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Protein

Matrilin-2

Gene

MATN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in matrix assembly.By similarity

Caution

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Matrilin-2
Gene namesi
Name:MATN2
ORF Names:UNQ193/PRO219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000132561.13
HGNCiHGNC:6908 MATN2
MIMi602108 gene
neXtProtiNX_O00339

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4147
OpenTargetsiENSG00000132561
PharmGKBiPA30651

Polymorphism and mutation databases

BioMutaiMATN2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000765524 – 956Matrilin-2Add BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi242 ↔ 253PROSITE-ProRule annotation
Disulfide bondi249 ↔ 262PROSITE-ProRule annotation
Disulfide bondi264 ↔ 277PROSITE-ProRule annotation
Disulfide bondi283 ↔ 294PROSITE-ProRule annotation
Disulfide bondi290 ↔ 303PROSITE-ProRule annotation
Disulfide bondi305 ↔ 318PROSITE-ProRule annotation
Disulfide bondi324 ↔ 335PROSITE-ProRule annotation
Disulfide bondi331 ↔ 344PROSITE-ProRule annotation
Disulfide bondi346 ↔ 359PROSITE-ProRule annotation
Disulfide bondi365 ↔ 376PROSITE-ProRule annotation
Disulfide bondi372 ↔ 385PROSITE-ProRule annotation
Disulfide bondi387 ↔ 400PROSITE-ProRule annotation
Disulfide bondi406 ↔ 417PROSITE-ProRule annotation
Disulfide bondi413 ↔ 426PROSITE-ProRule annotation
Disulfide bondi428 ↔ 441PROSITE-ProRule annotation
Disulfide bondi447 ↔ 458PROSITE-ProRule annotation
Disulfide bondi454 ↔ 467PROSITE-ProRule annotation
Disulfide bondi469 ↔ 482PROSITE-ProRule annotation
Disulfide bondi488 ↔ 499PROSITE-ProRule annotation
Disulfide bondi495 ↔ 508PROSITE-ProRule annotation
Disulfide bondi510 ↔ 523PROSITE-ProRule annotation
Disulfide bondi529 ↔ 540PROSITE-ProRule annotation
Disulfide bondi536 ↔ 549PROSITE-ProRule annotation
Disulfide bondi551 ↔ 564PROSITE-ProRule annotation
Disulfide bondi570 ↔ 581PROSITE-ProRule annotation
Disulfide bondi577 ↔ 590PROSITE-ProRule annotation
Disulfide bondi592 ↔ 605PROSITE-ProRule annotation
Disulfide bondi611 ↔ 622PROSITE-ProRule annotation
Disulfide bondi618 ↔ 631PROSITE-ProRule annotation
Disulfide bondi633 ↔ 646PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO00339
PaxDbiO00339
PeptideAtlasiO00339
PRIDEiO00339

PTM databases

iPTMnetiO00339
PhosphoSitePlusiO00339

Expressioni

Gene expression databases

BgeeiENSG00000132561
CleanExiHS_MATN2
ExpressionAtlasiO00339 baseline and differential
GenevisibleiO00339 HS

Organism-specific databases

HPAiCAB033879

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11031726 interactors.
DIPiDIP-47267N
IntActiO00339 6 interactors.
STRINGi9606.ENSP00000430487

Structurei

3D structure databases

ProteinModelPortaliO00339
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 232VWFA 1PROSITE-ProRule annotationAdd BLAST176
Domaini238 – 278EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini279 – 319EGF-like 2PROSITE-ProRule annotationAdd BLAST41
Domaini320 – 360EGF-like 3PROSITE-ProRule annotationAdd BLAST41
Domaini361 – 401EGF-like 4PROSITE-ProRule annotationAdd BLAST41
Domaini402 – 442EGF-like 5PROSITE-ProRule annotationAdd BLAST41
Domaini443 – 483EGF-like 6PROSITE-ProRule annotationAdd BLAST41
Domaini484 – 524EGF-like 7PROSITE-ProRule annotationAdd BLAST41
Domaini525 – 565EGF-like 8PROSITE-ProRule annotationAdd BLAST41
Domaini566 – 606EGF-like 9PROSITE-ProRule annotationAdd BLAST41
Domaini607 – 647EGF-like 10PROSITE-ProRule annotationAdd BLAST41
Domaini655 – 830VWFA 2PROSITE-ProRule annotationAdd BLAST176

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili917 – 955Sequence analysisAdd BLAST39

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR7H Eukaryota
ENOG410XSTY LUCA
GeneTreeiENSGT00910000144060
HOVERGENiHBG056906
InParanoidiO00339
OMAiDHGCEQL
OrthoDBiEOG091G02GA
TreeFamiTF330078

Family and domain databases

Gene3Di1.20.5.301 hit
3.40.50.4102 hits
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR009030 Growth_fac_rcpt_cys_sf
IPR030747 Matrilin-2
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR44734:SF1 PTHR44734:SF1, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 3 hits
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 10 hits
SM00179 EGF_CA, 10 hits
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF57184 SSF57184, 3 hits
SSF58002 SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 9 hits
PS01186 EGF_2, 9 hits
PS50026 EGF_3, 4 hits
PS50234 VWFA, 2 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O00339-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKMLAGCFL LILGQIVLLP AEARERSRGR SISRGRHART HPQTALLESS
60 70 80 90 100
CENKRADLVF IIDSSRSVNT HDYAKVKEFI VDILQFLDIG PDVTRVGLLQ
110 120 130 140 150
YGSTVKNEFS LKTFKRKSEV ERAVKRMRHL STGTMTGLAI QYALNIAFSE
160 170 180 190 200
AEGARPLREN VPRVIMIVTD GRPQDSVAEV AAKARDTGIL IFAIGVGQVD
210 220 230 240 250
FNTLKSIGSE PHEDHVFLVA NFSQIETLTS VFQKKLCTAH MCSTLEHNCA
260 270 280 290 300
HFCINIPGSY VCRCKQGYIL NSDQTTCRIQ DLCAMEDHNC EQLCVNVPGS
310 320 330 340 350
FVCQCYSGYA LAEDGKRCVA VDYCASENHG CEHECVNADG SYLCQCHEGF
360 370 380 390 400
ALNPDKKTCT KIDYCASSNH GCQHECVNTD DSYSCHCLKG FTLNPDKKTC
410 420 430 440 450
RRINYCALNK PGCEHECVNM EESYYCRCHR GYTLDPNGKT CSRVDHCAQQ
460 470 480 490 500
DHGCEQLCLN TEDSFVCQCS EGFLINEDLK TCSRVDYCLL SDHGCEYSCV
510 520 530 540 550
NMDRSFACQC PEGHVLRSDG KTCAKLDSCA LGDHGCEHSC VSSEDSFVCQ
560 570 580 590 600
CFEGYILRED GKTCRRKDVC QAIDHGCEHI CVNSDDSYTC ECLEGFRLAE
610 620 630 640 650
DGKRCRRKDV CKSTHHGCEH ICVNNGNSYI CKCSEGFVLA EDGRRCKKCT
660 670 680 690 700
EGPIDLVFVI DGSKSLGEEN FEVVKQFVTG IIDSLTISPK AARVGLLQYS
710 720 730 740 750
TQVHTEFTLR NFNSAKDMKK AVAHMKYMGK GSMTGLALKH MFERSFTQGE
760 770 780 790 800
GARPLSTRVP RAAIVFTDGR AQDDVSEWAS KAKANGITMY AVGVGKAIEE
810 820 830 840 850
ELQEIASEPT NKHLFYAEDF STMDEISEKL KKGICEALED SDGRQDSPAG
860 870 880 890 900
ELPKTVQQPT ESEPVTINIQ DLLSCSNFAV QHRYLFEEDN LLRSTQKLSH
910 920 930 940 950
STKPSGSPLE EKHDQCKCEN LIMFQNLANE EVRKLTQRLE EMTQRMEALE

NRLRYR
Length:956
Mass (Da):106,837
Last modified:June 28, 2011 - v4
Checksum:iD0868FBF62744EF2
GO
Isoform 2 (identifier: O00339-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     861-879: Missing.

