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1 to 25 of 59  Show
  1. 1
    "H. sapiens mRNA for phosphoinositide 3-kinase delta catalytic subunit."
    Mahlum C.E., Becker K.P., Morris A.J.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).
  2. 2
    "Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement."
    Sadhu C., Masinovsky B., Dick K., Sowell C.G., Staunton D.E.
    J. Immunol. 170:2647-2654(2003) [PubMed] [Europe PMC] [Abstract]
    Annotation: PI3K delta can play a selective role in the amplification of phosphatidylinositol (3 4 5) trisphosphate (PIP3) levels that lead to neutrophil polarization and regulate directional migration but not random locomotion.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 9 other entries.

  3. 3
    "Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia."
    Sujobert P., Bardet V., Cornillet-Lefebvre P., Hayflick J.S., Prie N., Verdier F., Vanhaesebroeck B., Muller O., Pesce F., Ifrah N., Hunault-Berger M., Berthou C., Villemagne B., Jourdan E., Audhuy B., Solary E., Witz B., Harousseau J.L.
    , Himberlin C., Lamy T., Lioure B., Cahn J.Y., Dreyfus F., Mayeux P., Lacombe C., Bouscary D.
    Blood 106:1063-1066(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: p110delta isoform of PI3K is consistently expressed at a high level in blast cells from AML in contrast to the other class I isoformsImported.
    Source: GeneRIF:5293.

    This publication is mapped to 9 other entries.

  4. 4
    "Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils."
    Condliffe A.M., Davidson K., Anderson K.E., Ellson C.D., Crabbe T., Okkenhaug K., Vanhaesebroeck B., Turner M., Webb L., Wymann M.P., Hirsch E., Ruckle T., Camps M., Rommel C., Jackson S.P., Chilvers E.R., Stephens L.R., Hawkins P.T.
    Blood 106:1432-1440(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: Stimulation of TNF-alpha-primed human neutrophils with fMLP results in biphasic activation of PI3K; the first phase is largely dependent on PI3Kgamma; the second phase is largely dependent on PI3Kdelta and regulates parallel activation of ROS productionImported.
    Source: GeneRIF:5293.

    This publication is mapped to 22 other entries.

  5. 5
    "Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase."
    Kang S., Denley A., Vanhaesebroeck B., Vogt P.K.
    Proc. Natl. Acad. Sci. U.S.A. 103:1289-1294(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: p110beta -gamma and -delta isoforms of class I phosphoinositide 3-kinase have roles in oncogenic transformationImported.
    Source: GeneRIF:5293.

    This publication is mapped to 20 other entries.

  6. 6
    "Identification of variations in the human phosphoinositide 3-kinase p110delta gene in children with primary B-cell immunodeficiency of unknown aetiology."
    Jou S.T., Chien Y.H., Yang Y.H., Wang T.C., Shyur S.D., Chou C.C., Chang M.L., Lin D.T., Lin K.H., Chiang B.L.
    Int. J. Immunogenet. 33:361-369(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: These findings could shed light on further understanding the polymorphisms of p110delta in B-cell immunodeficiency and different populations.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 9 other entries.

  7. 7
    "The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells."
    Okkenhaug K., Patton D.T., Bilancio A., Garcon F., Rowan W.C., Vanhaesebroeck B.
    J. Immunol. 177:5122-5128(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: p110delta contributes significantly to Th cell expansion and differentiation in vitro and in vivo also in the context of CD28 costimulation.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 25 other entries.

  8. 8
    "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?"
    Rommel C., Camps M., Ji H.
    Nat. Rev. Immunol. 7:191-201(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: This review describes the second-messenger PI3K delta signalling pathways that are involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.Imported.
    Source: GeneRIF:5293.

    This publication is cited by 1 and mapped to 12 other entries.

  9. 9
    "The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN."
    Papakonstanti E.A., Ridley A.J., Vanhaesebroeck B.
    EMBO J. 26:3050-3061(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: identifies the RhoA/ROCK pathway as a major target of p110delta-mediated PI3K signallingImported.
    Source: GeneRIF:5293.

    This publication is mapped to 32 other entries.

  10. 10
    "Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells."
    Boller D., Schramm A., Doepfner K.T., Shalaby T., von Bueren A.O., Eggert A., Grotzer M.A., Arcaro A.
    Clin. Cancer Res. 14:1172-1181(2008) [PubMed] [Europe PMC] [Abstract]
    Annotation: novel function of the class I(A) PI3K isoform p110delta in neuroblastoma growth and survival.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 9 other entries.

  11. 11
    "The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase."
    Tsuboi N., Utsunomiya T., Roberts R.L., Ito H., Takahashi K., Noda M., Takahashi T.
    Biochem. J. 413:193-200(2008) [PubMed] [Europe PMC] [Abstract]
    Annotation: These results demonstrate that CD148 may interact with and dephosphorylate p85 when it is phosphorylated and modulate the magnitude of phosphoinositide 3-kinase activity.Imported.
    Source: GeneRIF:5293.

    This publication is cited by 2 and mapped to 10 other entries.

  12. 12
    "Differential regulation of cytokine production by PI3Kdelta in human monocytes upon acute and chronic inflammatory conditions."
    Molnarfi N., Brandt K.J., Gruaz L., Dayer J.M., Burger D.
    Mol. Immunol. 45:3419-3427(2008) [PubMed] [Europe PMC] [Abstract]
    Annotation: In contrast with PI3Kalpha beta and gamma PI3Kdelta accounts for most of the PI3K-dependent signaling ruling the production of IL-1beta IL-6 TNF and sIL-1Ra in monocytes.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 9 other entries.

  13. 13
    "Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone."
    Ruano G., Bernene J., Windemuth A., Bower B., Wencker D., Seip R.L., Kocherla M., Holford T.R., Petit W.A., Hanks S.
    Clin. Chim. Acta 400:48-55(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Not Associated with PHARMACOGENOMIC: BMI- Edema rosiglitazone or pioglitazone.Imported, Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)Imported.
    Source: GAD:594653, GeneRIF:5293.

    This publication is mapped to 721 other entries.

  14. 14
    "Regulation of p110delta PI 3-kinase gene expression."
    Kok K., Nock G.E., Verrall E.A., Mitchell M.P., Hommes D.W., Peppelenbosch M.P., Vanhaesebroeck B.
    PLoS ONE 4:e5145-e5145(2009) [PubMed] [Europe PMC] [Abstract]
    Annotation: Results identify a conserved phosphoinositide 3-kinase p11delta promoter region that may account for the predominant leukocyte expression of p110delta.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 18 other entries.

  15. 15
    "RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia."
    Edwards H., Xie C., LaFiura K.M., Dombkowski A.A., Buck S.A., Boerner J.L., Taub J.W., Matherly L.H., Ge Y.
    Blood 114:2744-2752(2009) [PubMed] [Europe PMC] [Abstract]
    Annotation: RUNX1 may play a critical role in chemotherapy response in acute megakaryocytic leukemia by regulating the PI3-kinase/Akt pathway.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 22 other entries.

  16. 16
    Annotation: Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 18198 other entries.

  17. 17
    "Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment."
    Segat L., Brandao L.A., Guimaraes R.L., Pontillo A., Athanasakis E., de Oliveira R.M., Arraes L.C., de Lima Filho J.L., Crovella S.
    Vaccine 28:2201-2206(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 586 other entries.

  18. 18
    "PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans."
    Soond D.R., Bjorgo E., Moltu K., Dale V.Q., Patton D.T., Torgersen K.M., Galleway F., Twomey B., Clark J., Gaston J.S.H., Tasken K., Bunyard P., Okkenhaug K.
    Blood 115:2203-2213(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: These studies establish that previously activated memory T cells are at least as sensitive to p110delta inhibition as naive T cells and show that mouse models accurately predict p110delta function in human T cells.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 23 other entries.

  19. 19
    "Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors."
    Edgar K.A., Wallin J.J., Berry M., Lee L.B., Prior W.W., Sampath D., Friedman L.S., Belvin M.
    Cancer Res. 70:1164-1172(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Data show that similar responses were seen in cancer cells with wild-type or activated mutant PI3K genes treated with p110alpha/delta or p110alpha/beta/delta inhibitors in cell viability assays.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 24 other entries.

  20. 20
    Annotation: Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 29 other entries.

  21. 21
    "A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease."
    Marwick J.A., Caramori G., Casolari P., Mazzoni F., Kirkham P.A., Adcock I.M., Chung K.F., Papi A.
    J. Allergy Clin. Immunol. 125:1146-1153(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: PI3Kdelta expression and signaling is increased in the lungs of patients with COPD.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 9 other entries.

  22. 22
    "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?"
    Ruano G., Thompson P.D., Kane J.P., Pullinger C.R., Windemuth A., Seip R.L., Kocherla M., Holford T.R., Wu A.H.
    Pharmacogenomics 11:959-971(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 1150 other entries.

  23. 23
    "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
    Bailey S.D., Xie C., Do R., Montpetit A., Diaz R., Mohan V., Keavney B., Yusuf S., Gerstein H.C., Engert J.C., Anand S.
    Diabetes Care 33:2250-2253(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 18147 other entries.

  24. 24
    "A novel MEK2/PI3Kdelta pathway controls the expression of IL-1 receptor antagonist in IFN-beta-activated human monocytes."
    Brandt K.J., Carpintero R., Gruaz L., Molnarfi N., Burger D.
    J. Leukoc. Biol. 88:1191-1200(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: IFN-beta triggers an atypical MEK2/PI3Kdelta signaling cascade to regulate sIL-1Ra expression in monocytes.Imported.
    Source: GeneRIF:5293.

    This publication is mapped to 17 other entries.

  25. 25
    "Enhanced phosphoinositide 3-kinase delta activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death."
    Suarez-Fueyo A., Barber D.F., Martinez-Ara J., Zea-Mendoza A.C., Carrera A.C.
    J. Immunol. 187:2376-2385(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: These observations suggest that PI3Kdelta contributes to induction of enhanced systemic lupus erythematosus memory T cell survivalImported.
    Source: GeneRIF:5293.

    This publication is mapped to 9 other entries.

1 to 25 of 59  Show