Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-binding protein 3

Gene

STXBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.HMP:

GO - Molecular functioni

  • syntaxin-1 binding Source: Ensembl
  • syntaxin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-114516. Disinhibition of SNARE formation.
R-HSA-1445148. Translocation of GLUT4 to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 3
Alternative name(s):
Platelet Sec1 protein
Short name:
PSP
Protein unc-18 homolog 3
Short name:
Unc18-3
Protein unc-18 homolog C
Short name:
Unc-18C
Gene namesi
Name:STXBP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116266.10.
HGNCiHGNC:11446. STXBP3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6814.
OpenTargetsiENSG00000116266.
PharmGKBiPA36243.

Polymorphism and mutation databases

BioMutaiSTXBP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062851 – 592Syntaxin-binding protein 3Add BLAST592

Post-translational modificationi

Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00186.
MaxQBiO00186.
PaxDbiO00186.
PeptideAtlasiO00186.
PRIDEiO00186.

PTM databases

iPTMnetiO00186.
PhosphoSitePlusiO00186.
SwissPalmiO00186.

Expressioni

Tissue specificityi

Megakaryocytes and platelets.

Gene expression databases

BgeeiENSG00000116266.
CleanExiHS_STXBP3.
GenevisibleiO00186. HS.

Organism-specific databases

HPAiHPA027225.

Interactioni

Subunit structurei

Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4.HMP:1 Publication

GO - Molecular functioni

  • syntaxin-1 binding Source: Ensembl
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112683. 28 interactors.
IntActiO00186. 4 interactors.
MINTiMINT-4525992.
STRINGi9606.ENSP00000359025.

Structurei

3D structure databases

ProteinModelPortaliO00186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 255Mediates interaction with DOC2BHMP:Add BLAST255

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.IKR:

Phylogenomic databases

eggNOGiKOG1300. Eukaryota.
COG5158. LUCA.
GeneTreeiENSGT00390000005206.
HOGENOMiHOG000232146.
HOVERGENiHBG052710.
InParanoidiO00186.
KOiK15301.
OMAiVVWQKIK.
OrthoDBiEOG091G0WUI.
PhylomeDBiO00186.
TreeFamiTF313242.

Family and domain databases

InterProiView protein in InterPro
IPR001619. Sec1-like.
IPR036045. Sec1-like_sf.
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiView protein in Pfam
PF00995. Sec1. 1 hit.
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequencei

Sequence statusi: Complete.

O00186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPVAERGL KSVVWQKIKA TVFDDCKKEG EWKIMLLDEF TTKLLASCCK
60 70 80 90 100
MTDLLEEGIT VVENIYKNRE PVRQMKALYF ITPTSKSVDC FLHDFASKSE
110 120 130 140 150
NKYKAAYIYF TDFCPDNLFN KIKASCSKSI RRCKEINISF IPHESQVYTL
160 170 180 190 200
DVPDAFYYCY SPDPGNAKGK DAIMETMADQ IVTVCATLDE NPGVRYKSKP
210 220 230 240 250
LDNASKLAQL VEKKLEDYYK IDEKSLIKGK THSQLLIIDR GFDPVSTVLH
260 270 280 290 300
ELTFQAMAYD LLPIENDTYK YKTDGKEKEA ILEEEDDLWV RIRHRHIAVV
310 320 330 340 350
LEEIPKLMKE ISSTKKATEG KTSLSALTQL MKKMPHFRKQ ITKQVVHLNL
360 370 380 390 400
AEDCMNKFKL NIEKLCKTEQ DLALGTDAEG QKVKDSMRVL LPVLLNKNHD
410 420 430 440 450
NCDKIRAILL YIFSINGTTE ENLDRLIQNV KIENESDMIR NWSYLGVPIV
460 470 480 490 500
PQSQQGKPLR KDRSAEETFQ LSRWTPFIKD IMEDAIDNRL DSKEWPYCSQ
510 520 530 540 550
CPAVWNGSGA VSARQKPRAN YLEDRKNGSK LIVFVIGGIT YSEVRCAYEV
560 570 580 590
SQAHKSCEVI IGSTHVLTPK KLLDDIKMLN KPKDKVSLIK DE
Length:592
Mass (Da):67,764
Last modified:September 23, 2008 - v2
Checksum:iAAFA268E2D328EC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104K → R in AAH38099 (PubMed:15489334).IKR:1
Sequence conflicti150L → R in AAH38099 (PubMed:15489334).IKR:1
Sequence conflicti242F → I in BAD96890 (Ref. 4) IKR:1
Sequence conflicti277E → G in BAA19482 (PubMed:8824310).IKR:1
Sequence conflicti285E → D in BAF84011 (PubMed:14702039).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052470295R → Q. Corresponds to variant dbSNP:rs2275344Ensembl.1
Natural variantiVAR_017570433E → G1 PublicationCorresponds to variant dbSNP:rs1044136Ensembl.1
Natural variantiVAR_017571546C → G1 PublicationCorresponds to variant dbSNP:rs1044137Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63506 mRNA. Translation: BAA19482.1.
AF032922 mRNA. Translation: AAC69606.1.
AK290134 mRNA. Translation: BAF82823.1.
AK291322 mRNA. Translation: BAF84011.1.
AK312910 mRNA. Translation: BAG35756.1.
AK223170 mRNA. Translation: BAD96890.1.
AL591719 Genomic DNA. No translation available.
AL449266 Genomic DNA. No translation available.
CH471122 Genomic DNA. Translation: EAW56330.1.
BC038099 mRNA. Translation: AAH38099.1.
BC047764 mRNA. Translation: AAH47764.1.
CCDSiCCDS790.1.
RefSeqiNP_009200.2. NM_007269.3.
UniGeneiHs.530436.

Genome annotation databases

EnsembliENST00000370008; ENSP00000359025; ENSG00000116266.
GeneIDi6814.
KEGGihsa:6814.
UCSCiuc001dvy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTXB3_HUMAN
AccessioniPrimary (citable) accession number: O00186
Secondary accession number(s): A8K269
, A8K5K7, Q53FW1, Q86YJ3, Q9UPD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 23, 2008
Last modified: November 22, 2017
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families