Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Phosphatidylinositol 3-kinase delta catalytic subunit

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinase delta catalytic subunitImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiO00334
PRIDEiO00334

Structurei

3D structure databases

ProteinModelPortaliO00334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 105PI3K-ABDInterPro annotationAdd BLAST90
Domaini187 – 278PI3K-RBDInterPro annotationAdd BLAST92
Domaini284 – 441C2 PI3K-typeInterPro annotationAdd BLAST158
Domaini521 – 698PIK helicalInterPro annotationAdd BLAST178
Domaini798 – 1048PI3K/PI4KInterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000252911
HOVERGENiHBG052721

Family and domain databases

CDDicd05174 PI3Kc_IA_delta, 1 hit
Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR008290 PI3K_Vps34
IPR037703 PI3Kdelta_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 2 hits
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 3 hits
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequencei

Sequence statusi: Complete.

O00334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGVDCPME FWTKEENQRV VVDFLLPTGV YLNFPVSRNA NLSTIKQLLW
60 70 80 90 100
HRAQYEPLFH MLSAPKAYVF TCINQTAEQQ ELEDEQRRLC DVQPFLPVLR
110 120 130 140 150
LVAREGDRVK KLINSQISLL IGKGLHEFDS LCDPEVNDFR AKMCQFCEEA
160 170 180 190 200
AARRQQLGWE AWLQYSFPLQ LEPSAQTWGP GTLRLPNRAL LVNVKFEGSE
210 220 230 240 250
ESFTFQVSTK DVPLALMACA LRKKATVFRQ PLVEQPEDYT LQVNGRHEYL
260 270 280 290 300
YGSYPLCQFQ VQKPRAKPPP IPAKKPSSVS LWSLEQPFRI ELIQGSKVNA
310 320 330 340 350
DERMKLVVQA GLFHGNEMLC KTVSSSEVSV CSEPVWKQRL EFDINICDLP
360 370 380 390 400
RMARLCFALY AVIEKAKKAR STKKKSKKAD CPIAWANLML FDYKDQLKTG
410 420 430 440 450
ERCLYMWPSV PDEKGELLNP TGTVRSNPNT DSAAALLICL PEVAPHPVYY
460 470 480 490 500
PALEKLPGGM LLASREWRPE LLWMRLHAED SAPSRMIGVA MPGLGVLPGL
510 520 530 540 550
VQAPGDAECS RLLQILELGR HSECVHVTEE EQLQLREILE RRGSGELYEH
560 570 580 590 600
EKDLVWKLRH EVQEHFPEAL ARLLLVTKWN KHEDVAPDAL PAVSWPELPV
610 620 630 640 650
LSALELLDFS FPDCHVGSFA IKSLRKLTDD ELFQYLLQLV QVLKYESYLD
660 670 680 690 700
CELTKFLLER ALANRKIGHF LFWHLRSEMH VPSVALRFGL ILEAYCRGST
710 720 730 740 750
HHMKVLMKQG EALSKLKALN DFVKLSSQKT PKPQTKELMH LCMRQEAYLE
760 770 780 790 800
ALSHLQSPLD PSTLLAEVCV EQCTFMDSKM KPLWIMYSNE EAGSGGTVGI
810 820 830 840 850
IFKNGDDLRQ DMLTLQMIQL MDVLWKQEGL DLRMTPYGCL PTGDRTGLIE
860 870 880 890 900
VVLRSDTIAN IQLNKSNMAA TAAFNKDALL NWLKSKNPGE ALDRAIEEFT
910 920 930 940 950
LSCAGYCVAT YVLGIGDRHS DNIMIRESGQ LFHIDFGHFL GNFKTKFGIN
960 970 980 990 1000
RERVPFILTY DLVHVIQQGK TNNSEKFERF RGYCERAYTI LRRHGLLFLH
1010 1020 1030 1040 1050
LFALMRAAGL PELSCSKDIQ YLKDSLALGK TEEEALKHFR EKFNEALREG
1060
WKTKVNWLAH NVSKDNRQ
Length:1,068
Mass (Da):121,880
Last modified:July 1, 1997 - v1
Checksum:i2B342FDA445C9A31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57843 mRNA Translation: AAB53966.1
PIRiPC4348
UniGeneiHs.518451

Similar proteinsi

Entry informationi

Entry nameiO00334_HUMAN
AccessioniPrimary (citable) accession number: O00334
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health