMRHL STGTMTGLAI QYALNIAFSE AEGARPLREN VPRVIMIVTD GRPQDSVAEV 190 200 210 220 230 240 AAKARDTGIL IFAIGVGQVD FNTLKSIGSE PHEDHVFLVA NFSQIETLTS VFQKKLCTAH 250 260 270 280 290 300 MCSTLEHNCA HFCINIPGSY VCRCKQGYIL NSDQTTCRIQ DLCAMEDHNC EQLCVNVPGS 310 320 330 340 350 360 FVCQCYSGYA LAEDGKRCVA VDYCASENHG CEHECVNADG SYLCQCHEGF ALNPDKKTCT 370 380 390 400 410 420 KIDYCASSNH GCQHECVNTD DSYSCHCLKG FTLNPDKKTC RRINYCALNK PGCEHECVNM 430 440 450 460 470 480 EESYYCRCHR GYTLDPNGKT CSRVDHCAQQ DHGCEQLCLN TEDSFVCQCS EGFLINEDLK 490 500 510 520 530 540 TCSRVDYCLL SDHGCEYSCV NMDRSFACQC PEGHVLRSDG KTCAKLDSCA LGDHGCEHSC 550 560 570 580 590 600 VSSEDSFVCQ CFEGYILRED GKTCRRKDVC QAIDHGCEHI CVNSDDSYTC ECLEGFRLAE 610 620 630 640 650 660 DGKRCRRKDV CKSTHHGCEH ICVNNGNSYI CKCSEGFVLA EDGRRCKKCT EGPIDLVFVI 670 680 690 700 710 720 DGSKSLGEEN FEVVKQFVTG IIDSLTISPK AARVGLLQYS TQVHTEFTLR NFNSAKDMKK 730 740 750 760 770 780 AVAHMKYMGK GSMTGLALKH MFERSFTQGE GARPLSTRVP RAAIVFTDGR AQDDVSEWAS 790 800 810 820 830 840 KAKANGITMY AVGVGKAIEE ELQEIASEPT NKHLFYAEDF STMDEISEKL KKGICEALED 850 860 870 880 890 900 SDGRQDSPAG ELPKTVQQPT ESEPVTINIQ DLLSCSNFAV QHRYLFEEDN LLRSTQKLSH 910 920 930 940 950 STKPSGSPLE EKHDQCKCEN LIMFQNLANE EVRKLTQRLE EMTQRMEALE NRLRYR
	Isoform 2 (Short) [UniParc]. Checksum: 14FB20A486F3B9F0	FASTA	937	104,775
	10 20 30 40 50 60 MEKMLAGCFL LILGQIVLLP AEARERSRGR SISRGRHART HPQTALLESS CENKRADLVF 70 80 90 100 110 120 IIDSSRSVNT HDYAKVKEFI VDILQFLDIG PDVTRVGLLQ YGSTVKNEFS LKTFKRKSEV 130 140 150 160 170 180 ERAVKRMRHL STGTMTGLAI QYALNIAFSE AEGARPLREN VPRVIMIVTD GRPQDSVAEV 190 200 210 220 230 240 AAKARDTGIL IFAIGVGQVD FNTLKSIGSE PHEDHVFLVA NFSQIETLTS VFQKKLCTAH 250 260 270 280 290 300 MCSTLEHNCA HFCINIPGSY VCRCKQGYIL NSDQTTCRIQ DLCAMEDHNC EQLCVNVPGS 310 320 330 340 350 360 FVCQCYSGYA LAEDGKRCVA VDYCASENHG CEHECVNADG SYLCQCHEGF ALNPDKKTCT 370 380 390 400 410 420 KIDYCASSNH GCQHECVNTD DSYSCHCLKG FTLNPDKKTC RRINYCALNK PGCEHECVNM 430 440 450 460 470 480 EESYYCRCHR GYTLDPNGKT CSRVDHCAQQ DHGCEQLCLN TEDSFVCQCS EGFLINEDLK 490 500 510 520 530 540 TCSRVDYCLL SDHGCEYSCV NMDRSFACQC PEGHVLRSDG KTCAKLDSCA LGDHGCEHSC 550 560 570 580 590 600 VSSEDSFVCQ CFEGYILRED GKTCRRKDVC QAIDHGCEHI CVNSDDSYTC ECLEGFRLAE 610 620 630 640 650 660 DGKRCRRKDV CKSTHHGCEH ICVNNGNSYI CKCSEGFVLA EDGRRCKKCT EGPIDLVFVI 670 680 690 700 710 720 DGSKSLGEEN FEVVKQFVTG IIDSLTISPK AARVGLLQYS TQVHTEFTLR NFNSAKDMKK 730 740 750 760 770 780 AVAHMKYMGK GSMTGLALKH MFERSFTQGE GARPLSTRVP RAAIVFTDGR AQDDVSEWAS 790 800 810 820 830 840 KAKANGITMY AVGVGKAIEE ELQEIASEPT NKHLFYAEDF STMDEISEKL KKGICEALED 850 860 870 880 890 900 SDGRQDSPAG ELPKTVQQPT VQHRYLFEED NLLRSTQKLS HSTKPSGSPL EEKHDQCKCE 910 920 930 NLIMFQNLAN EEVRKLTQRL EEMTQRMEAL ENRLRYR
	Isoform 3 [UniParc]. Checksum: B8C245C6EA17CDC1	FASTA	915	102,232
	10 20 30 40 50 60 MEKMLAGCFL LILGQIVLLP AEARERSRGR SISRGRHART HPQTALLESS CENKRADLVF 70 80 90 100 110 120 IIDSSRSVNT HDYAKVKEFI VDILQFLDIG PDVTRVGLLQ YGSTVKNEFS LKTFKRKSEV 130 140 150 160 170 180 ERAVKRMRHL STGTMTGLAI QYALNIAFSE AEGARPLREN VPRVIMIVTD GRPQDSVAEV 190 200 210 220 230 240 AAKARDTGIL IFAIGVGQVD FNTLKSIGSE PHEDHVFLVA NFSQIETLTS VFQKKLCTAH 250 260 270 280 290 300 MCSTLEHNCA HFCINIPGSY VCRCKQGYIL NSDQTTCRIQ DLCAMEDHNC EQLCVNVPGS 310 320 330 340 350 360 FVCQCYSGYA LAEDGKRCVA VDYCASENHG CEHECVNADG SYLCQCHEGF ALNPDKKTCT 370 380 390 400 410 420 RINYCALNKP GCEHECVNME ESYYCRCHRG YTLDPNGKTC SRVDHCAQQD HGCEQLCLNT 430 440 450 460 470 480 EDSFVCQCSE GFLINEDLKT CSRVDYCLLS DHGCEYSCVN MDRSFACQCP EGHVLRSDGK 490 500 510 520 530 540 TCAKLDSCAL GDHGCEHSCV SSEDSFVCQC FEGYILREDG KTCRRKDVCQ AIDHGCEHIC 550 560 570 580 590 600 VNSDDSYTCE CLEGFRLAED GKRCRRKDVC KSTHHGCEHI CVNNGNSYIC KCSEGFVLAE 610 620 630 640 650 660 DGRRCKKCTE GPIDLVFVID GSKSLGEENF EVVKQFVTGI IDSLTISPKA ARVGLLQYST 670 680 690 700 710 720 QVHTEFTLRN FNSAKDMKKA VAHMKYMGKG SMTGLALKHM FERSFTQGEG ARPLSTRVPR 730 740 750 760 770 780 AAIVFTDGRA QDDVSEWASK AKANGITMYA VGVGKAIEEE LQEIASEPTN KHLFYAEDFS 790 800 810 820 830 840 TMDEISEKLK KGICEALEDS DGRQDSPAGE LPKTVQQPTE SEPVTINIQD LLSCSNFAVQ 850 860 870 880 890 900 HRYLFEEDNL LRSTQKLSHS TKPSGSPLEE KHDQCKCENL IMFQNLANEE VRKLTQRLEE 910 MTQRMEALEN RLRYR
	Isoform 4 [UniParc]. Checksum: 933562EE766C3EC6	FASTA	672	75,251
	10 20 30 40 50 60 MEDHNCEQLC VNVPGSFVCQ CYSGYALAED GKRCVAVDYC ASENHGCEHE CVNADGSYLC 70 80 90 100 110 120 QCHEGFALNP DKKTCTKIDY CASSNHGCQH ECVNTDDSYS CHCLKGFTLN PDKKTCRRIN 130 140 150 160 170 180 YCALNKPGCE HECVNMEESY YCRCHRGYTL DPNGKTCSRV DHCAQQDHGC EQLCLNTEDS 190 200 210 220 230 240 FVCQCSEGFL INEDLKTCSR VDYCLLSDHG CEYSCVNMDR SFACQCPEGH VLRSDGKTCA 250 260 270 280 290 300 KLDSCALGDH GCEHSCVSSE DSFVCQCFEG YILREDGKTC RRKDVCQAID HGCEHICVNS 310 320 330 340 350 360 DDSYTCECLE GFRLAEDGKR CRRKDVCKST HHGCEHICVN NGNSYICKCS EGFVLAEDGR 370 380 390 400 410 420 RCKKCTEGPI DLVFVIDGSK SLGEENFEVV KQFVTGIIDS LTISPKAARV GLLQYSTQVH 430 440 450 460 470 480 TEFTLRNFNS AKDMKKAVAH MKYMGKGSMT GLALKHMFER SFTQGEGARP LSTRVPRAAI 490 500 510 520 530 540 VFTDGRAQDD VSEWASKAKA NGITMYAVGV GKAIEEELQE IASEPTNKHL FYAEDFSTMD 550 560 570 580 590 600 EISEKLKKGI CEALEDSDGR QDSPAGELPK TVQQPTESEP VTINIQDLLS CSNFAVQHRY 610 620 630 640 650 660 LFEEDNLLRS TQKLSHSTKP SGSPLEEKHD QCKCENLIMF QNLANEEVRK LTQRLEEMTQ 670 RMEALENRLR YR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure of human matrilin-2, chromosome location of the MATN2 gene and conservation of an AT-AC intron in matrilin genes." Muratoglu S., Krysan K., Balazs M., Sheng H., Zakany R., Modis L., Kiss I., Deak F. Cytogenet. Cell Genet. 90:323-327(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT MET-187. Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLU-356. Tissue: Testis.
[5]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 242-956 (ISOFORM 1), VARIANT GLU-356. Tissue: Brain and Ovary.
[7]	"Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily." Deak F., Piecha D., Bachrati C., Paulsson M., Kiss I. J. Biol. Chem. 272:9268-9274(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 644-956.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U69263 mRNA. Translation: AAC51260.2. AY358895 mRNA. Translation: AAQ89254.1. AL137638 mRNA. Translation: CAB70853.2. AK289721 mRNA. Translation: BAF82410.1. AL833931 mRNA. Translation: CAD38787.1. Different initiation. AP002906 Genomic DNA. No translation available. AP003352 Genomic DNA. No translation available. BC010444 mRNA. Translation: AAH10444.1. BC016394 mRNA. Translation: AAH16394.1.
IPI	IPI00168520. IPI00473118. IPI00607598. IPI00981431.
RefSeq	NP_002371.3. NM_002380.3. NP_085072.2. NM_030583.2.
UniGene	Hs.189445.
3D structure databases
ProteinModelPortal	O00339.
SMR	O00339. Positions 57-647, 654-834.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47267N.
IntAct	O00339. 5 interactions.
STRING	9606.ENSP00000254898.
PTM databases
PhosphoSite	O00339.
Proteomic databases
PaxDb	O00339.
PRIDE	O00339.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000520016; ENSP00000430487; ENSG00000132561. ENST00000521689; ENSP00000429977; ENSG00000132561. ENST00000522025; ENSP00000429010; ENSG00000132561. ENST00000524308; ENSP00000430221; ENSG00000132561.
GeneID	4147.
KEGG	hsa:4147.
UCSC	uc003yic.3. human. uc003yid.3. human. uc010mbh.1. human.
Organism-specific databases
CTD	4147.
GeneCards	GC08P098881.
HGNC	HGNC:6908. MATN2.
HPA	CAB033879.
MIM	602108. gene.
neXtProt	NX_O00339.
PharmGKB	PA30651.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG297993.
HOVERGEN	HBG056906.
InParanoid	O00339.
Gene expression databases
ArrayExpress	O00339.
Bgee	O00339.
CleanEx	HS_MATN2.
Genevestigator	O00339.
GermOnline	ENSG00000132561. Homo sapiens.
Family and domain databases
Gene3D	1.20.5.30. 1 hit.
InterPro	IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR019466. Matrilin_coiled-coil_trimer. IPR002035. VWF_A. [Graphical view]
Pfam	PF00008. EGF. 1 hit. PF07645. EGF_CA. 5 hits. PF10393. Matrilin_ccoil. 1 hit. PF00092. VWA. 2 hits. [Graphical view]
SMART	SM00181. EGF. 9 hits. SM00179. EGF_CA. 1 hit. SM00327. VWA. 2 hits. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 9 hits. PS01186. EGF_2. 9 hits. PS50026. EGF_3. 4 hits. PS50234. VWFA. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MATN2. human.
GenomeRNAi	4147.
NextBio	16292.
SOURCE	Search...

Entry information

Entry name

MATN2_HUMAN

Accession

Primary (citable) accession number: O00339
Secondary accession number(s): A8K106 , E7EW74, E9PD48, E9PGL2, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 130 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.