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O00230

- CORT_HUMAN

UniProt

O00230 - CORT_HUMAN

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Protein

Cortistatin

Gene

CORT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: UniProtKB
  2. neuropeptide hormone activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  2. synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Cortistatin
Cleaved into the following 2 chains:
Gene namesi
Name:CORT
ORF Names:UNQ307/PRO350
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:2257. CORT.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 7456Sequence AnalysisPRO_0000033154Add
BLAST
Peptidei77 – 10529Cortistatin-29Sequence AnalysisPRO_0000033155Add
BLAST
Peptidei89 – 10517Cortistatin-17PRO_0000033156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi93 ↔ 104By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiO00230.
PRIDEiO00230.

Expressioni

Tissue specificityi

Expressed in a subset of GABAergic cells in the cortex and hippocampus.

Gene expression databases

BgeeiO00230.
CleanExiHS_CORT.
ExpressionAtlasiO00230. baseline.
GenevestigatoriO00230.

Interactioni

Protein-protein interaction databases

BioGridi107718. 5 interactions.
STRINGi9606.ENSP00000366248.

Structurei

3D structure databases

ProteinModelPortaliO00230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41278.
GeneTreeiENSGT00730000111752.
HOVERGENiHBG017816.
InParanoidiO00230.
KOiK05238.
OrthoDBiEOG77Q506.
PhylomeDBiO00230.

Family and domain databases

InterProiIPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00230-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL
60 70 80 90 100
AWWFEWTSQA SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT

FSSCK
Length:105
Mass (Da):11,532
Last modified:July 1, 1997 - v1
Checksum:i09578F4520201551
GO

Sequence cautioni

The sequence AAI19725.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI19726.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAQ89950.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI19195.1 differs from that shown. Reason: Erroneous initiation.
The sequence EAW71650.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000263 mRNA. Translation: BAA19770.1.
AF013252 mRNA. Translation: AAB66895.1.
AL354956 Genomic DNA. Translation: CAI19195.1. Different initiation.
CH471130 Genomic DNA. Translation: EAW71650.1. Different initiation.
BC119724 mRNA. Translation: AAI19725.1. Different initiation.
BC119725 mRNA. Translation: AAI19726.1. Different initiation.
AY358561 mRNA. Translation: AAQ89950.1. Different initiation.
CCDSiCCDS117.2.
PIRiJC5414.
RefSeqiNP_001293.3. NM_001302.4.
UniGeneiHs.412311.

Genome annotation databases

EnsembliENST00000377049; ENSP00000366248; ENSG00000241563.
GeneIDi1325.
KEGGihsa:1325.
UCSCiuc001ari.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000263 mRNA. Translation: BAA19770.1 .
AF013252 mRNA. Translation: AAB66895.1 .
AL354956 Genomic DNA. Translation: CAI19195.1 . Different initiation.
CH471130 Genomic DNA. Translation: EAW71650.1 . Different initiation.
BC119724 mRNA. Translation: AAI19725.1 . Different initiation.
BC119725 mRNA. Translation: AAI19726.1 . Different initiation.
AY358561 mRNA. Translation: AAQ89950.1 . Different initiation.
CCDSi CCDS117.2.
PIRi JC5414.
RefSeqi NP_001293.3. NM_001302.4.
UniGenei Hs.412311.

3D structure databases

ProteinModelPortali O00230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107718. 5 interactions.
STRINGi 9606.ENSP00000366248.

Proteomic databases

PaxDbi O00230.
PRIDEi O00230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377049 ; ENSP00000366248 ; ENSG00000241563 .
GeneIDi 1325.
KEGGi hsa:1325.
UCSCi uc001ari.4. human.

Organism-specific databases

CTDi 1325.
GeneCardsi GC01P010509.
HGNCi HGNC:2257. CORT.
MIMi 602784. gene.
neXtProti NX_O00230.
PharmGKBi PA26773.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41278.
GeneTreei ENSGT00730000111752.
HOVERGENi HBG017816.
InParanoidi O00230.
KOi K05238.
OrthoDBi EOG77Q506.
PhylomeDBi O00230.

Miscellaneous databases

GeneWikii Cortistatin_(neuropeptide).
GenomeRNAii 1325.
NextBioi 5399.
PROi O00230.
SOURCEi Search...

Gene expression databases

Bgeei O00230.
CleanExi HS_CORT.
ExpressionAtlasi O00230. baseline.
Genevestigatori O00230.

Family and domain databases

InterProi IPR018142. Somatostatin/Cortistatin_C.
[Graphical view ]
Pfami PF03002. Somatostatin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin."
    de Lecea L., Ruiz-Lozano P., Danielson P.E., Peelle-Kirley J., Foye P.E., Frankel W.N., Sutcliffe J.G.
    Genomics 42:499-506(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-104.

Entry informationi

Entry nameiCORT_HUMAN
AccessioniPrimary (citable) accession number: O00230
Secondary accession number(s): Q5T6G0, Q6UX11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3