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O00222

- GRM8_HUMAN

UniProt

O00222 - GRM8_HUMAN

Protein

Metabotropic glutamate receptor 8

Gene

GRM8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei156 – 1561GlutamateBy similarity
    Binding sitei227 – 2271GlutamateBy similarity
    Binding sitei309 – 3091GlutamateBy similarity
    Binding sitei401 – 4011GlutamateBy similarity

    GO - Molecular functioni

    1. glutamate receptor activity Source: UniProtKB
    2. G-protein coupled receptor activity Source: UniProtKB
    3. group III metabotropic glutamate receptor activity Source: RefGenome

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
    2. negative regulation of cAMP biosynthetic process Source: UniProtKB
    3. regulation of synaptic transmission, glutamatergic Source: RefGenome
    4. sensory perception of smell Source: UniProtKB-KW
    5. visual perception Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 8
    Short name:
    mGluR8
    Gene namesi
    Name:GRM8
    Synonyms:GPRC1H, MGLUR8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:4600. GRM8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome
    2. plasma membrane Source: Reactome
    3. presynaptic membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28997.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 908875Metabotropic glutamate receptor 8PRO_0000012941Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 106By similarity
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi246 ↔ 534By similarity
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi369 ↔ 384By similarity
    Disulfide bondi424 ↔ 431By similarity
    Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi516 ↔ 535By similarity
    Disulfide bondi520 ↔ 538By similarity
    Disulfide bondi541 ↔ 553By similarity
    Disulfide bondi556 ↔ 569By similarity
    Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
    Cross-linki882 – 882Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiO00222.
    PRIDEiO00222.

    PTM databases

    PhosphoSiteiO00222.

    Expressioni

    Gene expression databases

    ArrayExpressiO00222.
    BgeeiO00222.
    CleanExiHS_GRM8.
    GenevestigatoriO00222.

    Organism-specific databases

    HPAiHPA051481.

    Interactioni

    Subunit structurei

    Interacts with PICK1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO00222.
    SMRiO00222. Positions 38-849.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 583550ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini609 – 62012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini642 – 6476ExtracellularSequence Analysis
    Topological domaini669 – 69527CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini717 – 74630ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini769 – 78113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini804 – 81815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini844 – 90865CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei584 – 60825Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei621 – 64121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei648 – 66821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei696 – 71621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei747 – 76822Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei782 – 80322Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei819 – 84325Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni177 – 1793Glutamate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    HOVERGENiHBG107965.
    InParanoidiO00222.
    KOiK04608.
    OMAiRTHGQEY.
    OrthoDBiEOG7Z0JXG.
    PhylomeDBiO00222.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR000144. GPCR_3_mtglu_rcpt_8.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01058. MTABOTROPC8R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: O00222-1) [UniParc]FASTAAdd to Basket

    Also known as: mGluR8a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG    50
    LFPVHAKGER GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV 100
    RILDTCSRDT YALEQSLTFV QALIEKDASD VKCANGDPPI FTKPDKISGV 150
    IGAAASSVSI MVANILRLFK IPQISYASTA PELSDNTRYD FFSRVVPPDS 200
    YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR EIGGVCIAQS 250
    QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS 300
    GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL 350
    ANNRRNVWFA EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG 400
    KVQFVIDAVY SMAYALHNMH KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN 450
    FNGSAGTPVT FNENGDAPGR YDIFQYQITN KSTEYKVIGH WTNQLHLKVE 500
    DMQWAHREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER CEGYNYQVDE 550
    LSCELCPLDQ RPNMNRTGCQ LIPIIKLEWH SPWAVVPVFV AILGIIATTF 600
    VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF 650
    RRVFLGLGMC FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF 700
    SLISVQLLGV FVWFVVDPPH IIIDYGEQRT LDPEKARGVL KCDISDLSLI 750
    CSLGYSILLM VTCTVYAIKT RGVPETFNEA KPIGFTMYTT CIIWLAFIPI 800
    FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI IIFHPEQNVQ 850
    KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNTSSTKTTY 900
    ISYSNHSI 908
    Length:908
    Mass (Da):101,741
    Last modified:December 1, 2000 - v2
    Checksum:i95C2D5883DAF6FDE
    GO
    Isoform B (identifier: O00222-2) [UniParc]FASTAAdd to Basket

    Also known as: mGluR8b

    The sequence of this isoform differs from the canonical sequence as follows:
         893-908: TSSTKTTYISYSNHSI → SKSSVEFPMVKSGSTS

    Show »
    Length:908
    Mass (Da):101,608
    Checksum:i9F0D1EDB226C16D6
    GO
    Isoform C (identifier: O00222-3) [UniParc]FASTAAdd to Basket

    Also known as: mGluR8c

    The sequence of this isoform differs from the canonical sequence as follows:
         454-501: SAGTPVTFNE...TNQLHLKVED → CRRGIQMSLP...LDVMISSSIK
         502-908: Missing.

