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O00186

- STXB3_HUMAN

UniProt

O00186 - STXB3_HUMAN

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Protein

Syntaxin-binding protein 3

Gene

STXBP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.By similarity

GO - Molecular functioni

  1. syntaxin binding Source: UniProtKB

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. membrane organization Source: Reactome
  3. negative regulation of calcium ion-dependent exocytosis Source: UniProtKB
  4. neutrophil degranulation Source: UniProtKB
  5. platelet activation Source: Reactome
  6. platelet aggregation Source: UniProtKB
  7. protein heterooligomerization Source: Ensembl
  8. protein transport Source: UniProtKB-KW
  9. vesicle docking involved in exocytosis Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_1178. Disinhibition of SNARE formation.
REACT_147867. Translocation of GLUT4 to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 3
Alternative name(s):
Platelet Sec1 protein
Short name:
PSP
Protein unc-18 homolog 3
Short name:
Unc18-3
Protein unc-18 homolog C
Short name:
Unc-18C
Gene namesi
Name:STXBP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11446. STXBP3.

Subcellular locationi

Cytoplasmcytosol 1 Publication. Cell membrane 1 Publication
Note: In platelets, predominantly cytosolic. Low amounts membrane-associated.

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cytosol Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. plasma membrane Source: UniProtKB
  6. platelet alpha granule Source: UniProtKB
  7. specific granule Source: UniProtKB
  8. tertiary granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592Syntaxin-binding protein 3PRO_0000206285Add
BLAST

Post-translational modificationi

Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO00186.
PaxDbiO00186.
PRIDEiO00186.

PTM databases

PhosphoSiteiO00186.

Expressioni

Tissue specificityi

Megakaryocytes and platelets.

Gene expression databases

BgeeiO00186.
CleanExiHS_STXBP3.
GenevestigatoriO00186.

Organism-specific databases

HPAiHPA027225.

Interactioni

Subunit structurei

Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4.By similarity1 Publication

Protein-protein interaction databases

BioGridi112683. 15 interactions.
IntActiO00186. 3 interactions.
MINTiMINT-4525992.
STRINGi9606.ENSP00000359025.

Structurei

3D structure databases

ProteinModelPortaliO00186.
SMRiO00186. Positions 7-584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 255255Mediates interaction with DOC2BBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiCOG5158.
GeneTreeiENSGT00390000005206.
HOGENOMiHOG000232146.
HOVERGENiHBG052710.
InParanoidiO00186.
KOiK15301.
OMAiLCCKMTD.
OrthoDBiEOG78PV8M.
PhylomeDBiO00186.
TreeFamiTF313242.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequencei

Sequence statusi: Complete.

O00186-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPPVAERGL KSVVWQKIKA TVFDDCKKEG EWKIMLLDEF TTKLLASCCK
60 70 80 90 100
MTDLLEEGIT VVENIYKNRE PVRQMKALYF ITPTSKSVDC FLHDFASKSE
110 120 130 140 150
NKYKAAYIYF TDFCPDNLFN KIKASCSKSI RRCKEINISF IPHESQVYTL
160 170 180 190 200
DVPDAFYYCY SPDPGNAKGK DAIMETMADQ IVTVCATLDE NPGVRYKSKP
210 220 230 240 250
LDNASKLAQL VEKKLEDYYK IDEKSLIKGK THSQLLIIDR GFDPVSTVLH
260 270 280 290 300
ELTFQAMAYD LLPIENDTYK YKTDGKEKEA ILEEEDDLWV RIRHRHIAVV
310 320 330 340 350
LEEIPKLMKE ISSTKKATEG KTSLSALTQL MKKMPHFRKQ ITKQVVHLNL
360 370 380 390 400
AEDCMNKFKL NIEKLCKTEQ DLALGTDAEG QKVKDSMRVL LPVLLNKNHD
410 420 430 440 450
NCDKIRAILL YIFSINGTTE ENLDRLIQNV KIENESDMIR NWSYLGVPIV
460 470 480 490 500
PQSQQGKPLR KDRSAEETFQ LSRWTPFIKD IMEDAIDNRL DSKEWPYCSQ
510 520 530 540 550
CPAVWNGSGA VSARQKPRAN YLEDRKNGSK LIVFVIGGIT YSEVRCAYEV
560 570 580 590
SQAHKSCEVI IGSTHVLTPK KLLDDIKMLN KPKDKVSLIK DE
Length:592
Mass (Da):67,764
Last modified:September 23, 2008 - v2
Checksum:iAAFA268E2D328EC7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041K → R in AAH38099. (PubMed:15489334)Curated
Sequence conflicti150 – 1501L → R in AAH38099. (PubMed:15489334)Curated
Sequence conflicti242 – 2421F → I in BAD96890. 1 PublicationCurated
Sequence conflicti277 – 2771E → G in BAA19482. (PubMed:8824310)Curated
Sequence conflicti285 – 2851E → D in BAF84011. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti295 – 2951R → Q.
Corresponds to variant rs2275344 [ dbSNP | Ensembl ].
VAR_052470
Natural varianti433 – 4331E → G.1 Publication
Corresponds to variant rs1044136 [ dbSNP | Ensembl ].
VAR_017570
Natural varianti546 – 5461C → G.1 Publication
Corresponds to variant rs1044137 [ dbSNP | Ensembl ].
VAR_017571

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63506 mRNA. Translation: BAA19482.1.
AF032922 mRNA. Translation: AAC69606.1.
AK290134 mRNA. Translation: BAF82823.1.
AK291322 mRNA. Translation: BAF84011.1.
AK312910 mRNA. Translation: BAG35756.1.
AK223170 mRNA. Translation: BAD96890.1.
AL591719, AL449266 Genomic DNA. Translation: CAH72066.1.
AL449266, AL591719 Genomic DNA. Translation: CAI14350.1.
CH471122 Genomic DNA. Translation: EAW56330.1.
BC038099 mRNA. Translation: AAH38099.1.
BC047764 mRNA. Translation: AAH47764.1.
CCDSiCCDS790.1.
RefSeqiNP_009200.2. NM_007269.2.
UniGeneiHs.530436.

Genome annotation databases

EnsembliENST00000370008; ENSP00000359025; ENSG00000116266.
GeneIDi6814.
KEGGihsa:6814.
UCSCiuc001dvy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63506 mRNA. Translation: BAA19482.1 .
AF032922 mRNA. Translation: AAC69606.1 .
AK290134 mRNA. Translation: BAF82823.1 .
AK291322 mRNA. Translation: BAF84011.1 .
AK312910 mRNA. Translation: BAG35756.1 .
AK223170 mRNA. Translation: BAD96890.1 .
AL591719 , AL449266 Genomic DNA. Translation: CAH72066.1 .
AL449266 , AL591719 Genomic DNA. Translation: CAI14350.1 .
CH471122 Genomic DNA. Translation: EAW56330.1 .
BC038099 mRNA. Translation: AAH38099.1 .
BC047764 mRNA. Translation: AAH47764.1 .
CCDSi CCDS790.1.
RefSeqi NP_009200.2. NM_007269.2.
UniGenei Hs.530436.

3D structure databases

ProteinModelPortali O00186.
SMRi O00186. Positions 7-584.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112683. 15 interactions.
IntActi O00186. 3 interactions.
MINTi MINT-4525992.
STRINGi 9606.ENSP00000359025.

PTM databases

PhosphoSitei O00186.

Proteomic databases

MaxQBi O00186.
PaxDbi O00186.
PRIDEi O00186.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370008 ; ENSP00000359025 ; ENSG00000116266 .
GeneIDi 6814.
KEGGi hsa:6814.
UCSCi uc001dvy.3. human.

Organism-specific databases

CTDi 6814.
GeneCardsi GC01P109289.
HGNCi HGNC:11446. STXBP3.
HPAi HPA027225.
MIMi 608339. gene.
neXtProti NX_O00186.
PharmGKBi PA36243.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5158.
GeneTreei ENSGT00390000005206.
HOGENOMi HOG000232146.
HOVERGENi HBG052710.
InParanoidi O00186.
KOi K15301.
OMAi LCCKMTD.
OrthoDBi EOG78PV8M.
PhylomeDBi O00186.
TreeFami TF313242.

Enzyme and pathway databases

Reactomei REACT_1178. Disinhibition of SNARE formation.
REACT_147867. Translocation of GLUT4 to the plasma membrane.

Miscellaneous databases

ChiTaRSi STXBP3. human.
GeneWikii Syntaxin_binding_protein_3.
GenomeRNAii 6814.
NextBioi 26593.
PROi O00186.
SOURCEi Search...

Gene expression databases

Bgeei O00186.
CleanExi HS_STXBP3.
Genevestigatori O00186.

Family and domain databases

Gene3Di 3.40.50.1910. 2 hits.
InterProi IPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view ]
PANTHERi PTHR11679. PTHR11679. 1 hit.
Pfami PF00995. Sec1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMi SSF56815. SSF56815. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants."
    Gengyo-Ando K., Kitayama H., Mukaida M., Ikawa Y.
    J. Neurosci. 16:6695-6702(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-433 AND GLY-546.
    Tissue: Brain.
  2. "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion."
    Reed G.L., Houng A.K., Fitzgerald M.L.
    Blood 93:2617-2626(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH STX4, SUBCELLULAR LOCATION, PHOSPHORYLATION.
    Tissue: Leukemic T-cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus and Tongue.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTXB3_HUMAN
AccessioniPrimary (citable) accession number: O00186
Secondary accession number(s): A8K269
, A8K5K7, Q53FW1, Q86YJ3, Q9UPD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3