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O00230

- CORT_HUMAN

UniProt

O00230 - CORT_HUMAN

Protein

Cortistatin

Gene

CORT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

    GO - Molecular functioni

    1. G-protein coupled receptor binding Source: UniProtKB
    2. neuropeptide hormone activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
    2. synaptic transmission Source: UniProtKB

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cortistatin
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CORT
    ORF Names:UNQ307/PRO350
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2257. CORT.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26773.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 7456Sequence AnalysisPRO_0000033154Add
    BLAST
    Peptidei77 – 10529Cortistatin-29Sequence AnalysisPRO_0000033155Add
    BLAST
    Peptidei89 – 10517Cortistatin-17PRO_0000033156Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi93 ↔ 104By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiO00230.
    PRIDEiO00230.

    Expressioni

    Tissue specificityi

    Expressed in a subset of GABAergic cells in the cortex and hippocampus.

    Gene expression databases

    BgeeiO00230.
    CleanExiHS_CORT.
    GenevestigatoriO00230.

    Interactioni

    Protein-protein interaction databases

    BioGridi107718. 5 interactions.
    STRINGi9606.ENSP00000366248.

    Structurei

    3D structure databases

    ProteinModelPortaliO00230.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the somatostatin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41278.
    HOVERGENiHBG017816.
    KOiK05238.
    OrthoDBiEOG77Q506.
    PhylomeDBiO00230.

    Family and domain databases

    InterProiIPR018142. Somatostatin/Cortistatin_C.
    [Graphical view]
    PfamiPF03002. Somatostatin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O00230-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL    50
    AWWFEWTSQA SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT 100
    FSSCK 105
    Length:105
    Mass (Da):11,532
    Last modified:July 1, 1997 - v1
    Checksum:i09578F4520201551
    GO

    Sequence cautioni

    The sequence AAI19725.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI19726.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAQ89950.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI19195.1 differs from that shown. Reason: Erroneous initiation.
    The sequence EAW71650.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000263 mRNA. Translation: BAA19770.1.
    AF013252 mRNA. Translation: AAB66895.1.
    AL354956 Genomic DNA. Translation: CAI19195.1. Different initiation.
    CH471130 Genomic DNA. Translation: EAW71650.1. Different initiation.
    BC119724 mRNA. Translation: AAI19725.1. Different initiation.
    BC119725 mRNA. Translation: AAI19726.1. Different initiation.
    AY358561 mRNA. Translation: AAQ89950.1. Different initiation.
    CCDSiCCDS117.2.
    PIRiJC5414.
    RefSeqiNP_001293.3. NM_001302.4.
    UniGeneiHs.412311.

    Genome annotation databases

    EnsembliENST00000377049; ENSP00000366248; ENSG00000241563.
    GeneIDi1325.
    KEGGihsa:1325.
    UCSCiuc001ari.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000263 mRNA. Translation: BAA19770.1 .
    AF013252 mRNA. Translation: AAB66895.1 .
    AL354956 Genomic DNA. Translation: CAI19195.1 . Different initiation.
    CH471130 Genomic DNA. Translation: EAW71650.1 . Different initiation.
    BC119724 mRNA. Translation: AAI19725.1 . Different initiation.
    BC119725 mRNA. Translation: AAI19726.1 . Different initiation.
    AY358561 mRNA. Translation: AAQ89950.1 . Different initiation.
    CCDSi CCDS117.2.
    PIRi JC5414.
    RefSeqi NP_001293.3. NM_001302.4.
    UniGenei Hs.412311.

    3D structure databases

    ProteinModelPortali O00230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107718. 5 interactions.
    STRINGi 9606.ENSP00000366248.

    Proteomic databases

    PaxDbi O00230.
    PRIDEi O00230.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377049 ; ENSP00000366248 ; ENSG00000241563 .
    GeneIDi 1325.
    KEGGi hsa:1325.
    UCSCi uc001ari.4. human.

    Organism-specific databases

    CTDi 1325.
    GeneCardsi GC01P010509.
    HGNCi HGNC:2257. CORT.
    MIMi 602784. gene.
    neXtProti NX_O00230.
    PharmGKBi PA26773.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41278.
    HOVERGENi HBG017816.
    KOi K05238.
    OrthoDBi EOG77Q506.
    PhylomeDBi O00230.

    Miscellaneous databases

    GeneWikii Cortistatin_(neuropeptide).
    GenomeRNAii 1325.
    NextBioi 5399.
    PROi O00230.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00230.
    CleanExi HS_CORT.
    Genevestigatori O00230.

    Family and domain databases

    InterProi IPR018142. Somatostatin/Cortistatin_C.
    [Graphical view ]
    Pfami PF03002. Somatostatin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin."
      de Lecea L., Ruiz-Lozano P., Danielson P.E., Peelle-Kirley J., Foye P.E., Frankel W.N., Sutcliffe J.G.
      Genomics 42:499-506(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-104.

    Entry informationi

    Entry nameiCORT_HUMAN
    AccessioniPrimary (citable) accession number: O00230
    Secondary accession number(s): Q5T6G0, Q6UX11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3