Reviewed, UniProtKB/Swiss-Prot O00255 (MEN1_HUMAN)

Names and origin

Protein names

Recommended name:
    Menin

Gene names

Name:	MEN1
Synonyms:	SCG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in DNA repair. Ref.3
Subunit structure	Interacts with FANCD2 and DBF4. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Ref.3 Ref.4
Subcellular location	Nucleus. Note: Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation. Ref.3
Tissue specificity	Ubiquitous.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7 Ref.8
Involvement in disease	Defects in MEN1 are the cause of familial multiple endocrine neoplasia type I (MEN1) [MIM:131100]; an autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia. Ref.1 Ref.9 Ref.10 Ref.12 Ref.13 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.29 Ref.30 Ref.31 Ref.32 Ref.34 Ref.35 Ref.37 Ref.39 Ref.40 Ref.41 Ref.42 Ref.43 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.51 Defects in MEN1 are the cause of familial isolated hyperparathyroidism (FIHP) [MIM:145000]; also known as hyperparathyroidism type 1 (HRPT1). FIHP is an autosomal dominant disorder characterized by hypercalcemia, elevated parathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid tumors. Ref.29 Ref.14 Ref.15 Ref.36 Ref.38 Ref.44 Ref.45

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	DNA repair Ref.3 Non-traceable author statement. Source: UniProtKB MAPKKK cascade Inferred from direct assay. Source: UniProtKB negative regulation of JNK cascade Inferred from direct assay. Source: UniProtKB negative regulation of cell proliferation Inferred from direct assay. Source: UniProtKB negative regulation of cyclin-dependent protein kinase activity Inferred from mutant phenotype. Source: UniProtKB negative regulation of osteoblast differentiation Inferred from genetic interaction. Source: MGI negative regulation of protein amino acid phosphorylation Inferred from direct assay. Source: UniProtKB negative regulation of telomerase activity Inferred from mutant phenotype. Source: UniProtKB negative regulation of transcription factor activity Inferred from direct assay. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: UniProtKB osteoblast development Inferred from genetic interaction. Source: MGI positive regulation of transforming growth factor beta receptor signaling pathway Inferred from mutant phenotype. Source: UniProtKB response to UV Inferred from direct assay. Source: UniProtKB response to gamma radiation Ref.3 Inferred from direct assay. Source: UniProtKB
Cellular component	chromatin Ref.3 Inferred from direct assay. Source: UniProtKB cleavage furrow Inferred from direct assay. Source: UniProtKB cytosol Inferred from direct assay. Source: UniProtKB histone methyltransferase complex Ref.6 Inferred from direct assay. Source: MGI nuclear matrix Ref.3 Inferred from direct assay. Source: UniProtKB soluble fraction Ref.3 Inferred from direct assay. Source: UniProtKB
Molecular function	R-SMAD binding Inferred from physical interaction. Source: UniProtKB Y-form DNA binding Inferred from direct assay. Source: UniProtKB double-stranded DNA binding Inferred from direct assay. Source: UniProtKB four-way junction DNA binding Inferred from direct assay. Source: UniProtKB protein N-terminus binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EBF3	Q9H4W6	1	EBI-592789,EBI-2111898
FANCD2	Q9BXW9	4	EBI-592789,EBI-359343
MYH9	P35579	5	EBI-592789,EBI-350338
Nme1	Q05982	4	EBI-592789,EBI-1165329	From a different organism.
RPRM	Q9NS64	1	EBI-592789,EBI-1052363

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O00255-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O00255-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     149-153: Missing.

Isoform 3 (identifier: O00255-3)

