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O00222

- GRM8_HUMAN

UniProt

O00222 - GRM8_HUMAN

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Protein

Metabotropic glutamate receptor 8

Gene

GRM8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei156 – 1561GlutamateBy similarity
Binding sitei227 – 2271GlutamateBy similarity
Binding sitei309 – 3091GlutamateBy similarity
Binding sitei401 – 4011GlutamateBy similarity

GO - Molecular functioni

  1. glutamate receptor activity Source: UniProtKB
  2. G-protein coupled receptor activity Source: UniProtKB
  3. group III metabotropic glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  2. negative regulation of cAMP biosynthetic process Source: UniProtKB
  3. regulation of synaptic transmission, glutamatergic Source: RefGenome
  4. sensory perception of smell Source: UniProtKB-KW
  5. visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 8
Short name:
mGluR8
Gene namesi
Name:GRM8
Synonyms:GPRC1H, MGLUR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:4600. GRM8.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
  2. plasma membrane Source: Reactome
  3. presynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28997.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 908875Metabotropic glutamate receptor 8PRO_0000012941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 106By similarity
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi246 ↔ 534By similarity
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi369 ↔ 384By similarity
Disulfide bondi424 ↔ 431By similarity
Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi516 ↔ 535By similarity
Disulfide bondi520 ↔ 538By similarity
Disulfide bondi541 ↔ 553By similarity
Disulfide bondi556 ↔ 569By similarity
Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
Cross-linki882 – 882Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiO00222.
PaxDbiO00222.
PRIDEiO00222.

PTM databases

PhosphoSiteiO00222.

Expressioni

Gene expression databases

BgeeiO00222.
CleanExiHS_GRM8.
ExpressionAtlasiO00222. baseline.
GenevestigatoriO00222.

Organism-specific databases

HPAiHPA051481.

Interactioni

Subunit structurei

Interacts with PICK1.By similarity

Structurei

3D structure databases

ProteinModelPortaliO00222.
SMRiO00222. Positions 38-849.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 583550ExtracellularSequence AnalysisAdd
BLAST
Topological domaini609 – 62012CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini642 – 6476ExtracellularSequence Analysis
Topological domaini669 – 69527CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini717 – 74630ExtracellularSequence AnalysisAdd
BLAST
Topological domaini769 – 78113CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini804 – 81815ExtracellularSequence AnalysisAdd
BLAST
Topological domaini844 – 90865CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei584 – 60825Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei621 – 64121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei648 – 66821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei696 – 71621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei747 – 76822Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei782 – 80322Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei819 – 84325Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni177 – 1793Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118884.
HOVERGENiHBG107965.
InParanoidiO00222.
KOiK04608.
OMAiRTHGQEY.
OrthoDBiEOG7Z0JXG.
PhylomeDBiO00222.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000144. GPCR_3_mtglu_rcpt_8.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01058. MTABOTROPC8R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform A (identifier: O00222-1) [UniParc]FASTAAdd to Basket

Also known as: mGluR8a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG
60 70 80 90 100
LFPVHAKGER GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV
110 120 130 140 150
RILDTCSRDT YALEQSLTFV QALIEKDASD VKCANGDPPI FTKPDKISGV
160 170 180 190 200
IGAAASSVSI MVANILRLFK IPQISYASTA PELSDNTRYD FFSRVVPPDS
210 220 230 240 250
YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR EIGGVCIAQS
260 270 280 290 300
QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS
310 320 330 340 350
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL
360 370 380 390 400
ANNRRNVWFA EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG
410 420 430 440 450
KVQFVIDAVY SMAYALHNMH KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN
460 470 480 490 500
FNGSAGTPVT FNENGDAPGR YDIFQYQITN KSTEYKVIGH WTNQLHLKVE
510 520 530 540 550
DMQWAHREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER CEGYNYQVDE
560 570 580 590 600
LSCELCPLDQ RPNMNRTGCQ LIPIIKLEWH SPWAVVPVFV AILGIIATTF
610 620 630 640 650
VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF
660 670 680 690 700
RRVFLGLGMC FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF
710 720 730 740 750
SLISVQLLGV FVWFVVDPPH IIIDYGEQRT LDPEKARGVL KCDISDLSLI
760 770 780 790 800
CSLGYSILLM VTCTVYAIKT RGVPETFNEA KPIGFTMYTT CIIWLAFIPI
810 820 830 840 850
FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI IIFHPEQNVQ
860 870 880 890 900
KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNTSSTKTTY

ISYSNHSI
Length:908
Mass (Da):101,741
Last modified:December 1, 2000 - v2
Checksum:i95C2D5883DAF6FDE
GO
Isoform B (identifier: O00222-2) [UniParc]FASTAAdd to Basket

Also known as: mGluR8b

The sequence of this isoform differs from the canonical sequence as follows:
     893-908: TSSTKTTYISYSNHSI → SKSSVEFPMVKSGSTS

Show »
Length:908
Mass (Da):101,608
Checksum:i9F0D1EDB226C16D6
GO
Isoform C (identifier: O00222-3) [UniParc]FASTAAdd to Basket

Also known as: mGluR8c

The sequence of this isoform differs from the canonical sequence as follows:
     454-501: SAGTPVTFNE...TNQLHLKVED → CRRGIQMSLP...LDVMISSSIK
     502-908: Missing.

Show »
Length:501
Mass (Da):55,948
Checksum:iCF684628F8123919
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941R → A in AAB72040. (PubMed:9299241)Curated
Sequence conflicti460 – 4601T → I in AAB72040. (PubMed:9299241)Curated
Sequence conflicti591 – 5911A → V in ABY87924. 1 PublicationCurated
Sequence conflicti642 – 6421A → G in AAB72040. (PubMed:9299241)Curated
Sequence conflicti904 – 9041S → T in AAB72040. (PubMed:9299241)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101S → C.1 Publication
Corresponds to variant rs769194 [ dbSNP | Ensembl ].
VAR_014446
Natural varianti21 – 211F → C.
Corresponds to variant rs769202 [ dbSNP | Ensembl ].
VAR_014447
Natural varianti265 – 2651I → T.1 Publication
Corresponds to variant rs17150343 [ dbSNP | Ensembl ].
VAR_049278
Natural varianti343 – 3431R → Q.1 Publication
Corresponds to variant rs13309334 [ dbSNP | Ensembl ].
VAR_054752
Natural varianti362 – 3621F → Y.1 Publication
VAR_054477
Natural varianti368 – 3681G → D.1 Publication
VAR_054478
Natural varianti392 – 3921R → Q.
Corresponds to variant rs2234947 [ dbSNP | Ensembl ].
VAR_014448
Natural varianti430 – 4301L → F.1 Publication
VAR_054479
Natural varianti548 – 5481V → G.
Corresponds to variant rs2234948 [ dbSNP | Ensembl ].
VAR_014449
Natural varianti768 – 7681I → N.1 Publication
Corresponds to variant rs1051433 [ dbSNP | Ensembl ].
VAR_054753
Natural varianti902 – 9021S → I.
Corresponds to variant rs10225567 [ dbSNP | Ensembl ].
VAR_054754

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei454 – 50148SAGTP…LKVED → CRRGIQMSLPWPTLFTPSFS SSWAVLALLSLLMKTEMLLD VMISSSIK in isoform C. 1 PublicationVSP_002033Add
BLAST
Alternative sequencei502 – 908407Missing in isoform C. 1 PublicationVSP_002034Add
BLAST
Alternative sequencei893 – 90816TSSTK…SNHSI → SKSSVEFPMVKSGSTS in isoform B. 2 PublicationsVSP_002032Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U95025 mRNA. Translation: AAB72040.1.
U92459 mRNA. Translation: AAB51764.1.
AJ236921 mRNA. Translation: CAB36968.1.
AJ236922 mRNA. Translation: CAB36969.1.
AY608335 mRNA. Translation: AAT37959.1.
EU432125 mRNA. Translation: ABY87924.1.
EU368948 Genomic DNA. Translation: ABY59657.1.
CH236947 Genomic DNA. Translation: EAL24322.1.
BC093725 mRNA. Translation: AAH93725.1.
BC101675 mRNA. Translation: AAI01676.1.
CCDSiCCDS47696.1. [O00222-2]
CCDS5794.1. [O00222-1]
RefSeqiNP_000836.2. NM_000845.2. [O00222-1]
NP_001120795.1. NM_001127323.1. [O00222-2]
XP_006716001.1. XM_006715938.1. [O00222-1]
UniGeneiHs.449625.

