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Protein

Rho-related GTP-binding protein RhoD

Gene

RHOD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi71 – 75GTPBy similarity5
Nucleotide bindingi129 – 132GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW
  • protein kinase binding Source: Ensembl

GO - Biological processi

  • actin filament bundle assembly Source: UniProtKB
  • focal adhesion assembly Source: UniProtKB
  • lamellipodium assembly Source: UniProtKB
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • protein targeting Source: Ensembl
  • regulation of actin cytoskeleton reorganization Source: Ensembl
  • regulation of focal adhesion assembly Source: Ensembl
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • Rho protein signal transduction Source: ProtInc

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-5663220 RHO GTPases Activate Formins
SignaLinkiO00212

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoD
Alternative name(s):
Rho-related protein HP1
Short name:
RhoHP1
Gene namesi
Name:RHOD
Synonyms:ARHD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173156.6
HGNCiHGNC:670 RHOD
MIMi605781 gene
neXtProtiNX_O00212

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi207C → S: Abolishes endosomal localization. 1 Publication1

Organism-specific databases

DisGeNETi29984
PharmGKBiPA24952

Polymorphism and mutation databases

BioMutaiRHOD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988631 – 207Rho-related GTP-binding protein RhoDAdd BLAST207
PropeptideiPRO_0000223365208 – 210Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207Cysteine methyl esterBy similarity1
Lipidationi207S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO00212
MaxQBiO00212
PaxDbiO00212
PeptideAtlasiO00212
PRIDEiO00212

PTM databases

iPTMnetiO00212
PhosphoSitePlusiO00212

Expressioni

Tissue specificityi

Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.

Gene expression databases

BgeeiENSG00000173156
CleanExiHS_RHOD
ExpressionAtlasiO00212 baseline and differential
GenevisibleiO00212 HS

Interactioni

Subunit structurei

Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119010, 16 interactors
CORUMiO00212
IntActiO00212, 6 interactors
STRINGi9606.ENSP00000308576

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 24Combined sources8
Helixi30 – 38Combined sources9
Beta strandi52 – 60Combined sources9
Beta strandi63 – 71Combined sources9
Beta strandi89 – 97Combined sources9
Helixi101 – 109Combined sources9
Helixi111 – 118Combined sources8
Beta strandi124 – 129Combined sources6
Helixi131 – 134Combined sources4
Helixi137 – 145Combined sources9
Helixi153 – 162Combined sources10
Beta strandi166 – 170Combined sources5
Turni173 – 176Combined sources4
Helixi179 – 192Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J1LX-ray2.50A7-197[»]
ProteinModelPortaliO00212
SMRiO00212
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00212

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 54Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiO00212
KOiK07530
OrthoDBiEOG091G0KNI
PhylomeDBiO00212
TreeFamiTF331746

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV
60 70 80 90 100
FERYMVNLQV KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS
110 120 130 140 150
PNSFDNIFNR WYPEVNHFCK KVPIIVVGCK TDLCKDKSLV NKLRRNGLEP
160 170 180 190 200
VTYHRGQEMA RSVGAVAYLE CSARLHDNVH AVFQEAAEVA LSSRGRNFWR
210
RITQGFCVVT
Length:210
Mass (Da):23,413
Last modified:July 28, 2009 - v2
Checksum:i7B8A7AE8933C78B0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058408134C → R3 PublicationsCorresponds to variant dbSNP:rs4930409Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85815 Genomic DNA Translation: BAA19652.1
AF498973 mRNA Translation: AAM21120.1
AP000729 Genomic DNA No translation available.
BC001338 mRNA Translation: AAH01338.1
CCDSiCCDS8155.1
RefSeqiNP_055393.1, NM_014578.3
UniGeneiHs.15114

Genome annotation databases

EnsembliENST00000308831; ENSP00000308576; ENSG00000173156
GeneIDi29984
KEGGihsa:29984
UCSCiuc001ojv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRHOD_HUMAN
AccessioniPrimary (citable) accession number: O00212
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health