Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription initiation factor TFIID subunit 4

Gene

TAF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: CAFA
  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: InterPro
  • protein heterodimerization activity Source: InterPro
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
SIGNORiO00268

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 4
Alternative name(s):
RNA polymerase II TBP-associated factor subunit C
TBP-associated factor 4
Transcription initiation factor TFIID 130 kDa subunit
Short name:
TAF(II)130
Short name:
TAFII-130
Short name:
TAFII130
Transcription initiation factor TFIID 135 kDa subunit
Short name:
TAF(II)135
Short name:
TAFII-135
Short name:
TAFII135
Gene namesi
Name:TAF4
Synonyms:TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000130699.16
HGNCiHGNC:11537 TAF4
MIMi601796 gene
neXtProtiNX_O00268

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6874
OpenTargetsiENSG00000130699
PharmGKBiPA36312

Polymorphism and mutation databases

BioMutaiTAF4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188691 – 1085Transcription initiation factor TFIID subunit 4Add BLAST1085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphoserineCombined sources1
Modified residuei424Asymmetric dimethylarginineCombined sources1
Modified residuei435Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO00268
MaxQBiO00268
PaxDbiO00268
PeptideAtlasiO00268
PRIDEiO00268

PTM databases

iPTMnetiO00268
PhosphoSitePlusiO00268

Expressioni

Gene expression databases

BgeeiENSG00000130699
CleanExiHS_TAF4
ExpressionAtlasiO00268 baseline and differential
GenevisibleiO00268 HS

Organism-specific databases

HPAiCAB031484
HPA008599

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ATF7; the interaction inhibits ATF7-mediated tranactivation. Interacts with SV40 Large T antigen.6 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: CAFA
  • protein heterodimerization activity Source: InterPro

Protein-protein interaction databases

BioGridi112737, 53 interactors
CORUMiO00268
DIPiDIP-35350N
ELMiO00268
IntActiO00268, 22 interactors
MINTiO00268
STRINGi9606.ENSP00000252996

Structurei

Secondary structure

11085
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi585 – 593Combined sources9
Helixi599 – 604Combined sources6
Helixi614 – 620Combined sources7
Helixi623 – 628Combined sources6
Helixi634 – 644Combined sources11
Helixi653 – 657Combined sources5
Helixi661 – 666Combined sources6
Helixi671 – 677Combined sources7
Helixi875 – 887Combined sources13
Turni888 – 890Combined sources3
Helixi898 – 918Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H3OX-ray2.30A/C872-945[»]
2P6VX-ray2.00A575-688[»]
ProteinModelPortaliO00268
SMRiO00268
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00268

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini590 – 687TAFHPROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 42Poly-His4
Compositional biasi52 – 57Poly-Ala6
Compositional biasi98 – 101Poly-Gly4
Compositional biasi142 – 148Poly-Ala7
Compositional biasi270 – 277Poly-Pro8
Compositional biasi333 – 339Poly-Ala7
Compositional biasi682 – 685Poly-Pro4
Compositional biasi810 – 815Poly-Ala6
Compositional biasi830 – 833Poly-Asp4

Sequence similaritiesi

Belongs to the TAF4 family.Curated

Phylogenomic databases

eggNOGiKOG2341 Eukaryota
ENOG410XQS6 LUCA
GeneTreeiENSGT00390000011620
HOGENOMiHOG000154502
HOVERGENiHBG058585
InParanoidiO00268
KOiK03129
OMAiGQPSVHN
OrthoDBiEOG091G0GOS
PhylomeDBiO00268
TreeFamiTF316520

Family and domain databases

CDDicd08045 TAF4, 1 hit
Gene3Di1.10.20.10, 1 hit
1.20.120.1110, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007900 TAF4
IPR037249 TAFH/NHR1_dom_sf
IPR003894 TAFH_NHR1
PfamiView protein in Pfam
PF05236 TAF4, 1 hit
PF07531 TAFH, 1 hit
SMARTiView protein in SMART
SM00549 TAFH, 1 hit
SUPFAMiSSF158553 SSF158553, 1 hit
SSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS51119 TAFH, 1 hit

Sequencei

Sequence statusi: Complete.

O00268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSDLLDE VFFNSEVDEK VVSDLVGSLE SQLAASAAHH HHLAPRTPEV
60 70 80 90 100
RAAAAGALGN HVVSGSPAGA AGAGPAAPAE GAPGAAPEPP PAGRARPGGG
110 120 130 140 150
GPQRPGPPSP RRPLVPAGPA PPAAKLRPPP EGSAGSCAPV PAAAAVAAGP
160 170 180 190 200
EPAPAGPAKP AGPAALAARA GPGPGPGPGP GPGPGPGKPA GPGAAQTLNG
210 220 230 240 250
SAALLNSHHA AAPAVSLVNN GPAALLPLPK PAAPGTVIQT PPFVGAAAPP
260 270 280 290 300
APAAPSPPAA PAPAAPAAAP PPPPPAPATL ARPPGHPAGP PTAAPAVPPP
310 320 330 340 350
AAAQNGGSAG AAPAPAPAAG GPAGVSGQPG PGAAAAAPAP GVKAESPKRV
360 370 380 390 400
VQAAPPAAQT LAASGPASTA ASMVIGPTMQ GALPSPAAVP PPAPGTPTGL
410 420 430 440 450
PKGAAGAVTQ SLSRTPTATT SGIRATLTPT VLAPRLPQPP QNPTNIQNFQ
460 470 480 490 500
LPPGMVLVRS ENGQLLMIPQ QALAQMQAQA HAQPQTTMAP RPATPTSAPP
510 520 530 540 550
VQISTVQAPG TPIIARQVTP TTIIKQVSQA QTTVQPSATL QRSPGVQPQL
560 570 580 590 600
VLGGAAQTAS LGTATAVQTG TPQRTVPGAT TTSSAATETM ENVKKCKNFL
610 620 630 640 650
STLIKLASSG KQSTETAANV KELVQNLLDG KIEAEDFTSR LYRELNSSPQ
660 670 680 690 700
PYLVPFLKRS LPALRQLTPD SAAFIQQSQQ QPPPPTSQAT TALTAVVLSS
710 720 730 740 750
SVQRTAGKTA ATVTSALQPP VLSLTQPTQV GVGKQGQPTP LVIQQPPKPG
760 770 780 790 800
ALIRPPQVTL TQTPMVALRQ PHNRIMLTTP QQIQLNPLQP VPVVKPAVLP
810 820 830 840 850
GTKALSAVSA QAAAAQKNKL KEPGGGSFRD DDDINDVASM AGVNLSEESA
860 870 880 890 900
RILATNSELV GTLTRSCKDE TFLLQAPLQR RILEIGKKHG ITELHPDVVS
910 920 930 940 950
YVSHATQQRL QNLVEKISET AQQKNFSYKD DDRYEQASDV RAQLKFFEQL
960 970 980 990 1000
DQIEKQRKDE QEREILMRAA KSRSRQEDPE QLRLKQKAKE MQQQELAQMR
1010 1020 1030 1040 1050
QRDANLTALA AIGPRKKRKV DCPGPGSGAE GSGPGSVVPG SSGVGTPRQF
1060 1070 1080
TRQRITRVNL RDLIFCLENE RETSHSLLLY KAFLK
Length:1,085
Mass (Da):110,114
Last modified:December 7, 2004 - v2
Checksum:iBC2F5B5F143DB145
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105 – 117PGPPS…PLVPA → GRGLLQQRGGRES in AAC50901 (PubMed:8942982).CuratedAdd BLAST13
Sequence conflicti136S → A in CAA72189 (PubMed:9192867).Curated1
Sequence conflicti136S → A in AAC50901 (PubMed:8942982).Curated1
Sequence conflicti186 – 187Missing in CAA72189 (PubMed:9192867).Curated2
Sequence conflicti186 – 187Missing in AAC50901 (PubMed:8942982).Curated2
Sequence conflicti235 – 266Missing in AAC50901 (PubMed:8942982).CuratedAdd BLAST32
Sequence conflicti295P → L in AAC50901 (PubMed:8942982).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052258651P → L. Corresponds to variant dbSNP:rs6089604Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11354 mRNA Translation: CAA72189.1
AY623115 Genomic DNA Translation: AAT38111.1
AL109911 Genomic DNA No translation available.
AL137077 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75407.1
U75308 mRNA Translation: AAC50901.1
CCDSiCCDS33500.1
RefSeqiNP_003176.2, NM_003185.3
UniGeneiHs.18857

Genome annotation databases

EnsembliENST00000252996; ENSP00000252996; ENSG00000130699
GeneIDi6874
KEGGihsa:6874
UCSCiuc002ybs.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTAF4_HUMAN
AccessioniPrimary (citable) accession number: O00268
Secondary accession number(s): A6NGD9
, Q5TBP6, Q99721, Q9BR40, Q9BX42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health