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Protein

Cell division cycle 7-related protein kinase

Gene

CDC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90ATPPROSITE-ProRule annotation1
Active sitei177Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi64 – 72ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • cell cycle phase transition Source: BHF-UCL
  • cell division Source: UniProtKB-KW
  • DNA replication Source: Reactome
  • DNA replication initiation Source: GO_Central
  • double-strand break repair via break-induced replication Source: GO_Central
  • G1/S transition of mitotic cell cycle Source: Reactome
  • peptidyl-serine phosphorylation Source: GO_Central
  • phagocytosis Source: GO_Central
  • positive regulation of cell proliferation Source: HGNC
  • positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  • positive regulation of nuclear cell cycle DNA replication Source: UniProtKB
  • regulation of cell shape Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS01876-MONOMER.
BRENDAi2.7.11.1. 2681.
ReactomeiR-HSA-176187. Activation of ATR in response to replication stress.
R-HSA-68962. Activation of the pre-replicative complex.
SignaLinkiO00311.
SIGNORiO00311.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle 7-related protein kinase (EC:2.7.11.1)
Short name:
CDC7-related kinase
Short name:
HsCdc7
Short name:
huCdc7
Gene namesi
Name:CDC7
Synonyms:CDC7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1745. CDC7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • intercellular bridge Source: HPA
  • microtubule cytoskeleton Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8317.
OpenTargetsiENSG00000097046.
PharmGKBiPA26272.

Chemistry databases

ChEMBLiCHEMBL5443.
GuidetoPHARMACOLOGYi1960.

Polymorphism and mutation databases

BioMutaiCDC7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857631 – 574Cell division cycle 7-related protein kinaseAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Modified residuei503PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00311.
MaxQBiO00311.
PaxDbiO00311.
PeptideAtlasiO00311.
PRIDEiO00311.

PTM databases

iPTMnetiO00311.
PhosphoSitePlusiO00311.

Expressioni

Gene expression databases

BgeeiENSG00000097046.
CleanExiHS_CDC7.
ExpressionAtlasiO00311. baseline and differential.
GenevisibleiO00311. HS.

Organism-specific databases

HPAiCAB002669.
HPA035831.

Interactioni

Subunit structurei

Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.

Binary interactionsi

WithEntry#Exp.IntActNotes
MCMBPQ9BTE32EBI-374980,EBI-749378

Protein-protein interaction databases

BioGridi113914. 34 interactors.
DIPiDIP-31728N.
IntActiO00311. 38 interactors.
MINTiMINT-1201209.
STRINGi9606.ENSP00000234626.

Chemistry databases

BindingDBiO00311.

Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 50Combined sources9
Helixi52 – 56Combined sources5
Beta strandi59 – 66Combined sources8
Beta strandi68 – 79Combined sources12
Beta strandi84 – 92Combined sources9
Helixi98 – 110Combined sources13
Beta strandi121 – 126Combined sources6
Beta strandi129 – 135Combined sources7
Helixi142 – 146Combined sources5
Helixi151 – 170Combined sources20
Helixi180 – 182Combined sources3
Beta strandi183 – 186Combined sources4
Turni187 – 190Combined sources4
Beta strandi191 – 194Combined sources4
Helixi209 – 213Combined sources5
Turni217 – 219Combined sources3
Helixi377 – 379Combined sources3
Helixi382 – 385Combined sources4
Helixi394 – 409Combined sources16
Beta strandi412 – 415Combined sources4
Helixi420 – 431Combined sources12
Helixi433 – 442Combined sources10
Beta strandi445 – 451Combined sources7
Helixi458 – 465Combined sources8
Helixi540 – 549Combined sources10
Turni554 – 556Combined sources3
Helixi560 – 564Combined sources5
Helixi567 – 569Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F99X-ray2.33A37-574[»]
4F9AX-ray2.17A/C37-574[»]
4F9BX-ray2.50A/C37-574[»]
4F9CX-ray2.08A37-574[»]
ProteinModelPortaliO00311.
SMRiO00311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 574Protein kinasePROSITE-ProRule annotationAdd BLAST517

