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O00212

- RHOD_HUMAN

UniProt

O00212 - RHOD_HUMAN

Protein

Rho-related GTP-binding protein RhoD

Gene

RHOD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318GTPBy similarity
    Nucleotide bindingi71 – 755GTPBy similarity
    Nucleotide bindingi129 – 1324GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: ProtInc
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. GTP catabolic process Source: GOC
    2. regulation of small GTPase mediated signal transduction Source: Reactome
    3. Rho protein signal transduction Source: ProtInc
    4. small GTPase mediated signal transduction Source: Reactome

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.
    SignaLinkiO00212.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho-related GTP-binding protein RhoD
    Alternative name(s):
    Rho-related protein HP1
    Short name:
    RhoHP1
    Gene namesi
    Name:RHOD
    Synonyms:ARHD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:670. RHOD.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24952.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Rho-related GTP-binding protein RhoDPRO_0000198863Add
    BLAST
    Propeptidei208 – 2103Removed in mature formBy similarityPRO_0000223365

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei207 – 2071Cysteine methyl esterBy similarity
    Lipidationi207 – 2071S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiO00212.
    PaxDbiO00212.
    PRIDEiO00212.

    PTM databases

    PhosphoSiteiO00212.

    Expressioni

    Tissue specificityi

    Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.

    Gene expression databases

    ArrayExpressiO00212.
    BgeeiO00212.
    CleanExiHS_RHOD.
    GenevestigatoriO00212.

    Organism-specific databases

    HPAiHPA024394.

    Interactioni

    Subunit structurei

    In the GTP-bound form, interacts with DIAPH2 isoform 3. Interacts with PAK7/PAK5.2 Publications

    Protein-protein interaction databases

    BioGridi119010. 8 interactions.
    IntActiO00212. 5 interactions.
    STRINGi9606.ENSP00000308576.

    Structurei

    Secondary structure

    1
    210
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi17 – 248
    Helixi30 – 389
    Beta strandi52 – 609
    Beta strandi63 – 719
    Beta strandi89 – 979
    Helixi101 – 1099
    Helixi111 – 1188
    Beta strandi124 – 1296
    Helixi131 – 1344
    Helixi137 – 1459
    Helixi153 – 16210
    Beta strandi166 – 1705
    Turni173 – 1764
    Helixi179 – 19214

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2J1LX-ray2.50A7-197[»]
    ProteinModelPortaliO00212.
    SMRiO00212. Positions 15-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO00212.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 549Effector regionSequence Analysis

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233974.
    HOVERGENiHBG009351.
    InParanoidiO00212.
    KOiK07530.
    OMAiAGQVDYD.
    OrthoDBiEOG74TX0S.
    PhylomeDBiO00212.
    TreeFamiTF331746.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O00212-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV    50
    FERYMVNLQV KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS 100
    PNSFDNIFNR WYPEVNHFCK KVPIIVVGCK TDLCKDKSLV NKLRRNGLEP 150
    VTYHRGQEMA RSVGAVAYLE CSARLHDNVH AVFQEAAEVA LSSRGRNFWR 200
    RITQGFCVVT 210
    Length:210
    Mass (Da):23,413
    Last modified:July 28, 2009 - v2
    Checksum:i7B8A7AE8933C78B0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti134 – 1341C → R.3 Publications
    Corresponds to variant rs4930409 [ dbSNP | Ensembl ].
    VAR_058408

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85815 Genomic DNA. Translation: BAA19652.1.
    AF498973 mRNA. Translation: AAM21120.1.
    AP000729 Genomic DNA. No translation available.
    BC001338 mRNA. Translation: AAH01338.1.
    CCDSiCCDS8155.1.
    RefSeqiNP_055393.1. NM_014578.3.
    UniGeneiHs.15114.

    Genome annotation databases

    EnsembliENST00000308831; ENSP00000308576; ENSG00000173156.
    GeneIDi29984.
    KEGGihsa:29984.
    UCSCiuc001ojv.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85815 Genomic DNA. Translation: BAA19652.1 .
    AF498973 mRNA. Translation: AAM21120.1 .
    AP000729 Genomic DNA. No translation available.
    BC001338 mRNA. Translation: AAH01338.1 .
    CCDSi CCDS8155.1.
    RefSeqi NP_055393.1. NM_014578.3.
    UniGenei Hs.15114.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2J1L X-ray 2.50 A 7-197 [» ]
    ProteinModelPortali O00212.
    SMRi O00212. Positions 15-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119010. 8 interactions.
    IntActi O00212. 5 interactions.
    STRINGi 9606.ENSP00000308576.

    PTM databases

    PhosphoSitei O00212.

    Proteomic databases

    MaxQBi O00212.
    PaxDbi O00212.
    PRIDEi O00212.

    Protocols and materials databases

    DNASUi 29984.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308831 ; ENSP00000308576 ; ENSG00000173156 .
    GeneIDi 29984.
    KEGGi hsa:29984.
    UCSCi uc001ojv.3. human.

    Organism-specific databases

    CTDi 29984.
    GeneCardsi GC11P066824.
    HGNCi HGNC:670. RHOD.
    HPAi HPA024394.
    MIMi 605781. gene.
    neXtProti NX_O00212.
    PharmGKBi PA24952.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233974.
    HOVERGENi HBG009351.
    InParanoidi O00212.
    KOi K07530.
    OMAi AGQVDYD.
    OrthoDBi EOG74TX0S.
    PhylomeDBi O00212.
    TreeFami TF331746.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.
    SignaLinki O00212.

    Miscellaneous databases

    ChiTaRSi RHOD. human.
    EvolutionaryTracei O00212.
    GeneWikii RhoD.
    GenomeRNAii 29984.
    NextBioi 52746.
    PROi O00212.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00212.
    Bgeei O00212.
    CleanExi HS_RHOD.
    Genevestigatori O00212.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-134.
      Tissue: Placenta.
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-134.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-134.
      Tissue: Cervix.
    5. "RhoD regulates endosome dynamics through diaphanous-related formin and Src tyrosine kinase."
      Gasman S., Kalaidzidis Y., Zerial M.
      Nat. Cell Biol. 5:195-204(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DIAPH2.
    6. "Multiple Rho proteins regulate the subcellular targeting of PAK5."
      Wu X., Frost J.A.
      Biochem. Biophys. Res. Commun. 351:328-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PAK7.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiRHOD_HUMAN
    AccessioniPrimary (citable) accession number: O00212
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3