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O00182

- LEG9_HUMAN

UniProt

O00182 - LEG9_HUMAN

Protein

Galectin-9

Gene

LGALS9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481Beta-galactoside 1
    Binding sitei61 – 611Beta-galactoside 1
    Binding sitei65 – 651Beta-galactoside 1
    Binding sitei75 – 751Beta-galactoside 1
    Binding sitei267 – 2671Beta-galactoside 2
    Binding sitei271 – 2711Beta-galactoside 2
    Binding sitei281 – 2811Beta-galactoside 2By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: UniProtKB
    2. galactose binding Source: ProtInc
    3. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    2. signal transduction Source: GOC

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-9
    Short name:
    Gal-9
    Alternative name(s):
    Ecalectin
    Tumor antigen HOM-HD-21
    Gene namesi
    Name:LGALS9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6570. LGALS9.

    Subcellular locationi

    Cytoplasm By similarity. Secreted By similarity
    Note: May also be secreted by a non-classical secretory pathway.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30347.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Galectin-9PRO_0000076946Add
    BLAST

    Proteomic databases

    MaxQBiO00182.
    PRIDEiO00182.

    PTM databases

    PhosphoSiteiO00182.

    Expressioni

    Tissue specificityi

    Peripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin disease tissue.

    Gene expression databases

    ArrayExpressiO00182.
    BgeeiO00182.
    CleanExiHS_LGALS9.
    GenevestigatoriO00182.

    Organism-specific databases

    HPAiHPA046876.
    HPA047218.

    Interactioni

    Subunit structurei

    Monomer.2 Publications

    Protein-protein interaction databases

    BioGridi110156. 3 interactions.
    IntActiO00182. 12 interactions.
    STRINGi9606.ENSP00000378856.

    Structurei

    Secondary structure

    1
    355
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 73
    Beta strandi10 – 123
    Beta strandi15 – 206
    Beta strandi30 – 378
    Beta strandi39 – 413
    Beta strandi43 – 5614
    Beta strandi58 – 658
    Beta strandi71 – 788
    Beta strandi86 – 894
    Beta strandi98 – 1058
    Beta strandi107 – 1148
    Beta strandi117 – 1237
    Helixi128 – 1303
    Beta strandi133 – 14614
    Beta strandi225 – 2306
    Beta strandi240 – 2478
    Beta strandi253 – 2608
    Beta strandi263 – 2719
    Turni272 – 2754
    Beta strandi276 – 2838
    Beta strandi295 – 2973
    Beta strandi305 – 3128
    Beta strandi314 – 3218
    Beta strandi324 – 3307
    Helixi336 – 3383
    Beta strandi341 – 35414

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EAKX-ray1.97A/B/C1-148[»]
    2EALX-ray1.85A/B1-148[»]
    2YY1X-ray2.17A1-147[»]
    2ZHKX-ray1.80A/B1-148[»]
    2ZHLX-ray1.75A/B/C/D1-148[»]
    2ZHMX-ray1.84A/B/C/D1-148[»]
    2ZHNX-ray1.30A1-148[»]
    3LSDX-ray2.03A6-148[»]
    3LSEX-ray2.69A6-148[»]
    3NV1X-ray1.50A218-355[»]
    3NV2X-ray2.34A218-355[»]
    3NV3X-ray1.57A218-355[»]
    3NV4X-ray1.99A218-355[»]
    ProteinModelPortaliO00182.
    SMRiO00182. Positions 3-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO00182.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 148132Galectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini227 – 355129Galectin 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni82 – 887Beta-galactoside binding 1
    Regioni287 – 2937Beta-galactoside binding 2By similarity

    Domaini

    Contains two homologous but distinct carbohydrate-binding domains.

    Sequence similaritiesi

    Contains 2 galectin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOGENOMiHOG000290194.
    HOVERGENiHBG002412.
    InParanoidiO00182.
    KOiK10093.
    OMAiVCNTRQN.
    OrthoDBiEOG73Z2TM.
    PhylomeDBiO00182.
    TreeFamiTF315551.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PfamiPF00337. Gal-bind_lectin. 2 hits.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS51304. GALECTIN. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform Long (identifier: O00182-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFSGSQAPY LSPAVPFSGT IQGGLQDGLQ ITVNGTVLSS SGTRFAVNFQ    50
    TGFSGNDIAF HFNPRFEDGG YVVCNTRQNG SWGPEERKTH MPFQKGMPFD 100
    LCFLVQSSDF KVMVNGILFV QYFHRVPFHR VDTISVNGSV QLSYISFQNP 150
    RTVPVQPAFS TVPFSQPVCF PPRPRGRRQK PPGVWPANPA PITQTVIHTV 200
    QSAPGQMFST PAIPPMMYPH PAYPMPFITT ILGGLYPSKS ILLSGTVLPS 250
    AQRFHINLCS GNHIAFHLNP RFDENAVVRN TQIDNSWGSE ERSLPRKMPF 300
    VRGQSFSVWI LCEAHCLKVA VDGQHLFEYY HRLRNLPTIN RLEVGGDIQL 350
    THVQT 355
    Length:355
    Mass (Da):39,518
    Last modified:July 15, 1998 - v2
    Checksum:i4748C22FCAFA536A
    GO
    Isoform Short (identifier: O00182-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         149-180: Missing.