Genome annotation databases

EnsembliENST00000339582; ENSP00000344173; ENSG00000179603. [O00222-1]
ENST00000341617; ENSP00000345747; ENSG00000179603. [O00222-3]
ENST00000358373; ENSP00000351142; ENSG00000179603. [O00222-2]
ENST00000472701; ENSP00000419832; ENSG00000179603. [O00222-2]
GeneIDi2918.
KEGGihsa:2918.
UCSCiuc003vlr.2. human. [O00222-1]
uc003vlt.2. human. [O00222-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U95025 mRNA. Translation: AAB72040.1 .
U92459 mRNA. Translation: AAB51764.1 .
AJ236921 mRNA. Translation: CAB36968.1 .
AJ236922 mRNA. Translation: CAB36969.1 .
AY608335 mRNA. Translation: AAT37959.1 .
EU432125 mRNA. Translation: ABY87924.1 .
EU368948 Genomic DNA. Translation: ABY59657.1 .
CH236947 Genomic DNA. Translation: EAL24322.1 .
BC093725 mRNA. Translation: AAH93725.1 .
BC101675 mRNA. Translation: AAI01676.1 .
CCDSi CCDS47696.1. [O00222-2 ]
CCDS5794.1. [O00222-1 ]
RefSeqi NP_000836.2. NM_000845.2. [O00222-1 ]
NP_001120795.1. NM_001127323.1. [O00222-2 ]
XP_006716001.1. XM_006715938.1. [O00222-1 ]
UniGenei Hs.449625.

3D structure databases

ProteinModelPortali O00222.
SMRi O00222. Positions 38-849.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi O00222.
ChEMBLi CHEMBL3228.
GuidetoPHARMACOLOGYi 296.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O00222.

Proteomic databases

MaxQBi O00222.
PaxDbi O00222.
PRIDEi O00222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339582 ; ENSP00000344173 ; ENSG00000179603 . [O00222-1 ]
ENST00000341617 ; ENSP00000345747 ; ENSG00000179603 . [O00222-3 ]
ENST00000358373 ; ENSP00000351142 ; ENSG00000179603 . [O00222-2 ]
ENST00000472701 ; ENSP00000419832 ; ENSG00000179603 . [O00222-2 ]
GeneIDi 2918.
KEGGi hsa:2918.
UCSCi uc003vlr.2. human. [O00222-1 ]
uc003vlt.2. human. [O00222-2 ]

Organism-specific databases

CTDi 2918.
GeneCardsi GC07M126078.
H-InvDB HIX0025292.
HGNCi HGNC:4600. GRM8.
HPAi HPA051481.
MIMi 601116. gene.
neXtProti NX_O00222.
PharmGKBi PA28997.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00760000118884.
HOVERGENi HBG107965.
InParanoidi O00222.
KOi K04608.
OMAi RTHGQEY.
OrthoDBi EOG7Z0JXG.
PhylomeDBi O00222.
TreeFami TF313240.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Metabotropic_glutamate_receptor_8.
GenomeRNAii 2918.
NextBioi 11569.
PROi O00222.
SOURCEi Search...

Gene expression databases

Bgeei O00222.
CleanExi HS_GRM8.
ExpressionAtlasi O00222. baseline.
Genevestigatori O00222.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000144. GPCR_3_mtglu_rcpt_8.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01058. MTABOTROPC8R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1."
    Scherer S.W., Soder S., Duvoisin R.M., Huizenga J.J., Tsui L.-C.
    Genomics 44:232-236(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells."
    Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M.
    Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, VARIANT ASN-768.
  3. "Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8."
    Malherbe P., Kratzeisen C., Lundstrom K., Richards J.G., Faull R.L.M., Mutel V.
    Brain Res. Mol. Brain Res. 67:201-210(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C).
    Tissue: Fetal brain.
  4. "Homo sapiens metabotropic glutamate receptor."
    Stormann T.M., Simin R.T., Hammerland L.G., Fuller F.H.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
  5. Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Tissue: Brain.
  6. NIEHS SNPs program
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-10; THR-265; TYR-362; ASP-368 AND PHE-430.
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM A), VARIANT GLN-343.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Colon.

Entry informationi

Entry nameiGRM8_HUMAN
AccessioniPrimary (citable) accession number: O00222
Secondary accession number(s): A4D0Y3
, B0FZ74, B0M0L0, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3