O00298 (O00298_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Diadenosine triphosphate hydrolase EMBL AAB53793.1

Gene names

Name:

FHIT EMBL AAB53793.1

Organism

Homo sapiens (Human) EMBL AAB53793.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	47 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 HIT domain. SAAS SAAS011151

Ontologies

Keywords
Molecular function	Hydrolase EMBL AAB53793.1
Gene Ontology (GO)
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAB53793.1
	Non-terminal residue	47	1	EMBL AAB53793.1

Sequences

	Sequence		Length	Mass (Da)
	O00298 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 6C323613A6107936	FASTA	47	5,440
	10 20 30 40 VLVCPLRPVE RFHDLRPDEV ADLFQMTQRV GTVVEKHFHG TSLTFSM

References

[1]	"The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers." Ohta M., Inoue H., Cotticelli M.G., Kastury K., Baffa R., Palazzo J., Siprashvili Z., Mori M., McCue P., Druck T., Croce C.M., Huebner K. Cell 84:587-597(1996) [PubMed: 8598045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"FHIT mutations in human primary gastric cancer." Gemma A., Hagiwara K., Yang K., Burke L.M., Kahn M.A., Nagashima M., Bennett W.P., Harris C.C. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U88866 Genomic DNA. Translation: AAB53793.1.
IPI	IPI00028095.
UniGene	Hs.655995.
3D structure databases
HSSP	HSSP built from PDB template 4FIT based on UniProtKB P49789.
ProteinModelPortal	O00298.
ModBase	Search...
Protein-protein interaction databases
STRING	O00298.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	O00298.
Family and domain databases
InterPro	IPR011146. His_triad-like_motif. IPR011151. His_triad_motif. IPR001310. Histidine_triad_HIT. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 1 hit.
PANTHER	PTHR23089. HIT. 1 hit.
Pfam	PF01230. HIT. 1 hit. [Graphical view]
SUPFAM	SSF54197. His_triad-like_motif. 1 hit.
PROSITE	PS51084. HIT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O00298_HUMAN

Accession

Primary (citable) accession number: O00298

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 1997
Last sequence update:	July 1, 1997
Last modified:	November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.