The sequence of this isoform differs from the canonical sequence as follows:
     149-153: Missing.
     189-223: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 615	615	Menin		PRO_0000096411
Regions
	Region	219 – 395	177	Interaction with FANCD2
Amino acid modifications
	Modified residue	399	1	Phosphoserine Ref.7
	Modified residue	599	1	Phosphothreonine Ref.8
Natural variations
	Alternative sequence	149 – 153	5	Missing in isoform 2 and isoform 3.		VSP_004323
	Alternative sequence	189 – 223	35	Missing in isoform 3.		VSP_015854
	Natural variant	12	1	P → L in MEN1.		VAR_005425
	Natural variant	22	1	L → R in MEN1. Ref.1		VAR_005426
	Natural variant	26	1	E → K in parathyroid adenoma and MEN1. dbSNP rs28931612. Ref.16 Ref.11		VAR_005427
	Natural variant	39	1	L → W in MEN1. Ref.29 Ref.34 Ref.41		VAR_005428
	Natural variant	42	1	G → D in MEN1. Ref.12 Ref.41		VAR_005429
	Natural variant	45	1	E → G in MEN1. Ref.24 Ref.35 Ref.49		VAR_005430
	Natural variant	45	1	E → K in MEN1. Ref.24 Ref.35 Ref.49		VAR_039587
	Natural variant	98	1	R → L in MEN1. Ref.41		VAR_039588
	Natural variant	110	1	G → E in MEN1. Ref.50		VAR_039589
	Natural variant	119	1	Missing in MEN1. Ref.1 Ref.23 Ref.34 Ref.43		VAR_005431
	Natural variant	135	1	K → I in MEN1. Ref.22		VAR_005434
	Natural variant	139	1	H → D in MEN1. Ref.25 Ref.39 Ref.49		VAR_005432
	Natural variant	139	1	H → P in MEN1. Ref.25 Ref.39 Ref.49		VAR_039590
	Natural variant	139	1	H → R in MEN1. Ref.25 Ref.39 Ref.49		VAR_039591
	Natural variant	139	1	H → Y in MEN1; familial and sporadic cases. Ref.25 Ref.39 Ref.49		VAR_005433
	Natural variant	144	1	F → V in MEN1. Ref.51		VAR_005436
	Natural variant	158	1	D → V in MEN1 and FIHP.		VAR_039592
	Natural variant	159	1	S → I in MEN1. Ref.43		VAR_039593
	Natural variant	160	1	S → F in MEN1. Ref.31		VAR_039594
	Natural variant	161	1	G → D in MEN1 and parathyroid tumor.		VAR_008017
	Natural variant	165	1	A → P in MEN1. Ref.12 Ref.41		VAR_005437
	Natural variant	165	1	A → T in MEN1. Ref.12 Ref.41		VAR_039595
	Natural variant	167	1	V → F in MEN1. Ref.41		VAR_039596
	Natural variant	169	1	A → D in MEN1. Ref.12 Ref.41		VAR_005438
	Natural variant	170	1	C → R in MEN1. Ref.41 Ref.47		VAR_039597
	Natural variant	171 – 173	3	Missing in MEN1. Ref.16 Ref.23		VAR_005439
	Natural variant	173	1	L → P in MEN1. Ref.16		VAR_039598
	Natural variant	176	1	R → Q: dbSNP rs607969. Ref.1 Ref.10 Ref.20 Ref.29 Ref.49		VAR_005440
	Natural variant	177	1	D → Y in MEN1. Ref.29 Ref.41		VAR_005441
	Natural variant	181	1	A → P in MEN1.		VAR_005442
	Natural variant	184	1	E → D in MEN1. Ref.29 Ref.34 Ref.37 Ref.51		VAR_005443
	Natural variant	184	1	E → K in MEN1. Ref.29 Ref.34 Ref.37 Ref.51		VAR_039599
	Natural variant	184	1	E → Q in MEN1. Ref.29 Ref.34 Ref.37 Ref.51		VAR_039600
	Natural variant	186	1	H → R in MEN1. Ref.51		VAR_039601
	Natural variant	188	1	W → R in MEN1 and parathyroid tumor.		VAR_039602
	Natural variant	188	1	W → S in MEN1. Ref.10 Ref.12 Ref.27		VAR_005444
	Natural variant	189	1	V → E in FIHP. Ref.15		VAR_005445
	Natural variant	220	1	V → M in MEN1. Ref.35 Ref.51		VAR_039603
	Natural variant	228	1	L → P in MEN1. Ref.34 Ref.41 Ref.47		VAR_005446
	Natural variant	230	1	G → R in MEN1. Ref.27		VAR_039604
	Natural variant	234	1	R → L in MEN1. Ref.32		VAR_039605
	Natural variant	245	1	V → F in MEN1. Ref.41		VAR_039606
	Natural variant	246	1	C → F in MEN1. Ref.27 Ref.30 Ref.47		VAR_039607
	Natural variant	246	1	C → R in MEN1. Ref.27 Ref.30 Ref.47		VAR_008018
	Natural variant	246	1	C → Y in MEN1. Ref.27 Ref.30 Ref.47		VAR_039608
	Natural variant	247	1	A → V in MEN1.		VAR_005447
	Natural variant	258	1	S → P in MEN1. Ref.27		VAR_039609
	Natural variant	258	1	S → W in parathyroid tumor. Ref.27 Ref.33		VAR_039610
	Natural variant	260	1	E → K in FIHP. Ref.14		VAR_005448
	Natural variant	264	1	L → R in MEN1. Ref.51		VAR_039611
	Natural variant	265	1	Q → P in FIHP. Ref.38		VAR_039612
	Natural variant	266	1	Q → QLQ in MEN1.		VAR_039613
	Natural variant	269	1	L → P in MEN1. Ref.29		VAR_005449
	Natural variant	272	1	L → P in FIHP. Ref.29		VAR_005450
	Natural variant	279	1	E → A in parathyroid tumor. Ref.33		VAR_039614
	Natural variant	282	1	P → H in FIHP. Ref.44		VAR_039615
	Natural variant	286	1	G → R in MEN1. Ref.41 Ref.47		VAR_039616
	Natural variant	289	1	A → E in MEN1. Ref.12		VAR_005451
	Natural variant	289	1	A → P in parathyroid tumor. Ref.12 Ref.33		VAR_039617
	Natural variant	291	1	L → P in MEN1.		VAR_005452
	Natural variant	310	1	G → D in FIHP. Ref.36		VAR_039618
	Natural variant	314	1	A → P in MEN1.		VAR_005453
	Natural variant	316	1	T → P in MEN1. Ref.41 Ref.47		VAR_039619
	Natural variant	319	1	R → P in MEN1. Ref.41		VAR_005454
	Natural variant	322	1	H → R in MEN1. Ref.34 Ref.41 Ref.47		VAR_039620
	Natural variant	322	1	H → Y in MEN1. Ref.34 Ref.41 Ref.47		VAR_039621
	Natural variant	325	1	P → L in MEN1. Ref.19 Ref.51		VAR_039622
	Natural variant	325	1	P → R in MEN1. Ref.19 Ref.51		VAR_039623
	Natural variant	330	1	A → P in MEN1. Ref.46		VAR_039624
	Natural variant	342	1	A → D in MEN1. dbSNP rs2071312. Ref.34 Ref.41		VAR_005455
	Natural variant	342	1	A → P in MEN1. Ref.34 Ref.41		VAR_039625
	Natural variant	346	1	W → R in MEN1. Ref.41		VAR_005456
	Natural variant	347	1	A → P in MEN1. Ref.48		VAR_039626
	Natural variant	349	1	T → R in MEN1. Ref.35		VAR_005457
	Natural variant	353	1	I → N in MEN1. Ref.34		VAR_039627
	Natural variant	358	1	Y → D in MEN1. Ref.32		VAR_039628
	Natural variant	360	1	R → W in MEN1. Ref.51		VAR_039629
	Natural variant	362	1	D → H in MEN1. Ref.41		VAR_039630
	Natural variant	364	1	E → K in MEN1. Ref.22		VAR_005458
	Natural variant	368	1	Missing in MEN1. Ref.1 Ref.43		VAR_005459
	Natural variant	373	1	A → D in MEN1. Ref.41		VAR_005460
	Natural variant	377	1	I → M in MEN1. Ref.41		VAR_039631
	Natural variant	378	1	P → S in MEN1. Ref.32		VAR_039632
	Natural variant	390	1	A → V in MEN1. Ref.34		VAR_039633
	Natural variant	416	1	A → P in MEN1 and FIHP.		VAR_039634
	Natural variant	419	1	L → P in MEN1. Ref.40		VAR_039635
	Natural variant	420	1	R → P in MEN1. Ref.32		VAR_039636
	Natural variant	423 – 426	4	Missing in MEN1. Ref.20 Ref.41 Ref.43 Ref.47 Ref.50 Ref.51		VAR_005463
	Natural variant	423	1	D → H in MEN1. Ref.20 Ref.41 Ref.43 Ref.47 Ref.50		VAR_039637
	Natural variant	423	1	D → N in MEN1. Ref.20 Ref.41 Ref.43 Ref.47 Ref.50		VAR_005461
	Natural variant	423	1	Missing in MEN1. Ref.20 Ref.41 Ref.43 Ref.47 Ref.50		VAR_005462
	Natural variant	426	1	C → Y in MEN1. Ref.51		VAR_039638
	Natural variant	428	1	W → S in MEN1. Ref.21		VAR_039639
	Natural variant	432	1	S → R in MEN1. Ref.18		VAR_039640
	Natural variant	441	1	W → C in MEN1. Ref.1 Ref.51		VAR_039641
	Natural variant	441	1	W → R in MEN1. Ref.1 Ref.51		VAR_005464
	Natural variant	449	1	L → P in MEN1. Ref.26		VAR_039642
	Natural variant	452	1	F → S in MEN1; sporadic; with Zollinger-Ellison syndrome.		VAR_005465
	Natural variant	532	1	R → C in MEN1. Ref.41		VAR_039643
	Natural variant	545	1	P → S in MEN1. Ref.47		VAR_039644
	Natural variant	546	1	A → T: dbSNP rs2959656. Ref.19 Ref.20 Ref.27 Ref.29 Ref.49		VAR_005466
	Natural variant	549	1	P → S in MEN1. Ref.34		VAR_039645
	Natural variant	557	1	T → S in adrenal adenoma; somatic. Ref.28		VAR_039646
	Natural variant	560	1	S → N in MEN1. Ref.41		VAR_005467
	Natural variant	560	1	S → R in MEN1. Ref.41		VAR_039647

