O00230 (CORT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cortistatin

Cleaved into the following 2 chains:

1. Cortistatin-29
2. Cortistatin-17

Gene names

Name:	CORT
ORF Names:	UNQ307/PRO350

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
Subcellular location	Secreted.
Tissue specificity	Expressed in a subset of GABAergic cells in the cortex and hippocampus.
Sequence similarities	Belongs to the somatostatin family.
Sequence caution	The sequence AAI19725.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI19726.1 differs from that shown. Reason: Erroneous initiation. The sequence AAQ89950.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI19195.1 differs from that shown. Reason: Erroneous initiation. The sequence EAW71650.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Inferred from direct assay Ref.1. Source: UniProtKB synaptic transmission Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	extracellular space Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	neuropeptide hormone activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 74	56	Potential		PRO_0000033154
	Peptide	77 – 105	29	Cortistatin-29 Potential		PRO_0000033155
	Peptide	89 – 105	17	Cortistatin-17		PRO_0000033156
Amino acid modifications
	Disulfide bond	93 ↔ 104		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O00230 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 09578F4520201551	FASTA	105	11,532
	10 20 30 40 50 60 MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL AWWFEWTSQA 70 80 90 100 SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT FSSCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel human cortistatin-like peptide." Fukusumi S., Kitada C., Takekawa S., Kizawa H., Sakamoto J., Miyamoto M., Hinuma S., Kitano K., Fujino M. Biochem. Biophys. Res. Commun. 232:157-163(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin." de Lecea L., Ruiz-Lozano P., Danielson P.E., Peelle-Kirley J., Foye P.E., Frankel W.N., Sutcliffe J.G. Genomics 42:499-506(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-104.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB000263 mRNA. Translation: BAA19770.1. AF013252 mRNA. Translation: AAB66895.1. AL354956 Genomic DNA. Translation: CAI19195.1. Different initiation. CH471130 Genomic DNA. Translation: EAW71650.1. Different initiation. BC119724 mRNA. Translation: AAI19725.1. Different initiation. BC119725 mRNA. Translation: AAI19726.1. Different initiation. AY358561 mRNA. Translation: AAQ89950.1. Different initiation.
IPI	IPI00010859.
PIR	JC5414.
RefSeq	NP_001293.3. NM_001302.4.
UniGene	Hs.412311.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366248.
Proteomic databases
PaxDb	O00230.
PRIDE	O00230.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320498; ENSP00000317110; ENSG00000241563. ENST00000377049; ENSP00000366248; ENSG00000241563.
GeneID	1325.
KEGG	hsa:1325.
UCSC	uc001ari.3. human.
Organism-specific databases
CTD	1325.
GeneCards	GC01P010509.
HGNC	HGNC:2257. CORT.
MIM	602784. gene.
neXtProt	NX_O00230.
PharmGKB	PA26773.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41278.
HOVERGEN	HBG017816.
KO	K05238.
OrthoDB	EOG4FXR95.
Gene expression databases
ArrayExpress	O00230.
Bgee	O00230.
CleanEx	HS_CORT.
Genevestigator	O00230.
GermOnline	ENSG00000175279. Homo sapiens.
Family and domain databases
InterPro	IPR018142. Somatostatin/Cortistatin_C. [Graphical view]
Pfam	PF03002. Somatostatin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1325.
NextBio	5399.
SOURCE	Search...

Entry information

Entry name

CORT_HUMAN

Accession

Primary (citable) accession number: O00230
Secondary accession number(s): Q5T6G0, Q6UX11

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.