O00338 (ST1C2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sulfotransferase 1C2
Short name=ST1C2
EC=2.8.2.-

Alternative name(s):
Sulfotransferase 1C1
Short name=SULT1C#1
humSULTC2

Gene names

Name:	SULT1C2
Synonyms:	SULT1C1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
Subcellular location	Cytoplasm.
Tissue specificity	Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver.
Sequence similarities	Belongs to the sulfotransferase 1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process Traceable author statement. Source: Reactome amine metabolic process Traceable author statement Ref.1. Source: ProtInc sulfation Inferred from direct assay PubMed 20056724. Source: BHF-UCL xenobiotic metabolic process Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome microtubule cytoskeleton Inferred from direct assay. Source: HPA
Molecular_function	sulfotransferase activity Inferred from direct assay PubMed 20056724. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Short (identifier: O00338-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Long (identifier: O00338-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-113: GVEKAKAMPSPRILKTHLSTQ → ETGFHHVAQAGLKLLSSSNPPASTSQSAKITD

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 296

296

Sulfotransferase 1C2

PRO_0000085132

Regions

Nucleotide binding

49 – 54

6

PAPS

Nucleotide binding

228 – 233

6

PAPS

Nucleotide binding

256 – 260

5

PAPS

Region

107 – 109

3

Substrate binding By similarity

Sites

Active site

109

1

Proton acceptor By similarity

Binding site

131

1

PAPS

Binding site

139

1

PAPS

Binding site

194

1

PAPS

Natural variations

Alternative sequence

93 – 113

21

GVEKA…HLSTQ → ETGFHHVAQAGLKLLSSSNP PASTSQSAKITD in isoform Long.

VSP_006303

Natural variant

128

1

Y → H.
Corresponds to variant rs17036091 [ dbSNP | Ensembl ].

VAR_021986

Natural variant

255

1

S → A.
Corresponds to variant rs17036104 [ dbSNP | Ensembl ].

VAR_021987

Natural variant

282

1

R → T.
Corresponds to variant rs45515691 [ dbSNP | Ensembl ].

VAR_061888

Secondary structure

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296

Helix Strand Turn

Details...

