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Protein

Small acidic protein

Gene

SMAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small acidic protein
Gene namesi
Name:SMAP
Synonyms:C11orf58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:16990. C11orf58.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485353.

Polymorphism and mutation databases

BioMutaiSMAP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Small acidic proteinPRO_0000263656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151PhosphoserineCombined sources
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei63 – 631PhosphoserineCombined sources
Modified residuei87 – 871PhosphoserineCombined sources
Modified residuei127 – 1271PhosphoserineCombined sources
Modified residuei147 – 1471PhosphoserineCombined sources
Modified residuei174 – 1741N6-acetyllysineCombined sources
Modified residuei179 – 1791N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO00193.
MaxQBiO00193.
PaxDbiO00193.
PeptideAtlasiO00193.
PRIDEiO00193.
TopDownProteomicsiO00193.

PTM databases

iPTMnetiO00193.
PhosphoSiteiO00193.

Expressioni

Gene expression databases

BgeeiENSG00000110696.
CleanExiHS_C11orf58.
ExpressionAtlasiO00193. baseline and differential.
GenevisibleiO00193. HS.

Organism-specific databases

HPAiHPA036591.

Interactioni

Protein-protein interaction databases

BioGridi116144. 46 interactions.
IntActiO00193. 22 interactions.
MINTiMINT-5005829.
STRINGi9606.ENSP00000228136.

Structurei

3D structure databases

ProteinModelPortaliO00193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi109 – 13931Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the SMAP family.Curated

Phylogenomic databases

eggNOGiENOG410IVYQ. Eukaryota.
ENOG4111SCI. LUCA.
GeneTreeiENSGT00390000000687.
HOGENOMiHOG000247059.
HOVERGENiHBG055732.
InParanoidiO00193.
OMAiGFSEFQE.
OrthoDBiEOG091G11TG.
PhylomeDBiO00193.
TreeFamiTF328803.

Family and domain databases

InterProiIPR026714. SMAP.
IPR028124. SMAP_dom.
[Graphical view]
PANTHERiPTHR22175. PTHR22175. 1 hit.
PfamiPF15477. SMAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAARESHPH GVKRSASPDD DLGSSNWEAA DLGNEERKQK FLRLMGAGKK
60 70 80 90 100
EHTGRLVIGD HKSTSHFRTG EEDKKINEEL ESQYQQSMDS KLSGRYRRHC
110 120 130 140 150
GLGFSEVEDH DGEGDVAGDD DDDDDDSPDP ESPDDSESDS ESEKEESAEE
160 170 180
LQAAEHPDEV EDPKNKKDAK SNYKMMFVKS SGS
Length:183
Mass (Da):20,333
Last modified:July 1, 1997 - v1
Checksum:i509BA7377B699A74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51678 mRNA. Translation: AAB99729.1.
CR456882 mRNA. Translation: CAG33163.1.
AK315382 mRNA. Translation: BAG37775.1.
CH471064 Genomic DNA. Translation: EAW68455.1.
BC007103 mRNA. Translation: AAH07103.1.
BC016352 mRNA. Translation: AAH16352.1.
BC020937 mRNA. Translation: AAH20937.1.
BC103747 mRNA. Translation: AAI03748.1.
CCDSiCCDS7822.1.
RefSeqiNP_055082.1. NM_014267.5.
UniGeneiHs.368226.
Hs.645792.

Genome annotation databases

EnsembliENST00000228136; ENSP00000228136; ENSG00000110696.
GeneIDi10944.
KEGGihsa:10944.
UCSCiuc001mmk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51678 mRNA. Translation: AAB99729.1.
CR456882 mRNA. Translation: CAG33163.1.
AK315382 mRNA. Translation: BAG37775.1.
CH471064 Genomic DNA. Translation: EAW68455.1.
BC007103 mRNA. Translation: AAH07103.1.
BC016352 mRNA. Translation: AAH16352.1.
BC020937 mRNA. Translation: AAH20937.1.
BC103747 mRNA. Translation: AAI03748.1.
CCDSiCCDS7822.1.
RefSeqiNP_055082.1. NM_014267.5.
UniGeneiHs.368226.
Hs.645792.

3D structure databases

ProteinModelPortaliO00193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116144. 46 interactions.
IntActiO00193. 22 interactions.
MINTiMINT-5005829.
STRINGi9606.ENSP00000228136.

PTM databases

iPTMnetiO00193.
PhosphoSiteiO00193.

Polymorphism and mutation databases

BioMutaiSMAP.

Proteomic databases

EPDiO00193.
MaxQBiO00193.
PaxDbiO00193.
PeptideAtlasiO00193.
PRIDEiO00193.
TopDownProteomicsiO00193.

Protocols and materials databases

DNASUi10944.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228136; ENSP00000228136; ENSG00000110696.
GeneIDi10944.
KEGGihsa:10944.
UCSCiuc001mmk.3. human.

Organism-specific databases

CTDi10944.
GeneCardsiC11orf58.
HGNCiHGNC:16990. C11orf58.
HPAiHPA036591.
neXtProtiNX_O00193.
PharmGKBiPA143485353.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVYQ. Eukaryota.
ENOG4111SCI. LUCA.
GeneTreeiENSGT00390000000687.
HOGENOMiHOG000247059.
HOVERGENiHBG055732.
InParanoidiO00193.
OMAiGFSEFQE.
OrthoDBiEOG091G11TG.
PhylomeDBiO00193.
TreeFamiTF328803.

Miscellaneous databases

GeneWikiiC11orf58.
GenomeRNAii10944.
PROiO00193.

Gene expression databases

BgeeiENSG00000110696.
CleanExiHS_C11orf58.
ExpressionAtlasiO00193. baseline and differential.
GenevisibleiO00193. HS.

Family and domain databases

InterProiIPR026714. SMAP.
IPR028124. SMAP_dom.
[Graphical view]
PANTHERiPTHR22175. PTHR22175. 1 hit.
PfamiPF15477. SMAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMAP_HUMAN
AccessioniPrimary (citable) accession number: O00193
Secondary accession number(s): B2RD28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.