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified April 18, 2006. Version 3. Checksum: CDCE840EA5B71BC4	FASTA	615	67,993
	10 20 30 40 50 60 MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE 70 80 90 100 110 120 LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 130 140 150 160 170 180 VSDVIWNSLS RSYFKDRAHI QSLFSFITGW SPVGTKLDSS GVAFAVVGAC QALGLRDVHL 190 200 210 220 230 240 ALSEDHAWVV FGPNGEQTAE VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME 250 260 270 280 290 300 VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR 310 320 330 340 350 360 PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR 370 380 390 400 410 420 EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ GTQSQGSALQ DPECFAHLLR 430 440 450 460 470 480 FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEEPWGEEA 490 500 510 520 530 540 REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP RKPPGTVAGT ARGPEGGSTA 550 560 570 580 590 600 QVPAPAASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP 610 SDYTLSFLKR QRKGL
	Isoform 2 (Short). Checksum: 8BE945C030372F9F	FASTA	610	67,467
	10 20 30 40 50 60 MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE 70 80 90 100 110 120 LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 130 140 150 160 170 180 VSDVIWNSLS RSYFKDRAHI QSLFSFITGT KLDSSGVAFA VVGACQALGL RDVHLALSED 190 200 210 220 230 240 HAWVVFGPNG EQTAEVTWHG KGNEDRRGQT VNAGVAERSW LYLKGSYMRC DRKMEVAFMV 250 260 270 280 290 300 CAINPSIDLH TDSLELLQLQ QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT 310 320 330 340 350 360 LYHKGIASAK TYYRDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD YNYCREDEEI 370 380 390 400 410 420 YKEFFEVAND VIPNLLKEAA SLLEAGEERP GEQSQGTQSQ GSALQDPECF AHLLRFYDGI 430 440 450 460 470 480 CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ VRQKVRIVSR EAEAAEAEEP WGEEAREGRR 490 500 510 520 530 540 RGPRRESKPE EPPPPKKPAL DKGLGTGQGA VSGPPRKPPG TVAGTARGPE GGSTAQVPAP 550 560 570 580 590 600 AASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL 610 SFLKRQRKGL
	Isoform 3. Checksum: 2A17BF24446474D3	FASTA	575	63,718
	10 20 30 40 50 60 MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE 70 80 90 100 110 120 LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 130 140 150 160 170 180 VSDVIWNSLS RSYFKDRAHI QSLFSFITGT KLDSSGVAFA VVGACQALGL RDVHLALSED 190 200 210 220 230 240 HAWSWLYLKG SYMRCDRKME VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER 250 260 270 280 290 300 YPMALGNLAD LEELEPTPGR PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR 310 320 330 340 350 360 EALQAWADTA TVIQDYNYCR EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ 370 380 390 400 410 420 GTQSQGSALQ DPECFAHLLR FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV 430 440 450 460 470 480 RIVSREAEAA EAEEPWGEEA REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP 490 500 510 520 530 540 RKPPGTVAGT ARGPEGGSTA QVPAPAASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI 550 560 570 KLQLTAQSQV QMKKQKVSTP SDYTLSFLKR QRKGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Positional cloning of the gene for multiple endocrine neoplasia-type 1." Chandrasekharappa S.C., Guru S.C., Manickam P., Olufemi S.-E., Collins F.S., Emmert-Buck M.R., Debelenko L.V., Zhuang Z., Lubensky I.A., Liotta L.A., Crabtree J.S., Wang Y., Roe B.A., Weisemann J., Boguski M.S., Agarwal S.K., Kester M.B., Kim Y.S. , Heppner C., Dong Q., Spiegel A.M., Burns A.L., Marx S.J. Science 276:404-407(1997) [PubMed: 9103196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS MEN1 ARG-22; LYS-119 DEL; GLU-368 DEL AND ARG-441, VARIANT GLN-176. Tissue: Leukocyte.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Placenta.
[3]	"Menin associates with FANCD2, a protein involved in repair of DNA damage." Jin S., Mao H., Schnepp R.W., Sykes S.M., Silva A.C., D'Andrea A.D., Hua X. Cancer Res. 63:4204-4210(2003) [PubMed: 12874027] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FANCD2.
[4]	"Functional interaction between tumor suppressor menin and activator of S-phase kinase." Schnepp R.W., Hou Z., Wang H., Petersen C., Silva A., Masai H., Hua X. Cancer Res. 64:6791-6796(2004) [PubMed: 15374998] [Abstract] Cited for: INTERACTION WITH DBF4.
[5]	"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression." Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D.J., Kitabayashi I., Herr W., Cleary M.L. Mol. Cell. Biol. 24:5639-5649(2004) [PubMed: 15199122] [Abstract] Cited for: IDENTIFICATION IN THE MLL-LIKE COMPLEX.
[6]	"PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex." Cho Y.-W., Hong T., Hong S., Guo H., Yu H., Kim D., Guszczynski T., Dressler G.R., Copeland T.D., Kalkum M., Ge K. J. Biol. Chem. 282:20395-20406(2007) [PubMed: 17500065] [Abstract] Cited for: IDENTIFICATION IN THE MLL-LIKE COMPLEX.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-599, MASS SPECTROMETRY.
[9]	"Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states." Agarwal S.K., Kester M.B., Debelenko L.V., Heppner C., Emmert-Buck M.R., Skarulis M.C., Doppman J.L., Kim Y.S., Lubensky I.A., Zhuang Z., Green J.S., Guru S.C., Manickam P., Olufemi S.E., Liotta L.A., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Burns A.L., Marx S.J. Hum. Mol. Genet. 6:1169-1175(1997) [PubMed: 9215689] [Abstract] Cited for: VARIANTS MEN1.