    Show »
    Length:501
    Mass (Da):55,948
    Checksum:iCF684628F8123919
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti194 – 1941R → A in AAB72040. (PubMed:9299241)Curated
    Sequence conflicti460 – 4601T → I in AAB72040. (PubMed:9299241)Curated
    Sequence conflicti591 – 5911A → V in ABY87924. 1 PublicationCurated
    Sequence conflicti642 – 6421A → G in AAB72040. (PubMed:9299241)Curated
    Sequence conflicti904 – 9041S → T in AAB72040. (PubMed:9299241)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101S → C.1 Publication
    Corresponds to variant rs769194 [ dbSNP | Ensembl ].
    VAR_014446
    Natural varianti21 – 211F → C.
    Corresponds to variant rs769202 [ dbSNP | Ensembl ].
    VAR_014447
    Natural varianti265 – 2651I → T.1 Publication
    Corresponds to variant rs17150343 [ dbSNP | Ensembl ].
    VAR_049278
    Natural varianti343 – 3431R → Q.1 Publication
    Corresponds to variant rs13309334 [ dbSNP | Ensembl ].
    VAR_054752
    Natural varianti362 – 3621F → Y.1 Publication
    VAR_054477
    Natural varianti368 – 3681G → D.1 Publication
    VAR_054478
    Natural varianti392 – 3921R → Q.
    Corresponds to variant rs2234947 [ dbSNP | Ensembl ].
    VAR_014448
    Natural varianti430 – 4301L → F.1 Publication
    VAR_054479
    Natural varianti548 – 5481V → G.
    Corresponds to variant rs2234948 [ dbSNP | Ensembl ].
    VAR_014449
    Natural varianti768 – 7681I → N.1 Publication
    Corresponds to variant rs1051433 [ dbSNP | Ensembl ].
    VAR_054753
    Natural varianti902 – 9021S → I.
    Corresponds to variant rs10225567 [ dbSNP | Ensembl ].
    VAR_054754

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei454 – 50148SAGTP…LKVED → CRRGIQMSLPWPTLFTPSFS SSWAVLALLSLLMKTEMLLD VMISSSIK in isoform C. 1 PublicationVSP_002033Add
    BLAST
    Alternative sequencei502 – 908407Missing in isoform C. 1 PublicationVSP_002034Add
    BLAST
    Alternative sequencei893 – 90816TSSTK…SNHSI → SKSSVEFPMVKSGSTS in isoform B. 2 PublicationsVSP_002032Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95025 mRNA. Translation: AAB72040.1.
    U92459 mRNA. Translation: AAB51764.1.
    AJ236921 mRNA. Translation: CAB36968.1.
    AJ236922 mRNA. Translation: CAB36969.1.
    AY608335 mRNA. Translation: AAT37959.1.
    EU432125 mRNA. Translation: ABY87924.1.
    EU368948 Genomic DNA. Translation: ABY59657.1.
    CH236947 Genomic DNA. Translation: EAL24322.1.
    BC093725 mRNA. Translation: AAH93725.1.
    BC101675 mRNA. Translation: AAI01676.1.
    CCDSiCCDS47696.1. [O00222-2]
    CCDS5794.1. [O00222-1]
    RefSeqiNP_000836.2. NM_000845.2. [O00222-1]
    NP_001120795.1. NM_001127323.1. [O00222-2]
    XP_006716001.1. XM_006715938.1. [O00222-1]
    UniGeneiHs.449625.

    Genome annotation databases

    EnsembliENST00000339582; ENSP00000344173; ENSG00000179603. [O00222-1]
    ENST00000341617; ENSP00000345747; ENSG00000179603. [O00222-3]
    ENST00000358373; ENSP00000351142; ENSG00000179603. [O00222-2]
    ENST00000444921; ENSP00000409790; ENSG00000179603. [O00222-1]
    ENST00000472701; ENSP00000419832; ENSG00000179603. [O00222-2]
    GeneIDi2918.
    KEGGihsa:2918.
    UCSCiuc003vlr.2. human. [O00222-1]
    uc003vlt.2. human. [O00222-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95025 mRNA. Translation: AAB72040.1 .
    U92459 mRNA. Translation: AAB51764.1 .
    AJ236921 mRNA. Translation: CAB36968.1 .
    AJ236922 mRNA. Translation: CAB36969.1 .
    AY608335 mRNA. Translation: AAT37959.1 .
    EU432125 mRNA. Translation: ABY87924.1 .
    EU368948 Genomic DNA. Translation: ABY59657.1 .
    CH236947 Genomic DNA. Translation: EAL24322.1 .
    BC093725 mRNA. Translation: AAH93725.1 .
    BC101675 mRNA. Translation: AAI01676.1 .
    CCDSi CCDS47696.1. [O00222-2 ]
    CCDS5794.1. [O00222-1 ]
    RefSeqi NP_000836.2. NM_000845.2. [O00222-1 ]
    NP_001120795.1. NM_001127323.1. [O00222-2 ]
    XP_006716001.1. XM_006715938.1. [O00222-1 ]
    UniGenei Hs.449625.

    3D structure databases

    ProteinModelPortali O00222.
    SMRi O00222. Positions 38-849.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi O00222.
    ChEMBLi CHEMBL3228.
    DrugBanki DB00142. L-Glutamic Acid.
    GuidetoPHARMACOLOGYi 296.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O00222.

    Proteomic databases

    PaxDbi O00222.
    PRIDEi O00222.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339582 ; ENSP00000344173 ; ENSG00000179603 . [O00222-1 ]
    ENST00000341617 ; ENSP00000345747 ; ENSG00000179603 . [O00222-3 ]
    ENST00000358373 ; ENSP00000351142 ; ENSG00000179603 . [O00222-2 ]
    ENST00000444921 ; ENSP00000409790 ; ENSG00000179603 . [O00222-1 ]
    ENST00000472701 ; ENSP00000419832 ; ENSG00000179603 . [O00222-2 ]
    GeneIDi 2918.
    KEGGi hsa:2918.
    UCSCi uc003vlr.2. human. [O00222-1 ]
    uc003vlt.2. human. [O00222-2 ]

    Organism-specific databases

    CTDi 2918.
    GeneCardsi GC07M126078.
    H-InvDB HIX0025292.
    HGNCi HGNC:4600. GRM8.
    HPAi HPA051481.
    MIMi 601116. gene.
    neXtProti NX_O00222.
    PharmGKBi PA28997.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295200.
    HOVERGENi HBG107965.
    InParanoidi O00222.
    KOi K04608.
    OMAi RTHGQEY.
    OrthoDBi EOG7Z0JXG.
    PhylomeDBi O00222.
    TreeFami TF313240.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Metabotropic_glutamate_receptor_8.
    GenomeRNAii 2918.
    NextBioi 11569.
    PROi O00222.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00222.
    Bgeei O00222.
    CleanExi HS_GRM8.
    Genevestigatori O00222.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR000144. GPCR_3_mtglu_rcpt_8.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01058. MTABOTROPC8R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1."
      Scherer S.W., Soder S., Duvoisin R.M., Huizenga J.J., Tsui L.-C.
      Genomics 44:232-236(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    2. "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells."
      Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M.
      Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, VARIANT ASN-768.
    3. "Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8."
      Malherbe P., Kratzeisen C., Lundstrom K., Richards J.G., Faull R.L.M., Mutel V.
      Brain Res. Mol. Brain Res. 67:201-210(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C).
      Tissue: Fetal brain.
    4. "Homo sapiens metabotropic glutamate receptor."
      Stormann T.M., Simin R.T., Hammerland L.G., Fuller F.H.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
    5. Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
      Tissue: Brain.
    6. NIEHS SNPs program
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-10; THR-265; TYR-362; ASP-368 AND PHE-430.
    7. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM A), VARIANT GLN-343.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Tissue: Colon.

    Entry informationi

    Entry nameiGRM8_HUMAN
    AccessioniPrimary (citable) accession number: O00222
    Secondary accession number(s): A4D0Y3
    , B0FZ74, B0M0L0, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3