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O00230 (CORT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cortistatin

Cleaved into the following 2 chains:

  1. Cortistatin-29
  2. Cortistatin-17
Gene names
Name:CORT
ORF Names:UNQ307/PRO350
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length105 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

Subcellular location

Secreted.

Tissue specificity

Expressed in a subset of GABAergic cells in the cortex and hippocampus.

Sequence similarities

Belongs to the somatostatin family.

Sequence caution

The sequence AAI19725.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI19726.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAQ89950.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI19195.1 differs from that shown. Reason: Erroneous initiation.

The sequence EAW71650.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 7456 Potential
PRO_0000033154
Peptide77 – 10529Cortistatin-29 Potential
PRO_0000033155
Peptide89 – 10517Cortistatin-17
PRO_0000033156

Amino acid modifications

Disulfide bond93 ↔ 104 By similarity

Sequences

Sequence LengthMass (Da)Tools
O00230 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 09578F4520201551

FASTA10511,532
        10         20         30         40         50         60 
MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL AWWFEWTSQA 

        70         80         90        100 
SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT FSSCK 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel human cortistatin-like peptide."
Fukusumi S., Kitada C., Takekawa S., Kizawa H., Sakamoto J., Miyamoto M., Hinuma S., Kitano K., Fujino M.
Biochem. Biophys. Res. Commun. 232:157-163(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin."
de Lecea L., Ruiz-Lozano P., Danielson P.E., Peelle-Kirley J., Foye P.E., Frankel W.N., Sutcliffe J.G.
Genomics 42:499-506(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-104.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB000263 mRNA. Translation: BAA19770.1.
AF013252 mRNA. Translation: AAB66895.1.
AL354956 Genomic DNA. Translation: CAI19195.1. Different initiation.
CH471130 Genomic DNA. Translation: EAW71650.1. Different initiation.
BC119724 mRNA. Translation: AAI19725.1. Different initiation.
BC119725 mRNA. Translation: AAI19726.1. Different initiation.
AY358561 mRNA. Translation: AAQ89950.1. Different initiation.
CCDSCCDS117.2.
PIRJC5414.
RefSeqNP_001293.3. NM_001302.4.
UniGeneHs.412311.

3D structure databases

ProteinModelPortalO00230.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107718. 5 interactions.
STRING9606.ENSP00000366248.

Proteomic databases

PaxDbO00230.
PRIDEO00230.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320498; ENSP00000317110; ENSG00000241563.
ENST00000377049; ENSP00000366248; ENSG00000241563.
GeneID1325.
KEGGhsa:1325.
UCSCuc001ari.4. human.

Organism-specific databases

CTD1325.
GeneCardsGC01P010509.
HGNCHGNC:2257. CORT.
MIM602784. gene.
neXtProtNX_O00230.
PharmGKBPA26773.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41278.
HOVERGENHBG017816.
KOK05238.
OrthoDBEOG77Q506.
PhylomeDBO00230.

Gene expression databases

BgeeO00230.
CleanExHS_CORT.
GenevestigatorO00230.

Family and domain databases

InterProIPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamPF03002. Somatostatin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCortistatin_(neuropeptide).
GenomeRNAi1325.
NextBio5399.
PROO00230.
SOURCESearch...

Entry information

Entry nameCORT_HUMAN
AccessionPrimary (citable) accession number: O00230
Secondary accession number(s): Q5T6G0, Q6UX11
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM