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Protein

ETS translocation variant 2

Gene

ETV2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi240 – 320ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105672-MONOMER.
SIGNORiO00321.

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 2
Alternative name(s):
Ets-related protein 71
Gene namesi
Name:ETV2
Synonyms:ER71, ETSRP71
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3491. ETV2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105672.
PharmGKBiPA27905.

Polymorphism and mutation databases

BioMutaiETV2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041121 – 342ETS translocation variant 2Add BLAST342

Proteomic databases

PaxDbiO00321.
PRIDEiO00321.

PTM databases

iPTMnetiO00321.
PhosphoSitePlusiO00321.

Expressioni

Gene expression databases

BgeeiENSG00000105672.
CleanExiHS_ETV2.
ExpressionAtlasiO00321. baseline and differential.
GenevisibleiO00321. HS.

Organism-specific databases

HPAiCAB010100.

Interactioni

Protein-protein interaction databases

BioGridi108417. 1 interactor.
STRINGi9606.ENSP00000384524.

Structurei

3D structure databases

ProteinModelPortaliO00321.
SMRiO00321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000293214.
HOVERGENiHBG005616.
InParanoidiO00321.
KOiK09432.
OMAiDCTTSSK.
OrthoDBiEOG091G0F77.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O00321-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLWNWDEAS PQEVPPGNKL AGLEGAKLGF CFPDLALQGD TPTATAETCW
60 70 80 90 100
KGTSSSLASF PQLDWGSALL HPEVPWGAEP DSQALPWSGD WTDMACTAWD
110 120 130 140 150
SWSGASQTLG PAPLGPGPIP AAGSEGAAGQ NCVPVAGEAT SWSRAQAAGS
160 170 180 190 200
NTSWDCSVGP DGDTYWGSGL GGEPRTDCTI SWGGPAGPDC TTSWNPGLHA
210 220 230 240 250
GGTTSLKRYQ SSALTVCSEP SPQSDRASLA RCPKTNHRGP IQLWQFLLEL
260 270 280 290 300
LHDGARSSCI RWTGNSREFQ LCDPKEVARL WGERKRKPGM NYEKLSRGLR
310 320 330 340
YYYRRDIVRK SGGRKYTYRF GGRVPSLAYP DCAGGGRGAE TQ
Length:342
Mass (Da):36,633
Last modified:October 31, 2012 - v2
Checksum:i9B0103D5D4B1AB8C
GO
Isoform 2 (identifier: O00321-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: L → LGRLPRLPQRVWGGCPGGASADPNPLSPA

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):39,442
Checksum:i01A55C7D10160AF5
GO

Sequence cautioni

The sequence AAB57630 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214L → F in AAD00861 (Ref. 4) Curated1
Sequence conflicti303Y → L in AAD00861 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07106290D → N.1 PublicationCorresponds to variant rs2285419dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05548823L → LGRLPRLPQRVWGGCPGGAS ADPNPLSPA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097439 mRNA. Translation: BAG53472.1.
AC002115 Genomic DNA. Translation: AAB57630.1. Sequence problems.
BC140746 mRNA. Translation: AAI40747.1.
AF000671 mRNA. Translation: AAD00861.1.
CCDSiCCDS32995.2. [O00321-1]
RefSeqiNP_055024.2. NM_014209.3. [O00321-1]
XP_005258709.1. XM_005258652.2. [O00321-2]
UniGeneiHs.194061.

Genome annotation databases

EnsembliENST00000379026; ENSP00000368312; ENSG00000105672. [O00321-2]
ENST00000402764; ENSP00000384524; ENSG00000105672. [O00321-1]
ENST00000403402; ENSP00000385369; ENSG00000105672. [O00321-1]
GeneIDi2116.
KEGGihsa:2116.
UCSCiuc002oar.2. human. [O00321-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097439 mRNA. Translation: BAG53472.1.
AC002115 Genomic DNA. Translation: AAB57630.1. Sequence problems.
BC140746 mRNA. Translation: AAI40747.1.
AF000671 mRNA. Translation: AAD00861.1.
CCDSiCCDS32995.2. [O00321-1]
RefSeqiNP_055024.2. NM_014209.3. [O00321-1]
XP_005258709.1. XM_005258652.2. [O00321-2]
UniGeneiHs.194061.

3D structure databases

ProteinModelPortaliO00321.
SMRiO00321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108417. 1 interactor.
STRINGi9606.ENSP00000384524.

PTM databases

iPTMnetiO00321.
PhosphoSitePlusiO00321.

Polymorphism and mutation databases

BioMutaiETV2.

Proteomic databases

PaxDbiO00321.
PRIDEiO00321.

Protocols and materials databases

DNASUi2116.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379026; ENSP00000368312; ENSG00000105672. [O00321-2]
ENST00000402764; ENSP00000384524; ENSG00000105672. [O00321-1]
ENST00000403402; ENSP00000385369; ENSG00000105672. [O00321-1]
GeneIDi2116.
KEGGihsa:2116.
UCSCiuc002oar.2. human. [O00321-1]

Organism-specific databases

CTDi2116.
GeneCardsiETV2.
HGNCiHGNC:3491. ETV2.
HPAiCAB010100.
MIMi609358. gene.
neXtProtiNX_O00321.
OpenTargetsiENSG00000105672.
PharmGKBiPA27905.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000293214.
HOVERGENiHBG005616.
InParanoidiO00321.
KOiK09432.
OMAiDCTTSSK.
OrthoDBiEOG091G0F77.
TreeFamiTF316214.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105672-MONOMER.
SIGNORiO00321.

Miscellaneous databases

GenomeRNAii2116.
PROiO00321.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105672.
CleanExiHS_ETV2.
ExpressionAtlasiO00321. baseline and differential.
GenevisibleiO00321. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETV2_HUMAN
AccessioniPrimary (citable) accession number: O00321
Secondary accession number(s): A6NFN5
, B3KUL0, B9EIN1, Q9UEA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 31, 2012
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.