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O00339

- MATN2_HUMAN

UniProt

O00339 - MATN2_HUMAN

Protein

Matrilin-2

Gene

MATN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 4 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Involved in matrix assembly.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. axon guidance Source: Ensembl
    2. dendrite regeneration Source: Ensembl
    3. glial cell migration Source: Ensembl
    4. neuron migration Source: Ensembl
    5. response to axon injury Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrilin-2
    Gene namesi
    Name:MATN2
    ORF Names:UNQ193/PRO219
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:6908. MATN2.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: Ensembl
    2. proteinaceous extracellular matrix Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30651.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 956933Matrilin-2PRO_0000007655Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi242 ↔ 253PROSITE-ProRule annotation
    Disulfide bondi249 ↔ 262PROSITE-ProRule annotation
    Disulfide bondi264 ↔ 277PROSITE-ProRule annotation
    Disulfide bondi283 ↔ 294PROSITE-ProRule annotation
    Disulfide bondi290 ↔ 303PROSITE-ProRule annotation
    Disulfide bondi305 ↔ 318PROSITE-ProRule annotation
    Disulfide bondi324 ↔ 335PROSITE-ProRule annotation
    Disulfide bondi331 ↔ 344PROSITE-ProRule annotation
    Disulfide bondi346 ↔ 359PROSITE-ProRule annotation
    Disulfide bondi365 ↔ 376PROSITE-ProRule annotation
    Disulfide bondi372 ↔ 385PROSITE-ProRule annotation
    Disulfide bondi387 ↔ 400PROSITE-ProRule annotation
    Disulfide bondi406 ↔ 417PROSITE-ProRule annotation
    Disulfide bondi413 ↔ 426PROSITE-ProRule annotation
    Disulfide bondi428 ↔ 441PROSITE-ProRule annotation
    Disulfide bondi447 ↔ 458PROSITE-ProRule annotation
    Disulfide bondi454 ↔ 467PROSITE-ProRule annotation
    Disulfide bondi469 ↔ 482PROSITE-ProRule annotation
    Disulfide bondi488 ↔ 499PROSITE-ProRule annotation
    Disulfide bondi495 ↔ 508PROSITE-ProRule annotation
    Disulfide bondi510 ↔ 523PROSITE-ProRule annotation
    Disulfide bondi529 ↔ 540PROSITE-ProRule annotation
    Disulfide bondi536 ↔ 549PROSITE-ProRule annotation
    Disulfide bondi551 ↔ 564PROSITE-ProRule annotation
    Disulfide bondi570 ↔ 581PROSITE-ProRule annotation
    Disulfide bondi577 ↔ 590PROSITE-ProRule annotation
    Disulfide bondi592 ↔ 605PROSITE-ProRule annotation
    Disulfide bondi611 ↔ 622PROSITE-ProRule annotation
    Disulfide bondi618 ↔ 631PROSITE-ProRule annotation
    Disulfide bondi633 ↔ 646PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO00339.
    PaxDbiO00339.
    PRIDEiO00339.

    PTM databases

    PhosphoSiteiO00339.

    Expressioni

    Gene expression databases

    ArrayExpressiO00339.
    BgeeiO00339.
    CleanExiHS_MATN2.
    GenevestigatoriO00339.

    Organism-specific databases

    HPAiCAB033879.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATXN7O152652EBI-949020,EBI-708350
    CACNA1AO005552EBI-949020,EBI-766279

    Protein-protein interaction databases

    BioGridi110317. 12 interactions.
    DIPiDIP-47267N.
    IntActiO00339. 6 interactions.
    STRINGi9606.ENSP00000254898.

    Structurei

    3D structure databases

    ProteinModelPortaliO00339.
    SMRiO00339. Positions 57-647, 652-846.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 232176VWFA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini238 – 27841EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 31941EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini320 – 36041EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini361 – 40141EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini402 – 44241EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini443 – 48341EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 52441EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini525 – 56541EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini566 – 60641EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini607 – 64741EGF-like 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini655 – 830176VWFA 2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili917 – 95539Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 10 EGF-like domains.PROSITE-ProRule annotation
    Contains 2 VWFA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG297993.
    HOVERGENiHBG056906.
    InParanoidiO00339.
    OrthoDBiEOG70GMF3.
    TreeFamiTF330078.

