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O00222

- GRM8_HUMAN

UniProt

O00222 - GRM8_HUMAN

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Protein
Metabotropic glutamate receptor 8
Gene
GRM8, GPRC1H, MGLUR8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei156 – 1561Glutamate By similarity
Binding sitei227 – 2271Glutamate By similarity
Binding sitei309 – 3091Glutamate By similarity
Binding sitei401 – 4011Glutamate By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB
  2. glutamate receptor activity Source: UniProtKB
  3. group III metabotropic glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  2. negative regulation of cAMP biosynthetic process Source: UniProtKB
  3. regulation of synaptic transmission, glutamatergic Source: RefGenome
  4. sensory perception of smell Source: UniProtKB-KW
  5. visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 8
Short name:
mGluR8
Gene namesi
Name:GRM8
Synonyms:GPRC1H, MGLUR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:4600. GRM8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 583550Extracellular Reviewed prediction
Add
BLAST
Transmembranei584 – 60825Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini609 – 62012Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei621 – 64121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini642 – 6476Extracellular Reviewed prediction
Transmembranei648 – 66821Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini669 – 69527Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei696 – 71621Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini717 – 74630Extracellular Reviewed prediction
Add
BLAST
Transmembranei747 – 76822Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini769 – 78113Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei782 – 80322Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini804 – 81815Extracellular Reviewed prediction
Add
BLAST
Transmembranei819 – 84325Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini844 – 90865Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
  2. plasma membrane Source: Reactome
  3. presynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28997.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 908875Metabotropic glutamate receptor 8
PRO_0000012941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 106 By similarity
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi246 ↔ 534 By similarity
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi369 ↔ 384 By similarity
Disulfide bondi424 ↔ 431 By similarity
Glycosylationi452 – 4521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi480 – 4801N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi516 ↔ 535 By similarity
Disulfide bondi520 ↔ 538 By similarity
Disulfide bondi541 ↔ 553 By similarity
Disulfide bondi556 ↔ 569 By similarity
Glycosylationi565 – 5651N-linked (GlcNAc...) Reviewed prediction
Cross-linki882 – 882Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1) By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiO00222.
PRIDEiO00222.

PTM databases

PhosphoSiteiO00222.

Expressioni

Gene expression databases

ArrayExpressiO00222.
BgeeiO00222.
CleanExiHS_GRM8.
GenevestigatoriO00222.

Organism-specific databases

HPAiHPA051481.

Interactioni

Subunit structurei

Interacts with PICK1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliO00222.
SMRiO00222. Positions 38-849.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni177 – 1793Glutamate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
HOVERGENiHBG107965.
InParanoidiO00222.
KOiK04608.
OMAiRTHGQEY.
OrthoDBiEOG7Z0JXG.
PhylomeDBiO00222.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000144. GPCR_3_mtglu_rcpt_8.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01058. MTABOTROPC8R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform A (identifier: O00222-1) [UniParc]FASTAAdd to Basket

Also known as: mGluR8a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG    50
LFPVHAKGER GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV 100
RILDTCSRDT YALEQSLTFV QALIEKDASD VKCANGDPPI FTKPDKISGV 150
IGAAASSVSI MVANILRLFK IPQISYASTA PELSDNTRYD FFSRVVPPDS 200
YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR EIGGVCIAQS 250
QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS 300
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL 350
ANNRRNVWFA EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG 400
KVQFVIDAVY SMAYALHNMH KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN 450
FNGSAGTPVT FNENGDAPGR YDIFQYQITN KSTEYKVIGH WTNQLHLKVE 500
DMQWAHREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER CEGYNYQVDE 550
LSCELCPLDQ RPNMNRTGCQ LIPIIKLEWH SPWAVVPVFV AILGIIATTF 600
VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF 650
RRVFLGLGMC FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF 700
SLISVQLLGV FVWFVVDPPH IIIDYGEQRT LDPEKARGVL KCDISDLSLI 750
CSLGYSILLM VTCTVYAIKT RGVPETFNEA KPIGFTMYTT CIIWLAFIPI 800
FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI IIFHPEQNVQ 850
KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNTSSTKTTY 900
ISYSNHSI 908
Length:908
Mass (Da):101,741
Last modified:December 1, 2000 - v2
Checksum:i95C2D5883DAF6FDE
GO
Isoform B (identifier: O00222-2) [UniParc]FASTAAdd to Basket

Also known as: mGluR8b

The sequence of this isoform differs from the canonical sequence as follows:
     893-908: TSSTKTTYISYSNHSI → SKSSVEFPMVKSGSTS

Show »
Length:908
Mass (Da):101,608
Checksum:i9F0D1EDB226C16D6
GO
Isoform C (identifier: O00222-3) [UniParc]FASTAAdd to Basket

Also known as: mGluR8c

The sequence of this isoform differs from the canonical sequence as follows:
     454-501: SAGTPVTFNE...TNQLHLKVED → CRRGIQMSLP...LDVMISSSIK
     502-908: Missing.

Show »
Length:501
Mass (Da):55,948
Checksum:iCF684628F8123919
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101S → C.1 Publication
Corresponds to variant rs769194 [ dbSNP | Ensembl ].
VAR_014446
Natural varianti21 – 211F → C.
Corresponds to variant rs769202 [ dbSNP | Ensembl ].
VAR_014447
Natural varianti265 – 2651I → T.1 Publication
Corresponds to variant rs17150343 [ dbSNP | Ensembl ].
VAR_049278
Natural varianti343 – 3431R → Q.1 Publication
Corresponds to variant rs13309334 [ dbSNP | Ensembl ].
VAR_054752
Natural varianti362 – 3621F → Y.1 Publication
VAR_054477
Natural varianti368 – 3681G → D.1 Publication
VAR_054478
Natural varianti392 – 3921R → Q.
Corresponds to variant rs2234947 [ dbSNP | Ensembl ].
VAR_014448
Natural varianti430 – 4301L → F.1 Publication
VAR_054479
Natural varianti548 – 5481V → G.
Corresponds to variant rs2234948 [ dbSNP | Ensembl ].
VAR_014449
Natural varianti768 – 7681I → N.1 Publication
Corresponds to variant rs1051433 [ dbSNP | Ensembl ].
VAR_054753
Natural varianti902 – 9021S → I.
Corresponds to variant rs10225567 [ dbSNP | Ensembl ].
VAR_054754

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei454 – 50148SAGTP…LKVED → CRRGIQMSLPWPTLFTPSFS SSWAVLALLSLLMKTEMLLD VMISSSIK in isoform C.
VSP_002033Add
BLAST
Alternative sequencei502 – 908407Missing in isoform C.
VSP_002034Add
BLAST
Alternative sequencei893 – 90816TSSTK…SNHSI → SKSSVEFPMVKSGSTS in isoform B.
VSP_002032Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941R → A in AAB72040. 1 Publication
Sequence conflicti460 – 4601T → I in AAB72040. 1 Publication
Sequence conflicti591 – 5911A → V in ABY87924. 1 Publication
Sequence conflicti642 – 6421A → G in AAB72040. 1 Publication
Sequence conflicti904 – 9041S → T in AAB72040. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U95025 mRNA. Translation: AAB72040.1.
U92459 mRNA. Translation: AAB51764.1.
AJ236921 mRNA. Translation: CAB36968.1.
AJ236922 mRNA. Translation: CAB36969.1.
AY608335 mRNA. Translation: AAT37959.1.
EU432125 mRNA. Translation: ABY87924.1.
EU368948 Genomic DNA. Translation: ABY59657.1.
CH236947 Genomic DNA. Translation: EAL24322.1.
BC093725 mRNA. Translation: AAH93725.1.
BC101675 mRNA. Translation: AAI01676.1.
CCDSiCCDS47696.1. [O00222-2]
CCDS5794.1. [O00222-1]
RefSeqiNP_000836.2. NM_000845.2. [O00222-1]
NP_001120795.1. NM_001127323.1. [O00222-2]
XP_006716001.1. XM_006715938.1. [O00222-1]
UniGeneiHs.449625.

Genome annotation databases

EnsembliENST00000339582; ENSP00000344173; ENSG00000179603. [O00222-1]
ENST00000341617; ENSP00000345747; ENSG00000179603. [O00222-3]
ENST00000358373; ENSP00000351142; ENSG00000179603. [O00222-2]
ENST00000405249; ENSP00000385731; ENSG00000179603. [O00222-3]
ENST00000444921; ENSP00000409790; ENSG00000179603. [O00222-1]
ENST00000472701; ENSP00000419832; ENSG00000179603. [O00222-2]
GeneIDi2918.
KEGGihsa:2918.
UCSCiuc003vlr.2. human. [O00222-1]
uc003vlt.2. human. [O00222-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U95025 mRNA. Translation: AAB72040.1 .
U92459 mRNA. Translation: AAB51764.1 .
AJ236921 mRNA. Translation: CAB36968.1 .
AJ236922 mRNA. Translation: CAB36969.1 .
AY608335 mRNA. Translation: AAT37959.1 .
EU432125 mRNA. Translation: ABY87924.1 .
EU368948 Genomic DNA. Translation: ABY59657.1 .
CH236947 Genomic DNA. Translation: EAL24322.1 .
BC093725 mRNA. Translation: AAH93725.1 .
BC101675 mRNA. Translation: AAI01676.1 .
CCDSi CCDS47696.1. [O00222-2 ]
CCDS5794.1. [O00222-1 ]
RefSeqi NP_000836.2. NM_000845.2. [O00222-1 ]
NP_001120795.1. NM_001127323.1. [O00222-2 ]
XP_006716001.1. XM_006715938.1. [O00222-1 ]
UniGenei Hs.449625.

3D structure databases

ProteinModelPortali O00222.
SMRi O00222. Positions 38-849.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi O00222.
ChEMBLi CHEMBL3228.
DrugBanki DB00142. L-Glutamic Acid.
GuidetoPHARMACOLOGYi 296.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O00222.

Proteomic databases

PaxDbi O00222.
PRIDEi O00222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339582 ; ENSP00000344173 ; ENSG00000179603 . [O00222-1 ]
ENST00000341617 ; ENSP00000345747 ; ENSG00000179603 . [O00222-3 ]
ENST00000358373 ; ENSP00000351142 ; ENSG00000179603 . [O00222-2 ]
ENST00000405249 ; ENSP00000385731 ; ENSG00000179603 . [O00222-3 ]
ENST00000444921 ; ENSP00000409790 ; ENSG00000179603 . [O00222-1 ]
ENST00000472701 ; ENSP00000419832 ; ENSG00000179603 . [O00222-2 ]
GeneIDi 2918.
KEGGi hsa:2918.
UCSCi uc003vlr.2. human. [O00222-1 ]
uc003vlt.2. human. [O00222-2 ]

Organism-specific databases

CTDi 2918.
GeneCardsi GC07M126078.
H-InvDB HIX0025292.
HGNCi HGNC:4600. GRM8.
HPAi HPA051481.
MIMi 601116. gene.
neXtProti NX_O00222.
PharmGKBi PA28997.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295200.
HOVERGENi HBG107965.
InParanoidi O00222.
KOi K04608.
OMAi RTHGQEY.
OrthoDBi EOG7Z0JXG.
PhylomeDBi O00222.
TreeFami TF313240.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Metabotropic_glutamate_receptor_8.
GenomeRNAii 2918.
NextBioi 11569.
PROi O00222.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00222.
Bgeei O00222.
CleanExi HS_GRM8.
Genevestigatori O00222.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000144. GPCR_3_mtglu_rcpt_8.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01058. MTABOTROPC8R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1."
    Scherer S.W., Soder S., Duvoisin R.M., Huizenga J.J., Tsui L.-C.
    Genomics 44:232-236(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells."
    Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M.
    Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, VARIANT ASN-768.
  3. "Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8."
    Malherbe P., Kratzeisen C., Lundstrom K., Richards J.G., Faull R.L.M., Mutel V.
    Brain Res. Mol. Brain Res. 67:201-210(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C).
    Tissue: Fetal brain.
  4. "Homo sapiens metabotropic glutamate receptor."
    Stormann T.M., Simin R.T., Hammerland L.G., Fuller F.H.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
  5. Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Tissue: Brain.
  6. NIEHS SNPs program
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-10; THR-265; TYR-362; ASP-368 AND PHE-430.
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM A), VARIANT GLN-343.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Colon.

Entry informationi

Entry nameiGRM8_HUMAN
AccessioniPrimary (citable) accession number: O00222
Secondary accession number(s): A4D0Y3
, B0FZ74, B0M0L0, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi