Reviewed,
UniProtKB/Swiss-Prot O00220 (TR10A_HUMAN)
Last modified
June 16, 2009.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tumor necrosis factor receptor superfamily member 10A Alternative name(s): Death receptor 4 TNF-related apoptosis-inducing ligand receptor 1 Short name=TRAIL receptor 1 Short name=TRAIL-R1 CD_antigen=CD261 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 468 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Ref.6 |
| Subunit structure | Can interact with TRADD and RIP. Interacts with ARAP1. Ref.8 |
| Subcellular location | |
| Tissue specificity | Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells. |
| Sequence similarities | Contains 1 death domain. Contains 3 TNFR-Cys repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal Transmembrane |
| Molecular function | Receptor |
| PTM | Disulfide bond Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | activation of NF-kappaB-inducing kinase activity Ref.6 Non-traceable author statement. Source: UniProtKB activation of caspase activityNon-traceable author statement. Source: UniProtKB induction of apoptosis via death domain receptors Ref.1Non-traceable author statement. Source: UniProtKB |
| Cellular component | integral to membrane Inferred by curator. Source: UniProtKB |
| Molecular function | TRAIL binding Non-traceable author statement. Source: UniProtKB caspase activator activityNon-traceable author statement. Source: UniProtKB death receptor activity Ref.1Traceable author statement. Source: ProtInc transcription factor binding Ref.8Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | ||||||||
| Chain | 24 – 468 | 445 | Tumor necrosis factor receptor superfamily member 10A | PRO_0000034579 | |||||||
Regions | |||||||||||
| Topological domain | 24 – 239 | 216 | Extracellular Potential | ||||||||
| Transmembrane | 240 – 262 | 23 | Potential | ||||||||
| Topological domain | 263 – 468 | 206 | Cytoplasmic Potential | ||||||||
| Repeat | 107 – 145 | 39 | TNFR-Cys 1 | ||||||||
| Repeat | 147 – 188 | 42 | TNFR-Cys 2 | ||||||||
| Repeat | 189 – 229 | 41 | TNFR-Cys 3 | ||||||||
| Domain | 365 – 448 | 84 | Death | ||||||||
| Compositional bias | 29 – 32 | 4 | Poly-Ala | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 83 | 1 | Phosphoserine Ref.7 | ||||||||
| Modified residue | 463 | 1 | Phosphoserine Ref.7 | ||||||||
| Modified residue | 466 | 1 | Phosphoserine Ref.7 | ||||||||
| Glycosylation | 156 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 132 ↔ 145 | By similarity | |||||||||
| Disulfide bond | 148 ↔ 164 | By similarity | |||||||||
| Disulfide bond | 167 ↔ 180 | By similarity | |||||||||
| Disulfide bond | 170 ↔ 188 | By similarity | |||||||||
| Disulfide bond | 190 ↔ 204 | By similarity | |||||||||
| Disulfide bond | 207 ↔ 221 | By similarity | |||||||||
| Disulfide bond | 211 ↔ 229 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 11 | 1 | G → V: dbSNP rs34737614. | VAR_052349 | |||||||
| Natural variant | 33 | 1 | T → I: dbSNP rs20577. | VAR_016149 | |||||||
| Natural variant | 105 | 1 | P → R: dbSNP rs11986840. | VAR_052350 | |||||||
| Natural variant | 141 | 1 | H → R: dbSNP rs6557634. Ref.1 Ref.2 | VAR_016150 | |||||||
| Natural variant | 209 | 1 | R → T: dbSNP rs20575. Ref.1 Ref.2 | VAR_016151 | |||||||
| Natural variant | 228 | 1 | E → A: dbSNP rs20576. | VAR_016152 | |||||||
| Natural variant | 297 | 1 | N → H: dbSNP rs17088980. | VAR_052351 | |||||||
| Natural variant | 441 | 1 | K → R: dbSNP rs2230229. | VAR_052352 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 281 | 1 | W → C in BAF83988. Ref.2 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The receptor for the cytotoxic ligand TRAIL." Pan G., O'Rourke K., Chinnaiyan A.M., Gentz R., Ebner R., Ni J., Dixit V.M. Science 276:111-113(1997) [PubMed: 9082980] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-141 AND THR-209. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-141 AND THR-209. Tissue: Tongue. |
| [3] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary. |
| [6] | "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway." Chaudhary P.M., Eby M., Jasmin A., Bookwalter A., Murray J., Hood L. Immunity 7:821-830(1997) [PubMed: 9430227] [Abstract] Cited for: FUNCTION. |
| [7] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-463 AND SER-466, MASS SPECTROMETRY. Tissue: Epithelium. |
| [8] | "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." Simova S., Klima M., Cermak L., Sourkova V., Andera L. Apoptosis 13:423-436(2008) [PubMed: 18165900] [Abstract] Cited for: INTERACTION WITH ARAP1. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U90875 mRNA. Translation: AAC51226.1. AK291299 mRNA. Translation: BAF83988.1. BT006906 mRNA. Translation: AAP35552.1. EF064713 Genomic DNA. Translation: ABK41896.1. BC012866 mRNA. Translation: AAH12866.1. | |
| IPI | IPI00021975. |
| RefSeq | NP_003835.2. |
| UniGene | Hs.591834 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1D0G based on UniProtKB O14763. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O00220. 2 interactions. |
PTM databases | |
| PhosphoSite | O00220. |
Proteomic databases | |
| PRIDE | O00220. |
Genome annotation databases | |
| Ensembl | ENSG00000104689. Homo sapiens. [Contig view] |
| GeneID | 8797. |
| KEGG | hsa:8797. |
Organism-specific databases | |
| GeneCards | GC08M023104. |
| H-InvDB | HIX0022944. |
| HGNC | HGNC:11904. TNFRSF10A. |
| MIM | 603611. gene. |
| PharmGKB | PA36597. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O00220. |
| HOVERGEN | O00220. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | trail_pathway. TRAIL signaling pathway. |
Gene expression databases | |
| ArrayExpress | O00220. |
| Bgee | O00220. |
| CleanEx | HS_TNFRSF10A. |
| GermOnline | ENSG00000104689. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000488. Death. IPR011029. DEATH-like. IPR017301. TNF-rel_apoptosis-ind_lig_rcpt. IPR001368. TNFR_Cys_rich_reg. [Graphical view] |
| Gene3D | G3DSA:1.10.533.10. DEATH_like. 1 hit. |
| Pfam | PF00531. Death. 1 hit. PF00020. TNFR_c6. 2 hits. [Graphical view] |
| PIRSF | PIRSF037867. CD261_antigen. 1 hit. |
| SMART | SM00005. DEATH. 1 hit. SM00208. TNFR. 2 hits. [Graphical view] |
| PROSITE | PS50017. DEATH_DOMAIN. 1 hit. PS00652. TNFR_NGFR_1. 2 hits. PS50050. TNFR_NGFR_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 32996. |
| SOURCE | Search... |
Entry information
| Entry name | TR10A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O00220 Secondary accession number(s): A8K5I4, Q53Y72, Q96E62 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


