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O00337

- S28A1_HUMAN

UniProt

O00337 - S28A1_HUMAN

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Protein

Sodium/nucleoside cotransporter 1

Gene

SLC28A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.

GO - Molecular functioni

  1. nucleoside:sodium symporter activity Source: InterPro
  2. nucleoside binding Source: InterPro
  3. nucleoside transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. nucleobase-containing compound metabolic process Source: ProtInc
  2. nucleoside transmembrane transport Source: GOC
  3. nucleoside transport Source: ProtInc
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Protein family/group databases

TCDBi2.A.41.2.3. the concentrative nucleoside transporter (cnt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/nucleoside cotransporter 1
Alternative name(s):
Concentrative nucleoside transporter 1
Short name:
CNT 1
Short name:
hCNT1
Na(+)/nucleoside cotransporter 1
Sodium-coupled nucleoside transporter 1
Solute carrier family 28 member 1
Gene namesi
Name:SLC28A1
Synonyms:CNT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:11001. SLC28A1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi318 – 3181S → G: Enables transport of purine nucleosides. 1 Publication
Mutagenesisi319 – 3191Q → M: Increases transport of purine nucleosides; when associated with Gly-319. 1 Publication
Mutagenesisi352 – 3521S → T: Produces a full purine-type transporter; when associated with Gly-319 and Met-320. 1 Publication

Organism-specific databases

PharmGKBiPA387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 649649Sodium/nucleoside cotransporter 1PRO_0000070446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi643 – 6431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO00337.
PRIDEiO00337.

PTM databases

PhosphoSiteiO00337.

Expressioni

Tissue specificityi

Expressed in kidney.

Gene expression databases

BgeeiO00337.
CleanExiHS_SLC28A1.
ExpressionAtlasiO00337. baseline and differential.
GenevestigatoriO00337.

Organism-specific databases

HPAiHPA019551.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000286749.

Structurei

3D structure databases

ProteinModelPortaliO00337.
SMRiO00337. Positions 179-590.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8080CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini105 – 1095ExtracellularSequence Analysis
Topological domaini129 – 14719CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini168 – 17811ExtracellularSequence AnalysisAdd
BLAST
Topological domaini196 – 2016CytoplasmicSequence Analysis
Topological domaini223 – 26139ExtracellularSequence AnalysisAdd
BLAST
Topological domaini284 – 29411CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini319 – 33719ExtracellularSequence AnalysisAdd
BLAST
Topological domaini361 – 3666CytoplasmicSequence Analysis
Topological domaini387 – 42337ExtracellularSequence AnalysisAdd
BLAST
Topological domaini447 – 45711CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini480 – 53455ExtracellularSequence AnalysisAdd
BLAST
Topological domaini559 – 56911CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini593 – 64957ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei81 – 10424HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 12819HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16720HelicalSequence AnalysisAdd
BLAST
Transmembranei179 – 19517HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28322HelicalSequence AnalysisAdd
BLAST
Transmembranei295 – 31824HelicalSequence AnalysisAdd
BLAST
Transmembranei338 – 36023HelicalSequence AnalysisAdd
BLAST
Transmembranei367 – 38620HelicalSequence AnalysisAdd
BLAST
Transmembranei424 – 44623HelicalSequence AnalysisAdd
BLAST
Transmembranei458 – 47922HelicalSequence AnalysisAdd
BLAST
Transmembranei535 – 55824HelicalSequence AnalysisAdd
BLAST
Transmembranei570 – 59223HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi609 – 6124Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1972.
GeneTreeiENSGT00390000016025.
HOVERGENiHBG054073.
InParanoidiO00337.
KOiK11536.
OMAiPDIFENV.
OrthoDBiEOG7RV9FR.
PhylomeDBiO00337.
TreeFamiTF314131.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00337-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS
60 70 80 90 100
WSEAAPKPFS RWRNLQPALR ARSFCREHMQ LFRWIGTGLL CTGLSAFLLV
110 120 130 140 150
ACLLDFQRAL ALFVLTCVVL TFLGHRLLKR LLGPKLRRFL KPQGHPRLLL
160 170 180 190 200
WFKRGLALAA FLGLVLWLSL DTSQRPEQLV SFAGICVFVA LLFACSKHHC
210 220 230 240 250
AVSWRAVSWG LGLQFVLGLL VIRTEPGFIA FEWLGEQIRI FLSYTKAGSS
260 270 280 290 300
FVFGEALVKD VFAFQVLPII VFFSCVISVL YHVGLMQWVI LKIAWLMQVT
310 320 330 340 350
MGTTATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA
360 370 380 390 400
GSLLGAYISF GIDATSLIAA SVMAAPCALA LSKLVYPEVE ESKFRREEGV
410 420 430 440 450
KLTYGDAQNL IEAASTGAAI SVKVVANIAA NLIAFLAVLD FINAALSWLG
460 470 480 490 500
DMVDIQGLSF QLICSYILRP VAFLMGVAWE DCPVVAELLG IKLFLNEFVA
510 520 530 540 550
YQDLSKYKQR RLAGAEEWVG DRKQWISVRA EVLTTFALCG FANFSSIGIM
560 570 580 590 600
LGGLTSMVPQ RKSDFSQIVL RALFTGACVS LVNACMAGIL YMPRGAEVDC
610 620 630 640
MSLLNTTLSS SSFEIYQCCR EAFQSVNPEF SPEALDNCCR FYNHTICAQ
Length:649
Mass (Da):71,584
Last modified:May 5, 2009 - v2
Checksum:i42E952443B46B102
GO
Isoform 2 (identifier: O00337-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-175: GLALAAFLGLVLWLSLDTSQR → DPRPWSKEGPNQYLPQITWTV
     176-649: Missing.

Show »
Length:175
Mass (Da):20,180
Checksum:i34C7DD93D84F60EE
GO

Polymorphismi

Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341E → G in A. 2 Publications
VAR_009499
Natural varianti140 – 1401L → LV in A. 2 Publications
VAR_009500
Natural varianti189 – 1891V → I in A. 2 Publications
Corresponds to variant rs2290272 [ dbSNP | Ensembl ].
VAR_009501
Natural varianti190 – 1901A → S.
Corresponds to variant rs45523532 [ dbSNP | Ensembl ].
VAR_057194
Natural varianti237 – 2371Q → K.
Corresponds to variant rs8187758 [ dbSNP | Ensembl ].
VAR_057195
Natural varianti409 – 4091N → S in B. 1 Publication
VAR_009502
Natural varianti510 – 5101R → C.1 Publication
Corresponds to variant rs2242047 [ dbSNP | Ensembl ].
VAR_057196
Natural varianti521 – 5211D → N in B and C. 2 Publications
Corresponds to variant rs2242046 [ dbSNP | Ensembl ].
VAR_009503
Natural varianti546 – 5461S → P.
Corresponds to variant rs45584739 [ dbSNP | Ensembl ].
VAR_061802

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei155 – 17521GLALA…DTSQR → DPRPWSKEGPNQYLPQITWT V in isoform 2. 1 PublicationVSP_037221Add
BLAST
Alternative sequencei176 – 649474Missing in isoform 2. 1 PublicationVSP_037222Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62966 mRNA. Translation: AAB53837.1.
U62967 mRNA. Translation: AAB53838.1.
U62968 mRNA. Translation: AAB53839.1.
AF187978
, AF187969, AF187970, AF187971, AF187972, AF187973, AF187974, AF187975, AF187976, AF187977 Genomic DNA. Translation: AAF15353.1.
AK291997 mRNA. Translation: BAF84686.1.
AC087468 Genomic DNA. No translation available.
AC103741 Genomic DNA. No translation available.
BC029788 mRNA. Translation: AAH29788.1.
BC039898 mRNA. Translation: AAH39898.1.
BC126204 mRNA. Translation: AAI26205.1.
BC126206 mRNA. Translation: AAI26207.1.
CCDSiCCDS10334.1. [O00337-1]
CCDS10335.1. [O00337-2]
RefSeqiNP_001274691.1. NM_001287762.1. [O00337-1]
NP_004204.3. NM_004213.4. [O00337-1]
NP_964014.1. NM_201651.2. [O00337-2]
XP_005255046.1. XM_005254989.2. [O00337-1]
XP_005255048.1. XM_005254991.2. [O00337-1]
UniGeneiHs.459187.

