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Protein
Submitted name:

Prostaglandin E receptor 3 (Subtype EP3), isoform CRA_g

Gene

PTGER3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • prostaglandin E receptor activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin E receptor 3 (Subtype EP3), isoform CRA_gImported
Submitted name:
Prostaglandin E2 receptor EP3 subtypeImported
Submitted name:
Prostaglandin EP3 receptor subtype isoformImported
Gene namesi
Name:PTGER3Imported
ORF Names:hCG_1811960Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9595. PTGER3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7524HelicalSequence analysisAdd
BLAST
Transmembranei87 – 11226HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15322HelicalSequence analysisAdd
BLAST
Transmembranei173 – 19422HelicalSequence analysisAdd
BLAST
Transmembranei228 – 25326HelicalSequence analysisAdd
BLAST
Transmembranei284 – 30724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA288.

Expressioni

Gene expression databases

BgeeiENSG00000050628.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349003.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 346282G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOVERGENiHBG052720.

Family and domain databases

InterProiIPR001481. EP3_rcpt_2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000265. Prostglndn_EP3_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF10. PTHR11866:SF10. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00584. PRSTNOIDE32R.
PR00582. PRSTNOIDEP3R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV
60 70 80 90 100
SVAFPITMLL TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL
110 120 130 140 150
VGQLLTTPVV IVVYLSKQRW EHIDPSGRLC TFFGLTMTVF GLSSLFIASA
160 170 180 190 200
MAVERALAIR APHWYASHMK TRATRAVLLG VWLAVLAFAL LPVLGVGQYT
210 220 230 240 250
VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL ALTVTFSCNL
260 270 280 290 300
ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI
310 320 330 340 350
MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR
360 370 380 390 400
KILLRKFCQM RKRRLREQEM GPDGRCFCHA WRQVPRTWCS SHDREPCSVQ

LS
Length:402
Mass (Da):44,938
Last modified:July 1, 1997 - v1
Checksum:iD7449BB1538F12BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031429 Genomic DNA. No translation available.
AL158087 Genomic DNA. No translation available.
KF454969 Genomic DNA. No translation available.
D86097 mRNA. Translation: BAA19958.1.
CH471059 Genomic DNA. Translation: EAX06442.1.
PIRiD55995.
RefSeqiNP_942011.1. NM_198718.1.
UniGeneiHs.445000.

Genome annotation databases

EnsembliENST00000361210; ENSP00000424340; ENSG00000050628.
GeneIDi5733.
UCSCiuc057hmo.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031429 Genomic DNA. No translation available.
AL158087 Genomic DNA. No translation available.
KF454969 Genomic DNA. No translation available.
D86097 mRNA. Translation: BAA19958.1.
CH471059 Genomic DNA. Translation: EAX06442.1.
PIRiD55995.
RefSeqiNP_942011.1. NM_198718.1.
UniGeneiHs.445000.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349003.

Protocols and materials databases

DNASUi5733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361210; ENSP00000424340; ENSG00000050628.
GeneIDi5733.
UCSCiuc057hmo.1. human.

Organism-specific databases

CTDi5733.
HGNCiHGNC:9595. PTGER3.
PharmGKBiPA288.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOVERGENiHBG052720.

Miscellaneous databases

ChiTaRSiPTGER3. human.
GenomeRNAii5733.

Gene expression databases

BgeeiENSG00000050628.

Family and domain databases

InterProiIPR001481. EP3_rcpt_2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000265. Prostglndn_EP3_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF10. PTHR11866:SF10. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00584. PRSTNOIDE32R.
PR00582. PRSTNOIDEP3R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO00325_HUMAN
AccessioniPrimary (citable) accession number: O00325
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.