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Protein

Syntaxin-binding protein 3

Gene

STXBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.By similarity

GO - Molecular functioni

  • syntaxin-1 binding Source: Ensembl
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • brain development Source: Ensembl
  • cellular response to interferon-gamma Source: Ensembl
  • insulin secretion Source: Ensembl
  • negative regulation of calcium ion-dependent exocytosis Source: UniProtKB
  • negative regulation of glucose import in response to insulin stimulus Source: Ensembl
  • neutrophil degranulation Source: UniProtKB
  • platelet aggregation Source: UniProtKB
  • protein to membrane docking Source: Ensembl
  • response to insulin Source: Ensembl
  • vesicle docking involved in exocytosis Source: InterPro

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-114516 Disinhibition of SNARE formation
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 3
Alternative name(s):
Platelet Sec1 protein
Short name:
PSP
Protein unc-18 homolog 3
Short name:
Unc18-3
Protein unc-18 homolog C
Short name:
Unc-18C
Gene namesi
Name:STXBP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116266.10
HGNCiHGNC:11446 STXBP3
MIMi608339 gene
neXtProtiNX_O00186

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6814
OpenTargetsiENSG00000116266
PharmGKBiPA36243

Polymorphism and mutation databases

BioMutaiSTXBP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062851 – 592Syntaxin-binding protein 3Add BLAST592

Post-translational modificationi

Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00186
MaxQBiO00186
PaxDbiO00186
PeptideAtlasiO00186
PRIDEiO00186

PTM databases

iPTMnetiO00186
PhosphoSitePlusiO00186
SwissPalmiO00186

Expressioni

Tissue specificityi

Megakaryocytes and platelets.

Gene expression databases

BgeeiENSG00000116266
CleanExiHS_STXBP3
GenevisibleiO00186 HS

Organism-specific databases

HPAiHPA027225

Interactioni

Subunit structurei

Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4.By similarity1 Publication

GO - Molecular functioni

  • syntaxin-1 binding Source: Ensembl
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112683, 28 interactors
IntActiO00186, 4 interactors
STRINGi9606.ENSP00000359025

Structurei

3D structure databases

ProteinModelPortaliO00186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 255Mediates interaction with DOC2BBy similarityAdd BLAST255

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1300 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00390000005206
HOGENOMiHOG000232146
HOVERGENiHBG052710
InParanoidiO00186
KOiK15301
OMAiVVWQKIK
OrthoDBiEOG091G0WUI
PhylomeDBiO00186
TreeFamiTF313242

Family and domain databases

Gene3Di3.40.50.1910, 2 hits
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit

Sequencei

Sequence statusi: Complete.

O00186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPVAERGL KSVVWQKIKA TVFDDCKKEG EWKIMLLDEF TTKLLASCCK
60 70 80 90 100
MTDLLEEGIT VVENIYKNRE PVRQMKALYF ITPTSKSVDC FLHDFASKSE
110 120 130 140 150
NKYKAAYIYF TDFCPDNLFN KIKASCSKSI RRCKEINISF IPHESQVYTL
160 170 180 190 200
DVPDAFYYCY SPDPGNAKGK DAIMETMADQ IVTVCATLDE NPGVRYKSKP
210 220 230 240 250
LDNASKLAQL VEKKLEDYYK IDEKSLIKGK THSQLLIIDR GFDPVSTVLH
260 270 280 290 300
ELTFQAMAYD LLPIENDTYK YKTDGKEKEA ILEEEDDLWV RIRHRHIAVV
310 320 330 340 350
LEEIPKLMKE ISSTKKATEG KTSLSALTQL MKKMPHFRKQ ITKQVVHLNL
360 370 380 390 400
AEDCMNKFKL NIEKLCKTEQ DLALGTDAEG QKVKDSMRVL LPVLLNKNHD
410 420 430 440 450
NCDKIRAILL YIFSINGTTE ENLDRLIQNV KIENESDMIR NWSYLGVPIV
460 470 480 490 500
PQSQQGKPLR KDRSAEETFQ LSRWTPFIKD IMEDAIDNRL DSKEWPYCSQ
510 520 530 540 550
CPAVWNGSGA VSARQKPRAN YLEDRKNGSK LIVFVIGGIT YSEVRCAYEV
560 570 580 590
SQAHKSCEVI IGSTHVLTPK KLLDDIKMLN KPKDKVSLIK DE
Length:592
Mass (Da):67,764
Last modified:September 23, 2008 - v2
Checksum:iAAFA268E2D328EC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104K → R in AAH38099 (PubMed:15489334).Curated1
Sequence conflicti150L → R in AAH38099 (PubMed:15489334).Curated1
Sequence conflicti242F → I in BAD96890 (Ref. 4) Curated1
Sequence conflicti277E → G in BAA19482 (PubMed:8824310).Curated1
Sequence conflicti285E → D in BAF84011 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052470295R → Q. Corresponds to variant dbSNP:rs2275344Ensembl.1
Natural variantiVAR_017570433E → G1 PublicationCorresponds to variant dbSNP:rs1044136Ensembl.1
Natural variantiVAR_017571546C → G1 PublicationCorresponds to variant dbSNP:rs1044137Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63506 mRNA Translation: BAA19482.1
AF032922 mRNA Translation: AAC69606.1
AK290134 mRNA Translation: BAF82823.1
AK291322 mRNA Translation: BAF84011.1
AK312910 mRNA Translation: BAG35756.1
AK223170 mRNA Translation: BAD96890.1
AL591719 Genomic DNA No translation available.
AL449266 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56330.1
BC038099 mRNA Translation: AAH38099.1
BC047764 mRNA Translation: AAH47764.1
CCDSiCCDS790.1
RefSeqiNP_009200.2, NM_007269.3
UniGeneiHs.530436

Genome annotation databases

EnsembliENST00000370008; ENSP00000359025; ENSG00000116266
GeneIDi6814
KEGGihsa:6814
UCSCiuc001dvy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTXB3_HUMAN
AccessioniPrimary (citable) accession number: O00186
Secondary accession number(s): A8K269
, A8K5K7, Q53FW1, Q86YJ3, Q9UPD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health