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1167. Eukaryota.
ENOG410YKCM. LUCA.
GeneTreeiENSGT00550000075011.
HOGENOMiHOG000193450.
HOVERGENiHBG003991.
InParanoidiO00311.
KOiK02214.
OMAiMAFSPQR.
OrthoDBiEOG091G0O6H.
PhylomeDBiO00311.
TreeFamiTF101052.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced.
Isoform 1 (identifier: O00311-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEASLGIQMD EPMAFSPQRD RFQAEGSLKK NEQNFKLAGV KKDIEKLYEA
60 70 80 90 100
VPQLSNVFKI EDKIGEGTFS SVYLATAQLQ VGPEEKIALK HLIPTSHPIR
110 120 130 140 150
IAAELQCLTV AGGQDNVMGV KYCFRKNDHV VIAMPYLEHE SFLDILNSLS
160 170 180 190 200
FQEVREYMLN LFKALKRIHQ FGIVHRDVKP SNFLYNRRLK KYALVDFGLA
210 220 230 240 250
QGTHDTKIEL LKFVQSEAQQ ERCSQNKSHI ITGNKIPLSG PVPKELDQQS
260 270 280 290 300
TTKASVKRPY TNAQIQIKQG KDGKEGSVGL SVQRSVFGER NFNIHSSISH
310 320 330 340 350
ESPAVKLMKQ SKTVDVLSRK LATKKKAIST KVMNSAVMRK TASSCPASLT
360 370 380 390 400
CDCYATDKVC SICLSRRQQV APRAGTPGFR APEVLTKCPN QTTAIDMWSA
410 420 430 440 450
GVIFLSLLSG RYPFYKASDD LTALAQIMTI RGSRETIQAA KTFGKSILCS
460 470 480 490 500
KEVPAQDLRK LCERLRGMDS STPKLTSDIQ GHASHQPAIS EKTDHKASCL
510 520 530 540 550
VQTPPGQYSG NSFKKGDSNS CEHCFDEYNT NLEGWNEVPD EAYDLLDKLL
560 570
DLNPASRITA EEALLHPFFK DMSL
Length:574
Mass (Da):63,888
Last modified:July 1, 1997 - v1
Checksum:i90D549BEE20AE583
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89L → V in AAB97512 (PubMed:9405610).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01925523Q → P.1 PublicationCorresponds to variant rs13447459dbSNPEnsembl.1
Natural variantiVAR_01925699I → V.1 PublicationCorresponds to variant rs13447492dbSNPEnsembl.1
Natural variantiVAR_019257112G → W.1 PublicationCorresponds to variant rs13447493dbSNPEnsembl.1
Natural variantiVAR_019258162F → L.2 PublicationsCorresponds to variant rs13447503dbSNPEnsembl.1
Natural variantiVAR_040403208I → M.1 PublicationCorresponds to variant rs34979509dbSNPEnsembl.1
Natural variantiVAR_040404209E → D.1 PublicationCorresponds to variant rs56327502dbSNPEnsembl.1
Natural variantiVAR_019259441K → R.2 PublicationsCorresponds to variant rs13447539dbSNPEnsembl.1
Natural variantiVAR_040405472T → I.1 PublicationCorresponds to variant rs56381770dbSNPEnsembl.1
Natural variantiVAR_040406498S → A.1 PublicationCorresponds to variant rs35055915dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003698 mRNA. Translation: BAA19962.1.
AF015592 mRNA. Translation: AAC52080.1.
AF005209 mRNA. Translation: AAB97512.1.
AY585721 Genomic DNA. Translation: AAS79323.1.
AL355871 Genomic DNA. Translation: CAI14446.1.
CH471097 Genomic DNA. Translation: EAW73114.1.
CH471097 Genomic DNA. Translation: EAW73115.1.
BC110526 mRNA. Translation: AAI10527.1.
BC110527 mRNA. Translation: AAI10528.1.
BC111044 mRNA. Translation: AAI11045.1.
CCDSiCCDS734.1. [O00311-1]
RefSeqiNP_001127891.1. NM_001134419.1. [O00311-1]
NP_001127892.1. NM_001134420.1. [O00311-1]
NP_003494.1. NM_003503.3. [O00311-1]
XP_005271298.1. XM_005271241.2. [O00311-1]
UniGeneiHs.533573.

Genome annotation databases

EnsembliENST00000234626; ENSP00000234626; ENSG00000097046. [O00311-1]
ENST00000428239; ENSP00000393139; ENSG00000097046. [O00311-1]
GeneIDi8317.
KEGGihsa:8317.
UCSCiuc001doe.4. human. [O00311-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003698 mRNA. Translation: BAA19962.1.
AF015592 mRNA. Translation: AAC52080.1.
AF005209 mRNA. Translation: AAB97512.1.
AY585721 Genomic DNA. Translation: AAS79323.1.
AL355871 Genomic DNA. Translation: CAI14446.1.
CH471097 Genomic DNA. Translation: EAW73114.1.
CH471097 Genomic DNA. Translation: EAW73115.1.
BC110526 mRNA. Translation: AAI10527.1.
BC110527 mRNA. Translation: AAI10528.1.
BC111044 mRNA. Translation: AAI11045.1.
CCDSiCCDS734.1. [O00311-1]
RefSeqiNP_001127891.1. NM_001134419.1. [O00311-1]
NP_001127892.1. NM_001134420.1. [O00311-1]
NP_003494.1. NM_003503.3. [O00311-1]
XP_005271298.1. XM_005271241.2. [O00311-1]
UniGeneiHs.533573.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F99X-ray2.33A37-574[»]
4F9AX-ray2.17A/C37-574[»]
4F9BX-ray2.50A/C37-574[»]
4F9CX-ray2.08A37-574[»]
ProteinModelPortaliO00311.
SMRiO00311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113914. 34 interactors.
DIPiDIP-31728N.
IntActiO00311. 38 interactors.
MINTiMINT-1201209.
STRINGi9606.ENSP00000234626.

Chemistry databases

BindingDBiO00311.
ChEMBLiCHEMBL5443.
GuidetoPHARMACOLOGYi1960.

PTM databases

iPTMnetiO00311.
PhosphoSitePlusiO00311.

Polymorphism and mutation databases

BioMutaiCDC7.

Proteomic databases

EPDiO00311.
MaxQBiO00311.
PaxDbiO00311.
PeptideAtlasiO00311.
PRIDEiO00311.

Protocols and materials databases

DNASUi8317.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234626; ENSP00000234626; ENSG00000097046. [O00311-1]
ENST00000428239; ENSP00000393139; ENSG00000097046. [O00311-1]
GeneIDi8317.
KEGGihsa:8317.
UCSCiuc001doe.4. human. [O00311-1]

Organism-specific databases

CTDi8317.
DisGeNETi8317.
GeneCardsiCDC7.
HGNCiHGNC:1745. CDC7.
HPAiCAB002669.
HPA035831.
MIMi603311. gene.
neXtProtiNX_O00311.
OpenTargetsiENSG00000097046.
PharmGKBiPA26272.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1167. Eukaryota.
ENOG410YKCM. LUCA.
GeneTreeiENSGT00550000075011.
HOGENOMiHOG000193450.
HOVERGENiHBG003991.
InParanoidiO00311.
KOiK02214.
OMAiMAFSPQR.
OrthoDBiEOG091G0O6H.
PhylomeDBiO00311.
TreeFamiTF101052.

Enzyme and pathway databases

BioCyciZFISH:HS01876-MONOMER.
BRENDAi2.7.11.1. 2681.
ReactomeiR-HSA-176187. Activation of ATR in response to replication stress.
R-HSA-68962. Activation of the pre-replicative complex.
SignaLinkiO00311.
SIGNORiO00311.

Miscellaneous databases

GeneWikiiCell_division_cycle_7-related_protein_kinase.
GenomeRNAii8317.
PROiO00311.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000097046.
CleanExiHS_CDC7.
ExpressionAtlasiO00311. baseline and differential.
GenevisibleiO00311. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC7_HUMAN
AccessioniPrimary (citable) accession number: O00311
Secondary accession number(s): D3DT31, O00558, Q5T5U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 170 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.