Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ETS translocation variant 2

Gene

ETV2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.By similarity

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi240 – 320ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

SIGNORiO00321

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 2
Alternative name(s):
Ets-related protein 71
Gene namesi
Name:ETV2
Synonyms:ER71, ETSRP71
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105672.14
HGNCiHGNC:3491 ETV2
MIMi609358 gene
neXtProtiNX_O00321

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27905

Polymorphism and mutation databases

BioMutaiETV2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041121 – 342ETS translocation variant 2Add BLAST342

Proteomic databases

PaxDbiO00321
PeptideAtlasiO00321
PRIDEiO00321

PTM databases

iPTMnetiO00321
PhosphoSitePlusiO00321

Expressioni

Gene expression databases

BgeeiENSG00000105672
CleanExiHS_ETV2
ExpressionAtlasiO00321 baseline and differential
GenevisibleiO00321 HS

Interactioni

Protein-protein interaction databases

BioGridi1084171 interactor.
STRINGi9606.ENSP00000384524

Structurei

3D structure databases

ProteinModelPortaliO00321
SMRiO00321
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000293214
HOVERGENiHBG005616
InParanoidiO00321
KOiK09432
OMAiMDLWNWD
OrthoDBiEOG091G0F77
TreeFamiTF316214

Family and domain databases

Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O00321-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLWNWDEAS PQEVPPGNKL AGLEGAKLGF CFPDLALQGD TPTATAETCW
60 70 80 90 100
KGTSSSLASF PQLDWGSALL HPEVPWGAEP DSQALPWSGD WTDMACTAWD
110 120 130 140 150
SWSGASQTLG PAPLGPGPIP AAGSEGAAGQ NCVPVAGEAT SWSRAQAAGS
160 170 180 190 200
NTSWDCSVGP DGDTYWGSGL GGEPRTDCTI SWGGPAGPDC TTSWNPGLHA
210 220 230 240 250
GGTTSLKRYQ SSALTVCSEP SPQSDRASLA RCPKTNHRGP IQLWQFLLEL
260 270 280 290 300
LHDGARSSCI RWTGNSREFQ LCDPKEVARL WGERKRKPGM NYEKLSRGLR
310 320 330 340
YYYRRDIVRK SGGRKYTYRF GGRVPSLAYP DCAGGGRGAE TQ
Length:342
Mass (Da):36,633
Last modified:October 31, 2012 - v2
Checksum:i9B0103D5D4B1AB8C
GO
Isoform 2 (identifier: O00321-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: L → LGRLPRLPQRVWGGCPGGASADPNPLSPA

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):39,442
Checksum:i01A55C7D10160AF5
GO

Sequence cautioni

The sequence AAB57630 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214L → F in AAD00861 (Ref. 4) Curated1
Sequence conflicti303Y → L in AAD00861 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07106290D → N1 PublicationCorresponds to variant dbSNP:rs2285419Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05548823L → LGRLPRLPQRVWGGCPGGAS ADPNPLSPA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097439 mRNA Translation: BAG53472.1
AC002115 Genomic DNA Translation: AAB57630.1 Sequence problems.
BC140746 mRNA Translation: AAI40747.1
AF000671 mRNA Translation: AAD00861.1
CCDSiCCDS32995.2 [O00321-1]
RefSeqiNP_055024.2, NM_014209.3 [O00321-1]
XP_005258709.1, XM_005258652.2 [O00321-2]
UniGeneiHs.194061

Genome annotation databases

EnsembliENST00000379026; ENSP00000368312; ENSG00000105672 [O00321-2]
ENST00000402764; ENSP00000384524; ENSG00000105672 [O00321-1]
ENST00000403402; ENSP00000385369; ENSG00000105672 [O00321-1]
GeneIDi2116
KEGGihsa:2116
UCSCiuc002oar.2 human [O00321-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiETV2_HUMAN
AccessioniPrimary (citable) accession number: O00321
Secondary accession number(s): A6NFN5
, B3KUL0, B9EIN1, Q9UEA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 31, 2012
Last modified: March 28, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome