Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Galectin-9

Gene

LGALS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity).By similarity11 Publications
Isoform 2: Acts as an eosinophil chemoattractant (PubMed:9642261). It also inhibits angiogenesis (PubMed:24333696). Suppresses IFNG production by natural killer cells (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48Beta-galactoside 11
Binding sitei61Beta-galactoside 11
Binding sitei65Beta-galactoside 11
Binding sitei75Beta-galactoside 11
Binding sitei267Beta-galactoside 21
Binding sitei271Beta-galactoside 21
Binding sitei281Beta-galactoside 2By similarity1

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • disaccharide binding Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • galactose binding Source: ProtInc
  • signal transducer activity Source: UniProtKB

GO - Biological processi

  • cellular response to interferon-gamma Source: UniProtKB
  • cellular response to virus Source: UniProtKB
  • chemotaxis Source: UniProtKB-KW
  • ERK1 and ERK2 cascade Source: UniProtKB
  • female pregnancy Source: UniProtKB
  • inflammatory response Source: UniProtKB
  • maternal process involved in female pregnancy Source: UniProtKB
  • natural killer cell tolerance induction Source: UniProtKB
  • negative regulation of activated T cell proliferation Source: UniProtKB
  • negative regulation of CD4-positive, alpha-beta T cell proliferation Source: UniProtKB
  • negative regulation of chemokine production Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of interferon-gamma production Source: UniProtKB
  • negative regulation of mast cell degranulation Source: UniProtKB
  • negative regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
  • negative regulation of tumor necrosis factor production Source: UniProtKB
  • p38MAPK cascade Source: UniProtKB
  • positive regulation of activated T cell autonomous cell death Source: UniProtKB
  • positive regulation of CD4-positive, alpha-beta T cell proliferation Source: UniProtKB
  • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Source: UniProtKB
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: UniProtKB
  • positive regulation of dendritic cell apoptotic process Source: UniProtKB
  • positive regulation of dendritic cell chemotaxis Source: UniProtKB
  • positive regulation of dendritic cell differentiation Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • positive regulation of interferon-gamma secretion Source: UniProtKB
  • positive regulation of interleukin-10 secretion Source: UniProtKB
  • positive regulation of interleukin-12 secretion Source: UniProtKB
  • positive regulation of interleukin-13 secretion Source: UniProtKB
  • positive regulation of interleukin-1 beta secretion Source: UniProtKB
  • positive regulation of interleukin-4 production Source: UniProtKB
  • positive regulation of interleukin-6 secretion Source: UniProtKB
  • positive regulation of interleukin-8 secretion Source: UniProtKB
  • positive regulation of monocyte chemotactic protein-1 production Source: UniProtKB
  • positive regulation of NF-kappaB import into nucleus Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: UniProtKB
  • positive regulation of transforming growth factor beta production Source: UniProtKB
  • positive regulation of tumor necrosis factor secretion Source: UniProtKB
  • positive regulation of viral entry into host cell Source: UniProtKB
  • response to interleukin-1 Source: UniProtKB
  • response to lipopolysaccharide Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Chemotaxis, Immunity

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168961-MONOMER.
ReactomeiR-HSA-451927. Interleukin-2 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-9
Short name:
Gal-9
Alternative name(s):
Ecalectin
Tumor antigen HOM-HD-21
Gene namesi
Name:LGALS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6570. LGALS9.

Subcellular locationi

Isoform 2 :
Isoform 3 :

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • intracellular Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3965.
OpenTargetsiENSG00000168961.
PharmGKBiPA30347.

Chemistry databases

ChEMBLiCHEMBL5474.

Polymorphism and mutation databases

BioMutaiLGALS9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769461 – 355Galectin-9Add BLAST355

Proteomic databases

EPDiO00182.
MaxQBiO00182.
PaxDbiO00182.
PeptideAtlasiO00182.
PRIDEiO00182.

PTM databases

iPTMnetiO00182.
PhosphoSitePlusiO00182.

Expressioni

Tissue specificityi

Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525).3 Publications

Inductioni

By toll-like receptor ligands zymosan (TLR2 ligand), polyinosinic:polycytidylic acid (poly I:C) (TLR3 ligand) and lipopolysaccharides (LPS) (TLR4 ligand) and by proinflammatory cytokines IFNG, TNFA, IL1A and IL1B in mesenchymal stromal cells (PubMed:23817958). By IFNG in macrophages (PubMed:20209097). Up-regulated in dendritic cells following infection with dengue virus (PubMed:25754930). Up-regulated in Kupffer cells following infection with hepatitis C virus (PubMed:20209097). Up-regulated in plasma following infection with HIV-1 (PubMed:24786365).4 Publications

Gene expression databases

BgeeiENSG00000168961.
CleanExiHS_LGALS9.
ExpressionAtlasiO00182. baseline and differential.
GenevisibleiO00182. HS.