Beta strand

14 – 16

3

Beta strand

19 – 21

3

Helix

23 – 27

5

Helix

29 – 33

5

Beta strand

42 – 46

5

Helix

52 – 64

13

Helix

93 – 99

7

Beta strand

105 – 108

4

Turn

112 – 114

3

Helix

118 – 121

4

Beta strand

125 – 130

6

Helix

133 – 146

14

Helix

156 – 164

9

Helix

173 – 183

11

Turn

184 – 186

3

Beta strand

187 – 193

7

Helix

194 – 199

6

Helix

201 – 211

11

Helix

218 – 227

10

Helix

230 – 235

6

Helix

265 – 268

4

Helix

271 – 285

15

Sequences

	Sequence		Length	Mass (Da)
	Isoform Short [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 3DC01C8A8ED61EFD	FASTA	296	34,880
	10 20 30 40 50 60 MALTSDLGKQ IKLKEVEGTL LQPATVDNWS QIQSFEAKPD DLLICTYPKA GTTWIQEIVD 70 80 90 100 110 120 MIEQNGDVEK CQRAIIQHRH PFIEWARPPQ PSGVEKAKAM PSPRILKTHL STQLLPPSFW 130 140 150 160 170 180 ENNCKFLYVA RNAKDCMVSY YHFQRMNHML PDPGTWEEYF ETFINGKVVW GSWFDHVKGW 190 200 210 220 230 240 WEMKDRHQIL FLFYEDIKRD PKHEIRKVMQ FMGKKVDETV LDKIVQETSF EKMKENPMTN 250 260 270 280 290 RSTVSKSILD QSISSFMRKG TVGDWKNHFT VAQNERFDEI YRRKMEGTSI NFCMEL
	Isoform Long [UniParc]. Checksum: DB83191FA88BFAD1	FASTA	307	35,868
	10 20 30 40 50 60 MALTSDLGKQ IKLKEVEGTL LQPATVDNWS QIQSFEAKPD DLLICTYPKA GTTWIQEIVD 70 80 90 100 110 120 MIEQNGDVEK CQRAIIQHRH PFIEWARPPQ PSETGFHHVA QAGLKLLSSS NPPASTSQSA 130 140 150 160 170 180 KITDLLPPSF WENNCKFLYV ARNAKDCMVS YYHFQRMNHM LPDPGTWEEY FETFINGKVV 190 200 210 220 230 240 WGSWFDHVKG WWEMKDRHQI LFLFYEDIKR DPKHEIRKVM QFMGKKVDET VLDKIVQETS 250 260 270 280 290 300 FEKMKENPMT NRSTVSKSIL DQSISSFMRK GTVGDWKNHF TVAQNERFDE IYRRKMEGTS INFCMEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization." Her C., Kaur G.P., Athwal R.S., Weinshilboum R.M. Genomics 41:467-470(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver and Fetal spleen.
[2]	"Molecular characterization of ST1C1-related human sulfotransferase." Yoshinari K., Nagata K., Shimada M., Yamazoe Y. Carcinogenesis 19:951-953(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver.
[3]	"Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene." Sakakibara Y., Yanagisawa K., Katafuchi J., Ringer D.P., Takami Y., Nakayama T., Suiko M., Liu M.-C. J. Biol. Chem. 273:33929-33935(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Fetal lung.
[4]	"Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase." Hehonah N., Zhu X., Brix L., Bolton-Grob R., Barnett A., Windmill K., McManus M. Int. J. Biochem. Cell Biol. 31:869-882(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Stomach.
[5]	"Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization." Freimuth R.R., Raftogianis R.B., Wood T.C., Moon E., Kim U.-J., Xu J., Siciliano M.J., Weinshilboum R.M. Genomics 65:157-165(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[6]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT). Tissue: Kidney.
[8]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[11]	"Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP)." Dombrovski L., Dong A., Bochkarev A., Plotnikov A.N. Proteins 64:1091-1094(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 3-296 IN COMPLEX WITH ADENOSINE-3'- 5'-DIPHOSPHATE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U66036 mRNA. Translation: AAC51285.1.
AB008164 mRNA. Translation: BAA28346.1.
AF026303 mRNA. Translation: AAC00409.1.
AF186251 mRNA. Translation: AAF72799.1.
AF186252 mRNA. Translation: AAF72800.1.
AF186253 mRNA. Translation: AAF72801.1.
AF186254 mRNA. Translation: AAF72802.1.
AF186255 mRNA. Translation: AAF72803.1.
AF186256 mRNA. Translation: AAF72804.1.
AF186262 , AF186258, AF186260, AF186261 Genomic DNA. Translation: AAF72805.1.
AF186262 , AF186258, AF186259, AF186260, AF186261 Genomic DNA. Translation: AAF72806.1.
BT006951 mRNA. Translation: AAP35597.1.
AK313193 mRNA. Translation: BAG36010.1.
AC019100 Genomic DNA. Translation: AAY14790.1.
CH471182 Genomic DNA. Translation: EAW53889.1.
CH471182 Genomic DNA. Translation: EAW53890.1.
BC005353 mRNA. Translation: AAH05353.1.

IPI

IPI00011290.
IPI00220643.

RefSeq

NP_001047.1. NM_001056.3.
NP_789795.1. NM_176825.2.

UniGene

Hs.436123.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BFX	X-ray	1.80	A/B	3-296	[»]

ProteinModelPortal

O00338.

ModBase

Search...

Protein-protein interaction databases

IntAct

O00338. 2 interactions.

STRING

9606.ENSP00000319622.

Proteomic databases

PaxDb

O00338.

PRIDE

O00338.

Protocols and materials databases

DNASU

6819.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000251481; ENSP00000251481; ENSG00000198203.
ENST00000326853; ENSP00000319622; ENSG00000198203.

GeneID

6819.

KEGG

hsa:6819.

UCSC

uc002tdx.3. human.
uc002tdy.3. human.

Organism-specific databases

CTD

6819.

GeneCards

GC02P108905.

HGNC

HGNC:11456. SULT1C2.

HPA

HPA007190.

MIM

602385. gene.

neXtProt

NX_O00338.

PharmGKB

PA164742557.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG260792.

HOGENOM

HOG000037209.

HOVERGEN

HBG001195.

KO

K01025.

OrthoDB

EOG40S0G2.

Enzyme and pathway databases

BRENDA

2.8.2.1. 2681.

Reactome

REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

O00338.

Bgee

O00338.

CleanEx

HS_SULT1C2.

Genevestigator

O00338.

GermOnline

ENSG00000198203. Homo sapiens.

Family and domain databases

InterPro

IPR000863. Sulfotransferase_dom.
[Graphical view]

Pfam

PF00685. Sulfotransfer_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL1743295.

EvolutionaryTrace

O00338.

GenomeRNAi

6819.

NextBio

26627.

SOURCE

Search...

Entry information

Entry name

ST1C2_HUMAN

Accession

Primary (citable) accession number: O00338
Secondary accession number(s): B2R813, Q53SG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.