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O00203

- AP3B1_HUMAN

UniProt

O00203 - AP3B1_HUMAN

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Protein

AP-3 complex subunit beta-1

Gene

AP3B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

GO - Molecular functioni

  1. GTP-dependent protein binding Source: BHF-UCL
  2. protein phosphatase binding Source: UniProtKB

GO - Biological processi

  1. anterograde axon cargo transport Source: UniProtKB
  2. anterograde synaptic vesicle transport Source: UniProtKB
  3. antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: Ensembl
  4. blood coagulation Source: Ensembl
  5. intracellular protein transport Source: ProtInc
  6. melanosome organization Source: UniProtKB
  7. positive regulation of NK T cell differentiation Source: Ensembl
  8. protein targeting to lysosome Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit beta-1
Alternative name(s):
Adaptor protein complex AP-3 subunit beta-1
Adaptor-related protein complex 3 subunit beta-1
Beta-3A-adaptin
Clathrin assembly protein complex 3 beta-1 large chain
Gene namesi
Name:AP3B1
Synonyms:ADTB3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:566. AP3B1.

Subcellular locationi

Cytoplasmic vesicleclathrin-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Golgi apparatus By similarity
Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.By similarity

GO - Cellular componenti

  1. AP-3 adaptor complex Source: InterPro
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. Golgi apparatus Source: ProtInc
  4. lysosomal membrane Source: UniProtKB
  5. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Hermansky-Pudlak syndrome 2 (HPS2) [MIM:608233]: A form of Hermansky-Pudlak syndrome, a genetically heterogeneous autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. HPS2 differs from the other forms of HPS in that it includes immunodeficiency in its phenotype and patients with HPS2 have an increased susceptibility to infections.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti390 – 41021Missing in HPS2. 1 Publication
VAR_011595Add
BLAST
Natural varianti580 – 5801L → R in HPS2. 1 Publication
VAR_011596

Keywords - Diseasei

Albinism, Disease mutation, Hermansky-Pudlak syndrome

Organism-specific databases

MIMi203300. phenotype.
608233. phenotype.
Orphaneti183678. Hermansky-Pudlak syndrome with neutropenia.
PharmGKBiPA24857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10941094AP-3 complex subunit beta-1PRO_0000193746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761Phosphoserine3 Publications
Modified residuei609 – 6091Phosphoserine2 Publications
Modified residuei750 – 7501Phosphoserine1 Publication
Modified residuei752 – 7521Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated on serine residues.5 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO00203.
PaxDbiO00203.
PRIDEiO00203.

PTM databases

PhosphoSiteiO00203.

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

BgeeiO00203.
CleanExiHS_AP3B1.
GenevestigatoriO00203.

Organism-specific databases

HPAiHPA038737.
HPA045458.

Interactioni

Subunit structurei

AP-3 associates with the BLOC-1 complex (By similarity). Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).By similarity

Protein-protein interaction databases

BioGridi114116. 22 interactions.
DIPiDIP-24208N.
IntActiO00203. 5 interactions.
MINTiMINT-1538470.
STRINGi9606.ENSP00000255194.

Structurei

3D structure databases

ProteinModelPortaliO00203.
SMRiO00203. Positions 42-603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi677 – 802126Glu/Ser-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5096.
GeneTreeiENSGT00530000063546.
HOGENOMiHOG000033978.
HOVERGENiHBG050519.
InParanoidiO00203.
KOiK12397.
OMAiFVPMKTH.
OrthoDBiEOG74R1QG.
PhylomeDBiO00203.
TreeFamiTF314605.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026740. AP3_beta.
IPR029394. AP3B1_Ser.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PANTHERiPTHR11134. PTHR11134. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
PF14797. SEEEED. 1 hit.
[Graphical view]
PIRSFiPIRSF037096. AP3_complex_beta. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00203-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSNSFPYNE QSGGGEATEL GQEATSTISP SGAFGLFSSD LKKNEDLKQM
60 70 80 90 100
LESNKDSAKL DAMKRIVGMI AKGKNASELF PAVVKNVASK NIEIKKLVYV
110 120 130 140 150
YLVRYAEEQQ DLALLSISTF QRALKDPNQL IRASALRVLS SIRVPIIVPI
160 170 180 190 200
MMLAIKEASA DLSPYVRKNA AHAIQKLYSL DPEQKEMLIE VIEKLLKDKS
210 220 230 240 250
TLVAGSVVMA FEEVCPDRID LIHKNYRKLC NLLVDVEEWG QVVIIHMLTR
260 270 280 290 300
YARTQFVSPW KEGDELEDNG KNFYESDDDQ KEKTDKKKKP YTMDPDHRLL
310 320 330 340 350
IRNTKPLLQS RNAAVVMAVA QLYWHISPKS EAGIISKSLV RLLRSNREVQ
360 370 380 390 400
YIVLQNIATM SIQRKGMFEP YLKSFYVRST DPTMIKTLKL EILTNLANEA
410 420 430 440 450
NISTLLREFQ TYVKSQDKQF AAATIQTIGR CATNILEVTD TCLNGLVCLL
460 470 480 490 500
SNRDEIVVAE SVVVIKKLLQ MQPAQHGEII KHMAKLLDSI TVPVARASIL
510 520 530 540 550
WLIGENCERV PKIAPDVLRK MAKSFTSEDD LVKLQILNLG AKLYLTNSKQ
560 570 580 590 600
TKLLTQYILN LGKYDQNYDI RDRTRFIRQL IVPNVKSGAL SKYAKKIFLA
610 620 630 640 650
QKPAPLLESP FKDRDHFQLG TLSHTLNIKA TGYLELSNWP EVAPDPSVRN
660 670 680 690 700
VEVIELAKEW TPAGKAKQEN SAKKFYSESE EEEDSSDSSS DSESESGSES
710 720 730 740 750
GEQGESGEEG DSNEDSSEDS SSEQDSESGR ESGLENKRTA KRNSKAKGKS
760 770 780 790 800
DSEDGEKENE KSKTSDSSND ESSSIEDSSS DSESESEPES ESESRRVTKE
810 820 830 840 850
KEKKTKQDRT PLTKDVSLLD LDDFNPVSTP VALPTPALSP SLMADLEGLH
860 870 880 890 900
LSTSSSVISV STPAFVPTKT HVLLHRMSGK GLAAHYFFPR QPCIFGDKMV
910 920 930 940 950
SIQITLNNTT DRKIENIHIG EKKLPIGMKM HVFNPIDSLE PEGSITVSMG
960 970 980 990 1000
IDFCDSTQTA SFQLCTKDDC FNVNIQPPVG ELLLPVAMSE KDFKKEQGVL
1010 1020 1030 1040 1050
TGMNETSAVI IAAPQNFTPS VIFQKVVNVA NVGAVPSGQD NIHRFAAKTV
1060 1070 1080 1090
HSGSLMLVTV ELKEGSTAQL IINTEKTVIG SVLLRELKPV LSQG
Length:1,094
Mass (Da):121,320
Last modified:July 28, 2009 - v3
Checksum:iAC683CE18EF90555
GO
Isoform 2 (identifier: O00203-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.

Show »
Length:1,045
Mass (Da):116,195
Checksum:i28C0DFA3E2603570
GO

Sequence cautioni

The sequence CAD97982.1 differs from that shown. Reason: Wrong choice of CDS.Curated
The sequence CAD97982.1 differs from that shown. Reason: Frameshift at position 1011. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681K → R in CAD97982. (PubMed:17974005)Curated
Sequence conflicti379 – 3791S → P in CAD97982. (PubMed:17974005)Curated
Sequence conflicti804 – 8041Missing in AAD03778. (PubMed:9151686)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti390 – 41021Missing in HPS2. 1 Publication
VAR_011595Add
BLAST
Natural varianti580 – 5801L → R in HPS2. 1 Publication
VAR_011596
Natural varianti585 – 5851V → E.5 Publications
Corresponds to variant rs6453373 [ dbSNP | Ensembl ].
VAR_058404

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_054708Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91931 mRNA. Translation: AAD03778.1.
U81504 mRNA. Translation: AAB61638.1.
BX538041 mRNA. Translation: CAD97982.1. Sequence problems.
AC024568 Genomic DNA. No translation available.
AC024578 Genomic DNA. No translation available.
AC104108 Genomic DNA. No translation available.
AC112197 Genomic DNA. No translation available.
BC038444 mRNA. Translation: AAH38444.1.
AF247736 Genomic DNA. Translation: AAG01739.1.
CCDSiCCDS4041.1. [O00203-1]
CCDS64186.1. [O00203-3]
PIRiT50651.
T50652.
RefSeqiNP_001258698.1. NM_001271769.1. [O00203-3]
NP_003655.3. NM_003664.4. [O00203-1]
UniGeneiHs.532091.

Genome annotation databases

EnsembliENST00000255194; ENSP00000255194; ENSG00000132842. [O00203-1]
ENST00000519295; ENSP00000430597; ENSG00000132842. [O00203-3]
GeneIDi8546.
KEGGihsa:8546.
UCSCiuc003kfj.4. human. [O00203-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

AP3B1base

AP3B1 mutation db

Mutations of the ADTB3A gene

Retina International's Scientific Newsletter

Albinism database (ADB)

AP3B1 mutations

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91931 mRNA. Translation: AAD03778.1 .
U81504 mRNA. Translation: AAB61638.1 .
BX538041 mRNA. Translation: CAD97982.1 . Sequence problems.
AC024568 Genomic DNA. No translation available.
AC024578 Genomic DNA. No translation available.
AC104108 Genomic DNA. No translation available.
AC112197 Genomic DNA. No translation available.
BC038444 mRNA. Translation: AAH38444.1 .
AF247736 Genomic DNA. Translation: AAG01739.1 .
CCDSi CCDS4041.1. [O00203-1 ]
CCDS64186.1. [O00203-3 ]
PIRi T50651.
T50652.
RefSeqi NP_001258698.1. NM_001271769.1. [O00203-3 ]
NP_003655.3. NM_003664.4. [O00203-1 ]
UniGenei Hs.532091.

3D structure databases

ProteinModelPortali O00203.
SMRi O00203. Positions 42-603.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114116. 22 interactions.
DIPi DIP-24208N.
IntActi O00203. 5 interactions.
MINTi MINT-1538470.
STRINGi 9606.ENSP00000255194.

PTM databases

PhosphoSitei O00203.

Proteomic databases

MaxQBi O00203.
PaxDbi O00203.
PRIDEi O00203.

Protocols and materials databases

DNASUi 8546.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255194 ; ENSP00000255194 ; ENSG00000132842 . [O00203-1 ]
ENST00000519295 ; ENSP00000430597 ; ENSG00000132842 . [O00203-3 ]
GeneIDi 8546.
KEGGi hsa:8546.
UCSCi uc003kfj.4. human. [O00203-1 ]

Organism-specific databases

CTDi 8546.
GeneCardsi GC05M077296.
GeneReviewsi AP3B1.
HGNCi HGNC:566. AP3B1.
HPAi HPA038737.
HPA045458.
MIMi 203300. phenotype.
603401. gene.
608233. phenotype.
neXtProti NX_O00203.
Orphaneti 183678. Hermansky-Pudlak syndrome with neutropenia.
PharmGKBi PA24857.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5096.
GeneTreei ENSGT00530000063546.
HOGENOMi HOG000033978.
HOVERGENi HBG050519.
InParanoidi O00203.
KOi K12397.
OMAi FVPMKTH.
OrthoDBi EOG74R1QG.
PhylomeDBi O00203.
TreeFami TF314605.

Enzyme and pathway databases

Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSi AP3B1. human.
GeneWikii AP3B1.
GenomeRNAii 8546.
NextBioi 32018.
PROi O00203.
SOURCEi Search...

Gene expression databases

Bgeei O00203.
CleanExi HS_AP3B1.
Genevestigatori O00203.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR026740. AP3_beta.
IPR029394. AP3B1_Ser.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view ]
PANTHERi PTHR11134. PTHR11134. 1 hit.
Pfami PF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
PF14797. SEEEED. 1 hit.
[Graphical view ]
PIRSFi PIRSF037096. AP3_complex_beta. 1 hit.
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the adaptor-related protein complex, AP-3."
    Simpson F., Peden A.A., Christopoulou L., Robinson M.S.
    J. Cell Biol. 137:835-845(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT GLU-585.
    Tissue: Heart.
  2. "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3."
    Dell'Angelica E.C., Ooi C.E., Bonifacino J.S.
    J. Biol. Chem. 272:15078-15084(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PHOSPHORYLATION, TISSUE SPECIFICITY, VARIANT GLU-585.
    Tissue: Pancreas.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLU-585.
    Tissue: Colon.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-585.
    Tissue: Uterus.
  6. "Identification of CpG islands hypermethylated in human tumors by the arbitrarily primed-PCR method."
    Kisseljov F., Petrenko A., Eshilev E., Kisseljova N.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
    Tissue: Cervix.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276; SER-609; SER-750 AND SER-752, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor."
    Dell'Angelica E.C., Shotelersuk V., Aguilar R.C., Gahl W.A., Bonifacino J.S.
    Mol. Cell 3:11-21(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HPS2 390-LEU--GLN-410 DEL AND ARG-580.
  14. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-585, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAP3B1_HUMAN
AccessioniPrimary (citable) accession number: O00203
Secondary accession number(s): E5RJ68
, O00580, Q7Z393, Q9HD66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3