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O00193

- SMAP_HUMAN

UniProt

O00193 - SMAP_HUMAN

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Protein

Small acidic protein

Gene

SMAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small acidic protein
Gene namesi
Name:SMAP
Synonyms:C11orf58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16990. C11orf58.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Small acidic proteinPRO_0000263656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine3 Publications
Modified residuei17 – 171Phosphoserine5 Publications
Modified residuei127 – 1271Phosphoserine2 Publications
Modified residuei147 – 1471Phosphoserine3 Publications
Modified residuei174 – 1741N6-acetyllysine1 Publication
Modified residuei179 – 1791N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO00193.
PaxDbiO00193.
PeptideAtlasiO00193.
PRIDEiO00193.

PTM databases

PhosphoSiteiO00193.

Expressioni

Gene expression databases

BgeeiO00193.
CleanExiHS_C11orf58.
ExpressionAtlasiO00193. baseline and differential.
GenevestigatoriO00193.

Organism-specific databases

HPAiHPA036591.

Interactioni

Protein-protein interaction databases

BioGridi116144. 40 interactions.
IntActiO00193. 22 interactions.
MINTiMINT-5005829.
STRINGi9606.ENSP00000228136.

Structurei

3D structure databases

ProteinModelPortaliO00193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi109 – 13931Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the SMAP family.Curated

Phylogenomic databases

eggNOGiNOG39197.
GeneTreeiENSGT00390000000687.
HOGENOMiHOG000247059.
HOVERGENiHBG055732.
InParanoidiO00193.
OMAiMSGRNRR.
OrthoDBiEOG70CR8J.
PhylomeDBiO00193.
TreeFamiTF328803.

Family and domain databases

InterProiIPR026714. SMAP.
IPR028124. SMAP_dom.
[Graphical view]
PANTHERiPTHR22175. PTHR22175. 1 hit.
PfamiPF15477. SMAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00193-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAARESHPH GVKRSASPDD DLGSSNWEAA DLGNEERKQK FLRLMGAGKK
60 70 80 90 100
EHTGRLVIGD HKSTSHFRTG EEDKKINEEL ESQYQQSMDS KLSGRYRRHC
110 120 130 140 150
GLGFSEVEDH DGEGDVAGDD DDDDDDSPDP ESPDDSESDS ESEKEESAEE
160 170 180
LQAAEHPDEV EDPKNKKDAK SNYKMMFVKS SGS
Length:183
Mass (Da):20,333
Last modified:July 1, 1997 - v1
Checksum:i509BA7377B699A74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51678 mRNA. Translation: AAB99729.1.
CR456882 mRNA. Translation: CAG33163.1.
AK315382 mRNA. Translation: BAG37775.1.
CH471064 Genomic DNA. Translation: EAW68455.1.
BC007103 mRNA. Translation: AAH07103.1.
BC016352 mRNA. Translation: AAH16352.1.
BC020937 mRNA. Translation: AAH20937.1.
BC103747 mRNA. Translation: AAI03748.1.
CCDSiCCDS7822.1.
RefSeqiNP_055082.1. NM_014267.5.
UniGeneiHs.645792.

Genome annotation databases

EnsembliENST00000228136; ENSP00000228136; ENSG00000110696.
GeneIDi10944.
KEGGihsa:10944.
UCSCiuc001mmk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51678 mRNA. Translation: AAB99729.1 .
CR456882 mRNA. Translation: CAG33163.1 .
AK315382 mRNA. Translation: BAG37775.1 .
CH471064 Genomic DNA. Translation: EAW68455.1 .
BC007103 mRNA. Translation: AAH07103.1 .
BC016352 mRNA. Translation: AAH16352.1 .
BC020937 mRNA. Translation: AAH20937.1 .
BC103747 mRNA. Translation: AAI03748.1 .
CCDSi CCDS7822.1.
RefSeqi NP_055082.1. NM_014267.5.
UniGenei Hs.645792.

3D structure databases

ProteinModelPortali O00193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116144. 40 interactions.
IntActi O00193. 22 interactions.
MINTi MINT-5005829.
STRINGi 9606.ENSP00000228136.

PTM databases

PhosphoSitei O00193.

Proteomic databases

MaxQBi O00193.
PaxDbi O00193.
PeptideAtlasi O00193.
PRIDEi O00193.

Protocols and materials databases

DNASUi 10944.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000228136 ; ENSP00000228136 ; ENSG00000110696 .
GeneIDi 10944.
KEGGi hsa:10944.
UCSCi uc001mmk.2. human.

Organism-specific databases

CTDi 10944.
GeneCardsi GC11P016717.
HGNCi HGNC:16990. C11orf58.
HPAi HPA036591.
neXtProti NX_O00193.
PharmGKBi PA143485353.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39197.
GeneTreei ENSGT00390000000687.
HOGENOMi HOG000247059.
HOVERGENi HBG055732.
InParanoidi O00193.
OMAi MSGRNRR.
OrthoDBi EOG70CR8J.
PhylomeDBi O00193.
TreeFami TF328803.

Miscellaneous databases

GeneWikii C11orf58.
GenomeRNAii 10944.
NextBioi 41581.
PROi O00193.

Gene expression databases

Bgeei O00193.
CleanExi HS_C11orf58.
ExpressionAtlasi O00193. baseline and differential.
Genevestigatori O00193.

Family and domain databases

InterProi IPR026714. SMAP.
IPR028124. SMAP_dom.
[Graphical view ]
PANTHERi PTHR22175. PTHR22175. 1 hit.
Pfami PF15477. SMAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel genes expressed in the chick otocyst during development: identification using differential display of RNA."
    Gong T.-W., Hegeman A.D., Shin J.J., Lindberg K.H., Barald K.F., Lomax M.I.
    Int. J. Dev. Neurosci. 15:585-594(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
    Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.
    Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-174 AND LYS-179, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-17 AND SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-127 AND SER-147, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSMAP_HUMAN
AccessioniPrimary (citable) accession number: O00193
Secondary accession number(s): B2RD28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3