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Protein

Small acidic protein

Gene

SMAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small acidic protein
Gene namesi
Name:SMAP
Synonyms:C11orf58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110696.9
HGNCiHGNC:16990 C11orf58
neXtProtiNX_O00193

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110696
PharmGKBiPA143485353

Polymorphism and mutation databases

BioMutaiSMAP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636561 – 183Small acidic proteinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei15PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Cross-linki62Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei63PhosphoserineCombined sources1
Cross-linki75Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei87PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei174N6-acetyllysineCombined sources1
Modified residuei179N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO00193
MaxQBiO00193
PaxDbiO00193
PeptideAtlasiO00193
PRIDEiO00193
TopDownProteomicsiO00193

PTM databases

iPTMnetiO00193
PhosphoSitePlusiO00193

Expressioni

Gene expression databases

BgeeiENSG00000110696
CleanExiHS_C11orf58
ExpressionAtlasiO00193 baseline and differential
GenevisibleiO00193 HS

Organism-specific databases

HPAiHPA036591
HPA076406

Interactioni

Protein-protein interaction databases

BioGridi116144, 46 interactors
IntActiO00193, 22 interactors
MINTiO00193
STRINGi9606.ENSP00000228136

Structurei

3D structure databases

ProteinModelPortaliO00193
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 139Asp-richAdd BLAST31

Sequence similaritiesi

Belongs to the SMAP family.Curated

Phylogenomic databases

eggNOGiENOG410IVYQ Eukaryota
ENOG4111SCI LUCA
GeneTreeiENSGT00390000000687
HOGENOMiHOG000247059
HOVERGENiHBG055732
InParanoidiO00193
OMAiMDSTMSG
OrthoDBiEOG091G11TG
PhylomeDBiO00193
TreeFamiTF328803

Family and domain databases

InterProiView protein in InterPro
IPR028124 SMAP_dom
PfamiView protein in Pfam
PF15477 SMAP, 1 hit

Sequencei

Sequence statusi: Complete.

O00193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAARESHPH GVKRSASPDD DLGSSNWEAA DLGNEERKQK FLRLMGAGKK
60 70 80 90 100
EHTGRLVIGD HKSTSHFRTG EEDKKINEEL ESQYQQSMDS KLSGRYRRHC
110 120 130 140 150
GLGFSEVEDH DGEGDVAGDD DDDDDDSPDP ESPDDSESDS ESEKEESAEE
160 170 180
LQAAEHPDEV EDPKNKKDAK SNYKMMFVKS SGS
Length:183
Mass (Da):20,333
Last modified:July 1, 1997 - v1
Checksum:i509BA7377B699A74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51678 mRNA Translation: AAB99729.1
CR456882 mRNA Translation: CAG33163.1
AK315382 mRNA Translation: BAG37775.1
CH471064 Genomic DNA Translation: EAW68455.1
BC007103 mRNA Translation: AAH07103.1
BC016352 mRNA Translation: AAH16352.1
BC020937 mRNA Translation: AAH20937.1
BC103747 mRNA Translation: AAI03748.1
CCDSiCCDS7822.1
RefSeqiNP_055082.1, NM_014267.5
UniGeneiHs.368226
Hs.645792

Genome annotation databases

EnsembliENST00000228136; ENSP00000228136; ENSG00000110696
GeneIDi10944
KEGGihsa:10944
UCSCiuc001mmk.3 human

Similar proteinsi

Entry informationi

Entry nameiSMAP_HUMAN
AccessioniPrimary (citable) accession number: O00193
Secondary accession number(s): B2RD28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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