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Protein
Submitted name:

Phosphatidylinositol 3-kinase delta catalytic subunit

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. kinase activity Source: UniProtKB-KW
  3. phosphotransferase activity, alcohol group as acceptor Source: InterPro

GO - Biological processi

  1. phosphatidylinositol-mediated signaling Source: InterPro
  2. phosphatidylinositol phosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinase delta catalytic subunitImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiO00334.

Interactioni

Protein-protein interaction databases

MINTiMINT-1399339.

Structurei

3D structure databases

ProteinModelPortaliO00334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains PI3K/PI4K domain.SAAS annotation
Contains PIK helical domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000252911.
HOVERGENiHBG052721.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGVDCPME FWTKEENQRV VVDFLLPTGV YLNFPVSRNA NLSTIKQLLW
60 70 80 90 100
HRAQYEPLFH MLSAPKAYVF TCINQTAEQQ ELEDEQRRLC DVQPFLPVLR
110 120 130 140 150
LVAREGDRVK KLINSQISLL IGKGLHEFDS LCDPEVNDFR AKMCQFCEEA
160 170 180 190 200
AARRQQLGWE AWLQYSFPLQ LEPSAQTWGP GTLRLPNRAL LVNVKFEGSE
210 220 230 240 250
ESFTFQVSTK DVPLALMACA LRKKATVFRQ PLVEQPEDYT LQVNGRHEYL
260 270 280 290 300
YGSYPLCQFQ VQKPRAKPPP IPAKKPSSVS LWSLEQPFRI ELIQGSKVNA
310 320 330 340 350
DERMKLVVQA GLFHGNEMLC KTVSSSEVSV CSEPVWKQRL EFDINICDLP
360 370 380 390 400
RMARLCFALY AVIEKAKKAR STKKKSKKAD CPIAWANLML FDYKDQLKTG
410 420 430 440 450
ERCLYMWPSV PDEKGELLNP TGTVRSNPNT DSAAALLICL PEVAPHPVYY
460 470 480 490 500
PALEKLPGGM LLASREWRPE LLWMRLHAED SAPSRMIGVA MPGLGVLPGL
510 520 530 540 550
VQAPGDAECS RLLQILELGR HSECVHVTEE EQLQLREILE RRGSGELYEH
560 570 580 590 600
EKDLVWKLRH EVQEHFPEAL ARLLLVTKWN KHEDVAPDAL PAVSWPELPV
610 620 630 640 650
LSALELLDFS FPDCHVGSFA IKSLRKLTDD ELFQYLLQLV QVLKYESYLD
660 670 680 690 700
CELTKFLLER ALANRKIGHF LFWHLRSEMH VPSVALRFGL ILEAYCRGST
710 720 730 740 750
HHMKVLMKQG EALSKLKALN DFVKLSSQKT PKPQTKELMH LCMRQEAYLE
760 770 780 790 800
ALSHLQSPLD PSTLLAEVCV EQCTFMDSKM KPLWIMYSNE EAGSGGTVGI
810 820 830 840 850
IFKNGDDLRQ DMLTLQMIQL MDVLWKQEGL DLRMTPYGCL PTGDRTGLIE
860 870 880 890 900
VVLRSDTIAN IQLNKSNMAA TAAFNKDALL NWLKSKNPGE ALDRAIEEFT
910 920 930 940 950
LSCAGYCVAT YVLGIGDRHS DNIMIRESGQ LFHIDFGHFL GNFKTKFGIN
960 970 980 990 1000
RERVPFILTY DLVHVIQQGK TNNSEKFERF RGYCERAYTI LRRHGLLFLH
1010 1020 1030 1040 1050
LFALMRAAGL PELSCSKDIQ YLKDSLALGK TEEEALKHFR EKFNEALREG
1060
WKTKVNWLAH NVSKDNRQ
Length:1,068
Mass (Da):121,880
Last modified:July 1, 1997 - v1
Checksum:i2B342FDA445C9A31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57843 mRNA. Translation: AAB53966.1.
PIRiPC4348.
UniGeneiHs.518451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57843 mRNA. Translation: AAB53966.1.
PIRiPC4348.
UniGeneiHs.518451.

3D structure databases

ProteinModelPortaliO00334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1399339.

Proteomic databases

PRIDEiO00334.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000252911.
HOVERGENiHBG052721.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "H. sapiens mRNA for phosphoinositide 3-kinase delta catalytic subunit."
    Mahlum C.E., Becker K.P., Morris A.J.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily."
    Ho L.K., Liu D., Rozycka M., Brown R.A., Fry M.J.
    Biochem. Biophys. Res. Commun. 235:130-137(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO00334_HUMAN
AccessioniPrimary (citable) accession number: O00334
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: March 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.