##gff-version 3
O00291	UniProtKB	Chain	1	1037	.	.	.	ID=PRO_0000083986;Note=Huntingtin-interacting protein 1	
O00291	UniProtKB	Domain	32	160	.	.	.	Note=ENTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00243	
O00291	UniProtKB	Domain	771	1012	.	.	.	Note=I/LWEQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00292	
O00291	UniProtKB	Region	410	491	.	.	.	Note=PDED	
O00291	UniProtKB	Region	867	924	.	.	.	Note=Important for actin binding;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O00291	UniProtKB	Region	1017	1037	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O00291	UniProtKB	Coiled coil	368	644	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
O00291	UniProtKB	Modified residue	338	338	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569	
O00291	UniProtKB	Alternative sequence	1	40	.	.	.	ID=VSP_057400;Note=In isoform 4. MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQ->MMFPNPEPPPE;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1	
O00291	UniProtKB	Alternative sequence	803	853	.	.	.	ID=VSP_044736;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O00291	UniProtKB	Natural variant	263	263	.	.	.	ID=VAR_051032;Note=M->K;Dbxref=dbSNP:rs17149023	
O00291	UniProtKB	Mutagenesis	56	56	.	.	.	Note=Abolishes 3-phosphoinositide-binding%3B when associated with E-58. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16027218;Dbxref=PMID:16027218	
O00291	UniProtKB	Mutagenesis	58	58	.	.	.	Note=Abolishes 3-phosphoinositide-binding%3B when associated with E-56. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16027218;Dbxref=PMID:16027218	
O00291	UniProtKB	Mutagenesis	432	432	.	.	.	Note=Abolishes HIP1-induced cell death. F->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11007801;Dbxref=PMID:11007801	
O00291	UniProtKB	Mutagenesis	1005	1005	.	.	.	Note=Reduces AR-induced nuclear translocation. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16027218;Dbxref=PMID:16027218	
O00291	UniProtKB	Sequence conflict	89	89	.	.	.	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00291	UniProtKB	Sequence conflict	245	251	.	.	.	Note=KLHSCLP->EFAAAST;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00291	UniProtKB	Sequence conflict	357	357	.	.	.	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00291	UniProtKB	Sequence conflict	639	644	.	.	.	Note=LNQLEE->STRPRI;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00291	UniProtKB	Sequence conflict	688	688	.	.	.	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00291	UniProtKB	Helix	373	441	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3I00	
O00291	UniProtKB	Turn	459	461	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2QA7	
O00291	UniProtKB	Helix	462	465	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2QA7	
O00291	UniProtKB	Helix	482	580	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2NO2