Organism-specific databases

HPAiHPA046876.
HPA047218.

Interactioni

Subunit structurei

Monomer.2 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110156. 78 interactors.
IntActiO00182. 13 interactors.
STRINGi9606.ENSP00000378856.

Chemistry databases

BindingDBiO00182.

Structurei

Secondary structure

1355
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 7Combined sources3
Beta strandi10 – 12Combined sources3
Beta strandi15 – 20Combined sources6
Beta strandi30 – 37Combined sources8
Beta strandi39 – 41Combined sources3
Beta strandi43 – 56Combined sources14
Beta strandi58 – 65Combined sources8
Beta strandi71 – 78Combined sources8
Beta strandi86 – 89Combined sources4
Beta strandi98 – 105Combined sources8
Beta strandi107 – 114Combined sources8
Beta strandi117 – 123Combined sources7
Helixi128 – 130Combined sources3
Beta strandi133 – 146Combined sources14
Beta strandi193 – 198Combined sources6
Beta strandi208 – 215Combined sources8
Beta strandi225 – 230Combined sources6
Beta strandi240 – 247Combined sources8
Beta strandi253 – 260Combined sources8
Beta strandi263 – 271Combined sources9
Turni272 – 275Combined sources4
Beta strandi276 – 283Combined sources8
Beta strandi295 – 297Combined sources3
Beta strandi305 – 312Combined sources8
Beta strandi314 – 321Combined sources8
Beta strandi324 – 330Combined sources7
Helixi336 – 338Combined sources3
Beta strandi341 – 354Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EAKX-ray1.97A/B/C1-148[»]
2EALX-ray1.85A/B1-148[»]
2YY1X-ray2.17A1-147[»]
2ZHKX-ray1.80A/B1-148[»]
2ZHLX-ray1.75A/B/C/D1-148[»]
2ZHMX-ray1.84A/B/C/D1-148[»]
2ZHNX-ray1.30A1-148[»]
3LSDX-ray2.03A6-148[»]
3LSEX-ray2.69A6-148[»]
3NV1X-ray1.50A218-355[»]
3NV2X-ray2.34A218-355[»]
3NV3X-ray1.57A218-355[»]
3NV4X-ray1.99A218-355[»]
3WLUX-ray1.40A/B/C/D5-148[»]
3WV6X-ray1.95A/B1-148[»]
A/B210-355[»]
ProteinModelPortaliO00182.
SMRiO00182.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00182.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 148Galectin 1PROSITE-ProRule annotationAdd BLAST132
Domaini227 – 355Galectin 2PROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 88Beta-galactoside binding 17
Regioni287 – 293Beta-galactoside binding 2By similarity7

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiO00182.
KOiK10093.
OMAiERYATYA.
OrthoDBiEOG091G0WP8.
PhylomeDBiO00182.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O00182-1) [UniParc]FASTAAdd to basket
Also known as: Long, Gal-9FL1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSGSQAPY LSPAVPFSGT IQGGLQDGLQ ITVNGTVLSS SGTRFAVNFQ
60 70 80 90 100
TGFSGNDIAF HFNPRFEDGG YVVCNTRQNG SWGPEERKTH MPFQKGMPFD
110 120 130 140 150
LCFLVQSSDF KVMVNGILFV QYFHRVPFHR VDTISVNGSV QLSYISFQNP
160 170 180 190 200
RTVPVQPAFS TVPFSQPVCF PPRPRGRRQK PPGVWPANPA PITQTVIHTV
210 220 230 240 250
QSAPGQMFST PAIPPMMYPH PAYPMPFITT ILGGLYPSKS ILLSGTVLPS
260 270 280 290 300
AQRFHINLCS GNHIAFHLNP RFDENAVVRN TQIDNSWGSE ERSLPRKMPF
310 320 330 340 350
VRGQSFSVWI LCEAHCLKVA VDGQHLFEYY HRLRNLPTIN RLEVGGDIQL

THVQT
Length:355
Mass (Da):39,518
Last modified:July 15, 1998 - v2
Checksum:i4748C22FCAFA536A
GO
Isoform 2 (identifier: O00182-2) [UniParc]FASTAAdd to basket
Also known as: Medium, Gal-9delta51 Publication, D51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     149-180: Missing.

Show »
Length:323
Mass (Da):35,888
Checksum:i1A3EB2941FC7F377
GO
Isoform 3 (identifier: O00182-3) [UniParc]FASTAAdd to basket
Also known as: Short, Gal-9delta5/61 Publication, D5/61 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     149-180: Missing.
     181-192: Missing.

Show »
Length:311
Mass (Da):34,691
Checksum:i3D00232FE39D776C
GO
Isoform 4 (identifier: O00182-4) [UniParc]FASTAAdd to basket
Also known as: Gal-9delta5/101 Publication, D5/101 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     149-180: Missing.
     254-355: FHINLCSGNH...GDIQLTHVQT → CGSCVKLTASRWPWMVSTCLNTTIA

Show »
Length:246
Mass (Da):26,777
Checksum:i414EB1F6493EE81E
GO
Isoform 5 (identifier: O00182-5) [UniParc]FASTAAdd to basket
Also known as: Gal-9delta5/6/101 Publication, D5/6/101 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     149-180: Missing.
     181-192: Missing.
     254-355: FHINLCSGNH...GDIQLTHVQT → CGSCVKLTASRWPWMVSTCLNTTIA

Show »
Length:234
Mass (Da):25,579
Checksum:i29B8BF54B3F32BC3
GO
Isoform 6 (identifier: O00182-6) [UniParc]FASTAAdd to basket
Also known as: D61 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     181-192: Missing.

Show »
Length:343
Mass (Da):38,321
Checksum:i79BEC0B506CFA9DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48N → D in CAB93851 (Ref. 6) Curated1
Sequence conflicti79 – 81NGS → KGR in CAB93851 (Ref. 6) Curated3
Sequence conflicti88K → R in CAA88922 (PubMed:9045665).Curated1
Sequence conflicti89T → M in CAB93851 (Ref. 6) Curated1
Sequence conflicti93F → S in BAD96952 (Ref. 7) Curated1
Sequence conflicti135S → F in CAA88922 (PubMed:9045665).Curated1
Sequence conflicti270P → L in CAA88922 (PubMed:9045665).Curated1
Sequence conflicti313E → G in CAA88922 (PubMed:9045665).Curated1
Sequence conflicti326L → V in CAB93851 (Ref. 6) Curated1
Sequence conflicti341R → K in CAB93851 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0204535G → S.2 PublicationsCorresponds to variant rs3751093dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003096149 – 180Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 5 Publications1 PublicationAdd BLAST32
Alternative sequenceiVSP_057842181 – 192Missing in isoform 3, isoform 5 and isoform 6. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_057843254 – 355FHINL…THVQT → CGSCVKLTASRWPWMVSTCL NTTIA in isoform 4 and isoform 5. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49107 mRNA. Translation: CAA88922.1.
AB006782 mRNA. Translation: BAA22166.1.
AB005894 mRNA. Translation: BAA31542.1.
AB003517 mRNA. Translation: BAF76327.1.
AB008492 mRNA. Translation: BAF76328.1.
AB040130 Genomic DNA. Translation: BAB83623.1.
AB040130 Genomic DNA. Translation: BAB83625.1.
AB040130 Genomic DNA. Translation: BAB83624.1.
AJ288083
, AJ288084, AJ288085, AJ288086, AJ288087, AJ288088, AJ288089, AJ288090 Genomic DNA. Translation: CAB93851.1.
AK223232 mRNA. Translation: BAD96952.1.
AC015688 Genomic DNA. No translation available.
CH471159 Genomic DNA. Translation: EAW51037.1.
CH471159 Genomic DNA. Translation: EAW51038.1.
CH471159 Genomic DNA. Translation: EAW51039.1.
CH471159 Genomic DNA. Translation: EAW51044.1.
BC105942 mRNA. Translation: AAI05943.1.
BC105944 mRNA. Translation: AAI05945.1.
BC110340 mRNA. Translation: AAI10341.1.
CCDSiCCDS11222.1. [O00182-1]
CCDS32592.1. [O00182-2]
CCDS82093.1. [O00182-4]
RefSeqiNP_001317092.1. NM_001330163.1.
NP_002299.2. NM_002308.3. [O00182-2]
NP_033665.1. NM_009587.2. [O00182-1]
XP_006721955.1. XM_006721892.2. [O00182-3]
XP_006721958.1. XM_006721895.3. [O00182-5]
XP_016880112.1. XM_017024623.1. [O00182-6]
UniGeneiHs.81337.

