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Protein

Cortistatin

Gene

CORT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: UniProtKB
  • neuropeptide hormone activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  • chemical synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175279-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiO00230.

Names & Taxonomyi

Protein namesi
Recommended name:
Cortistatin
Cleaved into the following 2 chains:
Gene namesi
Name:CORT
ORF Names:UNQ307/PRO350
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2257. CORT.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1325.
OpenTargetsiENSG00000241563.
PharmGKBiPA26773.

Polymorphism and mutation databases

BioMutaiCORT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000003315419 – 74Sequence analysisAdd BLAST56
PeptideiPRO_000003315577 – 105Cortistatin-29Sequence analysisAdd BLAST29
PeptideiPRO_000003315689 – 105Cortistatin-17Add BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi93 ↔ 104By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiO00230.
PRIDEiO00230.

PTM databases

iPTMnetiO00230.
PhosphoSitePlusiO00230.

Expressioni

Tissue specificityi

Expressed in a subset of GABAergic cells in the cortex and hippocampus.

Gene expression databases

BgeeiENSG00000241563.
CleanExiHS_CORT.
GenevisibleiO00230. HS.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: UniProtKB
  • neuropeptide hormone activity Source: UniProtKB

Protein-protein interaction databases

BioGridi107718. 7 interactors.
STRINGi9606.ENSP00000366248.

Structurei

3D structure databases

ProteinModelPortaliO00230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3SG. Eukaryota.
ENOG411196C. LUCA.
GeneTreeiENSGT00730000111752.
HOVERGENiHBG017816.
InParanoidiO00230.
KOiK05238.
OMAiRMPLPLC.
OrthoDBiEOG091G157X.
PhylomeDBiO00230.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL
60 70 80 90 100
AWWFEWTSQA SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT

FSSCK
Length:105
Mass (Da):11,532
Last modified:July 1, 1997 - v1
Checksum:i09578F4520201551
GO

Sequence cautioni

The sequence AAI19725 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI19726 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ89950 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI19195 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW71650 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000263 mRNA. Translation: BAA19770.1.
AF013252 mRNA. Translation: AAB66895.1.
AL354956 Genomic DNA. Translation: CAI19195.1. Different initiation.
CH471130 Genomic DNA. Translation: EAW71650.1. Different initiation.
BC119724 mRNA. Translation: AAI19725.1. Different initiation.
BC119725 mRNA. Translation: AAI19726.1. Different initiation.
AY358561 mRNA. Translation: AAQ89950.1. Different initiation.
CCDSiCCDS117.2.
PIRiJC5414.
RefSeqiNP_001293.3. NM_001302.4.
UniGeneiHs.412311.

Genome annotation databases

EnsembliENST00000377049; ENSP00000366248; ENSG00000241563.
GeneIDi1325.
KEGGihsa:1325.
UCSCiuc001ari.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000263 mRNA. Translation: BAA19770.1.
AF013252 mRNA. Translation: AAB66895.1.
AL354956 Genomic DNA. Translation: CAI19195.1. Different initiation.
CH471130 Genomic DNA. Translation: EAW71650.1. Different initiation.
BC119724 mRNA. Translation: AAI19725.1. Different initiation.
BC119725 mRNA. Translation: AAI19726.1. Different initiation.
AY358561 mRNA. Translation: AAQ89950.1. Different initiation.
CCDSiCCDS117.2.
PIRiJC5414.
RefSeqiNP_001293.3. NM_001302.4.
UniGeneiHs.412311.

3D structure databases

ProteinModelPortaliO00230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107718. 7 interactors.
STRINGi9606.ENSP00000366248.

PTM databases

iPTMnetiO00230.
PhosphoSitePlusiO00230.

Polymorphism and mutation databases

BioMutaiCORT.

Proteomic databases

PaxDbiO00230.
PRIDEiO00230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377049; ENSP00000366248; ENSG00000241563.
GeneIDi1325.
KEGGihsa:1325.
UCSCiuc001ari.5. human.

Organism-specific databases

CTDi1325.
DisGeNETi1325.
GeneCardsiCORT.
HGNCiHGNC:2257. CORT.
MIMi602784. gene.
neXtProtiNX_O00230.
OpenTargetsiENSG00000241563.
PharmGKBiPA26773.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3SG. Eukaryota.
ENOG411196C. LUCA.
GeneTreeiENSGT00730000111752.
HOVERGENiHBG017816.
InParanoidiO00230.
KOiK05238.
OMAiRMPLPLC.
OrthoDBiEOG091G157X.
PhylomeDBiO00230.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175279-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiO00230.

Miscellaneous databases

GeneWikiiCortistatin_(neuropeptide).
GenomeRNAii1325.
PROiO00230.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241563.
CleanExiHS_CORT.
GenevisibleiO00230. HS.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCORT_HUMAN
AccessioniPrimary (citable) accession number: O00230
Secondary accession number(s): Q5T6G0, Q6UX11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.