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O00334 (O00334_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
OrganismHomo sapiens (Human) EMBL AAB53966.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1068 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PIK helical domain.

Contains PI3K/PI4K domain. SAAS SAAS015433

Contains PIK helical domain. SAAS SAAS018936

Sequences

Sequence LengthMass (Da)Tools
O00334 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 2B342FDA445C9A31

FASTA1,068121,880
        10         20         30         40         50         60 
MPPGVDCPME FWTKEENQRV VVDFLLPTGV YLNFPVSRNA NLSTIKQLLW HRAQYEPLFH 

        70         80         90        100        110        120 
MLSAPKAYVF TCINQTAEQQ ELEDEQRRLC DVQPFLPVLR LVAREGDRVK KLINSQISLL 

       130        140        150        160        170        180 
IGKGLHEFDS LCDPEVNDFR AKMCQFCEEA AARRQQLGWE AWLQYSFPLQ LEPSAQTWGP 

       190        200        210        220        230        240 
GTLRLPNRAL LVNVKFEGSE ESFTFQVSTK DVPLALMACA LRKKATVFRQ PLVEQPEDYT 

       250        260        270        280        290        300 
LQVNGRHEYL YGSYPLCQFQ VQKPRAKPPP IPAKKPSSVS LWSLEQPFRI ELIQGSKVNA 

       310        320        330        340        350        360 
DERMKLVVQA GLFHGNEMLC KTVSSSEVSV CSEPVWKQRL EFDINICDLP RMARLCFALY 

       370        380        390        400        410        420 
AVIEKAKKAR STKKKSKKAD CPIAWANLML FDYKDQLKTG ERCLYMWPSV PDEKGELLNP 

       430        440        450        460        470        480 
TGTVRSNPNT DSAAALLICL PEVAPHPVYY PALEKLPGGM LLASREWRPE LLWMRLHAED 

       490        500        510        520        530        540 
SAPSRMIGVA MPGLGVLPGL VQAPGDAECS RLLQILELGR HSECVHVTEE EQLQLREILE 

       550        560        570        580        590        600 
RRGSGELYEH EKDLVWKLRH EVQEHFPEAL ARLLLVTKWN KHEDVAPDAL PAVSWPELPV 

       610        620        630        640        650        660 
LSALELLDFS FPDCHVGSFA IKSLRKLTDD ELFQYLLQLV QVLKYESYLD CELTKFLLER 

       670        680        690        700        710        720 
ALANRKIGHF LFWHLRSEMH VPSVALRFGL ILEAYCRGST HHMKVLMKQG EALSKLKALN 

       730        740        750        760        770        780 
DFVKLSSQKT PKPQTKELMH LCMRQEAYLE ALSHLQSPLD PSTLLAEVCV EQCTFMDSKM 

       790        800        810        820        830        840 
KPLWIMYSNE EAGSGGTVGI IFKNGDDLRQ DMLTLQMIQL MDVLWKQEGL DLRMTPYGCL 

       850        860        870        880        890        900 
PTGDRTGLIE VVLRSDTIAN IQLNKSNMAA TAAFNKDALL NWLKSKNPGE ALDRAIEEFT 

       910        920        930        940        950        960 
LSCAGYCVAT YVLGIGDRHS DNIMIRESGQ LFHIDFGHFL GNFKTKFGIN RERVPFILTY 

       970        980        990       1000       1010       1020 
DLVHVIQQGK TNNSEKFERF RGYCERAYTI LRRHGLLFLH LFALMRAAGL PELSCSKDIQ 

      1030       1040       1050       1060 
YLKDSLALGK TEEEALKHFR EKFNEALREG WKTKVNWLAH NVSKDNRQ 

« Hide

References

[1]"H. sapiens mRNA for phosphoinositide 3-kinase delta catalytic subunit."
Mahlum C.E., Becker K.P., Morris A.J.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily."
Ho L.K., Liu D., Rozycka M., Brown R.A., Fry M.J.
Biochem. Biophys. Res. Commun. 235:130-137(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U57843 mRNA. Translation: AAB53966.1.
PIRPC4348.
UniGeneHs.518451.

3D structure databases

ProteinModelPortalO00334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1399339.

Proteomic databases

PRIDEO00334.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000252911.
HOVERGENHBG052721.

Family and domain databases

Gene3D1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERPTHR10048. PTHR10048. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameO00334_HUMAN
AccessionPrimary (citable) accession number: O00334
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.