    Family and domain databases

    Gene3Di1.20.5.30. 1 hit.
    3.40.50.410. 2 hits.
    InterProiIPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR019466. Matrilin_coiled-coil_trimer.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF10393. Matrilin_ccoil. 1 hit.
    PF00092. VWA. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 9 hits.
    SM00179. EGF_CA. 1 hit.
    SM00327. VWA. 2 hits.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 2 hits.
    SSF57184. SSF57184. 3 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 9 hits.
    PS01186. EGF_2. 9 hits.
    PS50026. EGF_3. 4 hits.
    PS50234. VWFA. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O00339-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKMLAGCFL LILGQIVLLP AEARERSRGR SISRGRHART HPQTALLESS    50
    CENKRADLVF IIDSSRSVNT HDYAKVKEFI VDILQFLDIG PDVTRVGLLQ 100
    YGSTVKNEFS LKTFKRKSEV ERAVKRMRHL STGTMTGLAI QYALNIAFSE 150
    AEGARPLREN VPRVIMIVTD GRPQDSVAEV AAKARDTGIL IFAIGVGQVD 200
    FNTLKSIGSE PHEDHVFLVA NFSQIETLTS VFQKKLCTAH MCSTLEHNCA 250
    HFCINIPGSY VCRCKQGYIL NSDQTTCRIQ DLCAMEDHNC EQLCVNVPGS 300
    FVCQCYSGYA LAEDGKRCVA VDYCASENHG CEHECVNADG SYLCQCHEGF 350
    ALNPDKKTCT KIDYCASSNH GCQHECVNTD DSYSCHCLKG FTLNPDKKTC 400
    RRINYCALNK PGCEHECVNM EESYYCRCHR GYTLDPNGKT CSRVDHCAQQ 450
    DHGCEQLCLN TEDSFVCQCS EGFLINEDLK TCSRVDYCLL SDHGCEYSCV 500
    NMDRSFACQC PEGHVLRSDG KTCAKLDSCA LGDHGCEHSC VSSEDSFVCQ 550
    CFEGYILRED GKTCRRKDVC QAIDHGCEHI CVNSDDSYTC ECLEGFRLAE 600
    DGKRCRRKDV CKSTHHGCEH ICVNNGNSYI CKCSEGFVLA EDGRRCKKCT 650
    EGPIDLVFVI DGSKSLGEEN FEVVKQFVTG IIDSLTISPK AARVGLLQYS 700
    TQVHTEFTLR NFNSAKDMKK AVAHMKYMGK GSMTGLALKH MFERSFTQGE 750
    GARPLSTRVP RAAIVFTDGR AQDDVSEWAS KAKANGITMY AVGVGKAIEE 800
    ELQEIASEPT NKHLFYAEDF STMDEISEKL KKGICEALED SDGRQDSPAG 850
    ELPKTVQQPT ESEPVTINIQ DLLSCSNFAV QHRYLFEEDN LLRSTQKLSH 900
    STKPSGSPLE EKHDQCKCEN LIMFQNLANE EVRKLTQRLE EMTQRMEALE 950
    NRLRYR 956
    Length:956
    Mass (Da):106,837
    Last modified:June 28, 2011 - v4
    Checksum:iD0868FBF62744EF2
    GO
    Isoform 2 (identifier: O00339-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         861-879: Missing.

    Show »
    Length:937
    Mass (Da):104,775
    Checksum:i14FB20A486F3B9F0
    GO
    Isoform 3 (identifier: O00339-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         361-401: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:915
    Mass (Da):102,232
    Checksum:iB8C245C6EA17CDC1
    GO
    Isoform 4 (identifier: O00339-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-284: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:672
    Mass (Da):75,251
    Checksum:i933562EE766C3EC6
    GO

    Sequence cautioni

    The sequence CAD38787.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581L → P in BAF82410. (PubMed:14702039)Curated
    Sequence conflicti594 – 5941E → V in AAC51260. (PubMed:11124542)Curated
    Sequence conflicti644 – 6441R → G no nucleotide entry (PubMed:9083061)Curated
    Sequence conflicti755 – 7551L → F in AAC51260. (PubMed:11124542)Curated
    Sequence conflicti890 – 8901N → D in BAF82410. (PubMed:14702039)Curated
    Sequence conflicti935 – 9351L → F no nucleotide entry (PubMed:9083061)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141G → A.
    Corresponds to variant rs35804177 [ dbSNP | Ensembl ].
    VAR_055753
    Natural varianti187 – 1871T → M.1 Publication
    Corresponds to variant rs2290472 [ dbSNP | Ensembl ].
    VAR_055754
    Natural varianti356 – 3561K → E.2 Publications
    Corresponds to variant rs1869609 [ dbSNP | Ensembl ].
    VAR_021568
    Natural varianti599 – 5991A → T.
    Corresponds to variant rs35120814 [ dbSNP | Ensembl ].
    VAR_055755
    Natural varianti855 – 8551T → M.
    Corresponds to variant rs2255317 [ dbSNP | Ensembl ].
    VAR_055756
    Natural varianti932 – 9321V → I.
    Corresponds to variant rs17831160 [ dbSNP | Ensembl ].
    VAR_055757

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 284284Missing in isoform 4. 1 PublicationVSP_014540Add
    BLAST
    Alternative sequencei361 – 40141Missing in isoform 3. 1 PublicationVSP_013284Add
    BLAST
    Alternative sequencei861 – 87919Missing in isoform 2. 3 PublicationsVSP_001399Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69263 mRNA. Translation: AAC51260.2.
    AY358895 mRNA. Translation: AAQ89254.1.
    AL137638 mRNA. Translation: CAB70853.2.
    AK289721 mRNA. Translation: BAF82410.1.
    AL833931 mRNA. Translation: CAD38787.1. Different initiation.
    AP002906 Genomic DNA. No translation available.
    AP003352 Genomic DNA. No translation available.
    BC010444 mRNA. Translation: AAH10444.1.
    BC016394 mRNA. Translation: AAH16394.1.
    CCDSiCCDS55264.1. [O00339-1]
    CCDS55265.1. [O00339-2]
    RefSeqiNP_002371.3. NM_002380.3. [O00339-1]
    NP_085072.2. NM_030583.2. [O00339-2]
    UniGeneiHs.189445.

