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O00244 (ATOX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Copper transport protein ATOX1
Alternative name(s):
Metal transport protein ATX1
Gene names
Name:ATOX1
Synonyms:HAH1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.

Subunit structure

Interacts with ATP7B. Ref.10

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the ATX1 family.

Contains 1 HMA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6868Copper transport protein ATOX1
PRO_0000212537

Regions

Domain2 – 6867HMA

Sites

Metal binding121Copper
Metal binding151Copper

Amino acid modifications

Modified residue601N6-acetyllysine By similarity

Secondary structure

.............. 68
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O00244 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 0B364B1BD1279314

FASTA687,402
        10         20         30         40         50         60 
MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK 


TVSYLGLE 

« Hide

References

« Hide 'large scale' references
[1]"Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis."
Klomp L.W.J., Lin S.-J., Yuan D.S., Klausner R.D., Culotta V.C., Gitlin J.D.
J. Biol. Chem. 272:9221-9226(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Genomic organization of ATOX1, a human copper chaperone."
Liu P.-C., Koeller D.M., Kaler S.G.
BMC Genet. 4:4-4(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[5]NIEHS SNPs program
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins."
Wernimont A.K., Huffman D.L., Lamb A.L., O'Halloran T.V., Rosenzweig A.C.
Nat. Struct. Biol. 7:766-771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS), COPPER-BINDING SITES, INTERACTION WITH ATP7B.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U70660 mRNA. Translation: AAC51227.1.
AY165037 Genomic DNA. Translation: AAN84554.1.
BT009786 mRNA. Translation: AAP88788.1.
AK293063 mRNA. Translation: BAF85752.1.
AY986502 Genomic DNA. Translation: AAX81411.1.
CH471062 Genomic DNA. Translation: EAW61663.1.
CH471062 Genomic DNA. Translation: EAW61664.1.
BC112248 mRNA. Translation: AAI12249.1.
BC112250 mRNA. Translation: AAI12251.1.
RefSeqNP_004036.1. NM_004045.3.
UniGeneHs.125213.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FE0X-ray1.75A/B1-68[»]
1FE4X-ray1.75A/B1-68[»]
1FEEX-ray1.80A/B1-68[»]
1TL4NMR-A1-68[»]
1TL5NMR-A1-68[»]
2K1RNMR-B1-68[»]
2LQ9NMR-A1-68[»]
3CJKX-ray1.80A2-68[»]
3IWLX-ray1.60A1-68[»]
3IWXX-ray2.14A/B1-68[»]
ProteinModelPortalO00244.
SMRO00244. Positions 2-67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106965. 3 interactions.
MINTMINT-105921.
STRING9606.ENSP00000316854.

PTM databases

PhosphoSiteO00244.

Proteomic databases

PaxDbO00244.
PeptideAtlasO00244.
PRIDEO00244.

Protocols and materials databases

DNASU475.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313115; ENSP00000316854; ENSG00000177556.
ENST00000522710; ENSP00000429814; ENSG00000177556.
ENST00000524142; ENSP00000430598; ENSG00000177556.
GeneID475.
KEGGhsa:475.
UCSCuc003luk.3. human.

Organism-specific databases

CTD475.
GeneCardsGC05M151122.
HGNCHGNC:798. ATOX1.
HPAHPA055036.
MIM602270. gene.
neXtProtNX_O00244.
PharmGKBPA25096.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238748.
HOGENOMHOG000038877.
HOVERGENHBG050610.
InParanoidO00244.
KOK07213.
PhylomeDBO00244.
TreeFamTF352589.

Enzyme and pathway databases

ReactomeREACT_120956. Cellular responses to stress.

Gene expression databases

ArrayExpressO00244.
BgeeO00244.
CleanExHS_ATOX1.
GenevestigatorO00244.

Family and domain databases

InterProIPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
[Graphical view]
PfamPF00403. HMA. 1 hit.
[Graphical view]
SUPFAMSSF55008. SSF55008. 1 hit.
PROSITEPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATOX1. human.
EvolutionaryTraceO00244.
GeneWikiATOX1.
GenomeRNAi475.
NextBio1967.
PROO00244.
SOURCESearch...

Entry information

Entry nameATOX1_HUMAN
AccessionPrimary (citable) accession number: O00244
Secondary accession number(s): A8KAJ8 expand/collapse secondary AC list , D3DQI2, Q2M1R6, Q56AP3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM