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Protein

Ras-related protein Rab-27B

Gene

RAB27B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in targeting uroplakins to urothelial apical membranes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24GTP9
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi133 – 136GTP4
Nucleotide bindingi163 – 165GTP3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • myosin V binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB

GO - Biological processi

  • melanosome transport Source: GO_Central
  • multivesicular body sorting pathway Source: UniProtKB
  • platelet degranulation Source: Reactome
  • positive regulation of exocytosis Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-8873719. RAB geranylgeranylation.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-27B
Alternative name(s):
C25KG
Gene namesi
Name:RAB27B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:9767. RAB27B.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • Golgi stack Source: UniProtKB
  • melanosome Source: UniProtKB
  • multivesicular body membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • platelet dense granule membrane Source: Reactome
  • secretory granule Source: GO_Central
  • trans-Golgi network transport vesicle Source: UniProtKB
  • zymogen granule membrane Source: Ensembl

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5874.
OpenTargetsiENSG00000041353.
PharmGKBiPA34118.

Polymorphism and mutation databases

BioMutaiRAB27B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001212242 – 218Ras-related protein Rab-27BAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1
Disulfide bondi123 ↔ 1881 Publication
Lipidationi216S-geranylgeranyl cysteineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO00194.
MaxQBiO00194.
PaxDbiO00194.
PeptideAtlasiO00194.
PRIDEiO00194.

2D gel databases

OGPiO00194.

PTM databases

iPTMnetiO00194.
PhosphoSitePlusiO00194.

Expressioni

Tissue specificityi

Expressed primarily in testis.

Gene expression databases

BgeeiENSG00000041353.
CleanExiHS_RAB27B.
ExpressionAtlasiO00194. baseline and differential.
GenevisibleiO00194. HS.

Organism-specific databases

HPAiCAB017712.
HPA019849.

Interactioni

Subunit structurei

Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • myosin V binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111812. 14 interactors.
DIPiDIP-48948N.
IntActiO00194. 3 interactors.
STRINGi9606.ENSP00000262094.

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 16Combined sources10
Helixi22 – 30Combined sources9
Beta strandi37 – 54Combined sources18
Beta strandi65 – 77Combined sources13
Helixi78 – 89Combined sources12
Beta strandi94 – 100Combined sources7
Helixi104 – 115Combined sources12
Turni122 – 124Combined sources3
Beta strandi127 – 133Combined sources7
Helixi138 – 140Combined sources3
Helixi145 – 154Combined sources10
Beta strandi159 – 162Combined sources4
Turni164 – 166Combined sources3
Helixi170 – 188Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F7SX-ray2.70A/B4-201[»]
ProteinModelPortaliO00194.
SMRiO00194.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00194.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0081. Eukaryota.
ENOG410XQ3T. LUCA.
GeneTreeiENSGT00890000139417.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiO00194.
KOiK07886.
OMAiQCVDKTQ.
OrthoDBiEOG091G0I51.
PhylomeDBiO00194.
TreeFamiTF312895.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR
60 70 80 90 100
VVYNAQGPNG SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD
110 120 130 140 150
LTSQQSFLNV RNWMSQLQAN AYCENPDIVL IGNKADLPDQ REVNERQARE
160 170 180 190 200
LADKYGIPYF ETSAATGQNV EKAVETLLDL IMKRMEQCVE KTQIPDTVNG
210
GNSGNLDGEK PPEKKCIC
Length:218
Mass (Da):24,608
Last modified:January 23, 2007 - v4
Checksum:i8ED640F0C15EDCD3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05171492A → T. Corresponds to variant dbSNP:rs9966265Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57093 mRNA. Translation: AAC51194.2.
AF329499 mRNA. Translation: AAK11243.1.
AF498954 mRNA. Translation: AAM21102.1.
AK314115 mRNA. Translation: BAG36807.1.
CH471096 Genomic DNA. Translation: EAW63010.1.
BC027474 mRNA. Translation: AAH27474.1.
CCDSiCCDS11958.1.
RefSeqiNP_004154.2. NM_004163.4.
XP_005266790.1. XM_005266733.1.
XP_016881402.1. XM_017025913.1.
XP_016881403.1. XM_017025914.1.
UniGeneiHs.25318.

Genome annotation databases

EnsembliENST00000262094; ENSP00000262094; ENSG00000041353.
GeneIDi5874.
KEGGihsa:5874.
UCSCiuc002lfr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRB27B_HUMAN
AccessioniPrimary (citable) accession number: O00194
Secondary accession number(s): B2RAB0, Q9BZB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 167 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families