Genome annotation databases

EnsembliENST00000286749; ENSP00000286749; ENSG00000156222. [O00337-1]
ENST00000338602; ENSP00000341629; ENSG00000156222. [O00337-2]
ENST00000394573; ENSP00000378074; ENSG00000156222. [O00337-1]
GeneIDi9154.
KEGGihsa:9154.
UCSCiuc002blf.3. human. [O00337-2]
uc002blg.3. human. [O00337-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62966 mRNA. Translation: AAB53837.1 .
U62967 mRNA. Translation: AAB53838.1 .
U62968 mRNA. Translation: AAB53839.1 .
AF187978
, AF187969 , AF187970 , AF187971 , AF187972 , AF187973 , AF187974 , AF187975 , AF187976 , AF187977 Genomic DNA. Translation: AAF15353.1 .
AK291997 mRNA. Translation: BAF84686.1 .
AC087468 Genomic DNA. No translation available.
AC103741 Genomic DNA. No translation available.
BC029788 mRNA. Translation: AAH29788.1 .
BC039898 mRNA. Translation: AAH39898.1 .
BC126204 mRNA. Translation: AAI26205.1 .
BC126206 mRNA. Translation: AAI26207.1 .
CCDSi CCDS10334.1. [O00337-1 ]
CCDS10335.1. [O00337-2 ]
RefSeqi NP_001274691.1. NM_001287762.1. [O00337-1 ]
NP_004204.3. NM_004213.4. [O00337-1 ]
NP_964014.1. NM_201651.2. [O00337-2 ]
XP_005255046.1. XM_005254989.2. [O00337-1 ]
XP_005255048.1. XM_005254991.2. [O00337-1 ]
UniGenei Hs.459187.

3D structure databases

ProteinModelPortali O00337.
SMRi O00337. Positions 179-590.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000286749.

Chemistry

BindingDBi O00337.
ChEMBLi CHEMBL5551.
DrugBanki DB00441. Gemcitabine.
DB00649. Stavudine.
DB00495. Zidovudine.

Protein family/group databases

TCDBi 2.A.41.2.3. the concentrative nucleoside transporter (cnt) family.

PTM databases

PhosphoSitei O00337.

Proteomic databases

PaxDbi O00337.
PRIDEi O00337.

Protocols and materials databases

DNASUi 9154.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286749 ; ENSP00000286749 ; ENSG00000156222 . [O00337-1 ]
ENST00000338602 ; ENSP00000341629 ; ENSG00000156222 . [O00337-2 ]
ENST00000394573 ; ENSP00000378074 ; ENSG00000156222 . [O00337-1 ]
GeneIDi 9154.
KEGGi hsa:9154.
UCSCi uc002blf.3. human. [O00337-2 ]
uc002blg.3. human. [O00337-1 ]

Organism-specific databases

CTDi 9154.
GeneCardsi GC15P085427.
HGNCi HGNC:11001. SLC28A1.
HPAi HPA019551.
MIMi 606207. gene.
neXtProti NX_O00337.
PharmGKBi PA387.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1972.
GeneTreei ENSGT00390000016025.
HOVERGENi HBG054073.
InParanoidi O00337.
KOi K11536.
OMAi PDIFENV.
OrthoDBi EOG7RV9FR.
PhylomeDBi O00337.
TreeFami TF314131.

Enzyme and pathway databases

Reactomei REACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

GeneWikii Concentrative_nucleoside_transporter_1.
GenomeRNAii 9154.
NextBioi 34343.
PROi O00337.
SOURCEi Search...

Gene expression databases

Bgeei O00337.
CleanExi HS_SLC28A1.
ExpressionAtlasi O00337. baseline and differential.
Genevestigatori O00337.

Family and domain databases

InterProi IPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view ]
PANTHERi PTHR10590. PTHR10590. 1 hit.
Pfami PF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00804. nupC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)."
    Ritzel M.W.L., Yao S.Y.M., Huang M.-Y., Elliott J.F., Cass C.E., Young J.D.
    Am. J. Physiol. 272:C707-C714(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS A GLY-34; VAL-140 INS AND ILE-189, VARIANTS B SER-409 AND ASN-521, VARIANT C ASN-521.
    Tissue: Kidney.
  2. "Genomic organization and sequence of the gene encoding the human sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1)."
    Ritzel M.W.L., Ritzel R.G., Cass C.E., Young J.D.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT A GLY-34.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT A ILE-189, VARIANT B ASN-521, VARIANT C ASN-521.
    Tissue: Small intestine.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS A VAL-140 INS AND CYS-510.
    Tissue: Colon.
  6. "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2."
    Loewen S.K., Ng A.M.L., Yao S.Y.M., Cass C.E., Baldwin S.A., Young J.D.
    J. Biol. Chem. 274:24475-24484(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF SER-318; GLN-319 AND SER-352.

Entry informationi

Entry nameiS28A1_HUMAN
AccessioniPrimary (citable) accession number: O00337
Secondary accession number(s): A0AV42
, A8K7I2, O00335, O00336, Q5U5S6, Q5U648, Q9UEZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3