Reviewed,
UniProtKB/Swiss-Prot O00253 (AGRP_HUMAN)
Last modified
July 13, 2010.
Version 96.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and originHide
| Protein names | Recommended name: Agouti-related protein | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributesHide
| Sequence length | 132 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)Hide
| Function | Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding. |
| Subcellular location | Secreted By similarity. |
| Tissue specificity | Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. |
| Domain | The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. |
| Involvement in disease | Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665]. |
| Sequence similarities | Contains 1 agouti domain. |
OntologiesHide
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Disease | Disease mutation Obesity |
| Domain | Knottin Signal |
| PTM | Disulfide bond |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | hormone-mediated signaling pathway Inferred from electronic annotation. Source: InterPro neuropeptide signaling pathwayTraceable author statement. Source: ProtInc |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | neuropeptide hormone activity Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)Hide
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||
Molecule processing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | ||||||||||||||||
| Chain | 21 – 132 | 112 | Agouti-related protein | PRO_0000001034 | |||||||||||||||
Regions | |||||||||||||||||||
| Domain | 87 – 129 | 43 | Agouti | ||||||||||||||||
Amino acid modifications | |||||||||||||||||||
| Disulfide bond | 87 ↔ 102 | Ref.7 | |||||||||||||||||
| Disulfide bond | 94 ↔ 108 | Ref.7 | |||||||||||||||||
| Disulfide bond | 101 ↔ 119 | Ref.7 | |||||||||||||||||
| Disulfide bond | 105 ↔ 129 | Ref.7 | |||||||||||||||||
| Disulfide bond | 110 ↔ 117 | Ref.7 | |||||||||||||||||
Natural variations | |||||||||||||||||||
| Natural variant | 67 | 1 | A → T in obesity; late onset. [dbSNP:rs5030980] Ref.3 Ref.10 | VAR_015385 | |||||||||||||||
Experimental info | |||||||||||||||||||
| Sequence conflict | 6 | 1 | V → L in AAB68621. Ref.2 | ||||||||||||||||
Secondary structure | |||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||
| Beta strand | 95 – 97 | 3 | |||||||||||||||||
| Beta strand | 101 – 103 | 3 | |||||||||||||||||
| Beta strand | 107 – 115 | 9 | |||||||||||||||||
| Beta strand | 117 – 120 | 4 | |||||||||||||||||
| Beta strand | 125 – 127 | 3 | |||||||||||||||||
SequencesHide
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ReferencesHide
| « Hide 'large scale' references | |
| [1] | "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice." Shutter J.R., Graham M., Kinsey A.C., Scully S., Luethy R., Stark K.L. Genes Dev. 11:593-602(1997) [PubMed: 9119224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein." Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., Barsh G.S. Science 278:135-138(1997) [PubMed: 9311920] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adrenal gland. |
| [3] | "The gene structure and minimal promoter of the human agouti related protein." Brown A.M., Mayfield D.K., Volaufova J., Argyropoulos G. Gene 277:231-238(2001) [PubMed: 11602360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-67. |
| [4] | "Association between an agouti-related protein gene polymorphism and anorexia nervosa." Vink T., Hinney A., van Elburg A.A., van Goozen S.H., Sandkuijl L.A., Sinke R.J., Herpertz-Dahlmann B.M., Hebebrand J., Remschmidt H., van Engeland H., Adan R.A. Mol. Psychiatry 6:325-328(2001) [PubMed: 11326303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | SeattleSNPs variation discovery resource Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation." Bures E.J., Hui J.O., Young Y., Chow D.T., Katta V., Rohde M.F., Zeni L., Rosenfeld R.D., Stark K.L., Haniu M. Biochemistry 37:12172-12177(1998) [PubMed: 9724530] [Abstract] Cited for: DISULFIDE BONDS. |
| [8] | "NMR structure of a minimized human agouti related protein prepared by total chemical synthesis." Bolin K.A., Anderson D.J., Trulson J.A., Thompson D.A., Wilken J., Kent S.B.H., Gantz I., Millhauser G.L. FEBS Lett. 451:125-131(1999) [PubMed: 10371151] [Abstract] Cited for: STRUCTURE BY NMR OF 87-132. |
| [9] | "Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity." Jackson P.J., McNulty J.C., Yang Y.K., Thompson D.A., Chai B., Gantz I., Barsh G.S., Millhauser G.L. Biochemistry 41:7565-7572(2002) [PubMed: 12056887] [Abstract] Cited for: STRUCTURE BY NMR OF 87-120. |
| [10] | "A polymorphism in the human agouti-related protein is associated with late-onset obesity." Argyropoulos G., Rankinen T., Neufeld D.R., Rice T., Province M.A., Leon A.S., Skinner J.S., Wilmore J.H., Rao D.C., Bouchard C. J. Clin. Endocrinol. Metab. 87:4198-4202(2002) [PubMed: 12213871] [Abstract] Cited for: VARIANT THR-67. |
| + | Additional computationally mapped references. |
Cross-referencesHide
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U88063 mRNA. Translation: AAB52240.1. U89485 mRNA. Translation: AAB68621.1. AF314194 Genomic DNA. Translation: AAL09457.1. AF281309 Genomic DNA. Translation: AAK96256.1. DQ374394 Genomic DNA. Translation: ABC88473.1. BC110443 mRNA. Translation: AAI10444.1. | ||||||||||||||||||||||||
| IPI | IPI00010869. | ||||||||||||||||||||||||
| RefSeq | NP_001129.1. | ||||||||||||||||||||||||
| UniGene | Hs.104633 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| STRING | O00253. | ||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||
| PRIDE | O00253. | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENST00000290953; ENSP00000290953; ENSG00000159723; Homo sapiens. [Genome view] ENST00000393941; ENSP00000377515; ENSG00000159723; Homo sapiens. [Genome view] | ||||||||||||||||||||||||
| GeneID | 181. | ||||||||||||||||||||||||
| KEGG | hsa:181. | ||||||||||||||||||||||||
| UCSC | uc002etg.1. human. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CTD | 181. | ||||||||||||||||||||||||
| GeneCards | GC16M066073. | ||||||||||||||||||||||||
| HGNC | HGNC:330. AGRP. | ||||||||||||||||||||||||
| MIM | 601665. phenotype. 602311. gene. | ||||||||||||||||||||||||
| PharmGKB | PA24627. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| eggNOG | prNOG20473. | ||||||||||||||||||||||||
| HOGENOM | HBG126983. | ||||||||||||||||||||||||
| HOVERGEN | HBG050467. | ||||||||||||||||||||||||
| InParanoid | O00253. | ||||||||||||||||||||||||
| OMA | QGAQMGL. | ||||||||||||||||||||||||
| OrthoDB | EOG9S4S23. | ||||||||||||||||||||||||
| PhylomeDB | O00253. | ||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||
| Pathway_Interaction_DB | syndecan_3_pathway. Syndecan-3-mediated signaling events. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | O00253. | ||||||||||||||||||||||||
| Bgee | O00253. | ||||||||||||||||||||||||
| CleanEx | HS_AGRP. | ||||||||||||||||||||||||
| Genevestigator | O00253. | ||||||||||||||||||||||||
| GermOnline | ENSG00000159723. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR007733. Agouti. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:4.10.760.10. Agouti. 1 hit. | ||||||||||||||||||||||||
| PANTHER | PTHR16551. Agouti. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF05039. Agouti. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| SMART | SM00792. Agouti. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| SUPFAM | SSF57055. Agouti. 1 hit. | ||||||||||||||||||||||||
| PROSITE | PS60024. AGOUTI_1. 1 hit. PS51150. AGOUTI_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| NextBio | 738. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry informationHide
| Entry name | AGRP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O00253 Secondary accession number(s): O15459, Q2TBD9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documentsHide
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