    Genome annotation databases

    EnsembliENST00000520016; ENSP00000430487; ENSG00000132561. [O00339-1]
    ENST00000521689; ENSP00000429977; ENSG00000132561. [O00339-2]
    ENST00000522025; ENSP00000429010; ENSG00000132561. [O00339-4]
    ENST00000524308; ENSP00000430221; ENSG00000132561. [O00339-3]
    GeneIDi4147.
    KEGGihsa:4147.
    UCSCiuc003yic.3. human. [O00339-1]
    uc003yid.3. human. [O00339-2]
    uc010mbh.1. human. [O00339-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69263 mRNA. Translation: AAC51260.2 .
    AY358895 mRNA. Translation: AAQ89254.1 .
    AL137638 mRNA. Translation: CAB70853.2 .
    AK289721 mRNA. Translation: BAF82410.1 .
    AL833931 mRNA. Translation: CAD38787.1 . Different initiation.
    AP002906 Genomic DNA. No translation available.
    AP003352 Genomic DNA. No translation available.
    BC010444 mRNA. Translation: AAH10444.1 .
    BC016394 mRNA. Translation: AAH16394.1 .
    CCDSi CCDS55264.1. [O00339-1 ]
    CCDS55265.1. [O00339-2 ]
    RefSeqi NP_002371.3. NM_002380.3. [O00339-1 ]
    NP_085072.2. NM_030583.2. [O00339-2 ]
    UniGenei Hs.189445.

    3D structure databases

    ProteinModelPortali O00339.
    SMRi O00339. Positions 57-647, 652-846.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110317. 12 interactions.
    DIPi DIP-47267N.
    IntActi O00339. 6 interactions.
    STRINGi 9606.ENSP00000254898.

    PTM databases

    PhosphoSitei O00339.

    Proteomic databases

    MaxQBi O00339.
    PaxDbi O00339.
    PRIDEi O00339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000520016 ; ENSP00000430487 ; ENSG00000132561 . [O00339-1 ]
    ENST00000521689 ; ENSP00000429977 ; ENSG00000132561 . [O00339-2 ]
    ENST00000522025 ; ENSP00000429010 ; ENSG00000132561 . [O00339-4 ]
    ENST00000524308 ; ENSP00000430221 ; ENSG00000132561 . [O00339-3 ]
    GeneIDi 4147.
    KEGGi hsa:4147.
    UCSCi uc003yic.3. human. [O00339-1 ]
    uc003yid.3. human. [O00339-2 ]
    uc010mbh.1. human. [O00339-3 ]

    Organism-specific databases

    CTDi 4147.
    GeneCardsi GC08P098881.
    HGNCi HGNC:6908. MATN2.
    HPAi CAB033879.
    MIMi 602108. gene.
    neXtProti NX_O00339.
    PharmGKBi PA30651.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297993.
    HOVERGENi HBG056906.
    InParanoidi O00339.
    OrthoDBi EOG70GMF3.
    TreeFami TF330078.

    Miscellaneous databases

    ChiTaRSi MATN2. human.
    GeneWikii MATN2.
    GenomeRNAii 4147.
    NextBioi 16292.
    PROi O00339.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00339.
    Bgeei O00339.
    CleanExi HS_MATN2.
    Genevestigatori O00339.

    Family and domain databases

    Gene3Di 1.20.5.30. 1 hit.
    3.40.50.410. 2 hits.
    InterProi IPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR019466. Matrilin_coiled-coil_trimer.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF10393. Matrilin_ccoil. 1 hit.
    PF00092. VWA. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 9 hits.
    SM00179. EGF_CA. 1 hit.
    SM00327. VWA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 2 hits.
    SSF57184. SSF57184. 3 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 9 hits.
    PS01186. EGF_2. 9 hits.
    PS50026. EGF_3. 4 hits.
    PS50234. VWFA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of human matrilin-2, chromosome location of the MATN2 gene and conservation of an AT-AC intron in matrilin genes."
      Muratoglu S., Krysan K., Balazs M., Sheng H., Zakany R., Modis L., Kiss I., Deak F.
      Cytogenet. Cell Genet. 90:323-327(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT MET-187.
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLU-356.
      Tissue: Testis.
    5. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 242-956 (ISOFORM 1), VARIANT GLU-356.
      Tissue: Brain and Ovary.
    7. "Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily."
      Deak F., Piecha D., Bachrati C., Paulsson M., Kiss I.
      J. Biol. Chem. 272:9268-9274(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 644-956.

    Entry informationi

    Entry nameiMATN2_HUMAN
    AccessioniPrimary (citable) accession number: O00339
    Secondary accession number(s): A8K106
    , E7EW74, E9PD48, E9PGL2, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 143 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3