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Protein

GTP-binding protein 1

Gene

GTPBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 174GTPSequence analysis8
Nucleotide bindingi252 – 256GTPSequence analysis5
Nucleotide bindingi308 – 311GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: ProtInc
  • poly(A) RNA binding Source: UniProtKB
  • translation elongation factor activity Source: GO_Central

GO - Biological processi

  • immune response Source: ProtInc
  • positive regulation of mRNA catabolic process Source: UniProtKB
  • signal transduction Source: ProtInc
  • translational elongation Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100226-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 1
Short name:
G-protein 1
Short name:
GP-1
Short name:
GP1
Gene namesi
Name:GTPBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:4669. GTPBP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic exosome (RNase complex) Source: UniProtKB
  • cytosol Source: UniProtKB
  • intracellular Source: GO_Central
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9567.
OpenTargetsiENSG00000100226.
PharmGKBiPA29057.

Polymorphism and mutation databases

BioMutaiGTPBP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224691 – 669GTP-binding protein 1Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei24PhosphoserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei580PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00178.
MaxQBiO00178.
PaxDbiO00178.
PeptideAtlasiO00178.
PRIDEiO00178.

PTM databases

iPTMnetiO00178.
PhosphoSitePlusiO00178.

Expressioni

Gene expression databases

BgeeiENSG00000100226.
CleanExiHS_GTPBP1.
ExpressionAtlasiO00178. baseline and differential.
GenevisibleiO00178. HS.

Organism-specific databases

HPAiHPA003166.
HPA064702.

Interactioni

Subunit structurei

Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity).By similarity

Protein-protein interaction databases

BioGridi114937. 32 interactors.
IntActiO00178. 14 interactors.
MINTiMINT-7944705.
STRINGi9606.ENSP00000216044.

Structurei

3D structure databases

ProteinModelPortaliO00178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 389tr-type GPROSITE-ProRule annotationAdd BLAST232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni167 – 174G1PROSITE-ProRule annotation8
Regioni206 – 210G2PROSITE-ProRule annotation5
Regioni252 – 255G3PROSITE-ProRule annotation4
Regioni308 – 311G4PROSITE-ProRule annotation4
Regioni366 – 368G5PROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 36Poly-Ala9

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
HOVERGENiHBG004471.
InParanoidiO00178.
OMAiPPGDEAC.
OrthoDBiEOG091G06LY.
PhylomeDBiO00178.
TreeFamiTF350446.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATERSRSAM DSPVPASMFA PEPSSPGAAR AAAAAARLHG GFDSDCSEDG
60 70 80 90 100
EALNGEPELD LTSKLVLVSP TSEQYDSLLR QMWERMDEGC GETIYVIGQG
110 120 130 140 150
SDGTEYGLSE ADMEASYATV KSMAEQIEAD VILLRERQEA GGRVRDYLVR
160 170 180 190 200
KRVGDNDFLE VRVAVVGNVD AGKSTLLGVL THGELDNGRG FARQKLFRHK
210 220 230 240 250
HEIESGRTSS VGNDILGFDS EGNVVNKPDS HGGSLEWTKI CEKSTKVITF
260 270 280 290 300
IDLAGHEKYL KTTVFGMTGH LPDFCMLMVG SNAGIVGMTK EHLGLALALN
310 320 330 340 350
VPVFVVVTKI DMCPANILQE TLKLLQRLLK SPGCRKIPVL VQSKDDVIVT
360 370 380 390 400
ASNFSSERMC PIFQISNVTG ENLDLLKMFL NLLSPRTSYR EEEPAEFQID
410 420 430 440 450
DTYSVPGVGT VVSGTTLRGL IKLNDTLLLG PDPLGNFLSI AVKSIHRKRM
460 470 480 490 500
PVKEVRGGQT ASFALKKIKR SSIRKGMVMV SPRLNPQASW EFEAEILVLH
510 520 530 540 550
HPTTISPRYQ AMVHCGSIRQ TATILSMDKD CLRTGDKATV HFRFIKTPEY
560 570 580 590 600
LHIDQRLVFR EGRTKAVGTI TKLLQTTNNS PMNSKPQQIK MQSTKKGPLT
610 620 630 640 650
KRDEGGPSGG PAVGAPPPGD EASSVGAGQP AASSNLQPQP KPSSGGRRRG
660
GQRHKVKSQG ACVTPASGC
Length:669
Mass (Da):72,454
Last modified:July 10, 2007 - v3
Checksum:i0814F4DC03740ABE
GO

Sequence cautioni

The sequence AAB51273 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG30387 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04949691G → R.Corresponds to variant rs11547402dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021707 Genomic DNA. Translation: CAI21603.2.
BC014075 mRNA. Translation: AAH14075.3.
CR456501 mRNA. Translation: CAG30387.1. Different initiation.
U87964 mRNA. Translation: AAB51273.1. Different initiation.
CCDSiCCDS13977.2.
PIRiJC5291.
RefSeqiNP_004277.2. NM_004286.4.
UniGeneiHs.276925.

Genome annotation databases

EnsembliENST00000216044; ENSP00000216044; ENSG00000100226.
GeneIDi9567.
KEGGihsa:9567.
UCSCiuc003awg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021707 Genomic DNA. Translation: CAI21603.2.
BC014075 mRNA. Translation: AAH14075.3.
CR456501 mRNA. Translation: CAG30387.1. Different initiation.
U87964 mRNA. Translation: AAB51273.1. Different initiation.
CCDSiCCDS13977.2.
PIRiJC5291.
RefSeqiNP_004277.2. NM_004286.4.
UniGeneiHs.276925.

3D structure databases

ProteinModelPortaliO00178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114937. 32 interactors.
IntActiO00178. 14 interactors.
MINTiMINT-7944705.
STRINGi9606.ENSP00000216044.

PTM databases

iPTMnetiO00178.
PhosphoSitePlusiO00178.

Polymorphism and mutation databases

BioMutaiGTPBP1.

Proteomic databases

EPDiO00178.
MaxQBiO00178.
PaxDbiO00178.
PeptideAtlasiO00178.
PRIDEiO00178.

Protocols and materials databases

DNASUi9567.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216044; ENSP00000216044; ENSG00000100226.
GeneIDi9567.
KEGGihsa:9567.
UCSCiuc003awg.4. human.

Organism-specific databases

CTDi9567.
DisGeNETi9567.
GeneCardsiGTPBP1.
H-InvDBHIX0016477.
HGNCiHGNC:4669. GTPBP1.
HPAiHPA003166.
HPA064702.
MIMi602245. gene.
neXtProtiNX_O00178.
OpenTargetsiENSG00000100226.
PharmGKBiPA29057.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
HOVERGENiHBG004471.
InParanoidiO00178.
OMAiPPGDEAC.
OrthoDBiEOG091G06LY.
PhylomeDBiO00178.
TreeFamiTF350446.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100226-MONOMER.

Miscellaneous databases

ChiTaRSiGTPBP1. human.
GeneWikiiGTPBP1.
GenomeRNAii9567.
PROiO00178.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100226.
CleanExiHS_GTPBP1.
ExpressionAtlasiO00178. baseline and differential.
GenevisibleiO00178. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTPB1_HUMAN
AccessioniPrimary (citable) accession number: O00178
Secondary accession number(s): Q6IC67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.