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O00180

- KCNK1_HUMAN

UniProt

O00180 - KCNK1_HUMAN

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Protein

Potassium channel subfamily K member 1

Gene
KCNK1, HOHO1, KCNO1, TWIK1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Weakly inward rectifying potassium channel.1 Publication

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: ProtInc

GO - Biological processi

  1. potassium ion transport Source: ProtInc
  2. response to nicotine Source: Ensembl
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 1
Alternative name(s):
Inward rectifying potassium channel protein TWIK-1
Potassium channel KCNO1
Gene namesi
Name:KCNK1
Synonyms:HOHO1, KCNO1, TWIK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6272. KCNK1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei21 – 4121Helical; Reviewed predictionAdd
BLAST
Intramembranei104 – 13027Pore-forming; Name=Pore-forming 1; Reviewed predictionAdd
BLAST
Transmembranei133 – 15321Helical; Reviewed predictionAdd
BLAST
Topological domaini154 – 17724Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei178 – 19821Helical; Reviewed predictionAdd
BLAST
Intramembranei212 – 23827Pore-forming; Name=Pore-forming 2; Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Reviewed predictionAdd
BLAST
Topological domaini268 – 33669Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. brush border membrane Source: Ensembl
  3. endosome Source: Ensembl
  4. plasma membrane Source: Reactome
  5. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi161 – 1611T → A: No effect on channel activity. 1 Publication

Organism-specific databases

PharmGKBiPA219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Potassium channel subfamily K member 1PRO_0000101740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 – 69Interchain1 Publication
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO00180.
PaxDbiO00180.
PRIDEiO00180.

PTM databases

PhosphoSiteiO00180.

Expressioni

Tissue specificityi

Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney.

Gene expression databases

ArrayExpressiO00180.
BgeeiO00180.
CleanExiHS_KCNK1.
GenevestigatoriO00180.

Organism-specific databases

HPAiCAB022588.
HPA016049.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

BioGridi109976. 4 interactions.
DIPiDIP-59532N.
IntActiO00180. 1 interaction.
STRINGi9606.ENSP00000355580.

Structurei

Secondary structure

1
336
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 6648
Helixi72 – 8615
Turni87 – 893
Helixi104 – 11512
Helixi128 – 16033
Turni163 – 1675
Helixi177 – 19519
Helixi197 – 20610
Beta strandi207 – 2093
Helixi212 – 22312
Beta strandi236 – 2383
Helixi242 – 26827
Helixi271 – 2788

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UKMX-ray3.40A/B/C/D19-288[»]
ProteinModelPortaliO00180.
SMRiO00180. Positions 19-281.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
InParanoidiO00180.
KOiK04912.
OMAiKQLRKMF.
OrthoDBiEOG7TTQ85.
PhylomeDBiO00180.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR001779. 2pore_dom_K_chnl_TWIK1.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01096. TWIK1CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

O00180-1 [UniParc]FASTAAdd to Basket

« Hide

MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED    50
LLRQELRKLK RRFLEEHECL SEQQLEQFLG RVLEASNYGV SVLSNASGNW 100
NWDFTSALFF ASTVLSTTGY GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT 150
AVVQRITVHV TRRPVLYFHI RWGFSKQVVA IVHAVLLGFV TVSCFFFIPA 200
AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK FRELYKIGIT 250
CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDQ VHIIEHDQLS 300
FSSITDQAAG MKEDQKQNEP FVATQSSACV DGPANH 336
Length:336
Mass (Da):38,143
Last modified:July 1, 1997 - v1
Checksum:i2A41D9501323215D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33632 mRNA. Translation: AAB01688.1.
U76996 mRNA. Translation: AAB97878.1.
U90065 mRNA. Translation: AAB51147.1.
AL356357 Genomic DNA. Translation: CAI21792.1.
CH471098 Genomic DNA. Translation: EAW69989.1.
BC018051 mRNA. Translation: AAH18051.1.
CCDSiCCDS1599.1.
PIRiS65566.
RefSeqiNP_002236.1. NM_002245.3.
UniGeneiHs.208544.

Genome annotation databases

EnsembliENST00000366621; ENSP00000355580; ENSG00000135750.
GeneIDi3775.
KEGGihsa:3775.
UCSCiuc010pxo.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33632 mRNA. Translation: AAB01688.1 .
U76996 mRNA. Translation: AAB97878.1 .
U90065 mRNA. Translation: AAB51147.1 .
AL356357 Genomic DNA. Translation: CAI21792.1 .
CH471098 Genomic DNA. Translation: EAW69989.1 .
BC018051 mRNA. Translation: AAH18051.1 .
CCDSi CCDS1599.1.
PIRi S65566.
RefSeqi NP_002236.1. NM_002245.3.
UniGenei Hs.208544.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UKM X-ray 3.40 A/B/C/D 19-288 [» ]
ProteinModelPortali O00180.
SMRi O00180. Positions 19-281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109976. 4 interactions.
DIPi DIP-59532N.
IntActi O00180. 1 interaction.
STRINGi 9606.ENSP00000355580.

Chemistry

DrugBanki DB00308. Ibutilide.
DB00908. Quinidine.

PTM databases

PhosphoSitei O00180.

Proteomic databases

MaxQBi O00180.
PaxDbi O00180.
PRIDEi O00180.

Protocols and materials databases

DNASUi 3775.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366621 ; ENSP00000355580 ; ENSG00000135750 .
GeneIDi 3775.
KEGGi hsa:3775.
UCSCi uc010pxo.1. human.

Organism-specific databases

CTDi 3775.
GeneCardsi GC01P233750.
HGNCi HGNC:6272. KCNK1.
HPAi CAB022588.
HPA016049.
MIMi 601745. gene.
neXtProti NX_O00180.
PharmGKBi PA219.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000286014.
HOVERGENi HBG052237.
InParanoidi O00180.
KOi K04912.
OMAi KQLRKMF.
OrthoDBi EOG7TTQ85.
PhylomeDBi O00180.
TreeFami TF313947.

Enzyme and pathway databases

Reactomei REACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Miscellaneous databases

ChiTaRSi KCNK1. human.
GeneWikii KCNK1.
GenomeRNAii 3775.
NextBioi 14807.
PROi O00180.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00180.
Bgeei O00180.
CleanExi HS_KCNK1.
Genevestigatori O00180.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR001779. 2pore_dom_K_chnl_TWIK1.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSi PR01333. 2POREKCHANEL.
PR01096. TWIK1CHANNEL.
PR01586. TWIKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure."
    Lesage F., Guillemare E., Fink M., Duprat F., Lazdunski M., Romey G., Barhanin J.
    EMBO J. 15:1004-1011(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF THR-161.
    Tissue: Kidney.
  2. "Sequence and function of the two P domain potassium channels: implications of an emerging superfamily."
    Goldstein S.A.N., Wang K.-W., Ilan N., Pausch M.H.
    J. Mol. Med. 76:13-20(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], REVIEW.
    Tissue: Brain.
  3. "Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments."
    Orias M., Velazquez H., Tung F., Lee G., Desir G.V.
    Am. J. Physiol. 273:F663-F666(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Crystal structure of the human two-pore domain potassium channel K2P1."
    Miller A.N., Long S.B.
    Science 335:432-436(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 23-288, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiKCNK1_HUMAN
AccessioniPrimary (citable) accession number: O00180
Secondary accession number(s): Q13307, Q5T5E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inhibited by barium, quinine, quinidine and internal acidification. Activated by protein kinase C.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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