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O00204

- ST2B1_HUMAN

UniProt

O00204 - ST2B1_HUMAN

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Protein

Sulfotransferase family cytosolic 2B member 1

Gene

SULT2B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.2 Publications

Catalytic activityi

3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.

Kineticsi

  1. KM=10.9 µM for DHEA (at 37 degrees Celsius, in the presence of 1mM MgCl2)2 Publications
  2. KM=3.8 µM for DHEA (at 37 degrees Celsius, in the presence of 10mM MgCl2)2 Publications
  3. KM=11.8 µM for pregnenolone (at 37 degrees Celsius, in the presence of 1mM MgCl2)2 Publications
  4. KM=0.6 µM for PAPS (at 37 degrees Celsius, in the presence of 1mM MgCl2)2 Publications

Vmax=1752 pmol/min/mg enzyme toward DHEA (at 37 degrees Celsius, in the presence of 10 mM MgCl2)2 Publications

Temperature dependencei

Optimum temperature is 37 degrees Celsius. Retains 70% and 20% of activity when incubated at 42 degrees Celsius for 45 and 120 minutes, respectively. Activity is lost after 200 minutes incubation at 42 degrees Celsius.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Substrate
Binding sitei103 – 1031Substrate
Active sitei125 – 1251Proton acceptor
Binding sitei125 – 1251Substrate
Binding sitei147 – 1471PAPS
Binding sitei155 – 1551PAPS
Binding sitei210 – 2101PAPS

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 756PAPS
Nucleotide bindingi244 – 2496PAPS
Nucleotide bindingi274 – 2763PAPS

GO - Molecular functioni

  1. alcohol sulfotransferase activity Source: Reactome
  2. steroid sulfotransferase activity Source: UniProtKB

GO - Biological processi

  1. 3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: Reactome
  2. small molecule metabolic process Source: Reactome
  3. steroid metabolic process Source: UniProtKB
  4. sulfate assimilation Source: Ensembl
  5. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.8.2.2. 2681.
ReactomeiREACT_6913. Cytosolic sulfonation of small molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase family cytosolic 2B member 1 (EC:2.8.2.2)
Short name:
ST2B1
Short name:
Sulfotransferase 2B1
Alternative name(s):
Alcohol sulfotransferase
Hydroxysteroid sulfotransferase 2
Gene namesi
Name:SULT2B1
Synonyms:HSST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11459. SULT2B1.

Subcellular locationi

Cytoplasm. Microsome. Nucleus
Note: Phosphorylation of Ser-348 is required for translocation to the nucleus.

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. endoplasmic reticulum Source: UniProtKB-KW
  4. extracellular vesicular exosome Source: UniProtKB
  5. intracellular membrane-bounded organelle Source: HPA
  6. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1 – 2323Missing: Loss of the cholesterol sulfotransferase activity. 1 PublicationAdd
BLAST
Mutagenesisi1 – 1818Missing: Increases the cholesterol sulfotransferase activity. 1 PublicationAdd
BLAST
Mutagenesisi19 – 191D → A: Increases the cholesterol sulfotransferase activity. 1 Publication
Mutagenesisi20 – 201I → A: Loss of the cholesterol sulfotransferase activity. 1 Publication
Mutagenesisi21 – 211S → A: Increases the cholesterol sulfotransferase activity. 1 Publication
Mutagenesisi22 – 221E → A: Increases the cholesterol sulfotransferase activity. 1 Publication
Mutagenesisi23 – 231I → A: Loss of the cholesterol sulfotransferase activity. 1 Publication
Mutagenesisi347 – 3471S → A: No change in subcellular localization. 1 Publication
Mutagenesisi348 – 3481S → D: 10-fold increase in specific activity for DHEA sulfation. 10-fold increase in substrate affinity for DHEA and pregnenolone. No effect on substrate affinity for PAPS. Increases enzyme stability. 1 Publication
Mutagenesisi348 – 3481S → G: Abolishes nuclear localization. 1 Publication
Mutagenesisi352 – 3521S → G: No change in subcellular localization. 1 Publication
Mutagenesisi357 – 3571S → G: No change in subcellular localization. 1 Publication

Organism-specific databases

PharmGKBiPA36249.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Sulfotransferase family cytosolic 2B member 1PRO_0000085149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei348 – 3481Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO00204.
PaxDbiO00204.
PRIDEiO00204.

PTM databases

PhosphoSiteiO00204.

Expressioni

Tissue specificityi

Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.1 Publication

Gene expression databases

BgeeiO00204.
CleanExiHS_SULT2B1.
GenevestigatoriO00204.

Organism-specific databases

HPAiCAB033013.
HPA041724.
HPA043539.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALS2CR12Q96Q353EBI-749441,EBI-750451

Protein-protein interaction databases

BioGridi112689. 4 interactions.
IntActiO00204. 2 interactions.
MINTiMINT-1440870.
STRINGi9606.ENSP00000201586.

Structurei

Secondary structure

1
365
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 257Combined sources
Beta strandi31 – 344Combined sources
Beta strandi37 – 415Combined sources
Helixi46 – 549Combined sources
Beta strandi63 – 686Combined sources
Helixi73 – 8412Combined sources
Turni85 – 873Combined sources
Helixi90 – 945Combined sources
Helixi97 – 1004Combined sources
Beta strandi103 – 1064Combined sources
Helixi110 – 1123Combined sources
Beta strandi121 – 1244Combined sources
Turni128 – 1303Combined sources
Helixi133 – 1353Combined sources
Beta strandi141 – 1466Combined sources
Helixi149 – 16214Combined sources
Beta strandi163 – 1664Combined sources
Helixi172 – 1809Combined sources
Helixi189 – 1968Combined sources
Helixi197 – 1993Combined sources
Beta strandi205 – 2095Combined sources
Helixi210 – 2156Combined sources
Helixi217 – 22812Combined sources
Helixi234 – 24411Combined sources
Helixi246 – 2505Combined sources
Turni253 – 2553Combined sources
Turni256 – 2594Combined sources
Turni262 – 2643Combined sources
Turni267 – 2693Combined sources
Helixi280 – 2834Combined sources
Helixi287 – 30014Combined sources
Turni301 – 3033Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q1QX-ray2.91A24-365[»]
1Q1ZX-ray2.40A19-312[»]
1Q20X-ray2.30A19-312[»]
1Q22X-ray2.50A19-312[»]
DisProtiDP00404.
ProteinModelPortaliO00204.
SMRiO00204. Positions 19-311.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00204.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi305 – 36561Pro/Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiNOG296990.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiO00204.
KOiK01015.
OMAiPVGIYSP.
OrthoDBiEOG7V49ZK.
PhylomeDBiO00204.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00204-1) [UniParc]FASTAAdd to Basket

Also known as: SULT2B1b, B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGPAEPQIP GLWDTYEDDI SEISQKLPGE YFRYKGVPFP VGLYSLESIS
60 70 80 90 100
LAENTQDVRD DDIFIITYPK SGTTWMIEII CLILKEGDPS WIRSVPIWER
110 120 130 140 150
APWCETIVGA FSLPDQYSPR LMSSHLPIQI FTKAFFSSKA KVIYMGRNPR
160 170 180 190 200
DVVVSLYHYS KIAGQLKDPG TPDQFLRDFL KGEVQFGSWF DHIKGWLRMK
210 220 230 240 250
GKDNFLFITY EELQQDLQGS VERICGFLGR PLGKEALGSV VAHSTFSAMK
260 270 280 290 300
ANTMSNYTLL PPSLLDHRRG AFLRKGVCGD WKNHFTVAQS EAFDRAYRKQ
310 320 330 340 350
MRGMPTFPWD EDPEEDGSPD PEPSPEPEPK PSLEPNTSLE REPRPNSSPS
360
PSPGQASETP HPRPS
Length:365
Mass (Da):41,308
Last modified:January 4, 2005 - v2
Checksum:i13E95248DD40DF91
GO
Isoform 2 (identifier: O00204-2) [UniParc]FASTAAdd to Basket

Also known as: SULT2B1a, A

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MDGPAEPQIPGLWDTYEDDISEI → MASPPPFH

Show »
Length:350
Mass (Da):39,599
Checksum:iCE5BAA8F8874E3A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501S → N in AAC78498. (PubMed:9799594)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511L → S.
Corresponds to variant rs16982149 [ dbSNP | Ensembl ].
VAR_020887
Natural varianti240 – 2401V → I.
Corresponds to variant rs2302947 [ dbSNP | Ensembl ].
VAR_021988
Natural varianti345 – 3451P → L.
Corresponds to variant rs17842463 [ dbSNP | Ensembl ].
VAR_020888

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323MDGPA…DISEI → MASPPPFH in isoform 2. 1 PublicationVSP_012510Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92314 mRNA. Translation: AAC78498.1.
U92315 mRNA. Translation: AAC78499.1.
U92322
, U92316, U92318, U92319, U92320, U92321 Genomic DNA. Translation: AAC78553.1.
U92322
, U92316, U92317, U92318, U92319, U92320, U92321 Genomic DNA. Translation: AAC78554.1.
AC008403 Genomic DNA. No translation available.
BC034694 mRNA. Translation: AAH34694.1.
CCDSiCCDS12723.1. [O00204-1]
CCDS12724.1. [O00204-2]
RefSeqiNP_004596.2. NM_004605.2. [O00204-2]
NP_814444.1. NM_177973.1. [O00204-1]
UniGeneiHs.369331.

Genome annotation databases

EnsembliENST00000201586; ENSP00000201586; ENSG00000088002. [O00204-1]
ENST00000323090; ENSP00000312880; ENSG00000088002. [O00204-2]
GeneIDi6820.
KEGGihsa:6820.
UCSCiuc002pjl.3. human. [O00204-1]
uc002pjm.3. human. [O00204-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92314 mRNA. Translation: AAC78498.1 .
U92315 mRNA. Translation: AAC78499.1 .
U92322
, U92316 , U92318 , U92319 , U92320 , U92321 Genomic DNA. Translation: AAC78553.1 .
U92322
, U92316 , U92317 , U92318 , U92319 , U92320 , U92321 Genomic DNA. Translation: AAC78554.1 .
AC008403 Genomic DNA. No translation available.
BC034694 mRNA. Translation: AAH34694.1 .
CCDSi CCDS12723.1. [O00204-1 ]
CCDS12724.1. [O00204-2 ]
RefSeqi NP_004596.2. NM_004605.2. [O00204-2 ]
NP_814444.1. NM_177973.1. [O00204-1 ]
UniGenei Hs.369331.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q1Q X-ray 2.91 A 24-365 [» ]
1Q1Z X-ray 2.40 A 19-312 [» ]
1Q20 X-ray 2.30 A 19-312 [» ]
1Q22 X-ray 2.50 A 19-312 [» ]
DisProti DP00404.
ProteinModelPortali O00204.
SMRi O00204. Positions 19-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112689. 4 interactions.
IntActi O00204. 2 interactions.
MINTi MINT-1440870.
STRINGi 9606.ENSP00000201586.

Chemistry

ChEMBLi CHEMBL1743297.

PTM databases

PhosphoSitei O00204.

Proteomic databases

MaxQBi O00204.
PaxDbi O00204.
PRIDEi O00204.

Protocols and materials databases

DNASUi 6820.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000201586 ; ENSP00000201586 ; ENSG00000088002 . [O00204-1 ]
ENST00000323090 ; ENSP00000312880 ; ENSG00000088002 . [O00204-2 ]
GeneIDi 6820.
KEGGi hsa:6820.
UCSCi uc002pjl.3. human. [O00204-1 ]
uc002pjm.3. human. [O00204-2 ]

Organism-specific databases

CTDi 6820.
GeneCardsi GC19P049055.
HGNCi HGNC:11459. SULT2B1.
HPAi CAB033013.
HPA041724.
HPA043539.
MIMi 604125. gene.
neXtProti NX_O00204.
PharmGKBi PA36249.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296990.
GeneTreei ENSGT00760000118932.
HOGENOMi HOG000037209.
HOVERGENi HBG001195.
InParanoidi O00204.
KOi K01015.
OMAi PVGIYSP.
OrthoDBi EOG7V49ZK.
PhylomeDBi O00204.
TreeFami TF321745.

Enzyme and pathway databases

BRENDAi 2.8.2.2. 2681.
Reactomei REACT_6913. Cytosolic sulfonation of small molecules.

Miscellaneous databases

EvolutionaryTracei O00204.
GeneWikii SULT2B1.
GenomeRNAii 6820.
NextBioi 26633.
PROi O00204.
SOURCEi Search...

Gene expression databases

Bgeei O00204.
CleanExi HS_SULT2B1.
Genevestigatori O00204.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene."
    Her C., Wood T.C., Eichler E.E., Mohrenweiser H.W., Ramagli L.S., Siciliano M.J., Weinshilboum R.M.
    Genomics 53:284-295(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  4. "Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase."
    Fuda H., Lee Y.C., Shimizu C., Javitt N.B., Strott C.A.
    J. Biol. Chem. 277:36161-36166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 1-MET--ASP-18; 1-MET--ILE-23; ASP-19; ILE-20; SER-21; GLU-22 AND ILE-23.
  5. "Characterization of proline-serine-rich carboxyl terminus in human sulfotransferase 2B1b: immunogenicity, subcellular localization, kinetic properties, and phosphorylation."
    He D., Falany C.N.
    Drug Metab. Dispos. 34:1749-1755(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  6. "Site-directed mutagenesis of human cytosolic sulfotransferase (SULT) 2B1b to phospho-mimetic Ser348Asp results in an isoform with increased catalytic activity."
    Salman E.D., He D., Runge-Morris M., Kocarek T.A., Falany C.N.
    J. Steroid Biochem. Mol. Biol. 127:315-323(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-348, MUTAGENESIS OF SER-347; SER-348; SER-352 AND SER-357.
  7. "Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms."
    Lee K.A., Fuda H., Lee Y.C., Negishi M., Strott C.A., Pedersen L.C.
    J. Biol. Chem. 278:44593-44599(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 19-312 IN COMPLEX WITH ADENOSINE-3'-5'-DIPHOSPHATE (PAP) AND PREGNENOLONE.

Entry informationi

Entry nameiST2B1_HUMAN
AccessioniPrimary (citable) accession number: O00204
Secondary accession number(s): O00205, O75814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3