Genome annotation databases

EnsembliENST00000302228; ENSP00000306228; ENSG00000168961. [O00182-2]
ENST00000313648; ENSP00000318214; ENSG00000168961. [O00182-4]
ENST00000395473; ENSP00000378856; ENSG00000168961. [O00182-1]
GeneIDi3965.
KEGGihsa:3965.
UCSCiuc002gzp.4. human. [O00182-1]
uc060cvd.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49107 mRNA. Translation: CAA88922.1.
AB006782 mRNA. Translation: BAA22166.1.
AB005894 mRNA. Translation: BAA31542.1.
AB003517 mRNA. Translation: BAF76327.1.
AB008492 mRNA. Translation: BAF76328.1.
AB040130 Genomic DNA. Translation: BAB83623.1.
AB040130 Genomic DNA. Translation: BAB83625.1.
AB040130 Genomic DNA. Translation: BAB83624.1.
AJ288083
, AJ288084, AJ288085, AJ288086, AJ288087, AJ288088, AJ288089, AJ288090 Genomic DNA. Translation: CAB93851.1.
AK223232 mRNA. Translation: BAD96952.1.
AC015688 Genomic DNA. No translation available.
CH471159 Genomic DNA. Translation: EAW51037.1.
CH471159 Genomic DNA. Translation: EAW51038.1.
CH471159 Genomic DNA. Translation: EAW51039.1.
CH471159 Genomic DNA. Translation: EAW51044.1.
BC105942 mRNA. Translation: AAI05943.1.
BC105944 mRNA. Translation: AAI05945.1.
BC110340 mRNA. Translation: AAI10341.1.
CCDSiCCDS11222.1. [O00182-1]
CCDS32592.1. [O00182-2]
CCDS82093.1. [O00182-4]
RefSeqiNP_001317092.1. NM_001330163.1.
NP_002299.2. NM_002308.3. [O00182-2]
NP_033665.1. NM_009587.2. [O00182-1]
XP_006721955.1. XM_006721892.2. [O00182-3]
XP_006721958.1. XM_006721895.3. [O00182-5]
XP_016880112.1. XM_017024623.1. [O00182-6]
UniGeneiHs.81337.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EAKX-ray1.97A/B/C1-148[»]
2EALX-ray1.85A/B1-148[»]
2YY1X-ray2.17A1-147[»]
2ZHKX-ray1.80A/B1-148[»]
2ZHLX-ray1.75A/B/C/D1-148[»]
2ZHMX-ray1.84A/B/C/D1-148[»]
2ZHNX-ray1.30A1-148[»]
3LSDX-ray2.03A6-148[»]
3LSEX-ray2.69A6-148[»]
3NV1X-ray1.50A218-355[»]
3NV2X-ray2.34A218-355[»]
3NV3X-ray1.57A218-355[»]
3NV4X-ray1.99A218-355[»]
3WLUX-ray1.40A/B/C/D5-148[»]
3WV6X-ray1.95A/B1-148[»]
A/B210-355[»]
ProteinModelPortaliO00182.
SMRiO00182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110156. 78 interactors.
IntActiO00182. 13 interactors.
STRINGi9606.ENSP00000378856.

Chemistry databases

BindingDBiO00182.
ChEMBLiCHEMBL5474.

PTM databases

iPTMnetiO00182.
PhosphoSitePlusiO00182.

Polymorphism and mutation databases

BioMutaiLGALS9.

Proteomic databases

EPDiO00182.
MaxQBiO00182.
PaxDbiO00182.
PeptideAtlasiO00182.
PRIDEiO00182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302228; ENSP00000306228; ENSG00000168961. [O00182-2]
ENST00000313648; ENSP00000318214; ENSG00000168961. [O00182-4]
ENST00000395473; ENSP00000378856; ENSG00000168961. [O00182-1]
GeneIDi3965.
KEGGihsa:3965.
UCSCiuc002gzp.4. human. [O00182-1]
uc060cvd.1. human.

Organism-specific databases

CTDi3965.
DisGeNETi3965.
GeneCardsiLGALS9.
HGNCiHGNC:6570. LGALS9.
HPAiHPA046876.
HPA047218.
MIMi601879. gene.
neXtProtiNX_O00182.
OpenTargetsiENSG00000168961.
PharmGKBiPA30347.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiO00182.
KOiK10093.
OMAiERYATYA.
OrthoDBiEOG091G0WP8.
PhylomeDBiO00182.
TreeFamiTF315551.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168961-MONOMER.
ReactomeiR-HSA-451927. Interleukin-2 signaling.

Miscellaneous databases

ChiTaRSiLGALS9. human.
EvolutionaryTraceiO00182.
GeneWikiiLGALS9.
GenomeRNAii3965.
PROiO00182.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168961.
CleanExiHS_LGALS9.
ExpressionAtlasiO00182. baseline and differential.
GenevisibleiO00182. HS.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEG9_HUMAN
AccessioniPrimary (citable) accession number: O00182
Secondary accession number(s): A7VJG6
, F8W9W4, O14532, O75028, Q3B8N1, Q53FQ0, Q8WYQ7, Q9NQ58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.