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Protein

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

Gene

GPR31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-444209. Free fatty acid receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
Short name:
12-(S)-HETE receptor
Short name:
12-HETER
Alternative name(s):
G-protein coupled receptor 31
Gene namesi
Name:GPR31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4486. GPR31.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence analysisAdd
BLAST
Transmembranei17 – 3721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini38 – 5215CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 9118ExtracellularSequence analysisAdd
BLAST
Transmembranei92 – 11019Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini111 – 13121CytoplasmicSequence analysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini153 – 18028ExtracellularSequence analysisAdd
BLAST
Transmembranei181 – 20121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini202 – 21918CytoplasmicSequence analysisAdd
BLAST
Transmembranei220 – 24021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini241 – 26525ExtracellularSequence analysisAdd
BLAST
Transmembranei266 – 28419Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini285 – 31935CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28874.

Polymorphism and mutation databases

BioMutaiGPR31.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31931912-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptorPRO_0000069551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO00270.
PRIDEiO00270.

Expressioni

Gene expression databases

BgeeiENSG00000120436.
CleanExiHS_GPR31.
GenevisibleiO00270. HS.

Organism-specific databases

HPAiHPA014014.
HPA027108.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355799.

Structurei

3D structure databases

ProteinModelPortaliO00270.
SMRiO00270. Positions 27-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE56. Eukaryota.
ENOG410ZU85. LUCA.
GeneTreeiENSGT00510000046798.
HOGENOMiHOG000285939.
HOVERGENiHBG100615.
InParanoidiO00270.
KOiK08406.
OMAiSTRCHSF.
OrthoDBiEOG091G0G4Y.
PhylomeDBiO00270.
TreeFamiTF337237.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFPNCSAPS TVVATAVGVL LGLECGLGLL GNAVALWTFL FRVRVWKPYA
60 70 80 90 100
VYLLNLALAD LLLAACLPFL AAFYLSLQAW HLGRVGCWAL HFLLDLSRSV
110 120 130 140 150
GMAFLAAVAL DRYLRVVHPR LKVNLLSPQA ALGVSGLVWL LMVALTCPGL
160 170 180 190 200
LISEAAQNST RCHSFYSRAD GSFSIIWQEA LSCLQFVLPF GLIVFCNAGI
210 220 230 240 250
IRALQKRLRE PEKQPKLQRA QALVTLVVVL FALCFLPCFL ARVLMHIFQN
260 270 280 290 300
LGSCRALCAV AHTSDVTGSL TYLHSVLNPV VYCFSSPTFR SSYRRVFHTL
310
RGKGQAAEPP DFNPRDSYS
Length:319
Mass (Da):35,075
Last modified:March 1, 2005 - v2
Checksum:i2ACD0350AD7FB53A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731F → L in AAH95537 (PubMed:15489334).Curated
Sequence conflicti277 – 2771L → V in AAC51375 (PubMed:9205127).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911H → R.4 Publications
Corresponds to variant rs6902566 [ dbSNP | Ensembl ].
VAR_049392

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65402 Genomic DNA. Translation: AAC51375.1.
EU432117 Genomic DNA. Translation: ABY87916.1.
AL121935 Genomic DNA. Translation: CAB99329.1.
CH471051 Genomic DNA. Translation: EAW47505.1.
BC095537 mRNA. Translation: AAH95537.1.
CCDSiCCDS5299.1.
RefSeqiNP_005290.2. NM_005299.2.
UniGeneiHs.248124.

Genome annotation databases

EnsembliENST00000366834; ENSP00000355799; ENSG00000120436.
GeneIDi2853.
KEGGihsa:2853.
UCSCiuc011egq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65402 Genomic DNA. Translation: AAC51375.1.
EU432117 Genomic DNA. Translation: ABY87916.1.
AL121935 Genomic DNA. Translation: CAB99329.1.
CH471051 Genomic DNA. Translation: EAW47505.1.
BC095537 mRNA. Translation: AAH95537.1.
CCDSiCCDS5299.1.
RefSeqiNP_005290.2. NM_005299.2.
UniGeneiHs.248124.

3D structure databases

ProteinModelPortaliO00270.
SMRiO00270. Positions 27-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355799.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPR31.

Proteomic databases

PaxDbiO00270.
PRIDEiO00270.

Protocols and materials databases

DNASUi2853.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366834; ENSP00000355799; ENSG00000120436.
GeneIDi2853.
KEGGihsa:2853.
UCSCiuc011egq.3. human.

Organism-specific databases

CTDi2853.
GeneCardsiGPR31.
HGNCiHGNC:4486. GPR31.
HPAiHPA014014.
HPA027108.
MIMi602043. gene.
neXtProtiNX_O00270.
PharmGKBiPA28874.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE56. Eukaryota.
ENOG410ZU85. LUCA.
GeneTreeiENSGT00510000046798.
HOGENOMiHOG000285939.
HOVERGENiHBG100615.
InParanoidiO00270.
KOiK08406.
OMAiSTRCHSF.
OrthoDBiEOG091G0G4Y.
PhylomeDBiO00270.
TreeFamiTF337237.

Enzyme and pathway databases

ReactomeiR-HSA-444209. Free fatty acid receptors.

Miscellaneous databases

GeneWikiiGPR31.
GenomeRNAii2853.
PROiO00270.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120436.
CleanExiHS_GPR31.
GenevisibleiO00270. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR31_HUMAN
AccessioniPrimary (citable) accession number: O00270
Secondary accession number(s): B0M0K2, Q4VBL3, Q9NQ20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.