    Show »
    Length:323
    Mass (Da):35,888
    Checksum:i1A3EB2941FC7F377
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481N → D in CAB93851. 1 PublicationCurated
    Sequence conflicti79 – 813NGS → KGR in CAB93851. 1 PublicationCurated
    Sequence conflicti88 – 881K → R in CAA88922. (PubMed:9045665)Curated
    Sequence conflicti89 – 891T → M in CAB93851. 1 PublicationCurated
    Sequence conflicti93 – 931F → S in BAD96952. 1 PublicationCurated
    Sequence conflicti135 – 1351S → F in CAA88922. (PubMed:9045665)Curated
    Sequence conflicti270 – 2701P → L in CAA88922. (PubMed:9045665)Curated
    Sequence conflicti313 – 3131E → G in CAA88922. (PubMed:9045665)Curated
    Sequence conflicti326 – 3261L → V in CAB93851. 1 PublicationCurated
    Sequence conflicti341 – 3411R → K in CAB93851. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51G → S.2 Publications
    Corresponds to variant rs3751093 [ dbSNP | Ensembl ].
    VAR_020453

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei149 – 18032Missing in isoform Short. 5 PublicationsVSP_003096Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49107 mRNA. Translation: CAA88922.1.
    AB006782 mRNA. Translation: BAA22166.1.
    AB005894 mRNA. Translation: BAA31542.1.
    AB003517 mRNA. Translation: BAF76327.1.
    AB008492 mRNA. Translation: BAF76328.1.
    AB040130 Genomic DNA. Translation: BAB83625.1.
    AB040130 Genomic DNA. Translation: BAB83624.1.
    AJ288083
    , AJ288084, AJ288085, AJ288086, AJ288087, AJ288088, AJ288089, AJ288090 Genomic DNA. Translation: CAB93851.1.
    AK223232 mRNA. Translation: BAD96952.1.
    CH471159 Genomic DNA. Translation: EAW51037.1.
    CH471159 Genomic DNA. Translation: EAW51044.1.
    BC105942 mRNA. Translation: AAI05943.1.
    BC105944 mRNA. Translation: AAI05945.1.
    BC110340 mRNA. Translation: AAI10341.1.
    CCDSiCCDS11222.1. [O00182-1]
    CCDS32592.1. [O00182-2]
    RefSeqiNP_002299.2. NM_002308.3. [O00182-2]
    NP_033665.1. NM_009587.2. [O00182-1]
    UniGeneiHs.81337.

    Genome annotation databases

    EnsembliENST00000302228; ENSP00000306228; ENSG00000168961. [O00182-2]
    ENST00000395473; ENSP00000378856; ENSG00000168961. [O00182-1]
    GeneIDi3965.
    KEGGihsa:3965.
    UCSCiuc002gzp.3. human. [O00182-1]
    uc002gzq.3. human. [O00182-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Galectin-9

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49107 mRNA. Translation: CAA88922.1 .
    AB006782 mRNA. Translation: BAA22166.1 .
    AB005894 mRNA. Translation: BAA31542.1 .
    AB003517 mRNA. Translation: BAF76327.1 .
    AB008492 mRNA. Translation: BAF76328.1 .
    AB040130 Genomic DNA. Translation: BAB83625.1 .
    AB040130 Genomic DNA. Translation: BAB83624.1 .
    AJ288083
    , AJ288084 , AJ288085 , AJ288086 , AJ288087 , AJ288088 , AJ288089 , AJ288090 Genomic DNA. Translation: CAB93851.1 .
    AK223232 mRNA. Translation: BAD96952.1 .
    CH471159 Genomic DNA. Translation: EAW51037.1 .
    CH471159 Genomic DNA. Translation: EAW51044.1 .
    BC105942 mRNA. Translation: AAI05943.1 .
    BC105944 mRNA. Translation: AAI05945.1 .
    BC110340 mRNA. Translation: AAI10341.1 .
    CCDSi CCDS11222.1. [O00182-1 ]
    CCDS32592.1. [O00182-2 ]
    RefSeqi NP_002299.2. NM_002308.3. [O00182-2 ]
    NP_033665.1. NM_009587.2. [O00182-1 ]
    UniGenei Hs.81337.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EAK X-ray 1.97 A/B/C 1-148 [» ]
    2EAL X-ray 1.85 A/B 1-148 [» ]
    2YY1 X-ray 2.17 A 1-147 [» ]
    2ZHK X-ray 1.80 A/B 1-148 [» ]
    2ZHL X-ray 1.75 A/B/C/D 1-148 [» ]
    2ZHM X-ray 1.84 A/B/C/D 1-148 [» ]
    2ZHN X-ray 1.30 A 1-148 [» ]
    3LSD X-ray 2.03 A 6-148 [» ]
    3LSE X-ray 2.69 A 6-148 [» ]
    3NV1 X-ray 1.50 A 218-355 [» ]
    3NV2 X-ray 2.34 A 218-355 [» ]
    3NV3 X-ray 1.57 A 218-355 [» ]
    3NV4 X-ray 1.99 A 218-355 [» ]
    ProteinModelPortali O00182.
    SMRi O00182. Positions 3-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110156. 3 interactions.
    IntActi O00182. 12 interactions.
    STRINGi 9606.ENSP00000378856.

    Chemistry

    BindingDBi O00182.
    ChEMBLi CHEMBL5474.

    PTM databases

    PhosphoSitei O00182.

    Proteomic databases

    MaxQBi O00182.
    PRIDEi O00182.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302228 ; ENSP00000306228 ; ENSG00000168961 . [O00182-2 ]
    ENST00000395473 ; ENSP00000378856 ; ENSG00000168961 . [O00182-1 ]
    GeneIDi 3965.
    KEGGi hsa:3965.
    UCSCi uc002gzp.3. human. [O00182-1 ]
    uc002gzq.3. human. [O00182-2 ]

    Organism-specific databases

    CTDi 3965.
    GeneCardsi GC17P025956.
    HGNCi HGNC:6570. LGALS9.
    HPAi HPA046876.
    HPA047218.
    MIMi 601879. gene.
    neXtProti NX_O00182.
    PharmGKBi PA30347.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000290194.
    HOVERGENi HBG002412.
    InParanoidi O00182.
    KOi K10093.
    OMAi VCNTRQN.
    OrthoDBi EOG73Z2TM.
    PhylomeDBi O00182.
    TreeFami TF315551.

    Miscellaneous databases

    ChiTaRSi lgals9. human.
    EvolutionaryTracei O00182.
    GeneWikii LGALS9.
    GenomeRNAii 3965.
    NextBioi 15562.
    PROi O00182.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00182.
    Bgeei O00182.
    CleanExi HS_LGALS9.
    Genevestigatori O00182.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    Pfami PF00337. Gal-bind_lectin. 2 hits.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS51304. GALECTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease."
      Tuereci O., Schmitt H., Fadle N., Pfreundschuh M., Sahin U.
      J. Biol. Chem. 272:6416-6422(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Tissue: Spleen.
    2. "Human galectin-9 isoform full-length cDNA from gastric adenocarcinoma."
      Kato S.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
      Tissue: Gastric carcinoma.
    3. "Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes."
      Matsumoto R., Matsumoto H., Seki M., Hata M., Asano Y., Kanegasaki S., Stevens R.L., Hirashima M.
      J. Biol. Chem. 273:16976-16984(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), VARIANT SER-5.
    4. "Cloning and expression of human urate transporter mRNA."
      Nakajima H., Shichiri M., Hamaguchi T.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
      Tissue: Kidney and Stomach.
    5. "Homo sapiens galectin-9 (LGALS9) / ecalectin gene, exon 2 through 11."
      Akiyama S.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Genomic organization of the human galectin-9 gene."
      Graessler J., Spitzenberger F., Schroeder H.E.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT), VARIANT SER-5.
      Tissue: Gastric mucosa.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
      Tissue: Colon.
    10. "The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity."
      Zhu C., Anderson A.C., Schubart A., Xiong H., Imitola J., Khoury S.J., Zheng X.X., Strom T.B., Kuchroo V.K.
      Nat. Immunol. 6:1245-1252(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS LIGAND FOR HAVCR2/TIM3.
    11. "Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue."
      Nagae M., Nishi N., Nakamura-Tsuruta S., Hirabayashi J., Wakatsuki S., Kato R.
      J. Mol. Biol. 375:119-135(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 1-148 IN COMPLEXES WITH LACTOSE AND COMPLEX BETA-GALACTOSIDE, SUBUNIT, CARBOHYDRATE SPECIFICITY, FUNCTION.
    12. "Crystal structure of N-terminal domain of human galectin-9 containing L-acetyllactosamine."
      RIKEN structural genomics initiative (RSGI)
      Submitted (APR-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 1-150 IN COMPLEX WITH L-ACETYLLACTOSAMINE.
    13. "Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain."
      Nagae M., Nishi N., Murata T., Usui T., Nakamura T., Wakatsuki S., Kato R.
      Glycobiology 19:112-117(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 1-148 IN COMPLEXES WITH N-ACETYLLACTOSAMINE OLIGOMERS, FUNCTION.
    14. "X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose."
      Yoshida H., Teraoka M., Nishi N., Nakakita S., Nakamura T., Hirashima M., Kamitori S.
      J. Biol. Chem. 285:36969-36976(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 186-323 IN COMPLEXES WITH OLIGOSACCHARIDES.

    Entry informationi

    Entry nameiLEG9_HUMAN
    AccessioniPrimary (citable) accession number: O00182
    Secondary accession number(s): A7VJG6
    , O14532, O75028, Q3B8N1, Q53FQ0, Q9NQ58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3