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O00334

- O00334_HUMAN

UniProt

O00334 - O00334_HUMAN

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Protein
Submitted name:

Phosphatidylinositol 3-kinase delta catalytic subunit

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. kinase activity Source: UniProtKB-KW
  3. phosphotransferase activity, alcohol group as acceptor Source: InterPro

GO - Biological processi

  1. phosphatidylinositol-mediated signaling Source: InterPro
  2. phosphatidylinositol phosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationsImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinase delta catalytic subunitImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiO00334.

Interactioni

Protein-protein interaction databases

MINTiMINT-1399339.

Structurei

3D structure databases

ProteinModelPortaliO00334.

Family & Domainsi

Sequence similaritiesi

Contains 1 PIK helical domain.
Contains PI3K/PI4K domain.SAAS annotations
Contains PIK helical domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000252911.
HOVERGENiHBG052721.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00334-1 [UniParc]FASTAAdd to Basket

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MPPGVDCPME FWTKEENQRV VVDFLLPTGV YLNFPVSRNA NLSTIKQLLW     50
HRAQYEPLFH MLSAPKAYVF TCINQTAEQQ ELEDEQRRLC DVQPFLPVLR 100
LVAREGDRVK KLINSQISLL IGKGLHEFDS LCDPEVNDFR AKMCQFCEEA 150
AARRQQLGWE AWLQYSFPLQ LEPSAQTWGP GTLRLPNRAL LVNVKFEGSE 200
ESFTFQVSTK DVPLALMACA LRKKATVFRQ PLVEQPEDYT LQVNGRHEYL 250
YGSYPLCQFQ VQKPRAKPPP IPAKKPSSVS LWSLEQPFRI ELIQGSKVNA 300
DERMKLVVQA GLFHGNEMLC KTVSSSEVSV CSEPVWKQRL EFDINICDLP 350
RMARLCFALY AVIEKAKKAR STKKKSKKAD CPIAWANLML FDYKDQLKTG 400
ERCLYMWPSV PDEKGELLNP TGTVRSNPNT DSAAALLICL PEVAPHPVYY 450
PALEKLPGGM LLASREWRPE LLWMRLHAED SAPSRMIGVA MPGLGVLPGL 500
VQAPGDAECS RLLQILELGR HSECVHVTEE EQLQLREILE RRGSGELYEH 550
EKDLVWKLRH EVQEHFPEAL ARLLLVTKWN KHEDVAPDAL PAVSWPELPV 600
LSALELLDFS FPDCHVGSFA IKSLRKLTDD ELFQYLLQLV QVLKYESYLD 650
CELTKFLLER ALANRKIGHF LFWHLRSEMH VPSVALRFGL ILEAYCRGST 700
HHMKVLMKQG EALSKLKALN DFVKLSSQKT PKPQTKELMH LCMRQEAYLE 750
ALSHLQSPLD PSTLLAEVCV EQCTFMDSKM KPLWIMYSNE EAGSGGTVGI 800
IFKNGDDLRQ DMLTLQMIQL MDVLWKQEGL DLRMTPYGCL PTGDRTGLIE 850
VVLRSDTIAN IQLNKSNMAA TAAFNKDALL NWLKSKNPGE ALDRAIEEFT 900
LSCAGYCVAT YVLGIGDRHS DNIMIRESGQ LFHIDFGHFL GNFKTKFGIN 950
RERVPFILTY DLVHVIQQGK TNNSEKFERF RGYCERAYTI LRRHGLLFLH 1000
LFALMRAAGL PELSCSKDIQ YLKDSLALGK TEEEALKHFR EKFNEALREG 1050
WKTKVNWLAH NVSKDNRQ 1068
Length:1,068
Mass (Da):121,880
Last modified:July 1, 1997 - v1
Checksum:i2B342FDA445C9A31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57843 mRNA. Translation: AAB53966.1.
PIRiPC4348.
UniGeneiHs.518451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57843 mRNA. Translation: AAB53966.1 .
PIRi PC4348.
UniGenei Hs.518451.

3D structure databases

ProteinModelPortali O00334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1399339.

Proteomic databases

PRIDEi O00334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000252911.
HOVERGENi HBG052721.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
SMARTi SM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "H. sapiens mRNA for phosphoinositide 3-kinase delta catalytic subunit."
    Mahlum C.E., Becker K.P., Morris A.J.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily."
    Ho L.K., Liu D., Rozycka M., Brown R.A., Fry M.J.
    Biochem. Biophys. Res. Commun. 235:130-137(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO00334_HUMAN
AccessioniPrimary (citable) accession number: O00334
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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