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Protein

Small acidic protein

Gene

SMAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small acidic protein
Gene namesi
Name:SMAP
Synonyms:C11orf58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110696.9.
HGNCiHGNC:16990. C11orf58.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110696.
PharmGKBiPA143485353.

Polymorphism and mutation databases

BioMutaiSMAP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636561 – 183Small acidic proteinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei15PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Cross-linki62Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei63PhosphoserineCombined sources1
Cross-linki75Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei87PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei174N6-acetyllysineCombined sources1
Modified residuei179N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO00193.
MaxQBiO00193.
PaxDbiO00193.
PeptideAtlasiO00193.
PRIDEiO00193.
TopDownProteomicsiO00193.

PTM databases

iPTMnetiO00193.
PhosphoSitePlusiO00193.

Expressioni

Gene expression databases

BgeeiENSG00000110696.
CleanExiHS_C11orf58.
ExpressionAtlasiO00193. baseline and differential.
GenevisibleiO00193. HS.

Organism-specific databases

HPAiHPA036591.
HPA076406.

Interactioni

Protein-protein interaction databases

BioGridi116144. 46 interactors.
IntActiO00193. 22 interactors.
MINTiMINT-5005829.
STRINGi9606.ENSP00000228136.

Structurei

3D structure databases

ProteinModelPortaliO00193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 139Asp-richAdd BLAST31

Sequence similaritiesi

Belongs to the SMAP family.Curated

Phylogenomic databases

eggNOGiENOG410IVYQ. Eukaryota.
ENOG4111SCI. LUCA.
GeneTreeiENSGT00390000000687.
HOGENOMiHOG000247059.
HOVERGENiHBG055732.
InParanoidiO00193.
OMAiMDSTMSG.
OrthoDBiEOG091G11TG.
PhylomeDBiO00193.
TreeFamiTF328803.

Family and domain databases

InterProiView protein in InterPro
IPR026714. SMAP.
IPR028124. SMAP_dom.
PANTHERiPTHR22175. PTHR22175. 2 hits.
PfamiView protein in Pfam
PF15477. SMAP. 1 hit.

Sequencei

Sequence statusi: Complete.

O00193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAARESHPH GVKRSASPDD DLGSSNWEAA DLGNEERKQK FLRLMGAGKK
60 70 80 90 100
EHTGRLVIGD HKSTSHFRTG EEDKKINEEL ESQYQQSMDS KLSGRYRRHC
110 120 130 140 150
GLGFSEVEDH DGEGDVAGDD DDDDDDSPDP ESPDDSESDS ESEKEESAEE
160 170 180
LQAAEHPDEV EDPKNKKDAK SNYKMMFVKS SGS
Length:183
Mass (Da):20,333
Last modified:July 1, 1997 - v1
Checksum:i509BA7377B699A74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51678 mRNA. Translation: AAB99729.1.
CR456882 mRNA. Translation: CAG33163.1.
AK315382 mRNA. Translation: BAG37775.1.
CH471064 Genomic DNA. Translation: EAW68455.1.
BC007103 mRNA. Translation: AAH07103.1.
BC016352 mRNA. Translation: AAH16352.1.
BC020937 mRNA. Translation: AAH20937.1.
BC103747 mRNA. Translation: AAI03748.1.
CCDSiCCDS7822.1.
RefSeqiNP_055082.1. NM_014267.5.
UniGeneiHs.368226.
Hs.645792.

Genome annotation databases

EnsembliENST00000228136; ENSP00000228136; ENSG00000110696.
GeneIDi10944.
KEGGihsa:10944.
UCSCiuc001mmk.3. human.

Similar proteinsi

Entry informationi

Entry nameiSMAP_HUMAN
AccessioniPrimary (citable) accession number: O00193
Secondary accession number(s): B2RD28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 1, 1997
Last modified: October 25, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families