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Reviewed, UniProtKB/Swiss-Prot O00232 (PSD12_HUMAN)

Last modified July 7, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    26S proteasome non-ATPase regulatory subunit 12
Alternative name(s):
    26S proteasome regulatory subunit p55
Gene names
Name: PSMD12
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Subunit structure

Component of the PA700 complex.

Sequence similarities

Belongs to the proteasome subunit p55 family.

Contains 1 PCI domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 45645526S proteasome non-ATPase regulatory subunit 12
PRO_0000173861

Regions

Domain237 – 417181PCI

Amino acid modifications

Modified residue21N-acetylalanine Ref.4

Natural variations

Natural variant3581V → A: dbSNP rs2230680.
VAR_051558

Experimental info

Sequence conflict3001P → S in BAD96399. Ref.2
Sequence conflict3981V → D in BAD96399. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O00232-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 97D0BDBDB0C96195

FASTA45652,904
        10         20         30         40         50         60 
MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL EKQTRTASDM 

        70         80         90        100        110        120 
VSTSRILVAV VKMCYEAKEW DLLNENIMLL SKRRSQLKQA VAKMVQQCCT YVEEITDLPI 

       130        140        150        160        170        180 
KLRLIDTLRM VTEGKIYVEI ERARLTKTLA TIKEQNGDVK EAASILQELQ VETYGSMEKK 

       190        200        210        220        230        240 
ERVEFILEQM RLCLAVKDYI RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEGSY 

       250        260        270        280        290        300 
LSICKHYRAI YDTPCIQAES EKWQQALKSV VLYVILAPFD NEQSDLVHRI SGDKKLEEIP 

       310        320        330        340        350        360 
KYKDLLKLFT TMELMRWSTL VEDYGMELRK GSLESPATDV FGSTEEGEKR WKDLKNRVVE 

       370        380        390        400        410        420 
HNIRIMAKYY TRITMKRMAQ LLDLSVDESE AFLSNLVVNK TIFAKVDRLA GIINFQRPKD 

       430        440        450 
PNNLLNDWSQ KLNSLMSLVN KTTHLIAKEE MIHNLQ 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome."
Saito A., Watanabe T.K., Shimada Y., Fujiwara T., Slaughter C.A., DeMartino G.N., Tanahashi N., Tanaka K.
Gene 203:241-250(1997) [PubMed: 9426256] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle and Testis.
[4]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-12, ACETYLATION AT ALA-2.
Tissue: Platelet.
[5]"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.
Biochemistry 46:3553-3565(2007) [PubMed: 17323924] [Abstract]
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases

AB003103 mRNA. Translation: BAA19749.1.
AK222679 mRNA. Translation: BAD96399.1.
BC019062 mRNA. Translation: AAH19062.1.
BC065826 mRNA. Translation: AAH65826.1. Different initiation.
IPIIPI00185374.
PIRJC6523. PC6501.
RefSeqNP_002807.1.
UniGeneHs.646575

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:27549N.
IntActO00232. 9 interactions.

PTM databases

PhosphoSiteO00232.

Proteomic databases

PeptideAtlasO00232.
PRIDEO00232.

Genome annotation databases

EnsemblENSG00000197170. Homo sapiens. [Contig view]
GeneID5718.
KEGGhsa:5718.
UCSCuc002jfy.1. human.

Organism-specific databases

GeneCardsGC17M062764.
H-InvDBHIX0014093.
HGNCHGNC:9557. PSMD12.
MIM604450. gene.
PharmGKBPA33903.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO00232.
HOVERGENO00232.
OMAO00232. WDALNEN.

Enzyme and pathway databases

ReactomeREACT_11045. Signaling by Wnt.
REACT_13. Metabolism of amino acids.
REACT_13635. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_152. Cell Cycle, Mitotic.
REACT_1538. Cell Cycle Checkpoints.
REACT_383. DNA Replication.
REACT_578. Apoptosis.
REACT_6185. HIV Infection.
REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_9035. APC/C:Cdh1-mediated degradation of Skp2.

Gene expression databases

ArrayExpressO00232.
BgeeO00232.
CleanExHS_PSMD12.
GermOnlineENSG00000197170. Homo sapiens.

Family and domain databases

InterProIPR000717. PCI.
IPR011991. Wing_hlx_DNA_bd.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PfamPF01399. PCI. 1 hit.
[Graphical view]
SMARTSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio22216.
SOURCESearch...

Entry information

Entry namePSD12_HUMAN
AccessionPrimary (citable) accession number: O00232
Secondary accession number(s): Q53HA2, Q6P053
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: January 23, 2007
Last modified: July 7, 2009
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents