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Protein

Activator of apoptosis harakiri

Gene

HRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes apoptosis.2 Publications

GO - Biological processi

  • apoptotic process Source: ProtInc
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of protein homooligomerization Source: BHF-UCL
  • positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135116-MONOMER.
SIGNORiO00198.

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of apoptosis harakiri
Alternative name(s):
BH3-interacting domain-containing protein 3
Neuronal death protein DP5
Gene namesi
Name:HRK
Synonyms:BID3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5185. HRK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 87HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi8739.
OpenTargetsiENSG00000135116.
PharmGKBiPA29459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431061 – 91Activator of apoptosis harakiriAdd BLAST91

Proteomic databases

PaxDbiO00198.
PRIDEiO00198.

Expressioni

Gene expression databases

BgeeiENSG00000135116.
CleanExiHS_HRK.
ExpressionAtlasiO00198. baseline and differential.
GenevisibleiO00198. HS.

Organism-specific databases

HPAiCAB025973.

Interactioni

Subunit structurei

Interacts with BCL2 and BCL2L1. Interacts with C1QBP.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L1Q07817-13EBI-701322,EBI-287195
C1QBPQ070217EBI-701322,EBI-347528

Protein-protein interaction databases

BioGridi114276. 6 interactors.
IntActiO00198. 7 interactors.
MINTiMINT-1174819.
STRINGi9606.ENSP00000257572.

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 51Combined sources24
Helixi69 – 85Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L58NMR-A22-53[»]
2L5BNMR-A61-91[»]
ProteinModelPortaliO00198.
SMRiO00198.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00198.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 47BH3Add BLAST15

Domaini

The BH3 motif is required for the induction of cell death.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2PJ. Eukaryota.
ENOG41113ZW. LUCA.
GeneTreeiENSGT00390000007050.
HOGENOMiHOG000112951.
HOVERGENiHBG005990.
InParanoidiO00198.
KOiK02512.
OMAiAVCACSS.
OrthoDBiEOG091G16Q4.
PhylomeDBiO00198.
TreeFamiTF338168.

Family and domain databases

InterProiIPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PANTHERiPTHR15056. PTHR15056. 1 hit.
PfamiPF15196. Harakiri. 1 hit.
[Graphical view]
PIRSFiPIRSF037635. BID3. 1 hit.
PROSITEiPS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPCPLHRGR GPPAVCACSA GRLGLRSSAA QLTAARLKAL GDELHQRTMW
60 70 80 90
RRRARSRRAP APGALPTYWP WLCAAAQVAA LAAWLLGRRN L
Length:91
Mass (Da):9,884
Last modified:July 1, 1997 - v1
Checksum:i22E45FA2B0B7AA00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76376 mRNA. Translation: AAC34931.1.
AC083806 Genomic DNA. No translation available.
CCDSiCCDS9181.1.
RefSeqiNP_003797.1. NM_003806.2.
XP_016875635.1. XM_017020146.1.
UniGeneiHs.87247.

Genome annotation databases

EnsembliENST00000257572; ENSP00000257572; ENSG00000135116.
GeneIDi8739.
KEGGihsa:8739.
UCSCiuc001twe.5. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76376 mRNA. Translation: AAC34931.1.
AC083806 Genomic DNA. No translation available.
CCDSiCCDS9181.1.
RefSeqiNP_003797.1. NM_003806.2.
XP_016875635.1. XM_017020146.1.
UniGeneiHs.87247.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L58NMR-A22-53[»]
2L5BNMR-A61-91[»]
ProteinModelPortaliO00198.
SMRiO00198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114276. 6 interactors.
IntActiO00198. 7 interactors.
MINTiMINT-1174819.
STRINGi9606.ENSP00000257572.

Proteomic databases

PaxDbiO00198.
PRIDEiO00198.

Protocols and materials databases

DNASUi8739.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257572; ENSP00000257572; ENSG00000135116.
GeneIDi8739.
KEGGihsa:8739.
UCSCiuc001twe.5. human.

Organism-specific databases

CTDi8739.
DisGeNETi8739.
GeneCardsiHRK.
HGNCiHGNC:5185. HRK.
HPAiCAB025973.
MIMi603447. gene.
neXtProtiNX_O00198.
OpenTargetsiENSG00000135116.
PharmGKBiPA29459.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2PJ. Eukaryota.
ENOG41113ZW. LUCA.
GeneTreeiENSGT00390000007050.
HOGENOMiHOG000112951.
HOVERGENiHBG005990.
InParanoidiO00198.
KOiK02512.
OMAiAVCACSS.
OrthoDBiEOG091G16Q4.
PhylomeDBiO00198.
TreeFamiTF338168.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135116-MONOMER.
SIGNORiO00198.

Miscellaneous databases

EvolutionaryTraceiO00198.
GeneWikiiHRK_(gene).
GenomeRNAii8739.
PROiO00198.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135116.
CleanExiHS_HRK.
ExpressionAtlasiO00198. baseline and differential.
GenevisibleiO00198. HS.

Family and domain databases

InterProiIPR017249. Apoptosis_activator_harakiri.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PANTHERiPTHR15056. PTHR15056. 1 hit.
PfamiPF15196. Harakiri. 1 hit.
[Graphical view]
PIRSFiPIRSF037635. BID3. 1 hit.
PROSITEiPS01259. BH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRK_HUMAN
AccessioniPrimary (citable) accession number: O00198
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.