O00212 (RHOD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho-related GTP-binding protein RhoD

Alternative name(s):
Rho-related protein HP1
Short name=RhoHP1

Gene names

Name:	RHOD
Synonyms:	ARHD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton By similarity.
Subunit structure	In the GTP-bound form, interacts with DIAPH2 isoform 3. Interacts with PAK7/PAK5. Ref.5 Ref.6
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
Sequence similarities	Belongs to the small GTPase superfamily. Rho family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Rho protein signal transduction Traceable author statement Ref.1. Source: ProtInc regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 207

207

Rho-related GTP-binding protein RhoD

PRO_0000198863

Propeptide

208 – 210

3

Removed in mature form By similarity

PRO_0000223365

Regions

Nucleotide binding

24 – 31

8

GTP By similarity

Nucleotide binding

71 – 75

5

GTP By similarity

Nucleotide binding

129 – 132

4

GTP By similarity

Motif

46 – 54

9

Effector region Potential

Amino acid modifications

Modified residue

207

1

Cysteine methyl ester By similarity

Lipidation

207

1

S-geranylgeranyl cysteine By similarity

Natural variations

Natural variant

134

1

C → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs4930409 [ dbSNP | Ensembl ].

VAR_058408

Secondary structure

1

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210

Helix Strand Turn

Details...

Beta strand

17 – 24

8

Helix

30 – 38

9

Beta strand

52 – 60

9

Beta strand

63 – 71

9

Beta strand

89 – 97

9

Helix

101 – 109

9

Helix

111 – 118

8

Beta strand

124 – 129

6

Helix

131 – 134

4

Helix

137 – 145

9

Helix

153 – 162

10

Beta strand

166 – 170

5

Turn

173 – 176

4

Helix

179 – 192

14

Sequences

	Sequence		Length	Mass (Da)
	O00212 [UniParc]. Last modified July 28, 2009. Version 2. Checksum: 7B8A7AE8933C78B0	FASTA	210	23,413
	10 20 30 40 50 60 MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV FERYMVNLQV 70 80 90 100 110 120 KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS PNSFDNIFNR WYPEVNHFCK 130 140 150 160 170 180 KVPIIVVGCK TDLCKDKSLV NKLRRNGLEP VTYHRGQEMA RSVGAVAYLE CSARLHDNVH 190 200 210 AVFQEAAEVA LSSRGRNFWR RITQGFCVVT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel human cDNA (rhoHP1) homologous to rho genes." Shimizu F., Watanabe T.K., Okuno S., Omori Y., Fujiwara T., Takahashi E., Nakamura Y. Biochim. Biophys. Acta 1351:13-16(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-134. Tissue: Placenta.
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-134.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-134. Tissue: Cervix.
[5]	"RhoD regulates endosome dynamics through diaphanous-related formin and Src tyrosine kinase." Gasman S., Kalaidzidis Y., Zerial M. Nat. Cell Biol. 5:195-204(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DIAPH2.
[6]	"Multiple Rho proteins regulate the subcellular targeting of PAK5." Wu X., Frost J.A. Biochem. Biophys. Res. Commun. 351:328-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PAK7.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D85815 Genomic DNA. Translation: BAA19652.1.
AF498973 mRNA. Translation: AAM21120.1.
AP000729 Genomic DNA. No translation available.
BC001338 mRNA. Translation: AAH01338.1.

IPI

IPI00010841.

RefSeq

NP_055393.1. NM_014578.3.

UniGene

Hs.15114.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2J1L	X-ray	2.50	A	7-197	[»]

ProteinModelPortal

O00212.

ModBase

Search...

Protein-protein interaction databases

IntAct

O00212. 5 interactions.

STRING

9606.ENSP00000308576.

PTM databases

PhosphoSite

O00212.

Proteomic databases

PaxDb

O00212.

PRIDE

O00212.

Protocols and materials databases

DNASU

29984.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000308831; ENSP00000308576; ENSG00000173156.

GeneID

29984.

KEGG

hsa:29984.

UCSC

uc001ojv.3. human.

Organism-specific databases

CTD

29984.

GeneCards

GC11P066824.

HGNC

HGNC:670. RHOD.

HPA

HPA024394.

MIM

605781. gene.

neXtProt

NX_O00212.

PharmGKB

PA24952.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1100.

HOGENOM

HOG000233974.

HOVERGEN

HBG009351.

InParanoid

O00212.

KO

K07530.

OMA

AGQVDYD.

OrthoDB

EOG4P5KB3.

PhylomeDB

O00212.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

O00212.

Bgee

O00212.

CleanEx

HS_RHOD.

Genevestigator

O00212.

GermOnline

ENSG00000173156. Homo sapiens.

Family and domain databases

InterPro

IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]

Pfam

PF00071. Ras. 1 hit.
[Graphical view]

PRINTS

PR00449. RASTRNSFRMNG.

SMART

SM00174. RHO. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00231. small_GTP. 1 hit.

PROSITE

PS51420. RHO. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RHOD. human.

EvolutionaryTrace

O00212.

GenomeRNAi

29984.

NextBio

52746.

SOURCE

Search...

Entry information

Entry name

RHOD_HUMAN

Accession

Primary (citable) accession number: O00212

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.