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Protein

Rho-related GTP-binding protein RhoD

Gene

RHOD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi71 – 75GTPBy similarity5
Nucleotide bindingi129 – 132GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • actin filament bundle assembly Source: UniProtKB
  • focal adhesion assembly Source: UniProtKB
  • lamellipodium assembly Source: UniProtKB
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • protein targeting Source: Ensembl
  • regulation of actin cytoskeleton reorganization Source: Ensembl
  • regulation of focal adhesion assembly Source: Ensembl
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • Rho protein signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173156-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-5663220. RHO GTPases Activate Formins.
SignaLinkiO00212.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoD
Alternative name(s):
Rho-related protein HP1
Short name:
RhoHP1
Gene namesi
Name:RHOD
Synonyms:ARHD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:670. RHOD.

Subcellular locationi

  • Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
  • Early endosome 1 Publication

  • Note: Colocalizes with RAB5 to early endosomes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi207C → S: Abolishes endosomal localization. 1 Publication1

Organism-specific databases

DisGeNETi29984.
PharmGKBiPA24952.

Polymorphism and mutation databases

BioMutaiRHOD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988631 – 207Rho-related GTP-binding protein RhoDAdd BLAST207
PropeptideiPRO_0000223365208 – 210Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207Cysteine methyl esterBy similarity1
Lipidationi207S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO00212.
PaxDbiO00212.
PeptideAtlasiO00212.
PRIDEiO00212.

PTM databases

iPTMnetiO00212.
PhosphoSitePlusiO00212.

Expressioni

Tissue specificityi

Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.

Gene expression databases

BgeeiENSG00000173156.
CleanExiHS_RHOD.
ExpressionAtlasiO00212. baseline and differential.
GenevisibleiO00212. HS.

Organism-specific databases

HPAiHPA024394.

Interactioni

Subunit structurei

Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.5 Publications

Protein-protein interaction databases

BioGridi119010. 15 interactors.
IntActiO00212. 6 interactors.
STRINGi9606.ENSP00000308576.

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 24Combined sources8
Helixi30 – 38Combined sources9
Beta strandi52 – 60Combined sources9
Beta strandi63 – 71Combined sources9
Beta strandi89 – 97Combined sources9
Helixi101 – 109Combined sources9
Helixi111 – 118Combined sources8
Beta strandi124 – 129Combined sources6
Helixi131 – 134Combined sources4
Helixi137 – 145Combined sources9
Helixi153 – 162Combined sources10
Beta strandi166 – 170Combined sources5
Turni173 – 176Combined sources4
Helixi179 – 192Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J1LX-ray2.50A7-197[»]
ProteinModelPortaliO00212.
SMRiO00212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00212.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 54Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiO00212.
KOiK07530.
OrthoDBiEOG091G0KNI.
PhylomeDBiO00212.
TreeFamiTF331746.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV
60 70 80 90 100
FERYMVNLQV KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS
110 120 130 140 150
PNSFDNIFNR WYPEVNHFCK KVPIIVVGCK TDLCKDKSLV NKLRRNGLEP
160 170 180 190 200
VTYHRGQEMA RSVGAVAYLE CSARLHDNVH AVFQEAAEVA LSSRGRNFWR
210
RITQGFCVVT
Length:210
Mass (Da):23,413
Last modified:July 28, 2009 - v2
Checksum:i7B8A7AE8933C78B0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058408134C → R.3 PublicationsCorresponds to variant rs4930409dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85815 Genomic DNA. Translation: BAA19652.1.
AF498973 mRNA. Translation: AAM21120.1.
AP000729 Genomic DNA. No translation available.
BC001338 mRNA. Translation: AAH01338.1.
CCDSiCCDS8155.1.
RefSeqiNP_055393.1. NM_014578.3.
UniGeneiHs.15114.

Genome annotation databases

EnsembliENST00000308831; ENSP00000308576; ENSG00000173156.
GeneIDi29984.
KEGGihsa:29984.
UCSCiuc001ojv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85815 Genomic DNA. Translation: BAA19652.1.
AF498973 mRNA. Translation: AAM21120.1.
AP000729 Genomic DNA. No translation available.
BC001338 mRNA. Translation: AAH01338.1.
CCDSiCCDS8155.1.
RefSeqiNP_055393.1. NM_014578.3.
UniGeneiHs.15114.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J1LX-ray2.50A7-197[»]
ProteinModelPortaliO00212.
SMRiO00212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119010. 15 interactors.
IntActiO00212. 6 interactors.
STRINGi9606.ENSP00000308576.

PTM databases

iPTMnetiO00212.
PhosphoSitePlusiO00212.

Polymorphism and mutation databases

BioMutaiRHOD.

Proteomic databases

MaxQBiO00212.
PaxDbiO00212.
PeptideAtlasiO00212.
PRIDEiO00212.

Protocols and materials databases

DNASUi29984.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308831; ENSP00000308576; ENSG00000173156.
GeneIDi29984.
KEGGihsa:29984.
UCSCiuc001ojv.4. human.

Organism-specific databases

CTDi29984.
DisGeNETi29984.
GeneCardsiRHOD.
HGNCiHGNC:670. RHOD.
HPAiHPA024394.
MIMi605781. gene.
neXtProtiNX_O00212.
PharmGKBiPA24952.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiO00212.
KOiK07530.
OrthoDBiEOG091G0KNI.
PhylomeDBiO00212.
TreeFamiTF331746.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173156-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-5663220. RHO GTPases Activate Formins.
SignaLinkiO00212.

Miscellaneous databases

ChiTaRSiRHOD. human.
EvolutionaryTraceiO00212.
GeneWikiiRhoD.
GenomeRNAii29984.
PROiO00212.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173156.
CleanExiHS_RHOD.
ExpressionAtlasiO00212. baseline and differential.
GenevisibleiO00212. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHOD_HUMAN
AccessioniPrimary (citable) accession number: O00212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.