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O00212 (RHOD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho-related GTP-binding protein RhoD
Alternative name(s):
Rho-related protein HP1
Short name=RhoHP1
Gene names
Name:RHOD
Synonyms:ARHD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton By similarity.

Subunit structure

In the GTP-bound form, interacts with DIAPH2 isoform 3 Interacts with PAK7/PAK5. Ref.5 Ref.6

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Rho-related GTP-binding protein RhoD
PRO_0000198863
Propeptide208 – 2103Removed in mature form By similarity
PRO_0000223365

Regions

Nucleotide binding24 – 318GTP By similarity
Nucleotide binding71 – 755GTP By similarity
Nucleotide binding129 – 1324GTP By similarity
Motif46 – 549Effector region Potential

Amino acid modifications

Modified residue2071Cysteine methyl ester By similarity
Lipidation2071S-geranylgeranyl cysteine By similarity

Natural variations

Natural variant1341C → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs4930409 [ dbSNP | Ensembl ].
VAR_058408

Secondary structure

............................. 210
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O00212 [UniParc].

Last modified July 28, 2009. Version 2.
Checksum: 7B8A7AE8933C78B0

FASTA21023,413
        10         20         30         40         50         60 
MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV FERYMVNLQV 

        70         80         90        100        110        120 
KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS PNSFDNIFNR WYPEVNHFCK 

       130        140        150        160        170        180 
KVPIIVVGCK TDLCKDKSLV NKLRRNGLEP VTYHRGQEMA RSVGAVAYLE CSARLHDNVH 

       190        200        210 
AVFQEAAEVA LSSRGRNFWR RITQGFCVVT 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a novel human cDNA (rhoHP1) homologous to rho genes."
Shimizu F., Watanabe T.K., Okuno S., Omori Y., Fujiwara T., Takahashi E., Nakamura Y.
Biochim. Biophys. Acta 1351:13-16(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-134.
Tissue: Placenta.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-134.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-134.
Tissue: Cervix.
[5]"RhoD regulates endosome dynamics through diaphanous-related formin and Src tyrosine kinase."
Gasman S., Kalaidzidis Y., Zerial M.
Nat. Cell Biol. 5:195-204(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DIAPH2.
[6]"Multiple Rho proteins regulate the subcellular targeting of PAK5."
Wu X., Frost J.A.
Biochem. Biophys. Res. Commun. 351:328-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PAK7.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D85815 Genomic DNA. Translation: BAA19652.1.
AF498973 mRNA. Translation: AAM21120.1.
AP000729 Genomic DNA. No translation available.
BC001338 mRNA. Translation: AAH01338.1.
RefSeqNP_055393.1. NM_014578.3.
UniGeneHs.15114.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2J1LX-ray2.50A7-197[»]
ProteinModelPortalO00212.
SMRO00212. Positions 15-193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119010. 7 interactions.
IntActO00212. 5 interactions.
STRING9606.ENSP00000308576.

PTM databases

PhosphoSiteO00212.

Proteomic databases

PaxDbO00212.
PRIDEO00212.

Protocols and materials databases

DNASU29984.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308831; ENSP00000308576; ENSG00000173156.
GeneID29984.
KEGGhsa:29984.
UCSCuc001ojv.3. human.

Organism-specific databases

CTD29984.
GeneCardsGC11P066824.
HGNCHGNC:670. RHOD.
HPAHPA024394.
MIM605781. gene.
neXtProtNX_O00212.
PharmGKBPA24952.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233974.
HOVERGENHBG009351.
InParanoidO00212.
KOK07530.
OMAAGQVDYD.
OrthoDBEOG74TX0S.
PhylomeDBO00212.
TreeFamTF331746.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkO00212.

Gene expression databases

ArrayExpressO00212.
BgeeO00212.
CleanExHS_RHOD.
GenevestigatorO00212.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRHOD. human.
EvolutionaryTraceO00212.
GeneWikiRhoD.
GenomeRNAi29984.
NextBio52746.
PROO00212.
SOURCESearch...

Entry information

Entry nameRHOD_HUMAN
AccessionPrimary (citable) accession number: O00212
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM