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Protein

Copper transport protein ATOX1

Gene

ATOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Copper1
Metal bindingi15Copper1

GO - Molecular functioni

  • copper chaperone activity Source: UniProtKB
  • copper-dependent protein binding Source: UniProtKB
  • copper ion binding Source: UniProtKB
  • copper ion transmembrane transporter activity Source: Ensembl
  • metallochaperone activity Source: UniProtKB

GO - Biological processi

  • cellular copper ion homeostasis Source: ProtInc
  • copper ion transport Source: UniProtKB
  • intracellular copper ion transport Source: GO_Central
  • response to oxidative stress Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177556-MONOMER.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.
R-HSA-6803544. Ion influx/efflux at host-pathogen interface.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper transport protein ATOX1
Alternative name(s):
Metal transport protein ATX1
Gene namesi
Name:ATOX1
Synonyms:HAH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:798. ATOX1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi475.
OpenTargetsiENSG00000177556.
PharmGKBiPA25096.

Polymorphism and mutation databases

BioMutaiATOX1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125371 – 68Copper transport protein ATOX1Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineCombined sources1
Modified residuei60N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO00244.
MaxQBiO00244.
PaxDbiO00244.
PeptideAtlasiO00244.
PRIDEiO00244.
TopDownProteomicsiO00244.

PTM databases

iPTMnetiO00244.
PhosphoSitePlusiO00244.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000177556.
CleanExiHS_ATOX1.
ExpressionAtlasiO00244. baseline and differential.
GenevisibleiO00244. HS.

Organism-specific databases

HPAiHPA055036.

Interactioni

Subunit structurei

Interacts with ATP7B (PubMed:10966647). Interacts with ATP7A (PubMed:21667063).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
C21orf2O438223EBI-10179267,EBI-2835332
FAM118AQ9NWS65EBI-10179267,EBI-8638992
GGPS1O957493EBI-10179267,EBI-10179283

GO - Molecular functioni

  • copper-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106965. 13 interactors.
IntActiO00244. 5 interactors.
MINTiMINT-105921.
STRINGi9606.ENSP00000316854.

Structurei

Secondary structure

168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi13 – 26Combined sources14
Beta strandi28 – 34Combined sources7
Turni35 – 38Combined sources4
Beta strandi39 – 46Combined sources8
Helixi48 – 56Combined sources9
Turni57 – 59Combined sources3
Beta strandi62 – 66Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FE0X-ray1.75A/B1-68[»]
1FE4X-ray1.75A/B1-68[»]
1FEEX-ray1.80A/B1-68[»]
1TL4NMR-A1-68[»]
1TL5NMR-A1-68[»]
2K1RNMR-B1-68[»]
2LQ9NMR-A1-68[»]
3CJKX-ray1.80A2-68[»]
3IWLX-ray1.60A1-68[»]
3IWXX-ray2.14A/B1-68[»]
4QOTX-ray2.20A/B1-68[»]
4YDXX-ray1.60A2-68[»]
4YEAX-ray2.14A/B2-68[»]
5T7LX-ray2.83A2-68[»]
ProteinModelPortaliO00244.
SMRiO00244.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00244.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 68HMAPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the ATX1 family.Curated
Contains 1 HMA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1603. Eukaryota.
COG2608. LUCA.
GeneTreeiENSGT00390000005805.
HOGENOMiHOG000038877.
HOVERGENiHBG050610.
InParanoidiO00244.
KOiK07213.
PhylomeDBiO00244.
TreeFamiTF352589.

Family and domain databases

CDDicd00371. HMA. 1 hit.
InterProiIPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
[Graphical view]
PfamiPF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
PROSITEiPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT
60
LLATLKKTGK TVSYLGLE
Length:68
Mass (Da):7,402
Last modified:July 1, 1997 - v1
Checksum:i0B364B1BD1279314
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70660 mRNA. Translation: AAC51227.1.
AY165037 Genomic DNA. Translation: AAN84554.1.
BT009786 mRNA. Translation: AAP88788.1.
AK293063 mRNA. Translation: BAF85752.1.
AY986502 Genomic DNA. Translation: AAX81411.1.
CH471062 Genomic DNA. Translation: EAW61663.1.
CH471062 Genomic DNA. Translation: EAW61664.1.
BC112248 mRNA. Translation: AAI12249.1.
BC112250 mRNA. Translation: AAI12251.1.
CCDSiCCDS47317.1.
RefSeqiNP_004036.1. NM_004045.3.
UniGeneiHs.125213.

Genome annotation databases

EnsembliENST00000313115; ENSP00000316854; ENSG00000177556.
ENST00000522710; ENSP00000429814; ENSG00000177556.
ENST00000524142; ENSP00000430598; ENSG00000177556.
GeneIDi475.
KEGGihsa:475.
UCSCiuc003luk.4. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70660 mRNA. Translation: AAC51227.1.
AY165037 Genomic DNA. Translation: AAN84554.1.
BT009786 mRNA. Translation: AAP88788.1.
AK293063 mRNA. Translation: BAF85752.1.
AY986502 Genomic DNA. Translation: AAX81411.1.
CH471062 Genomic DNA. Translation: EAW61663.1.
CH471062 Genomic DNA. Translation: EAW61664.1.
BC112248 mRNA. Translation: AAI12249.1.
BC112250 mRNA. Translation: AAI12251.1.
CCDSiCCDS47317.1.
RefSeqiNP_004036.1. NM_004045.3.
UniGeneiHs.125213.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FE0X-ray1.75A/B1-68[»]
1FE4X-ray1.75A/B1-68[»]
1FEEX-ray1.80A/B1-68[»]
1TL4NMR-A1-68[»]
1TL5NMR-A1-68[»]
2K1RNMR-B1-68[»]
2LQ9NMR-A1-68[»]
3CJKX-ray1.80A2-68[»]
3IWLX-ray1.60A1-68[»]
3IWXX-ray2.14A/B1-68[»]
4QOTX-ray2.20A/B1-68[»]
4YDXX-ray1.60A2-68[»]
4YEAX-ray2.14A/B2-68[»]
5T7LX-ray2.83A2-68[»]
ProteinModelPortaliO00244.
SMRiO00244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106965. 13 interactors.
IntActiO00244. 5 interactors.
MINTiMINT-105921.
STRINGi9606.ENSP00000316854.

PTM databases

iPTMnetiO00244.
PhosphoSitePlusiO00244.

Polymorphism and mutation databases

BioMutaiATOX1.

Proteomic databases

EPDiO00244.
MaxQBiO00244.
PaxDbiO00244.
PeptideAtlasiO00244.
PRIDEiO00244.
TopDownProteomicsiO00244.

Protocols and materials databases

DNASUi475.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313115; ENSP00000316854; ENSG00000177556.
ENST00000522710; ENSP00000429814; ENSG00000177556.
ENST00000524142; ENSP00000430598; ENSG00000177556.
GeneIDi475.
KEGGihsa:475.
UCSCiuc003luk.4. human.

Organism-specific databases

CTDi475.
DisGeNETi475.
GeneCardsiATOX1.
HGNCiHGNC:798. ATOX1.
HPAiHPA055036.
MIMi602270. gene.
neXtProtiNX_O00244.
OpenTargetsiENSG00000177556.
PharmGKBiPA25096.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1603. Eukaryota.
COG2608. LUCA.
GeneTreeiENSGT00390000005805.
HOGENOMiHOG000038877.
HOVERGENiHBG050610.
InParanoidiO00244.
KOiK07213.
PhylomeDBiO00244.
TreeFamiTF352589.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177556-MONOMER.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.
R-HSA-6803544. Ion influx/efflux at host-pathogen interface.

Miscellaneous databases

ChiTaRSiATOX1. human.
EvolutionaryTraceiO00244.
GeneWikiiATOX1.
GenomeRNAii475.
PROiO00244.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177556.
CleanExiHS_ATOX1.
ExpressionAtlasiO00244. baseline and differential.
GenevisibleiO00244. HS.

Family and domain databases

CDDicd00371. HMA. 1 hit.
InterProiIPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
[Graphical view]
PfamiPF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
PROSITEiPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATOX1_HUMAN
AccessioniPrimary (citable) accession number: O00244
Secondary accession number(s): A8KAJ8
, D3DQI2, Q2M1R6, Q56AP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.