[10]	"Identification of the multiple endocrine neoplasia type 1 (MEN1) gene." The european consortium on MEN1 Lemmens I., Van de Ven W.J.M., Kas K., Zhang C.X., Giraud S., Wautot V., Buisson N., De Witte K., Salandre J., Lenoir G., Pugeat M., Calender A., Parente F., Quincey D., Gaudray P., De Wit M.J., Lips C.J.M., Hoeppener J.W.M. , Khodaei S., Grant A.L., Weber G., Kytoelae S., Teh B.T., Farnebo F., Phelan C., Hayward N., Larsson C., Pannett A.A.J., Forbes S.A., Basset J.H.D., Thakker R.V. Hum. Mol. Genet. 6:1177-1183(1997) [PubMed: 9215690] [Abstract] Cited for: VARIANT MEN1 SER-188, VARIANT GLN-176.
[11]	"Somatic mutation of the MEN1 gene in parathyroid tumours." Heppner C., Kester M.B., Agarwal S.K., Debelenko L.V., Emmert-Buck M.R., Guru S.C., Manickam P., Olufemi S.-E., Skarulis M.C., Doppman J.L., Alexander R.H., Kim Y.S., Saggar S.K., Lubensky I.A., Zhuang Z., Liotta L.A., Chandrasekharappa S.C., Collins F.S. , Spiegel A.M., Burns A.L., Marx S.J. Nat. Genet. 16:375-378(1997) [PubMed: 9241276] [Abstract] Cited for: VARIANT PARATHYROID ADENOMA LYS-26.
[12]	"Characterization of mutations in patients with multiple endocrine neoplasia type 1." Bassett J.H.D., Forbes S.A., Pannett A.A.J., Lloyd S.E., Christie P.T., Wooding C., Harding B., Besser G.M., Edwards C.R., Monson J.P., Sampson J., Wass J.A.H., Wheeler M.H., Thakker R.V. Am. J. Hum. Genet. 62:232-244(1998) [PubMed: 9463336] [Abstract] Cited for: VARIANTS MEN1 ASP-42; PRO-165; ASP-169; SER-188 AND GLU-289.
[13]	"Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders." Giraud S., Zhang C.X., Serova-Sinilnikova O., Wautot V., Salandre J., Buisson N., Waterlot C., Bauters C., Porchet N., Aubert J.-P., Emy P., Cadiot G., Delemer B., Chabre O., Niccoli P., Leprat F., Duron F., Emperauger B. , Cougard P., Goudet P., Sarfati E., Riou J.-P., Guichard S., Rodier M., Meyrier A., Caron P., Vantyghem M.-C., Assayag M., Peix J.-L., Pugeat M., Rohmer V., Vallotton M., Lenoir G., Gaudray P., Proye C., Conte-Devolx B., Chanson P., Shugart Y.Y., Goldgar D., Murat A., Calender A. Am. J. Hum. Genet. 63:455-467(1998) [PubMed: 9683585] [Abstract] Cited for: VARIANTS MEN1.
[14]	"A family with isolated hyperparathyroidism segregating a missense MEN1 mutation and showing loss of the wild-type alleles in the parathyroid tumors." Teh B.T., Esapa C.T., Houlston R., Grandell U., Farnebo F., Nordenskjoeld M., Pearce C.J., Carmichael D., Larsson C., Harris P.E. Am. J. Hum. Genet. 63:1544-1549(1998) [PubMed: 9792884] [Abstract] Cited for: VARIANT FIHP LYS-260.
[15]	"Novel V184E MEN1 germline mutation in a Japanese kindred with familial hyperparathyroidism." Fujimori M., Shirahama S., Sakurai A., Hashizume K., Hama Y., Ito K., Shingu K., Kobayashi S., Amano J., Fukushima Y. Am. J. Med. Genet. 80:221-222(1998) [PubMed: 9843042] [Abstract] Cited for: VARIANT FIHP GLU-189.
[16]	"MEN1 gene mutations in 12 MEN1 families and their associated tumors." Bartsch D., Kopp I., Bergenfelz A., Rieder H., Muench K., Jaeger K., Deiss Y., Schudy A., Barth P., Arnold R., Rothmund M., Simon B. Eur. J. Endocrinol. 139:416-420(1998) [PubMed: 9820618] [Abstract] Cited for: VARIANTS MEN1 LYS-26 AND PRO-173.
[17]	"Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families." Agarwal S.K., Debelenko L.V., Kester M.B., Guru S.C., Manickam P., Olufemi S.-E., Skarulis M.C., Heppner C., Crabtree J.S., Lubensky I.A., Zhuang Z., Kim Y.S., Chandrasekharappa S.C., Collins F.S., Liotta L.A., Spiegel A.M., Burns A.L., Emmert-Buck M.R., Marx S.J. Hum. Mutat. 12:75-82(1998) [PubMed: 9671267] [Abstract] Cited for: VARIANTS MEN1.
[18]	"Five novel mutations in the familial multiple endocrine neoplasia type 1 (MEN1) gene." Cote G.J., Lee J.E., Evans D.B., Huang E., Schultz P.N., Dang G.T., Qiu H., Shetelbine S., Sellin R.V., Gagel R.F. Hum. Mutat. 12:219-219(1998) [PubMed: 10660339] [Abstract] Cited for: VARIANT MEN1 ARG-432.
[19]	"Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese." Tanaka C., Yoshimoto K., Yamada S., Nishioka H., Ii S., Moritani M., Yamaoka T., Itakura M. J. Clin. Endocrinol. Metab. 83:960-965(1998) [PubMed: 9506756] [Abstract] Cited for: VARIANT MEN1 LEU-325, VARIANT THR-546.
[20]	"Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism." Teh B.T., Kytoelae S., Farnebo F., Bergman L., Wong F.K., Weber G., Hayward N., Larsson C., Skogseid B., Beckers A., Phelan C., Edwards M., Epstein M., Alford F., Hurley D., Grimmond S., Silins G., Walters M. , Stewart C., Cardinal J., Khodaei S., Parente F., Tranebjaerg L., Jorde R., Menon J., Khir A., Tan T.T., Chan S.P., Zaini A., Khalid B.A.K., Sandelin K., Thompson N., Brandi M.-L., Warth M., Stock J., Leisti J., Cameron D., Shepherd J.J., Oeberg K., Nordenskjoeld M., Salmela P. J. Clin. Endocrinol. Metab. 83:2621-2626(1998) [PubMed: 9709921] [Abstract] Cited for: VARIANT MEN1 ASN-423, VARIANTS GLN-176 AND THR-546.
[21]	"Menin mutations in MEN1 patients." Mayr B., Brabant G., von zur Muehlen A. J. Clin. Endocrinol. Metab. 83:3004-3005(1998) [PubMed: 9709985] [Abstract] Cited for: VARIANT MEN1 SER-428.
[22]	"Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas." Boeni R., Vortmeyer A.O., Pack S., Park W.-S., Burg G., Hofbauer G., Darling T., Liotta L., Zhuang Z. J. Invest. Dermatol. 111:539-540(1998) [PubMed: 9740255] [Abstract] Cited for: VARIANTS MEN1 ILE-135 AND LYS-364.
[23]	"Novel MEN1 gene mutations in familial multiple endocrine neoplasia type 1." Sakurai A., Shirahama S., Fujimori M., Katai M., Itakura Y., Kobayashi S., Amano J., Fukushima Y., Hashizume K. J. Hum. Genet. 43:199-201(1998) [PubMed: 9747036] [Abstract] Cited for: VARIANTS MEN1 LYS-119 DEL AND 171-GLN--LEU-173 DEL.
[24]	"Identification of five novel germline mutations of the MEN1 gene in Japanese multiple endocrine neoplasia type 1 (MEN1) families." Sato M., Matsubara S., Miyauchi A., Ohye H., Imachi H., Murao K., Takahara J. J. Med. Genet. 35:915-919(1998) [PubMed: 9832038] [Abstract] Cited for: VARIANT MEN1 GLY-45.
[25]	"Molecular pathology of multiple endocrine neoplasia type I: two novel germline mutations and updated classification of mutations affecting MEN1 gene." Martin-Campos J.M., Catasus L., Chico A., Mayoral C., Lagarda E., Gallart L., Mato E., Rodriguez-Espinosa J., Matias-Guiu X., De Leiva A., Blanco-Vaca F. Diagn. Mol. Pathol. 8:195-204(1999) [PubMed: 10617276] [Abstract] Cited for: VARIANT MEN1 ARG-139.
[26]	"A new mutation of the MEN1 gene in an italian kindred with multiple endocrine neoplasia type 1." Cetani F., Pardi E., Cianferotti L., Vignali E., Picone A., Miccoli P., Pinchera A., Marcocci C. Eur. J. Endocrinol. 140:429-433(1999) [PubMed: 10229909] [Abstract] Cited for: VARIANT MEN1 PRO-449.
[27]	"Germline MEN1 mutations in sixteen Japanese families with multiple endocrine neoplasia type 1 (MEN1)." Hai N., Aoki N., Matsuda A., Mori T., Kosugi S. Eur. J. Endocrinol. 141:475-480(1999) [PubMed: 10576763] [Abstract] Cited for: VARIANTS MEN1 ARG-188; ARG-230; TYR-246 AND PRO-258, VARIANT THR-546.
[28]	"MEN I gene mutations in sporadic adrenal adenomas." Schulte K.-M., Heinze M., Mengel M., Simon D., Scheuring S., Koehrer K., Roeher H.-D. Hum. Genet. 105:603-610(1999) [PubMed: 10647896] [Abstract] Cited for: VARIANT ADRENAL ADENOMA SER-557.
[29]	"Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases." Poncin J., Abs R., Velkeniers B., Bonduelle M., Abramowicz M., Legros J.-J., Verloes A., Meurisse M., van Gaal L., Verellen C., Koulischer L., Beckers A. Hum. Mutat. 13:54-60(1999) [PubMed: 9888389] [Abstract] Cited for: VARIANTS MEN1 TRP-39; TYR-177; ASP-184 AND PRO-269, VARIANT FIHP PRO-272, VARIANTS GLN-176 AND THR-546.
[30]	"Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects." Mutch M.G., Dilley W.G., Sanjurjo F., Debenedetti M.K., Doherty G.M., Wells S.A. Jr., Goodfellow P.J., Lairmore T.C. Hum. Mutat. 13:175-185(1999) [PubMed: 10090472] [Abstract] Cited for: VARIANTS MEN1 ASP-161 AND ARG-246.
[31]	"Germline mutations in the MEN1 gene: creation of a new splice acceptor site and insertion of 7 intron nucleotides into the mRNA." Engelbach M., Forst T., Hankeln T., Tratzky M., Heerdt S., Pfuetzner A., Kann P., Kunt T., Schneider S., Schmidt E.R., Beyer J. Int. J. Mol. Med. 4:483-485(1999) [PubMed: 10534569] [Abstract] Cited for: VARIANT MEN1 PHE-160.
[32]	"Identification of MEN1 gene mutations in families with MEN 1 and related disorders." Bergman L., Teh B.T., Cardinal J., Palmer J., Walters M., Shepherd J., Cameron D., Hayward N. Br. J. Cancer 83:1009-1014(2000) [PubMed: 10993647] [Abstract] Cited for: VARIANTS MEN1 LEU-234; ASP-358; SER-378 AND PRO-420.
[33]	"Screening of the MEN1 gene and discovery of germ-line and somatic mutations in apparently sporadic parathyroid tumors." Uchino S., Noguchi S., Sato M., Yamashita H., Yamashita H., Watanabe S., Murakami T., Toda M., Ohshima A., Futata T., Mizukoshi T., Koike E., Takatsu K., Terao K., Wakiya S., Nagatomo M., Adachi M. Cancer Res. 60:5553-5557(2000) [PubMed: 11034102] [Abstract] Cited for: VARIANTS PARATHYROID TUMOR ASP-161; ARG-188; TRP-258; ALA-279 AND PRO-289.
[34]	"Criteria for mutation analysis in MEN 1-suspected patients: MEN 1 case-finding." Roijers J.F.M., de Wit M.J., van der Luijt R.B., Ploos van Amstel H.K., Hoeppener J.W.M., Lips C.J.M. Eur. J. Clin. Invest. 30:487-492(2000) [PubMed: 10849016] [Abstract] Cited for: VARIANTS MEN1 TRP-39; LYS-119 DEL; GLN-184; PRO-228; ARG-322; PRO-342; ASN-353; VAL-390 AND SER-549.
[35]	"MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1." Morelli A., Falchetti A., Martineti V., Becherini L., Mark M., Friedman E., Brandi M.L. Eur. J. Endocrinol. 142:131-137(2000) [PubMed: 10664520] [Abstract] Cited for: VARIANTS MEN1 LYS-45; MET-220 AND ARG-349.
[36]	"A novel mutation of the MEN1 gene in a Japanese kindred with familial isolated primary hyperparathyroidism." Honda M., Tsukada T., Tanaka H., Maruyama K., Yamaguchi K., Obara T., Yamaji T., Ishibashi M. Eur. J. Endocrinol. 142:138-143(2000) [PubMed: 10664521] [Abstract] Cited for: VARIANT FIHP ASP-310.
[37]	"A novel mutation E179K of the MEN1 gene predisposes for multiple endocrine neoplasia-type 1 (MEN1)." Weinhaeusel A., Vierhapper H., Schlegl R., Wagner T., Muhr D., Scheuba C., Niederle B., Haas O.A. Hum. Mutat. 16:533-533(2000) [PubMed: 11102994] [Abstract] Cited for: VARIANT MEN1 LYS-184.
[38]	"Familial isolated hyperparathyroidism as a variant of multiple endocrine neoplasia type 1 in a large Danish pedigree." Kassem M., Kruse T.A., Wong F.K., Larsson C., Teh B.T. J. Clin. Endocrinol. Metab. 85:165-167(2000) [PubMed: 10634381] [Abstract] Cited for: VARIANT FIHP PRO-265.
[39]	"Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1." Stratakis C.A., Schussheim D.H., Freedman S.M., Keil M.F., Pack S.D., Agarwal S.K., Skarulis M.C., Weil R.J., Lubensky I.A., Zhuang Z., Oldfield E.H., Marx S.J. J. Clin. Endocrinol. Metab. 85:4776-4780(2000) [PubMed: 11134142] [Abstract] Cited for: VARIANT MEN1 ASP-139.
[40]	"Identification of three novel menin mutations (c.741delGTCA, c.1348T>C, c.1785delA) in unrelated Italian families affected with multiple endocrine neoplasia type 1: additional information for mutational screening." Asteria C., Faglia G., Roncoroni R., Borretta G., Ribotto P., Beck-Peccoz P. Hum. Mutat. 17:237-237(2001) [PubMed: 11241849] [Abstract] Cited for: VARIANT MEN1 PRO-419.
[41]	"Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein." Wautot V., Vercherat C., Lespinasse J., Chambe B., Lenoir G.M., Zhang C.X., Porchet N., Cordier M., Beroud C., Calender A. Hum. Mutat. 20:35-47(2002) [PubMed: 12112656] [Abstract] Cited for: VARIANTS MEN1 TRP-39; ASP-42; LEU-98; PRO-165; THR-165; PHE-167; ASP-169; ARG-170; TYR-177; PRO-228; PHE-245; ARG-286; PRO-316; PRO-319; TYR-322; ARG-322; ASP-342; ARG-346; HIS-362; ASP-373; MET-377; ASN-423; CYS-532; ASN-560 AND ARG-560.
[42]	"A novel six-nucleotide insertion in exon 4 of the MEN1 gene, 878insCTGCAG, in three patients with familial insulinoma and primary hyperparathyroidism." Okamoto H., Tamada A., Hai N., Doi M., Uchimura I., Hirata Y., Kosugi S. Jpn. J. Clin. Oncol. 32:368-370(2002) [PubMed: 12417605] [Abstract] Cited for: VARIANT MEN1 LEU-GLN-266 INS.
[43]	"Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1." Turner J.J.O., Leotlela P.D., Pannett A.A.J., Forbes S.A., Bassett J.H.D., Harding B., Christie P.T., Bowen-Jones D., Ellard S., Hattersley A., Jackson C.E., Pope R., Quarrell O.W., Trembath R., Thakker R.V. J. Clin. Endocrinol. Metab. 87:2688-2693(2002) [PubMed: 12050235] [Abstract] Cited for: VARIANTS MEN1 LYS-119 DEL; ILE-159; GLU-368 DEL AND ASN-423.
[44]	"Genetic screening for MEN1 mutations in families presenting with familial primary hyperparathyroidism." Perrier N.D., Villablanca A., Larsson C., Wong M., Ituarte P., Teh B.T., Clark O.H. World J. Surg. 26:907-913(2002) [PubMed: 12016470] [Abstract] Cited for: VARIANT FIHP HIS-282.
[45]	"Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism." Pannett A.A.J., Kennedy A.M., Turner J.J.O., Forbes S.A., Cavaco B.M., Bassett J.H.D., Cianferotti L., Harding B., Shine B., Flinter F., Maidment C.G.H., Trembath R., Thakker R.V. Clin. Endocrinol. (Oxf.) 58:639-646(2003) [PubMed: 12699448] [Abstract] Cited for: VARIANTS FIHP VAL-158 AND PRO-416.
[46]	"Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders." Park J.-H., Kim I.-J., Kang H.C., Lee S.-H., Shin Y., Kim K.-H., Lim S.-B., Kang S.-B., Lee K.U., Kim S.Y., Lee M.-S., Lee M.-K., Park J.-H., Moon S.-D., Park J.-G. Clin. Genet. 64:48-53(2003) [PubMed: 12791038] [Abstract] Cited for: VARIANT MEN1 PRO-330.
[47]	"Efficient mutation detection in MEN1 gene using a combination of single-strand conformation polymorphism (MDGA) and heteroduplex analysis." Groupe d'etude des neoplasies emdocriniennes multiples Crepin M., Escande F., Pigny P., Buisine M.-P., Calender A., Porchet N., Odou M.-F. Electrophoresis 24:26-33(2003) [PubMed: 12652570] [Abstract] Cited for: VARIANTS MEN1 ARG-170; PRO-228; PHE-246; ARG-286; PRO-316; TYR-322; ASN-423 AND SER-545.
[48]	"A novel missense mutation of the MEN1 gene in a multiple endocrine neoplasia type 1 patient associated with carcinoid syndrome." Ukita C., Yamaguchi M., Tanaka T., Shigeta H., Nishikawa M. Intern. Med. 42:1112-1116(2003) [PubMed: 14686752] [Abstract] Cited for: VARIANT MEN1 PRO-347.
[49]	"Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients." Cebrian A., Ruiz-Llorente S., Cascon A., Pollan M., Diez J.J., Pico A., Telleria D., Benitez J., Robledo M. J. Med. Genet. 40:E72-E72(2003) [PubMed: 12746426] [Abstract] Cited for: VARIANTS MEN1 LYS-45 AND PRO-139, VARIANTS GLN-176 AND THR-546.
[50]	"Novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1." Jap T.-S., Chiu C.-Y., Won J.G.-S., Wu Y.-C., Chen H.-S. Clin. Endocrinol. (Oxf.) 62:336-342(2005) [PubMed: 15730416] [Abstract] Cited for: VARIANTS MEN1 GLU-110 AND HIS-423.
[51]	"Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory." Klein R.D., Salih S., Bessoni J., Bale A.E. Genet. Med. 7:131-138(2005) [PubMed: 15714081] [Abstract] Cited for: VARIANTS MEN1 VAL-144; ASP-161; ASP-184; LYS-184; ARG-186; MET-220; ARG-264; ARG-325; TRP-360; TYR-426; CYS-441 AND ARG-441.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

GeneReviews

Cross-references

Sequence databases
EMBLGenBankDDBJ	U93236 mRNA. Translation: AAC51228.1. U93237 Genomic DNA. Translation: AAC51229.1. U93237 Genomic DNA. Translation: AAC51230.1. BC002544 mRNA. Translation: AAH02544.1.
IPI	IPI00182106. IPI00328838. IPI00651636.
RefSeq	NP_000235.2. NP_570711.1. NP_570712.1. NP_570713.1. NP_570714.1. NP_570715.1. NP_570716.1.
UniGene	Hs.423348
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:24236N.
IntAct	O00255. 11 interactions.
PTM databases
PhosphoSite	O00255.
Proteomic databases
PRIDE	O00255.
Genome annotation databases
Ensembl	ENSG00000133895. Homo sapiens. [Contig view]
GeneID	4221.
KEGG	hsa:4221.
Organism-specific databases
GeneCards	GC11M064327.
H-InvDB	HIX0009771.
HGNC	HGNC:7010. MEN1.
MIM	131100. gene+phenotype. 145000. phenotype.
Orphanet	99879. Hyperparathyroidism, familial, isolated (FIHPT). 2207. Hyperparathyroidism, primary, familial. 652. Multiple endocrine neoplasia type 1. 99877. Parathyroid adenoma. 913. Zollinger-Ellison syndrome.
PharmGKB	PA38241.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O00255.
HOVERGEN	O00255.
Gene expression databases
Bgee	O00255.
CleanEx	HS_MEN1. HS_SCG2.
GermOnline	ENSG00000133895. Homo sapiens.
Family and domain databases
InterPro	IPR007747. Menin. [Graphical view]
PANTHER	PTHR12693. Menin. 1 hit.
Pfam	PF05053. Menin. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	16643.
SOURCE	Search...

Entry information

Entry name

MEN1_HUMAN

Accession

Primary (citable) accession number: O00255
Secondary accession number(s): O00632, Q9BUK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	April 18, 2006
Last modified:	June 16, 2009
This is version 87 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)