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Protein

Signal-regulatory protein beta-1

Gene

SIRPB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • innate immune response Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101307-MONOMER.
ReactomeiR-HSA-2172127. DAP12 interactions.
R-HSA-391160. Signal regulatory protein (SIRP) family interactions.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein beta-1
Short name:
SIRP-beta-1
Alternative name(s):
CD172 antigen-like family member B
CD_antigen: CD172b
Gene namesi
Name:SIRPB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15928. SIRPB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 371ExtracellularSequence analysisAdd BLAST342
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 398CytoplasmicSequence analysis6

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10326.
OpenTargetsiENSG00000101307.
PharmGKBiPA38051.

Polymorphism and mutation databases

BioMutaiYIF1A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001495630 – 398Signal-regulatory protein beta-1Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 120PROSITE-ProRule annotation1 Publication
Disulfide bondi169 ↔ 227PROSITE-ProRule annotation
Glycosylationi244N-linked (GlcNAc...)1 Publication1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi320InterchainPROSITE-ProRule annotation1 Publication

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO00241.
PeptideAtlasiO00241.
PRIDEiO00241.

PTM databases

iPTMnetiO00241.
PhosphoSitePlusiO00241.

Expressioni

Tissue specificityi

Detected in monocytes and dendritic cells.1 Publication

Gene expression databases

BgeeiENSG00000101307.
CleanExiHS_SIRPB1.
ExpressionAtlasiO00241. baseline and differential.
GenevisibleiO00241. HS.

Organism-specific databases

HPAiHPA047463.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DAB1O755533EBI-10179231,EBI-7875264
MEOX2A4D1273EBI-10179231,EBI-10172134
RBPMSQ930623EBI-10179231,EBI-740322
TYROBPO439144EBI-2615458,EBI-2214794

Protein-protein interaction databases

BioGridi115609. 5 interactors.
IntActiO00241. 6 interactors.

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 45Combined sources6
Beta strandi50 – 52Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi65 – 69Combined sources5
Beta strandi76 – 84Combined sources9
Beta strandi89 – 91Combined sources3
Beta strandi95 – 99Combined sources5
Beta strandi105 – 107Combined sources3
Helixi112 – 114Combined sources3
Beta strandi116 – 124Combined sources9
Beta strandi127 – 129Combined sources3
Beta strandi131 – 135Combined sources5
Beta strandi139 – 144Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9CNMR-A32-154[»]
2JJUX-ray1.19A/B30-148[»]
ProteinModelPortaliO00241.
SMRiO00241.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00241.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 136Ig-like V-typeAdd BLAST107
Domaini147 – 246Ig-like C1-type 1Add BLAST100
Domaini253 – 347Ig-like C1-type 2Add BLAST95

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00440000033339.
HOVERGENiHBG056632.
InParanoidiO00241.
PhylomeDBiO00241.
TreeFamiTF341862.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O00241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVPASWPHL PSPFLLMTLL LGRLTGVAGE DELQVIQPEK SVSVAAGESA
60 70 80 90 100
TLRCAMTSLI PVGPIMWFRG AGAGRELIYN QKEGHFPRVT TVSELTKRNN
110 120 130 140 150
LDFSISISNI TPADAGTYYC VKFRKGSPDD VEFKSGAGTE LSVRAKPSAP
160 170 180 190 200
VVSGPAVRAT PEHTVSFTCE SHGFSPRDIT LKWFKNGNEL SDFQTNVDPA
210 220 230 240 250
GDSVSYSIHS TARVVLTRGD VHSQVICEIA HITLQGDPLR GTANLSEAIR
260 270 280 290 300
VPPTLEVTQQ PMRAENQANV TCQVSNFYPR GLQLTWLENG NVSRTETAST
310 320 330 340 350
LIENKDGTYN WMSWLLVNTC AHRDDVVLTC QVEHDGQQAV SKSYALEISA
360 370 380 390
HQKEHGSDIT HEAALAPTAP LLVALLLGPK LLLVVGVSAI YICWKQKA
Length:398
Mass (Da):43,211
Last modified:November 2, 2010 - v5
Checksum:iC9C5E759514E212E
GO
Isoform 2 (identifier: O00241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-361: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):19,394
Checksum:i9EF21141C1DF3CBC
GO
Isoform 3 (identifier: Q5TFQ8-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5TFQ8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:398
Mass (Da):43,359
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102D → N in CAA71404 (PubMed:9062191).Curated1
Sequence conflicti106S → R in BAG36297 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02878923R → G.Corresponds to variant rs1535882dbSNPEnsembl.1
Natural variantiVAR_02879053R → H.Corresponds to variant rs2746603dbSNPEnsembl.1
Natural variantiVAR_028791229I → M.2 PublicationsCorresponds to variant rs2253427dbSNPEnsembl.1
Natural variantiVAR_028792363A → P.3 PublicationsCorresponds to variant rs2243603dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007026145 – 361Missing in isoform 2. 1 PublicationAdd BLAST217

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10376 mRNA. Translation: CAA71404.1.
AK313517 mRNA. Translation: BAG36297.1.
AL049634, AL138804 Genomic DNA. Translation: CAI21864.1.
AL049634, AL138804 Genomic DNA. Translation: CAI21865.1.
BC025286 mRNA. Translation: AAH25286.1.
BC075835 mRNA. Translation: AAH75835.1.
CCDSiCCDS13019.1. [O00241-1]
CCDS42850.1. [O00241-2]
RefSeqiNP_001077379.1. NM_001083910.3. [O00241-2]
NP_001317568.1. NM_001330639.1.
NP_006056.2. NM_006065.4. [O00241-1]
XP_016883066.1. XM_017027577.1. [O00241-1]
UniGeneiHs.664861.

Genome annotation databases

EnsembliENST00000381603; ENSP00000371016; ENSG00000101307. [O00241-2]
ENST00000381605; ENSP00000371018; ENSG00000101307. [O00241-1]
GeneIDi10326.
UCSCiuc002wfk.5. human. [O00241-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10376 mRNA. Translation: CAA71404.1.
AK313517 mRNA. Translation: BAG36297.1.
AL049634, AL138804 Genomic DNA. Translation: CAI21864.1.
AL049634, AL138804 Genomic DNA. Translation: CAI21865.1.
BC025286 mRNA. Translation: AAH25286.1.
BC075835 mRNA. Translation: AAH75835.1.
CCDSiCCDS13019.1. [O00241-1]
CCDS42850.1. [O00241-2]
RefSeqiNP_001077379.1. NM_001083910.3. [O00241-2]
NP_001317568.1. NM_001330639.1.
NP_006056.2. NM_006065.4. [O00241-1]
XP_016883066.1. XM_017027577.1. [O00241-1]
UniGeneiHs.664861.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9CNMR-A32-154[»]
2JJUX-ray1.19A/B30-148[»]
ProteinModelPortaliO00241.
SMRiO00241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115609. 5 interactors.
IntActiO00241. 6 interactors.

PTM databases

iPTMnetiO00241.
PhosphoSitePlusiO00241.

Polymorphism and mutation databases

BioMutaiYIF1A.

Proteomic databases

EPDiO00241.
PeptideAtlasiO00241.
PRIDEiO00241.

Protocols and materials databases

DNASUi10326.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381603; ENSP00000371016; ENSG00000101307. [O00241-2]
ENST00000381605; ENSP00000371018; ENSG00000101307. [O00241-1]
GeneIDi10326.
UCSCiuc002wfk.5. human. [O00241-1]

Organism-specific databases

CTDi10326.
DisGeNETi10326.
GeneCardsiSIRPB1.
HGNCiHGNC:15928. SIRPB1.
HPAiHPA047463.
MIMi603889. gene.
neXtProtiNX_O00241.
OpenTargetsiENSG00000101307.
PharmGKBiPA38051.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00440000033339.
HOVERGENiHBG056632.
InParanoidiO00241.
PhylomeDBiO00241.
TreeFamiTF341862.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101307-MONOMER.
ReactomeiR-HSA-2172127. DAP12 interactions.
R-HSA-391160. Signal regulatory protein (SIRP) family interactions.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiO00241.
GeneWikiiSIRPB1.
GenomeRNAii10326.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101307.
CleanExiHS_SIRPB1.
ExpressionAtlasiO00241. baseline and differential.
GenevisibleiO00241. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIRB1_HUMAN
AccessioniPrimary (citable) accession number: O00241
Secondary accession number(s): A6NLM2
, B2R8V0, Q5TFQ9, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 157 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.