Show »
Length:937
Mass (Da):104,775
Checksum:i14FB20A486F3B9F0
GO
Isoform 3 (identifier: O00339-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     361-401: Missing.

Note: No experimental confirmation available.
Show »
Length:915
Mass (Da):102,232
Checksum:iB8C245C6EA17CDC1
GO
Isoform 4 (identifier: O00339-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-284: Missing.

Note: No experimental confirmation available.
Show »
Length:672
Mass (Da):75,251
Checksum:i933562EE766C3EC6
GO

Sequence cautioni

The sequence CAD38787 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58L → P in BAF82410 (PubMed:14702039).Curated1
Sequence conflicti594E → V in AAC51260 (PubMed:11124542).Curated1
Sequence conflicti644R → G no nucleotide entry (PubMed:9083061).Curated1
Sequence conflicti755L → F in AAC51260 (PubMed:11124542).Curated1
Sequence conflicti890N → D in BAF82410 (PubMed:14702039).Curated1
Sequence conflicti935L → F no nucleotide entry (PubMed:9083061).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05575314G → A. Corresponds to variant dbSNP:rs35804177Ensembl.1
Natural variantiVAR_055754187T → M1 PublicationCorresponds to variant dbSNP:rs2290472Ensembl.1
Natural variantiVAR_021568356K → E2 PublicationsCorresponds to variant dbSNP:rs1869609Ensembl.1
Natural variantiVAR_055755599A → T. Corresponds to variant dbSNP:rs35120814Ensembl.1
Natural variantiVAR_055756855T → M. Corresponds to variant dbSNP:rs2255317Ensembl.1
Natural variantiVAR_055757932V → I. Corresponds to variant dbSNP:rs17831160Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0145401 – 284Missing in isoform 4. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_013284361 – 401Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_001399861 – 879Missing in isoform 2. 3 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69263 mRNA Translation: AAC51260.2
AY358895 mRNA Translation: AAQ89254.1
AL137638 mRNA Translation: CAB70853.2
AK289721 mRNA Translation: BAF82410.1
AL833931 mRNA Translation: CAD38787.1 Different initiation.
AP002906 Genomic DNA No translation available.
AP003352 Genomic DNA No translation available.
BC010444 mRNA Translation: AAH10444.1
BC016394 mRNA Translation: AAH16394.1
CCDSiCCDS55264.1 [O00339-1]
CCDS55265.1 [O00339-2]
CCDS83309.1 [O00339-3]
RefSeqiNP_001304677.1, NM_001317748.1 [O00339-3]
NP_002371.3, NM_002380.4 [O00339-1]
NP_085072.2, NM_030583.3 [O00339-2]
UniGeneiHs.189445
Hs.737531

Genome annotation databases

EnsembliENST00000254898; ENSP00000254898; ENSG00000132561 [O00339-1]
ENST00000520016; ENSP00000430487; ENSG00000132561 [O00339-1]
ENST00000521689; ENSP00000429977; ENSG00000132561 [O00339-2]
ENST00000522025; ENSP00000429010; ENSG00000132561 [O00339-4]
ENST00000524308; ENSP00000430221; ENSG00000132561 [O00339-3]
GeneIDi4147
KEGGihsa:4147
UCSCiuc003yic.4 human [O00339-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMATN2_HUMAN
AccessioniPrimary (citable) accession number: O00339
Secondary accession number(s): A8K106
, E7EW74, E9PD48, E9PGL2, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 28, 2011
Last modified: April 25, 2018
This is version 177 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome