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O00337

- S28A1_HUMAN

UniProt

O00337 - S28A1_HUMAN

Protein

Sodium/nucleoside cotransporter 1

Gene

SLC28A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.

    GO - Molecular functioni

    1. nucleoside:sodium symporter activity Source: InterPro
    2. nucleoside binding Source: InterPro
    3. nucleoside transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. nucleobase-containing compound metabolic process Source: ProtInc
    2. nucleoside transmembrane transport Source: GOC
    3. nucleoside transport Source: ProtInc
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.41.2.3. the concentrative nucleoside transporter (cnt) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/nucleoside cotransporter 1
    Alternative name(s):
    Concentrative nucleoside transporter 1
    Short name:
    CNT 1
    Short name:
    hCNT1
    Na(+)/nucleoside cotransporter 1
    Sodium-coupled nucleoside transporter 1
    Solute carrier family 28 member 1
    Gene namesi
    Name:SLC28A1
    Synonyms:CNT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:11001. SLC28A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi318 – 3181S → G: Enables transport of purine nucleosides. 1 Publication
    Mutagenesisi319 – 3191Q → M: Increases transport of purine nucleosides; when associated with Gly-319. 1 Publication
    Mutagenesisi352 – 3521S → T: Produces a full purine-type transporter; when associated with Gly-319 and Met-320. 1 Publication

    Organism-specific databases

    PharmGKBiPA387.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 649649Sodium/nucleoside cotransporter 1PRO_0000070446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi643 – 6431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO00337.
    PRIDEiO00337.

    PTM databases

    PhosphoSiteiO00337.

    Expressioni

    Tissue specificityi

    Expressed in kidney.

    Gene expression databases

    ArrayExpressiO00337.
    BgeeiO00337.
    CleanExiHS_SLC28A1.
    GenevestigatoriO00337.

    Organism-specific databases

    HPAiHPA019551.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000286749.

    Structurei

    3D structure databases

    ProteinModelPortaliO00337.
    SMRiO00337. Positions 179-590.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8080CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini105 – 1095ExtracellularSequence Analysis
    Topological domaini129 – 14719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini168 – 17811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini196 – 2016CytoplasmicSequence Analysis
    Topological domaini223 – 26139ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini284 – 29411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini319 – 33719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini361 – 3666CytoplasmicSequence Analysis
    Topological domaini387 – 42337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini447 – 45711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini480 – 53455ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini559 – 56911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini593 – 64957ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei81 – 10424HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 12819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19517HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31824HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 36023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei535 – 55824HelicalSequence AnalysisAdd
    BLAST
    Transmembranei570 – 59223HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi609 – 6124Poly-Ser

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1972.
    HOVERGENiHBG054073.
    InParanoidiO00337.
    KOiK11536.
    OMAiPDIFENV.
    OrthoDBiEOG7RV9FR.
    PhylomeDBiO00337.
    TreeFamiTF314131.

    Family and domain databases

    InterProiIPR008276. C_nuclsd_transpt.
    IPR018270. C_nuclsd_transpt_met_bac.
    IPR011657. CNT_C_dom.
    IPR002668. CNT_N_dom.
    IPR011642. Nucleoside_recog_Gate.
    [Graphical view]
    PANTHERiPTHR10590. PTHR10590. 1 hit.
    PfamiPF07670. Gate. 1 hit.
    PF07662. Nucleos_tra2_C. 1 hit.
    PF01773. Nucleos_tra2_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00804. nupC. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O00337-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS    50
    WSEAAPKPFS RWRNLQPALR ARSFCREHMQ LFRWIGTGLL CTGLSAFLLV 100
    ACLLDFQRAL ALFVLTCVVL TFLGHRLLKR LLGPKLRRFL KPQGHPRLLL 150
    WFKRGLALAA FLGLVLWLSL DTSQRPEQLV SFAGICVFVA LLFACSKHHC 200
    AVSWRAVSWG LGLQFVLGLL VIRTEPGFIA FEWLGEQIRI FLSYTKAGSS 250
    FVFGEALVKD VFAFQVLPII VFFSCVISVL YHVGLMQWVI LKIAWLMQVT 300
    MGTTATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA 350
    GSLLGAYISF GIDATSLIAA SVMAAPCALA LSKLVYPEVE ESKFRREEGV 400
    KLTYGDAQNL IEAASTGAAI SVKVVANIAA NLIAFLAVLD FINAALSWLG 450
    DMVDIQGLSF QLICSYILRP VAFLMGVAWE DCPVVAELLG IKLFLNEFVA 500
    YQDLSKYKQR RLAGAEEWVG DRKQWISVRA EVLTTFALCG FANFSSIGIM 550
    LGGLTSMVPQ RKSDFSQIVL RALFTGACVS LVNACMAGIL YMPRGAEVDC 600
    MSLLNTTLSS SSFEIYQCCR EAFQSVNPEF SPEALDNCCR FYNHTICAQ 649
    Length:649
    Mass (Da):71,584
    Last modified:May 5, 2009 - v2
    Checksum:i42E952443B46B102
    GO
    Isoform 2 (identifier: O00337-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         155-175: GLALAAFLGLVLWLSLDTSQR → DPRPWSKEGPNQYLPQITWTV
         176-649: Missing.

    Show »
    Length:175
    Mass (Da):20,180
    Checksum:i34C7DD93D84F60EE
    GO

    Polymorphismi

    Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341E → G in A. 2 Publications
    VAR_009499
    Natural varianti140 – 1401L → LV in A. 2 Publications
    VAR_009500
    Natural varianti189 – 1891V → I in A. 2 Publications
    Corresponds to variant rs2290272 [ dbSNP | Ensembl ].
    VAR_009501
    Natural varianti190 – 1901A → S.
    Corresponds to variant rs45523532 [ dbSNP | Ensembl ].
    VAR_057194
    Natural varianti237 – 2371Q → K.
    Corresponds to variant rs8187758 [ dbSNP | Ensembl ].
    VAR_057195
    Natural varianti409 – 4091N → S in B. 1 Publication
    VAR_009502
    Natural varianti510 – 5101R → C.1 Publication
    Corresponds to variant rs2242047 [ dbSNP | Ensembl ].
    VAR_057196
    Natural varianti521 – 5211D → N in B and C. 2 Publications
    Corresponds to variant rs2242046 [ dbSNP | Ensembl ].
    VAR_009503
    Natural varianti546 – 5461S → P.
    Corresponds to variant rs45584739 [ dbSNP | Ensembl ].
    VAR_061802

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei155 – 17521GLALA…DTSQR → DPRPWSKEGPNQYLPQITWT V in isoform 2. 1 PublicationVSP_037221Add
    BLAST
    Alternative sequencei176 – 649474Missing in isoform 2. 1 PublicationVSP_037222Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62966 mRNA. Translation: AAB53837.1.
    U62967 mRNA. Translation: AAB53838.1.
    U62968 mRNA. Translation: AAB53839.1.
    AF187978
    , AF187969, AF187970, AF187971, AF187972, AF187973, AF187974, AF187975, AF187976, AF187977 Genomic DNA. Translation: AAF15353.1.
    AK291997 mRNA. Translation: BAF84686.1.
    AC087468 Genomic DNA. No translation available.
    AC103741 Genomic DNA. No translation available.
    BC029788 mRNA. Translation: AAH29788.1.
    BC039898 mRNA. Translation: AAH39898.1.
    BC126204 mRNA. Translation: AAI26205.1.
    BC126206 mRNA. Translation: AAI26207.1.
    CCDSiCCDS10334.1. [O00337-1]
    CCDS10335.1. [O00337-2]
    RefSeqiNP_001274691.1. NM_001287762.1. [O00337-1]
    NP_004204.3. NM_004213.4. [O00337-1]
    NP_964014.1. NM_201651.2. [O00337-2]
    XP_005255046.1. XM_005254989.2. [O00337-1]
    XP_005255048.1. XM_005254991.2. [O00337-1]
    UniGeneiHs.459187.

    Genome annotation databases

    EnsembliENST00000286749; ENSP00000286749; ENSG00000156222. [O00337-1]
    ENST00000338602; ENSP00000341629; ENSG00000156222. [O00337-2]
    ENST00000394573; ENSP00000378074; ENSG00000156222. [O00337-1]
    GeneIDi9154.
    KEGGihsa:9154.
    UCSCiuc002blf.3. human. [O00337-2]
    uc002blg.3. human. [O00337-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62966 mRNA. Translation: AAB53837.1 .
    U62967 mRNA. Translation: AAB53838.1 .
    U62968 mRNA. Translation: AAB53839.1 .
    AF187978
    , AF187969 , AF187970 , AF187971 , AF187972 , AF187973 , AF187974 , AF187975 , AF187976 , AF187977 Genomic DNA. Translation: AAF15353.1 .
    AK291997 mRNA. Translation: BAF84686.1 .
    AC087468 Genomic DNA. No translation available.
    AC103741 Genomic DNA. No translation available.
    BC029788 mRNA. Translation: AAH29788.1 .
    BC039898 mRNA. Translation: AAH39898.1 .
    BC126204 mRNA. Translation: AAI26205.1 .
    BC126206 mRNA. Translation: AAI26207.1 .
    CCDSi CCDS10334.1. [O00337-1 ]
    CCDS10335.1. [O00337-2 ]
    RefSeqi NP_001274691.1. NM_001287762.1. [O00337-1 ]
    NP_004204.3. NM_004213.4. [O00337-1 ]
    NP_964014.1. NM_201651.2. [O00337-2 ]
    XP_005255046.1. XM_005254989.2. [O00337-1 ]
    XP_005255048.1. XM_005254991.2. [O00337-1 ]
    UniGenei Hs.459187.

    3D structure databases

    ProteinModelPortali O00337.
    SMRi O00337. Positions 179-590.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000286749.

    Chemistry

    BindingDBi O00337.
    ChEMBLi CHEMBL5551.

    Protein family/group databases

    TCDBi 2.A.41.2.3. the concentrative nucleoside transporter (cnt) family.

    PTM databases

    PhosphoSitei O00337.

    Proteomic databases

    PaxDbi O00337.
    PRIDEi O00337.

    Protocols and materials databases

    DNASUi 9154.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286749 ; ENSP00000286749 ; ENSG00000156222 . [O00337-1 ]
    ENST00000338602 ; ENSP00000341629 ; ENSG00000156222 . [O00337-2 ]
    ENST00000394573 ; ENSP00000378074 ; ENSG00000156222 . [O00337-1 ]
    GeneIDi 9154.
    KEGGi hsa:9154.
    UCSCi uc002blf.3. human. [O00337-2 ]
    uc002blg.3. human. [O00337-1 ]

    Organism-specific databases

    CTDi 9154.
    GeneCardsi GC15P085427.
    HGNCi HGNC:11001. SLC28A1.
    HPAi HPA019551.
    MIMi 606207. gene.
    neXtProti NX_O00337.
    PharmGKBi PA387.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1972.
    HOVERGENi HBG054073.
    InParanoidi O00337.
    KOi K11536.
    OMAi PDIFENV.
    OrthoDBi EOG7RV9FR.
    PhylomeDBi O00337.
    TreeFami TF314131.

    Enzyme and pathway databases

    Reactomei REACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

    Miscellaneous databases

    GeneWikii Concentrative_nucleoside_transporter_1.
    GenomeRNAii 9154.
    NextBioi 34343.
    PROi O00337.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00337.
    Bgeei O00337.
    CleanExi HS_SLC28A1.
    Genevestigatori O00337.

    Family and domain databases

    InterProi IPR008276. C_nuclsd_transpt.
    IPR018270. C_nuclsd_transpt_met_bac.
    IPR011657. CNT_C_dom.
    IPR002668. CNT_N_dom.
    IPR011642. Nucleoside_recog_Gate.
    [Graphical view ]
    PANTHERi PTHR10590. PTHR10590. 1 hit.
    Pfami PF07670. Gate. 1 hit.
    PF07662. Nucleos_tra2_C. 1 hit.
    PF01773. Nucleos_tra2_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00804. nupC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)."
      Ritzel M.W.L., Yao S.Y.M., Huang M.-Y., Elliott J.F., Cass C.E., Young J.D.
      Am. J. Physiol. 272:C707-C714(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS A GLY-34; VAL-140 INS AND ILE-189, VARIANTS B SER-409 AND ASN-521, VARIANT C ASN-521.
      Tissue: Kidney.
    2. "Genomic organization and sequence of the gene encoding the human sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1)."
      Ritzel M.W.L., Ritzel R.G., Cass C.E., Young J.D.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT A GLY-34.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT A ILE-189, VARIANT B ASN-521, VARIANT C ASN-521.
      Tissue: Small intestine.
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS A VAL-140 INS AND CYS-510.
      Tissue: Colon.
    6. "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2."
      Loewen S.K., Ng A.M.L., Yao S.Y.M., Cass C.E., Baldwin S.A., Young J.D.
      J. Biol. Chem. 274:24475-24484(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF SER-318; GLN-319 AND SER-352.

    Entry informationi

    Entry nameiS28A1_HUMAN
    AccessioniPrimary (citable) accession number: O00337
    Secondary accession number(s): A0AV42
    , A8K7I2, O00335, O00336, Q5U5S6, Q5U648, Q9UEZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3